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133920-06-6,MFCD02752403
Catalog No.:AA00804G

133920-06-6 | Benzene,(6-isothiocyanatohexyl)-

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Purity
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25mg
≥98%
2 weeks  
$306.00   $214.00
- +
100mg
≥98%
2 weeks  
$465.00   $326.00
- +
250mg
≥98%
2 weeks  
$816.00   $572.00
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500mg
≥98%
2 weeks  
$1,168.00   $817.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00804G
Chemical Name:
Benzene,(6-isothiocyanatohexyl)-
CAS Number:
133920-06-6
Molecular Formula:
C13H17NS
Molecular Weight:
219.3458
MDL Number:
MFCD02752403
SMILES:
S=C=NCCCCCCc1ccccc1
Properties
Computed Properties
 
Complexity:
191  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5.4  

Literature

Title: Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia.

Journal: Journal of hematology & oncology 20120101

Title: Cancer chemoprevention by targeting the epigenome.

Journal: Current drug targets 20111201

Title: [Inhibitory effect of phenylhexyl isothiocyanate on notch signaling of multiple myeloma cells in vitro].

Journal: Zhongguo shi yan xue ye xue za zhi 20110801

Title: Antileukemic activity of the leaf extract of Bischofia javanica blume on human leukemic cell lines.

Journal: Indian journal of pharmacology 20110401

Title: Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

Journal: Journal of medicinal chemistry 20110210

Title: [PHI regulates histone methylation and acetylation in Burkitt lymphoma Daudi cell line].

Journal: Zhongguo shi yan xue ye xue za zhi 20110201

Title: A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome.

Journal: Journal of hematology & oncology 20110101

Title: Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

Journal: Clinical epigenetics 20110101

Title: [Modulation of histone acetylation and induction of apoptosis in SMMC-7721 cells by phenylhexyl isothiocyanate].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20101101

Title: [Phenylhexyl isothiocyanate induces gene p15 re-expression by regulating histone methylation and DNA demethylation in Molt-4 cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20100601

Title: Phytochemicals in cancer prevention and therapy: truth or dare?

Journal: Toxins 20100401

Title: [Phenylhexyl isothiocyanate (PHI) regulates histone methylation and acetylation and induces apoptosis in SMMC-7721 cells].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100301

Title: Deficient histone acetylation in acute leukemia and the correction by an isothiocyanate.

Journal: Acta haematologica 20100101

Title: Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin.

Journal: Journal of hematology & oncology 20100101

Title: Regulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin.

Journal: Evidence-based complementary and alternative medicine : eCAM 20090601

Title: [Effect of phenylhexyl isothiocyanate on adriamycin resistance of K562/A02 cell line].

Journal: Zhongguo shi yan xue ye xue za zhi 20090401

Title: [Phenylhexyl isothiocyanate induces gene p15 demethylation by down-regulating DNA methyltransferases in Molt-4 cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090401

Title: New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer.

Journal: Journal of hematology & oncology 20090101

Title: [Phenylhexyl isothiocyanate reducing U266 cell line methylation level of p16 gene].

Journal: Zhongguo shi yan xue ye xue za zhi 20081001

Title: [Effect of phenylhexyl isothiocyanate on inducing apoptosis of multiple myeloma cells in vitro].

Journal: Zhongguo shi yan xue ye xue za zhi 20080201

Title: Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways.

Journal: Journal of hematology & oncology 20080101

Title: Effects of eleven isothiocyanates on P450 2A6- and 2A13-catalyzed coumarin 7-hydroxylation.

Journal: Chemical research in toxicology 20070901

Title: [Experiment study of PHI on histone methylation and acetylation in Molt-4 cells].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070901

Title: The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo.

Journal: Oncology reports 20061201

Title: Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells.

Journal: International journal of oncology 20060501

Title: Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells.

Journal: Anticancer research 20060101

Title: Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion.

Journal: Toxicology letters 20050315

Title: Inhibitory effects of 2-mercaptoethane sulfonate and 6-phenylhexyl isothiocyanate on urinary bladder tumorigenesis in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Journal: Cancer letters 20030410

Title: Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.

Journal: Pharmaceutical research 20021001

Title: Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

Journal: Chemical research in toxicology 20010901

Title: Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.

Journal: Cancer letters 20010110

Title: Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.

Journal: Journal of toxicology and environmental health. Part A 19991210

Title: Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

Journal: Cancer research 19980201

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