Home Other Building Blocks 1346133-11-6
1346133-11-6,MFCD32067413
Catalog No.:AA01V51Z

1346133-11-6 | LY2444296

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
1 week  
$133.00   $93.00
- +
10mg
95%
1 week  
$199.00   $140.00
- +
25mg
98+%
1 week  
$294.00   $206.00
- +
50mg
95%
1 week  
$418.00   $292.00
- +
250mg
98+%
1 week  
$1,437.00   $1,006.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01V51Z
Chemical Name:
LY2444296
CAS Number:
1346133-11-6
Molecular Formula:
C24H21F2N2O2
Molecular Weight:
407.4325
MDL Number:
MFCD32067413
SMILES:
Fc1cccc(c1)[C]1CCCN1Cc1ccc(cc1)Oc1ccc(cc1F)C(=O)N
Properties

Downstream Synthesis Route

[1]Mitch,CharlesH.;Quimby,StevenJ.;Diaz,Nuria;Pedregal,Concepcion;DeLaTorre,MartaG.;Jimenez,Alma;Shi,Qing;Canada,EmilyJ.;Kahl,StevenD.;Statnick,MichaelA.;McKinzie,DavidL.;Benesh,DanaR.;Rash,KarenS.;Barth,VanessaN.[JournalofMedicinalChemistry,2011,vol.54,#23,p.8000-8012]

[1]Mitch,CharlesH.;Quimby,StevenJ.;Diaz,Nuria;Pedregal,Concepcion;DeLaTorre,MartaG.;Jimenez,Alma;Shi,Qing;Canada,EmilyJ.;Kahl,StevenD.;Statnick,MichaelA.;McKinzie,DavidL.;Benesh,DanaR.;Rash,KarenS.;Barth,VanessaN.[JournalofMedicinalChemistry,2011,vol.54,#23,p.8000-8012]

[1]Mitch,CharlesH.;Quimby,StevenJ.;Diaz,Nuria;Pedregal,Concepcion;DeLaTorre,MartaG.;Jimenez,Alma;Shi,Qing;Canada,EmilyJ.;Kahl,StevenD.;Statnick,MichaelA.;McKinzie,DavidL.;Benesh,DanaR.;Rash,KarenS.;Barth,VanessaN.[JournalofMedicinalChemistry,2011,vol.54,#23,p.8000-8012]

[1]OrganicLetters,2017,vol.19,p.4215-4218

[2]JournalofMedicinalChemistry,2011,vol.54,p.8000-8012

[1]Locationinpatent:experimentalpartMitch,CharlesH.;Quimby,StevenJ.;Diaz,Nuria;Pedregal,Concepcion;DeLaTorre,MartaG.;Jimenez,Alma;Shi,Qing;Canada,EmilyJ.;Kahl,StevenD.;Statnick,MichaelA.;McKinzie,DavidL.;Benesh,DanaR.;Rash,KarenS.;Barth,VanessaN.[JournalofMedicinalChemistry,2011,vol.54,#23,p.8000-8012]

Literature

Title: Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20.

Title: Valenza M, et al. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231.

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