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133920-70-4,MFCD18089833
Catalog No.:AA00A1CX

133920-70-4 | FK 960

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00A1CX
Chemical Name:
FK 960
CAS Number:
133920-70-4
Molecular Formula:
C13H16FN3O2
Molecular Weight:
265.2834
MDL Number:
MFCD18089833
SMILES:
CC(=O)N1CCN(CC1)NC(=O)C2=CC=C(C=C2)F
Properties
Computed Properties
 
Complexity:
335  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
0.8  

Literature

Title: FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats.

Journal: European journal of pharmacology 20051219

Title: Increase by FK960, a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes.

Journal: Biochemical pharmacology 20040715

Title: Modulation of Ca2+ channel currents by a novel antidementia drug N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate (FK960) in rat hippocampal neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20040101

Title: The potential of activation of somatostatinergic neurotransmission with FK960 in Alzheimer's disease.

Journal: Expert opinion on investigational drugs 20040101

Title: Effect of N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate (FK960), an antidementia drug with a novel mechanism of action, on regional cerebral blood flow and glucose metabolism in aged rhesus macaques studied with positron emission tomography.

Journal: The Journal of pharmacology and experimental therapeutics 20030701

Title: Measurement of brain concentration of FK960 for development of a novel antidementia drug: a PET study in conscious rhesus monkeys.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030101

Title: The anti-dementia drug FK960 stimulates glial glutamate release via a PKA pathway.

Journal: Brain research. Molecular brain research 20021230

Title: FK960, a potential anti-dementia drug, increases synaptic density in the hippocampal CA3 region of aged rats.

Journal: Brain research 20021227

Title: Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats.

Journal: Pharmacology, biochemistry, and behavior 20021001

Title: Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission.

Journal: Brain research. Molecular brain research 20011216

Title: Effect of FK960, a putative cognitive enhancer, on synaptic transmission in CA1 neurons of rat hippocampus.

Journal: The Journal of pharmacology and experimental therapeutics 20010501

Title: FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices.

Journal: Brain research 20010216

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