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Home Pyridines 1342278-01-6
1342278-01-6,MFCD26142658
Catalog No.:AA009CBT

1342278-01-6 | 1-[(3-Hydroxyphenyl)methyl]-3-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]urea

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Price(USD)
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5mg
≥98%
in stock  
$88.00   $61.00
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10mg
≥98%
in stock  
$156.00   $109.00
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50mg
≥98%
in stock  
$603.00   $422.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CBT
Chemical Name:
1-[(3-Hydroxyphenyl)methyl]-3-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]urea
CAS Number:
1342278-01-6
Molecular Formula:
C16H14N4O2S
Molecular Weight:
326.3730
MDL Number:
MFCD26142658
SMILES:
O=C(Nc1scc(n1)c1ccncc1)NCc1cccc(c1)O
Properties
Computed Properties
 
Complexity:
392  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:H.LEEMOFFITTCANCERCENTER&RESEARCHINSTITUTE-WO2011/130740,2011,A2Locationinpatent:Page/Pagecolumn92-93

[2]Pireddu,Roberta;Forinash,KaraD.;Sun,NanN.;Martin,MathewP.;Sung,Shen-Shu;Alexander,Brian;Zhu,Jin-Yi;Guida,WayneC.;Schönbrunn,Ernst;Sebti,SaïdM.;Lawrence,NicholasJ.[MedChemComm,2012,vol.3,#6,p.699-709]

[1]CurrentPatentAssignee:H.LEEMOFFITTCANCERCENTER&RESEARCHINSTITUTE-WO2011/130740,2011,A2Locationinpatent:Page/Pagecolumn94

[2]Pireddu,Roberta;Forinash,KaraD.;Sun,NanN.;Martin,MathewP.;Sung,Shen-Shu;Alexander,Brian;Zhu,Jin-Yi;Guida,WayneC.;Schönbrunn,Ernst;Sebti,SaïdM.;Lawrence,NicholasJ.[MedChemComm,2012,vol.3,#6,p.699-709]

[1]MedChemComm,2012,vol.3,p.699-709

[1]Pireddu,Roberta;Forinash,KaraD.;Sun,NanN.;Martin,MathewP.;Sung,Shen-Shu;Alexander,Brian;Zhu,Jin-Yi;Guida,WayneC.;Schönbrunn,Ernst;Sebti,SaïdM.;Lawrence,NicholasJ.[MedChemComm,2012,vol.3,#6,p.699-709]

Literature

Title: Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).

Journal: MedChemComm 20120601

Title: Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34.

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SDS
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Tags:1342278-01-6 Molecular Formula|1342278-01-6 MDL|1342278-01-6 SMILES|1342278-01-6 1-[(3-Hydroxyphenyl)methyl]-3-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]urea