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134-50-9,MFCD00012663
Catalog No.:AA009ALT

134-50-9 | Acridin-9-amine hydrochloride

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Technical Information
Catalog Number:
AA009ALT
Chemical Name:
Acridin-9-amine hydrochloride
CAS Number:
134-50-9
Molecular Formula:
C13H11ClN2
Molecular Weight:
230.6928
MDL Number:
MFCD00012663
SMILES:
Nc1c2ccccc2nc2c1cccc2.Cl
NSC Number:
7571
Properties
Computed Properties
 
Complexity:
207  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  

Literature

Title: Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160601

Title: Inhibition of the mutagenic effects of N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine by indenopyridines in the Salmonella typhimurium tester strain 1537 and E. coli.

Journal: Drug and chemical toxicology 20141001

Title: Studies on the inclusion behavior of 9-Aminoacridine into cyclodextrins: spectroscopic and theoretical evidences.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20130215

Title: Spectroscopic investigation on the interaction of 9-aminoacridine with certain dyes.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

Title: Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes.

Journal: Chemistry and physics of lipids 20120701

Title: Investigations on photoinduced interaction of 9-aminoacridine with certain catechols and rutin.

Journal: Journal of fluorescence 20120701

Title: Antigenotoxic properties of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine-induced mutagenesis.

Journal: Journal of biochemical and molecular toxicology 20120701

Title: 9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma.

Journal: Cancer chemotherapy and pharmacology 20120601

Title: Photoacoustic and luminescence characterization of nitrogen heterocyclic aromatic UV-MALDI matrices in solution.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120601

Title: Synthesis and biological evaluation of acridine derivatives as antimalarial agents.

Journal: ChemMedChem 20120401

Title: MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix.

Journal: Analytical chemistry 20120306

Title: Studying the interactions of a platinum(II) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS.

Journal: Dalton transactions (Cambridge, England : 2003) 20120107

Title: An investigation on the fluorescence quenching of 9-aminoacridine by certain pyrimidines.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101

Title: Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.

Journal: American journal of physiology. Cell physiology 20111001

Title: DNA cleavage activity of Fe(II)N4Py under photo irradiation in the presence of 1,8-naphthalimide and 9-aminoacridine: unexpected effects of reactive oxygen species scavengers.

Journal: Inorganic chemistry 20110905

Title: Protective effects of methanol extracts from Cladonia rangiformis and Umbilicaria vellea against known mutagens sodium azide and 9-aminoacridine.

Journal: Toxicology and industrial health 20110901

Title: Imaging of complex sulfatides SM3 and SB1a in mouse kidney using MALDI-TOF/TOF mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20110701

Title: Quinacrine and 9-amino acridine inhibit B-Z and B-H(l) form DNA conformational transitions.

Journal: DNA and cell biology 20110701

Title: The sequence selectivity of DNA-targeted 9-aminoacridine cisplatin analogues in a telomere-containing DNA sequence.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110601

Title: Microscale MALDI imaging of outer-layer lipids in intact egg chambers from Drosophila melanogaster.

Journal: Analytical chemistry 20110515

Title: Sphingomyelin is more sensitively detectable as a negative ion than phosphatidylcholine: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study using 9-aminoacridine (9-AA) as matrix.

Journal: Rapid communications in mass spectrometry : RCM 20110430

Title: Use of fluorescence lifetime technology to provide efficient protection from false hits in screening applications.

Journal: Analytical biochemistry 20110201

Title: Excited state properties of 9-amino acridine surface adsorbed onto αZr-phosphate particles.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110201

Title: Measurement of the ΔpH and electric field developed across Arabidopsis thylakoids in the light.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: Voltage-dependent and -independent block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor channels.

Journal: Journal of neurochemistry 20101201

Title: 9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays.

Journal: Chemical communications (Cambridge, England) 20101007

Title: Mononuclear Fe(II)-N4Py complexes in oxidative DNA cleavage: structure, activity and mechanism.

Journal: Dalton transactions (Cambridge, England : 2003) 20100914

Title: MALDI-TOF/MS analysis of archaebacterial lipids in lyophilized membranes dry-mixed with 9-aminoacridine.

Journal: Journal of lipid research 20100901

Title: Lipidomic analysis of porcine olfactory epithelial membranes and cilia.

Journal: Lipids 20100701

Title: Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix.

Journal: Journal of lipid research 20100601

Title: Significant sensitivity improvements by matrix optimization: a MALDI-TOF mass spectrometric study of lipids from hen egg yolk.

Journal: Chemistry and physics of lipids 20100601

Title: The intact muscle lipid composition of bulls: an investigation by MALDI-TOF MS and 31P NMR.

Journal: Chemistry and physics of lipids 20100201

Title: Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions.

Journal: BMC cancer 20100101

Title: Phosphatidylcholines and -ethanolamines can be easily mistaken in phospholipid mixtures: a negative ion MALDI-TOF MS study with 9-aminoacridine as matrix and egg yolk as selected example.

Journal: Analytical and bioanalytical chemistry 20091201

Title: Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds.

Journal: ChemMedChem 20091201

Title: Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.

Journal: Bioorganic & medicinal chemistry letters 20091015

Title: Binding of TCA to the prion protein: mechanism, implication for therapy, and application as probe for complex formation of bio-macromolecules.

Journal: Journal of biomolecular structure & dynamics 20091001

Title: Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20090908

Title: On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: In situ primary metabolites localization on a rat brain section by chemical mass spectrometry imaging.

Journal: Analytical chemistry 20090701

Title: Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

Journal: Bioorganic & medicinal chemistry letters 20090401

Title: 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways.

Journal: Oncogene 20090226

Title: Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives.

Journal: Neuroscience letters 20090213

Title: 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.

Journal: Virology journal 20090101

Title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte-matrix interactions.

Journal: Analytical chemistry 20081001

Title: New palladium(II) and platinum(II) complexes with 9-aminoacridine: structures, luminiscence, theoretical calculations, and antitumor activity.

Journal: Inorganic chemistry 20080804

Title: Isolation and characterization of novel phenotype CHO cell mutants defective in peroxisome assembly, using ICR191 as a potent mutagenic agent.

Journal: Cell biochemistry and function 20080801

Title: Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.

Journal: Biophysical chemistry 20080601

Title: Negative ion mode matrix-assisted laser desorption/ionisation time-of-flight mass spectrometric analysis of oligosaccharides using halide adducts and 9-aminoacridine matrix.

Journal: Rapid communications in mass spectrometry : RCM 20080401

Title: Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation.

Journal: Virology journal 20080101

Title: Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors.

Journal: Molecular cancer 20080101

Title: Thermodynamic analysis of binding between drugs and glycosaminoglycans by isothermal titration calorimetry and fluorescence spectroscopy.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071001

Title: A role of the 9-aminoacridines and their conjugates in a life science.

Journal: Current protein & peptide science 20071001

Title: The electrochemical behavior and direct determination of tyrosine at a glassy carbon electrode modified with poly (9-aminoacridine).

Journal: Annali di chimica 20071001

Title: Frameshift mutations produced by 9-aminoacridine in wild-type, uvrA and recA strains of Escherichia coli; specificity within a hotspot.

Journal: Journal of radiation research 20070901

Title: Identification of an aminoacridine derivative that binds to RNA tetraloops.

Journal: Journal of medicinal chemistry 20070823

Title: Unexpected reactivity of the 9-aminoacridine chromophore in guanidylation reactions.

Journal: The Journal of organic chemistry 20070706

Title: Exciton self-trapping in tetrafluoro-dimethyl-aminoacridine single crystals.

Journal: The Journal of chemical physics 20070621

Title: [Attempts to reduce drug resistance of bacteria and cancer cells].

Journal: Orvosi hetilap 20070603

Title: Tautomerism of acridin-9-amines substituted at the exocyclic nitrogen atom: spectroscopic investigations and theoretical studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070401

Title: Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.

Journal: The Journal of general virology 20070401

Title: Effectiveness of a honey dressing for healing pressure ulcers.

Journal: Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 20070101

Title: Quantitative detection of metabolites using matrix-assisted laser desorption/ionization mass spectrometry with 9-aminoacridine as the matrix.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.

Journal: Journal of chemical information and modeling 20070101

Title: Isolation and characterization of dominant and recessive IL-3-independent hematopoietic transformants.

Journal: Oncogene 20061026

Title: Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.

Journal: Bioorganic & medicinal chemistry letters 20060915

Title: New peptide conjugates with 9-aminoacridine: synthesis and binding to DNA.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20060701

Title: A modified Vibrio harveyi mutagenicity assay based on bioluminescence induction.

Journal: Letters in applied microbiology 20060601

Title: PsbS enhances nonphotochemical fluorescence quenching in the absence of zeaxanthin.

Journal: FEBS letters 20060403

Title: Study on the inclusion behavior of p-sulphonatocalix[4]arene with 9-amino-acridine by spectrofluorometric titrations.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060201

Title: Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum.

Journal: Bioorganic & medicinal chemistry 20060115

Title: Mutagenesis.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: Rational design and synthesis of a double-stranded DNA-binder library.

Journal: Biopolymers 20060101

Title: Synergistic interaction between proton pump inhibitors and resistance modifiers: promoting effects of antibiotics and plasmid curing.

Journal: In vivo (Athens, Greece) 20060101

Title: Acridin-9-yl exchange: a proposal for the action of some 9-aminoacridine drugs.

Journal: Biopolymers 20060101

Title: An investigation of DNA mismatch repair capacity under normal culture conditions and under conditions of supra-physiological challenge in human CD4+T cell clones from donors of different ages.

Journal: Experimental gerontology 20051201

Title: Frameshift mutations induced by the acridine mustard ICR-191 in embryos and in the adult gill and hepatopancreas of rpsL transgenic zebrafish.

Journal: Mutation research 20051015

Title: Induced mutation spectra at the upp locus in Salmonella typhimurium: response of the target gene in the FU assay to mechanistically different mutagens.

Journal: Mutation research 20051015

Title: Fluorescence of acridinic dyes in anionic surfactant solution.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001

Title: Excited-state intramolecular charge transfer in 9-aminoacridine derivative.

Journal: The journal of physical chemistry. A 20050714

Title: Metabolomic analysis of eukaryotic tissue and prokaryotes using negative mode MALDI time-of-flight mass spectrometry.

Journal: Analytical chemistry 20050401

Title: Antigenotoxic potential of glucomannan on four model test systems.

Journal: Cell biology and toxicology 20041101

Title: Self-assembling peptide nanotubes from enantiomeric pairs of cyclic peptides with alternating D and L amino acid residues.

Journal: Journal of the American Chemical Society 20040324

Title: Chloroplast mutations induced by 9-aminoacridine hydrochloride are independent of the plastome mutator in Oenothera.

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 20040201

Title: Anti-stress activity of Propionibacterium freudenreichii : identification of a reactivative protein.

Journal: Antonie van Leeuwenhoek 20040101

Title: A transient product of DNA alkylation can be stabilized by binding localization.

Journal: Journal of the American Chemical Society 20031119

Title: Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline.

Journal: Mutation research 20030929

Title: Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone.

Journal: International journal of antimicrobial agents 20030901

Title: Study of T-cell signaling by somatic cell mutagenesis and complementation cloning.

Journal: Journal of immunological methods 20030701

Title: Superior duplex DNA strand invasion by acridine conjugated peptide nucleic acids.

Journal: Journal of the American Chemical Society 20030528

Title: Changes in [Ca2+]i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20030501

Title: Acridine mutagenesis of zebrafish (Danio rerio).

Journal: Mutation research 20030409

Title: Lipid membrane with low proton permeability.

Journal: Biochimica et biophysica acta 20030401

Title: 9-Aminoacridine: an efficient reagent to improve human and plant chromosome banding patterns and to standardize chromosome image analysis.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030101

Title: Analysis of 2-aminoacridone-derivatized complex oligosaccharides using micellar electrokinetic capillary chromatography and laser-induced fluorescence detection.

Journal: Methods in molecular biology (Clifton, N.J.) 20030101

Title: Interaction of antitumoral 9-aminoacridine drug with DNA and dextran sulfate studied by fluorescence and surface-enhanced Raman spectroscopy.

Journal: Biopolymers 20030101

Title: Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: potency of responses and relationship to slipped mispairing models.

Journal: Environmental and molecular mutagenesis 20030101

Title: Staggering of subunits in NMDAR channels.

Journal: Biophysical journal 20021201

Title: Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal.

Journal: Biochemistry 20020416

Title: Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating.

Journal: Neuron 20020103

Title: Anacardic acid-mediated changes in membrane potential and pH gradient across liposomal membranes.

Journal: Biochimica et biophysica acta 20020102

Title: Blocker studies of the functional architecture of the NMDA receptor channel.

Journal: Neuroscience and behavioral physiology 20020101

Title: Surface-enhanced Raman and steady fluorescence study of interaction between antitumoral drug 9-aminoacridine and trypsin-like protease related to metastasis processes, guanidinobenzoatase.

Journal: Biopolymers 20010101

Title: [Synthesis and antibacterial activity of the new 9-aminoacridine, 10,11-dihydro-5H-dibenzo[b,f]azepine, polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

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Tags:134-50-9 Molecular Formula|134-50-9 MDL|134-50-9 SMILES|134-50-9 Acridin-9-amine hydrochloride