Home Other Building Blocks 134615-37-5
134615-37-5,MFCD00912537
Catalog No.:AA007ZTL

134615-37-5 | Reveromycin A

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1mg
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$1,006.00   $704.00
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007ZTL
Chemical Name:
Reveromycin A
CAS Number:
134615-37-5
Molecular Formula:
C33H50O8
Molecular Weight:
574.7453
MDL Number:
MFCD00912537
SMILES:
CCCCC1(OC)CCC2(OC1C=CC(=CC(=O)O)C)CCC(C(O2)CC=C(C=CC(C(C=CC(=O)O)C)O)C)C
Properties
Computed Properties
 
Complexity:
1250  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
5  
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
18  
Undefined Atom Stereocenter Count:
7  
XLogP3:
5.9  

Literature

Title: Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.

Journal: Cancer science 20091101

Title: Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.

Journal: Cancer science 20080801

Title: Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival.

Journal: Journal of pharmacological sciences 20080401

Title: Development and application of bioprobes for Mammalian cell cycle analyses.

Journal: Current medicinal chemistry 20030501

Title: Reveromycin A inhibits antigen receptor-mediated antigen presentation by B lymphoma cells via its effect on intracellular trafficking of the antigen.

Journal: The Journal of antibiotics 20021001

Title: Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A.

Journal: The Journal of biological chemistry 20020809

Title: H Takahashi , et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J Antibiot (Tokyo). 1992 Sep;45(9):1414-9.

Title: Je-Tae Woo, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34.

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