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133407-86-0,MFCD00671410
Catalog No.:AA01E12Y

133407-86-0 | MG-115

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1mg
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5mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E12Y
Chemical Name:
MG-115
CAS Number:
133407-86-0
Molecular Formula:
C25H39N3O5
Molecular Weight:
461.5943
MDL Number:
MFCD00671410
SMILES:
CCCC(NC(=O)C(NC(=O)C(NC(=O)OCc1ccccc1)CC(C)C)CC(C)C)C=O
Properties
Computed Properties
 
Complexity:
617  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
15  
XLogP3:
4.4  

Literature

Title: Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.

Journal: Parasitology 20110801

Title: Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway.

Journal: Physiological genomics 20110601

Title: Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.

Journal: Oncology 20110101

Title: DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.

Journal: Chemical research in toxicology 20100719

Title: Activation of PERK kinase in neural cells by proteasome inhibitor treatment.

Journal: Journal of neurochemistry 20100101

Title: EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis.

Journal: Molecular cancer 20100101

Title: Capillary electrophoresis for screening of 20S proteasome inhibitors.

Journal: Analytical biochemistry 20091101

Title: Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades.

Journal: Journal of cellular physiology 20090801

Title: Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation.

Journal: Journal of neurochemistry 20090101

Title: Steroidogenic acute regulatory protein gene expression, steroid-hormone secretion and proliferative activity of adrenocortical cells in the presence of proteasome inhibitors: in vivo studies on the regenerating rat adrenal cortex.

Journal: International journal of molecular medicine 20080501

Title: A novel class of intrinsic proteasome inhibitory gene transfer peptides.

Journal: Bioconjugate chemistry 20080101

Title: Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus.

Journal: Developmental biology 20070801

Title: Effects of proteasome inhibitors on fertilization of the sea urchin Anthocidaris crassispina.

Journal: Biological & pharmaceutical bulletin 20070701

Title: Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27.

Journal: Oncology 20070101

Title: Accumulation of steroidogenic acute regulatory protein mRNA, and decrease in the secretory and proliferative activity of rat adrenocortical cells in the presence of proteasome inhibitors.

Journal: International journal of molecular medicine 20060501

Title: Proteasome inhibition sensitizes hepatocellular carcinoma cells to TRAIL by suppressing caspase inhibitors and AKT pathway.

Journal: Anti-cancer drugs 20060301

Title: Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.

Journal: Experimental cell research 20060215

Title: Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappaB.

Journal: Antiviral therapy 20060101

Title: The proteasome metabolizes peptide-mediated nonviral gene delivery systems.

Journal: Gene therapy 20051101

Title: Proteasome comprising a beta1 inducible subunit acts as a negative regulator of NADPH oxidase during elicitation of plant defense reactions.

Journal: FEBS letters 20050829

Title: Schistosoma mansoni: functional proteasomes are required for development in the vertebrate host.

Journal: Experimental parasitology 20050401

Title: Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.

Journal: Molecular and cellular biochemistry 20050101

Title: Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures.

Journal: Journal of neurochemistry 20041201

Title: Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

Journal: Toxicology and applied pharmacology 20040915

Title: Estrogen increases proteasome activity in murine microglial cells.

Journal: Neuroscience letters 20040826

Title: Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.

Journal: Journal of cellular biochemistry 20040701

Title: Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells.

Journal: Molecular pharmacology 20040201

Title: Nuclear factor-kappaB contributes to interleukin-4- and interferon-dependent polymeric immunoglobulin receptor expression in human intestinal epithelial cells.

Journal: Immunology 20040101

Title: Proteasome inhibitors and their combination with antiandrogens: effects on apoptosis, cellular proliferation and viability of prostatic adenocarcinoma cell cultures.

Journal: Prostate cancer and prostatic diseases 20040101

Title: Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

Journal: Cytokine 20031107

Title: Caspase-3-dependent apoptosis in vascular smooth muscle cell by proteasome inhibition.

Journal: Journal of cardiovascular pharmacology 20031001

Title: Participation of proteasomes in Xenopus embryogenesis.

Journal: Journal of biochemistry 20030901

Title: Characterization of chronic low-level proteasome inhibition on neural homeostasis.

Journal: Journal of neurochemistry 20030701

Title: Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells.

Journal: Hepatology (Baltimore, Md.) 20030601

Title: Activation of multiple caspases and modification of cell surface fas (CD95) in proteasome inhibitor-induced apoptosis of rat natural killer cells.

Journal: Journal of cellular biochemistry 20030215

Title: Involvement of the proteasome in IL-1beta induced suppression of islets of Langerhans in the rat.

Journal: Upsala journal of medical sciences 20030101

Title: Relationship of Mcl-1 isoforms, ratio p21WAF1/cyclin A, and Jun kinase phosphorylation to apoptosis in human breast carcinomas.

Journal: Biochemical and biophysical research communications 20021004

Title: Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi.

Journal: Molecular reproduction and development 20020601

Title: Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.

Journal: Journal of neurochemistry 20010501

Title: Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.

Journal: Biochemical pharmacology 20010401

Title: Proteasome inhibitors sensitize human vascular smooth muscle cells to Fas (CD95)-mediated death.

Journal: Biochemical and biophysical research communications 20010223

Title: Apoptosis in caspase-inhibited neurons.

Journal: Molecular medicine (Cambridge, Mass.) 20010101

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Tags:133407-86-0 Molecular Formula|133407-86-0 MDL|133407-86-0 SMILES|133407-86-0 MG-115