Home Other Building Blocks 1333146-24-9
1333146-24-9,MFCD29472239
Catalog No.:AA009CFP

1333146-24-9 | ILK-IN-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$24.00   $17.00
- +
5mg
98+%
in stock  
$57.00   $40.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CFP
Chemical Name:
ILK-IN-1
CAS Number:
1333146-24-9
Molecular Formula:
C30H30F3N5O
Molecular Weight:
533.5873
MDL Number:
MFCD29472239
SMILES:
CNC(=O)CCc1nn(c(c1)c1ccc(cc1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)N1CCNCC1
Properties
Computed Properties
 
Complexity:
767  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5.1  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2011,vol.54,p.6364-6374

Literature

Title: Identification and characterization of a novel integrin-linked kinase inhibitor.

Journal: Journal of medicinal chemistry 20110922

Title: Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma.

Journal: PloS one 20110101

Title: Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

Journal: Oncogene 20100610

Title: Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma.

Journal: Virchows Archiv : an international journal of pathology 20100301

Title: ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway.

Journal: The Journal of pathology 20060101

Title: Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid.

Journal: The Journal of pathology 20031001

Title: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.

Journal: The Journal of biological chemistry 20030620

Title: Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma.

Journal: Virchows Archiv : an international journal of pathology 20030201

Title: Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase.

Journal: The Biochemical journal 20021015

Title: Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.

Journal: The Journal of biological chemistry 20010720

Title: Integrin-linked kinase expression increases with prostate tumor grade.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010701

Title: Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase.

Journal: The Journal of biological chemistry 20010511

Title: Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20000328

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19980915

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SDS
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