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134418-28-3,MFCD03093712
Catalog No.:AA009ADQ

134418-28-3 | Dehydroandrographolide

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10mg
98%
in stock  
$6.00   $4.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA009ADQ
Chemical Name:
Dehydroandrographolide
CAS Number:
134418-28-3
Molecular Formula:
C20H28O4
Molecular Weight:
332.4339
MDL Number:
MFCD03093712
SMILES:
OC[C@]1(C)[C@H](O)CC[C@@]2([C@@H]1CCC(=C)[C@@H]2C/C=C/1\C=COC1=O)C
Properties
Computed Properties
 
Complexity:
605  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.4  

Literature

Title: Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6.

Title: Chao WW, et al. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010 May 13;5:17.

Title: Basak A, et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999 Feb 15;338 ( Pt 1):107-13.

Title: Zhu T, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.

Title: Chen H, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9.

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Tags:134418-28-3 Molecular Formula|134418-28-3 MDL|134418-28-3 SMILES|134418-28-3 Dehydroandrographolide