Home Other Building Blocks 133550-34-2
133550-34-2,MFCD00209865
Catalog No.:AA0080D7

133550-34-2 | AG 555

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Purity
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1mg
98%
in stock  
$9.00   $7.00
- +
5mg
98%
in stock  
$21.00   $15.00
- +
10mg
98%
in stock  
$32.00   $22.00
- +
50mg
98%
in stock  
$78.00   $55.00
- +
100mg
98%
in stock  
$124.00   $87.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0080D7
Chemical Name:
AG 555
CAS Number:
133550-34-2
Molecular Formula:
C19H18N2O3
Molecular Weight:
322.3578
MDL Number:
MFCD00209865
SMILES:
N#CC(=Cc1ccc(c(c1)O)O)C(=O)NCCCc1ccccc1
Properties
Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,1991,vol.34,p.1896-1907

[1]JournalofMedicinalChemistry,1991,vol.34,p.1896-1907

Literature

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081015

Title: S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.

Journal: The Journal of biological chemistry 20071019

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma.

Journal: Gene 20031127

Title: Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.

Journal: Journal of medicinal chemistry 20031023

Title: Tyrphostin AG 555 inhibits bovine papillomavirus transcription by changing the ratio between E2 transactivator/repressor function.

Journal: The Journal of biological chemistry 20030926

Title: Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.

Journal: Developmental cell 20020901

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.

Journal: Biochemistry 19951121

Title: Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.

Journal: Journal of medicinal chemistry 19910601

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SDS
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