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135062-02-1,MFCD00906179
Catalog No.:AA00387U

135062-02-1 | 2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid

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10mg
98%
in stock  
$6.00   $4.00
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50mg
99%
in stock  
$6.00   $4.00
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100mg
99%
in stock  
$10.00   $7.00
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250mg
99%
in stock  
$15.00   $10.00
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1g
99%
in stock  
$29.00   $20.00
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5g
98%
in stock  
$120.00   $84.00
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10g
98%
in stock  
$226.00   $158.00
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25g
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$485.00   $340.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00387U
Chemical Name:
2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid
CAS Number:
135062-02-1
Molecular Formula:
C27H36N2O4
Molecular Weight:
452.5857
MDL Number:
MFCD00906179
SMILES:
CCOc1cc(ccc1C(=O)O)CC(=O)N[C@H](c1ccccc1N1CCCCC1)CC(C)C
NSC Number:
759893
Properties
Computed Properties
 
Complexity:
619  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
5.2  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,1998,vol.41,p.5219-5246

[2]Patent:CN109970681,2019,A.Locationinpatent:Paragraph0043;0053;0054

[3]AsianJournalofChemistry,2013,vol.25,p.9345-9350

[4]Patent:US2008/200684,2008,A1.Locationinpatent:Page/Pagecolumn4

[5]Patent:US2010/197732,2010,A1.Locationinpatent:Page/Pagecolumn13-14

[6]Patent:WO2004/103983,2004,A1.Locationinpatent:Page7;8

[7]Chimia,2006,vol.60,p.593-597

[8]Patent:EP2019097,2009,A1.Locationinpatent:Page/Pagecolumn8

[9]Patent:WO2004/101540,2004,A2.Locationinpatent:Page/Pagecolumn13-14

[10]Patent:WO2004/101540,2004,A2.Locationinpatent:Page/Pagecolumn15-16

[11]Patent:EP2177221,2010,A1.Locationinpatent:Page/Pagecolumn15

110-89-4   
tritylthiosemicarbazideresin 
  135062-02-1 

[1]Chimia,2006,vol.60,p.593-597

[1]Chimia,2006,vol.60,p.593-597

[1]Chimia,2006,vol.60,p.593-597

[1]Chimia,2006,vol.60,p.593-597

[2]JournalofMedicinalChemistry,1998,vol.41,p.5219-5246

[3]AsianJournalofChemistry,2013,vol.25,p.9345-9350

[4]Patent:CN109970681,2019,A

[5]Patent:CN109970681,2019,A

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Journal: Diabetes care 20101201

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Journal: European journal of clinical pharmacology 20101201

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Journal: Diabetes care 20101201

Title: Acute pancreatitis in association with type 2 diabetes and antidiabetic drugs: a population-based cohort study.

Journal: Diabetes care 20101201

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Journal: Diabetes care 20101201

Title: Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

Journal: British journal of clinical pharmacology 20101201

Title: Dapagliflozin: a sodium glucose cotransporter 2 inhibitor in development for type 2 diabetes.

Journal: Diabetes therapy : research, treatment and education of diabetes and related disorders 20101201

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Journal: Diabetes care 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

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Journal: Indian journal of pharmacology 20101001

Title: [Sulfonylureas dosage: from therapeutic monitoring to differential diagnosis of hyperinsulinism].

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Title: In vitro characterization and invivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles.

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Journal: Diabetes care 20100801

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Journal: Diabetes care 20100801

Title: Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery.

Journal: Therapeutic delivery 20100701

Title: Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil.

Journal: Acta diabetologica 20100601

Title: Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis.

Journal: International journal of clinical practice 20100601

Title: Neuropathy, retinopathy, and glucose-lowering treatments.

Journal: Diabetes care 20100601

Title: IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population.

Journal: Acta pharmacologica Sinica 20100601

Title: Effect of the bile acid sequestrant colesevelam on the pharmacokinetics of pioglitazone, repaglinide, estrogen estradiol, norethindrone, levothyroxine, and glyburide.

Journal: Journal of clinical pharmacology 20100501

Title: The nasty surprise of a complex drug-drug interaction.

Journal: Drug discovery today 20100501

Title: Effects of short-term therapy with different insulin secretagogues on glucose metabolism, lipid parameters and oxidative stress in newly diagnosed Type 2 Diabetes Mellitus.

Journal: Diabetes research and clinical practice 20100401

Title: Coping with changes in the Defined Daily Dose in a longitudinal drug consumption database.

Journal: Pharmacy world & science : PWS 20100401

Title: Symptomatic hypoglycemia associated with trimethoprim/sulfamethoxazole and repaglinide in a diabetic patient.

Journal: The Annals of pharmacotherapy 20100401

Title: Evidence for treating rheumatoid arthritis to target: results of a systematic literature search.

Journal: Annals of the rheumatic diseases 20100401

Title: A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese.

Journal: Acta pharmacologica Sinica 20100401

Title: KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.

Journal: Clinical pharmacology and therapeutics 20100301

Title: Post-prandial lipid levels for assessing target goal achievement in type 2 diabetic patients taking statin.

Journal: Journal of Korean medical science 20100301

Title: Comparison of insulin sensitivity, glucose sensitivity, and first phase insulin secretion in patients treated with repaglinide or gliclazide.

Journal: Archives of pharmacal research 20100301

Title: Opening of ATP-sensitive potassium channel by insulin in the brain-induced insulin secretion in Wistar rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100201

Title: Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers.

Journal: Journal of clinical pharmacology 20100201

Title: Diabetes under control: Understanding oral antidiabetic agents.

Journal: The American journal of nursing 20100201

Title: Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm.

Journal: Journal of clinical pharmacy and therapeutics 20100201

Title: Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits.

Journal: Bioscience trends 20100201

Title: Aspects of insulin treatment.

Journal: Diabetes care 20100101

Title: Development of repaglinide loaded solid lipid nanocarrier: selection of fabrication method.

Journal: Current drug delivery 20100101

Title: Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus.

Journal: Diabetes technology & therapeutics 20100101

Title: Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract.

Journal: Nutrition & metabolism 20100101

Title: Effects of lifestyle measures, antiobesity agents, and bariatric surgery on serological markers of inflammation in obese patients.

Journal: Mediators of inflammation 20100101

Title: Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial.

Journal: BMJ (Clinical research ed.) 20100101

Title: Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk.

Journal: Vascular health and risk management 20100101

Title: Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.

Journal: Current chemical genomics 20100101

Title: Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.

Journal: BMJ (Clinical research ed.) 20100101

Title: CYP3A4 genetic polymorphism influences repaglinide's pharmacokinetics.

Journal: Pharmacology 20100101

Title: Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society.

Journal: Diabetology & metabolic syndrome 20100101

Title: Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects.

Journal: PloS one 20100101

Title: The well-being and treatment satisfaction of diabetic patients in primary care.

Journal: Health and quality of life outcomes 20100101

Title: The tsim tsoum approaches for prevention of cardiovascular disease.

Journal: Cardiology research and practice 20100101

Title: Association of hypoglycemic symptoms with patients' rating of their health-related quality of life state: a cross sectional study.

Journal: Health and quality of life outcomes 20100101

Title: Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors.

Journal: Cardiovascular diabetology 20100101

Title: Development of Spectrofluorimetric and HPLC Methods for In vitro Analysis of Repaglinide.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Characteristics of coronary artery disease in symptomatic type 2 diabetic patients: evaluation with CT angiography.

Journal: Cardiovascular diabetology 20100101

Title: Long-term effect of metformin on blood glucose control in non-obese patients with type 2 diabetes mellitus.

Journal: Nutrition & metabolism 20100101

Title: Carbamazepine-loaded porous microspheres for short-term sustained drug delivery.

Journal: Journal of young pharmacists : JYP 20100101

Title: In vitro Evaluation of Novel Sustained Release Microspheres of Glipizide Prepared by the Emulsion Solvent Diffusion-Evaporation Method.

Journal: Journal of young pharmacists : JYP 20100101

Title: Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an update.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

Title: Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes - a review.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

Title: Pharmacology, efficacy and safety of liraglutide in the management of type 2 diabetes.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

Title: Impact of rosiglitazone meta-analysis on use of glucose-lowering medications.

Journal: Open medicine : a peer-reviewed, independent, open-access journal 20100101

Title: Design and optimization of floating drug delivery system of acyclovir.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Nateglinide versus repaglinide for type 2 diabetes mellitus in China.

Journal: Acta diabetologica 20091201

Title: Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans.

Journal: Diabetes care 20091201

Title: CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20091201

Title: Practical guidance on intensification of insulin therapy with BIAsp 30: a consensus statement.

Journal: International journal of clinical practice 20091101

Title: Implications of postprandial glucose and weight control in people with type 2 diabetes: understanding and implementing the International Diabetes Federation guidelines.

Journal: Diabetes care 20091101

Title: Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? Yes.

Journal: Diabetes care 20091101

Title: Metabolomics applied to diabetes research: moving from information to knowledge.

Journal: Diabetes 20091101

Title: Twice-daily and three-times-daily dosing of a repaglinide/metformin fixed-dose combination tablet provide similar glycaemic control.

Journal: Diabetes, obesity & metabolism 20091001

Title: Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

Journal: Diabetes 20091001

Title: Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial.

Journal: Diabetes care 20091001

Title: Accuracy of Veterans Affairs databases for diagnoses of chronic diseases.

Journal: Preventing chronic disease 20091001

Title: Impact of OATP transporters on pharmacokinetics.

Journal: British journal of pharmacology 20091001

Title: Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet.

Journal: Diabetes, obesity & metabolism 20090901

Title: The role of transporters in the pharmacokinetics of orally administered drugs.

Journal: Pharmaceutical research 20090901

Title: Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.

Journal: Pharmacogenomics 20090901

Title: Global variation in CYP2C8-CYP2C9 functional haplotypes.

Journal: The pharmacogenomics journal 20090801

Title: Thiazolidinediones and cardiovascular risk - a question of balance.

Journal: Current cardiology reviews 20090801

Title: Change in glucometer settings as a cause of sudden deterioration of glycemic control in type 2 diabetes.

Journal: Diabetes technology & therapeutics 20090701

Title: Successful treatment of repaglinide-induced hypoglycemia with octreotide.

Journal: The American journal of emergency medicine 20090701

Title: Metformin/Repaglinide (PrandiMet) for type 2 diabetes.

Journal: The Medical letter on drugs and therapeutics 20090601

Title: Modulation of nitrosative/oxidative stress in the lung of hyperglycemic rabbits by two antidiabetics, pioglitazone and repaglinide.

Journal: Experimental lung research 20090601

Title: Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant.

Journal: Journal of chromatography. A 20090515

Title: Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type 2 diabetes mellitus who have a metabolic syndrome and normal glucose tolerance without changes in C-reactive protein or fibrinogen.

Journal: Clinics (Sao Paulo, Brazil) 20090501

Title: Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2.

Journal: Journal of medicinal chemistry 20090409

Title: Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.

Journal: Journal of proteome research 20090401

Title: Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1.

Journal: The Journal of biological chemistry 20090313

Title: Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control.

Journal: Acta diabetologica 20090301

Title: Repaglinide plus single-dose insulin glargine: a safe regimen for low-risk type 2 diabetic patients who insist on fasting in Ramadan.

Journal: Acta diabetologica 20090301

Title: Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial.

Journal: Current medical research and opinion 20090301

Title: Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus.

Journal: Journal of diabetes 20090301

Title: Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes.

Journal: Diabetes care 20090101

Title: Standards of medical care in diabetes--2009.

Journal: Diabetes care 20090101

Title: The investigation of the efficacy of insulin glargine on glycemic control when combined with either repaglinide or acarbose in obese Type 2 diabetic patients.

Journal: Journal of endocrinological investigation 20090101

Title: Postprandial hyperglycemia as an etiological factor in vascular failure.

Journal: Cardiovascular diabetology 20090101

Title: Hypoglycaemia with oral antidiabetic drugs: results from prescription-event monitoring cohorts of rosiglitazone, pioglitazone, nateglinide and repaglinide.

Journal: Drug safety 20090101

Title: DreamTel; Diabetes risk evaluation and management tele-monitoring study protocol.

Journal: BMC endocrine disorders 20090101

Title: Indices of insulin sensitivity and secretion from a standard liquid meal test in subjects with type 2 diabetes, impaired or normal fasting glucose.

Journal: Nutrition journal 20090101

Title: Co-solvent solubilization of some poorly-soluble antidiabetic drugs.

Journal: Pharmaceutical development and technology 20090101

Title: Acute heart failure in a patient with metabolic syndrome and diabetes mellitus: clinical evidence for direct positive influence of antidiabetic therapy on left ventricular function.

Journal: Congestive heart failure (Greenwich, Conn.) 20090101

Title: A cardiologic approach to non-insulin antidiabetic pharmacotherapy in patients with heart disease.

Journal: Cardiovascular diabetology 20090101

Title: Evaluation of the repaglinide efficiency in comparison to the glimepiride in the type 2 diabetes patients poorly regulated by the metmorfine administration.

Journal: Bratislavske lekarske listy 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Diabetic nephropathy.

Journal: Diabetology & metabolic syndrome 20090101

Title: Post-transplant diabetes mellitus.

Journal: Diabetology & metabolic syndrome 20090101

Title: Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.

Journal: BMJ (Clinical research ed.) 20090101

Title: Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

Journal: BMJ (Clinical research ed.) 20090101

Title: Glinide, but not sulfonylurea, can evoke insulin exocytosis by repetitive stimulation: imaging analysis of insulin exocytosis by secretagogue-induced repetitive stimulations.

Journal: Experimental diabetes research 20090101

Title: Effect of Ramadan fasting on anthropometric parameters and food consumption in 276 type 2 diabetic obese women.

Journal: International journal of diabetes in developing countries 20090101

Title: Repaglinide induced acute hepototoxicity.

Journal: JNMA; journal of the Nepal Medical Association 20090101

Title: Role of potassium channels in stretch-promoted atrial natriuretic factor secretion.

Journal: Journal of the American Society of Hypertension : JASH 20090101

Title: pH-Sensitive Mebeverine Microspheres for Colon Delivery.

Journal: Indian journal of pharmaceutical sciences 20090101

Title: Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

Title: Biphasic insulin aspart 30/70 (BIAsp 30) in the treatment of type 1 and type 2 diabetes.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

Title: Fixed combination of repaglinide and metformin in the management of type 2 diabetes.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

Title: Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column.

Journal: Journal of chromatography. A 20081226

Title: Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20081201

Title: The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range.

Journal: British journal of clinical pharmacology 20081201

Title: Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes.

Journal: Vascular health and risk management 20081201

Title: Alpha-glucosidase inhibitors in the early treatment of type 2 diabetes.

Journal: Vascular health and risk management 20081201

Title: Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

Journal: Diabetes care 20081101

Title: Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.

Journal: Pharmacogenetics and genomics 20081101

Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

Journal: Journal of medicinal chemistry 20081009

Title: Weight change in diabetes and glycemic and blood pressure control.

Journal: Diabetes care 20081001

Title: Reversible binding of antidiabetic drugs, repaglinide and gliclazide, with human serum albumin.

Journal: Chemical biology & drug design 20081001

Title: International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20081001

Title: Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.

Journal: Clinical pharmacology and therapeutics 20081001

Title: The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo.

Journal: Clinical pharmacology and therapeutics 20080901

Title: Application of software design principles and debugging methods to an analgesia prescription reduces risk of severe injury from medical use of opioids.

Journal: Clinical pharmacology and therapeutics 20080901

Title: Glycemic control in diabetes: a tale of three studies.

Journal: Diabetes care 20080901

Title: Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism.

Journal: The pharmacogenomics journal 20080801

Title: Synthesis of hydantoin analogues of (2S,3R,4S)-4-hydroxyisoleucine with insulinotropic properties.

Journal: Bioorganic & medicinal chemistry letters 20080801

Title: Approaches to treatment of type 2 diabetes.

Journal: Diabetes care 20080801

Title: Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients.

Journal: Acta pharmacologica Sinica 20080801

Title: Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence.

Journal: Diabetes 20080701

Title: Drugs for type 2 diabetes.

Journal: Treatment guidelines from the Medical Letter 20080701

Title: Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

Journal: Diabetes 20080601

Title: Interaction of Aqueous Extract of Pleurotus pulmonarius (Fr.) Quel-Champ. with Glyburide in Alloxan Induced Diabetic Mice.

Journal: Evidence-based complementary and alternative medicine : eCAM 20080601

Title: Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.

Journal: The AAPS journal 20080601

Title: Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

Journal: Pharmaceutical research 20080501

Title: Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes.

Journal: European journal of endocrinology 20080501

Title: Severe hypoglycemia from clarithromycin-repaglinide drug interaction.

Journal: Pharmacotherapy 20080501

Title: Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of nateglinide, cilostazol and its active metabolite 3,4-dehydro-cilostazol in Wistar rat plasma and its application to pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401

Title: [Clinical evaluation of efficacy and safety of nateglinide in the treatment of type 2 diabetes].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20080401

Title: Therapeutic options for elderly diabetic subjects: open label, randomized clinical trial of insulin glargine added to oral antidiabetic drugs versus increased dosage of oral antidiabetic drugs.

Journal: Acta diabetologica 20080301

Title: Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.

Journal: Journal of clinical pharmacology 20080301

Title: Hypoglycaemia in Type 2 diabetes.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20080301

Title: Spermicidal activity of sulfonylureas and meglitinide analogues: role of intrasperm Ca2+ elevation.

Journal: The Journal of pharmacy and pharmacology 20080301

Title: Achieving glycosylated hemoglobin targets using the combination of repaglinide and metformin in type 2 diabetes: a reanalysis of earlier data in terms of current targets.

Journal: Clinical therapeutics 20080301

Title: Postprandial hyperglycemia: are all sulfonylureas created equal?

Journal: The American journal of cardiology 20080215

Title: Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

Journal: European journal of clinical pharmacology 20080201

Title: Ameliorating effects of sulfonylurea drugs on insulin resistance in Otsuka long-evans Tokushima Fatty rats.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20080201

Title: Safety and efficacy of repaglinide in combination with metformin and bedtime NPH insulin as an insulin treatment regimen in type 2 diabetes.

Journal: Diabetes research and clinical practice 20080101

Title: Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes.

Journal: European journal of endocrinology 20080101

Title: Electrochemical determination of the antidiabetic drug repaglinide.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080101

Title: Radioiodinated naphthylalanine derivatives targeting pancreatic beta cells in normal and nonobese diabetic mice.

Journal: Experimental diabetes research 20080101

Title: The relationship between type of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the Seniors' Pharmacare Program in Nova Scotia, Canada.

Journal: BMC health services research 20080101

Title: A comparative study of first-derivative spectrophotometry and column high-performance liquid chromatography applied to the determination of repaglinide in tablets and for dissolution testing.

Journal: Journal of AOAC International 20080101

Title: Fixed-dose combination tablet of repaglinide and metformin is bioequivalent to concomitantly administered individual tablets of repaglinide and metformin : randomized, single-blind, three-period crossover study in healthy subjects.

Journal: Clinical drug investigation 20080101

Title: Effect of adjunct metformin treatment in patients with type-1 diabetes and persistent inadequate glycaemic control. A randomized study.

Journal: PloS one 20080101

Title: Diabetes: glycaemic control in type 2.

Journal: BMJ clinical evidence 20080101

Title: Patients with type 2 diabetes inadequately controlled on premixed insulin: effect of initiating insulin glargine plus oral antidiabetic agents on glycaemic control in daily practice.

Journal: International journal of clinical practice 20071201

Title: A review of nateglinide in the management of patients with type 2 diabetes.

Journal: Vascular health and risk management 20071201

Title: Optimizing combination treatment in the management of type 2 diabetes.

Journal: Vascular health and risk management 20071001

Title: A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes.

Journal: Vascular health and risk management 20071001

Title: Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus.

Journal: Annals of internal medicine 20070918

Title: Multi-component plasma quantitation of anti-hyperglycemic pharmaceutical compounds using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury.

Journal: The Journal of clinical investigation 20070801

Title: Effects of early use of pioglitazone in combination with metformin in patients with newly diagnosed type 2 diabetes.

Journal: Current medical research and opinion 20070801

Title: Rapidly dissolving repaglinide powders produced by the ultra-rapid freezing process.

Journal: AAPS PharmSciTech 20070720

Title: A randomized controlled trial examining combinations of repaglinide, metformin and NPH insulin.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20070701

Title: Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial.

Journal: Diabetes, obesity & metabolism 20070701

Title: Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Pioglitazone and sulfonylureas: effectively treating type 2 diabetes.

Journal: International journal of clinical practice. Supplement 20070601

Title: Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial.

Journal: Diabetes, obesity & metabolism 20070501

Title: Meglitinide analogues for type 2 diabetes mellitus.

Journal: The Cochrane database of systematic reviews 20070418

Title: Method development and validation of repaglinide in human plasma by HPLC and its application in pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis 20070411

Title: New oral agents for type 2 diabetes.

Journal: Clinical medicine (London, England) 20070401

Title: Porous carrier based floating granular delivery system of repaglinide.

Journal: Drug development and industrial pharmacy 20070401

Title: [Chronic kidney disease and antidiabetic treatment].

Journal: Revue medicale suisse 20070307

Title: A comparison of glycemic effects of glimepiride, repaglinide, and insulin glargine in type 2 diabetes mellitus during Ramadan fasting.

Journal: Diabetes research and clinical practice 20070201

Title: Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.

Journal: Vascular pharmacology 20070201

Title: Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

Journal: Coronary artery disease 20070201

Title: Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20070201

Title: Use of repaglinide on a pregnant woman during embryogenesis.

Journal: Diabetes, obesity & metabolism 20070101

Title: Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide.

Journal: Clinical pharmacokinetics 20070101

Title: Examining correlates of treatment satisfaction for injectable insulin in type 2 diabetes: lessons learned from a clinical trial comparing biphasic and basal analogues.

Journal: Health and quality of life outcomes 20070101

Title: Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetes.

Journal: Cardiovascular diabetology 20070101

Title: Defining the role of repaglinide in the management of type 2 diabetes mellitus: a review.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

Title: Rapid identification of P-glycoprotein substrates and inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201

Title: Preprandial repaglinide decreases exogenous insulin requirements and HbA1c levels in type 2 diabetic patients taking intensive insulin treatment.

Journal: Acta diabetologica 20061201

Title: Effect of SLCO1B1 genetic polymorphism on the pharmacokinetics of nateglinide.

Journal: British journal of clinical pharmacology 20061101

Title: Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay.

Journal: Biomedical chromatography : BMC 20061001

Title: Use of repaglinide during the first weeks of pregnancy in two type 2 diabetic women.

Journal: Diabetes care 20061001

Title: Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels.

Journal: Diabetologia 20060901

Title: Cyclosporine A increases plasma concentrations and effects of repaglinide.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060901

Title: Pharmacological interaction between cyclosporine a and repaglinide. Is it clinically relevant?

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060901

Title: Safety of type 2 diabetes treatment with repaglinide compared with glibenclamide in elderly people: A randomized, open-label, two-period, cross-over trial.

Journal: Diabetes care 20060801

Title: Thailand diabetes registry project: glycemic control in Thai type 2 diabetes and its relation to hypoglycemic agent usage.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

Title: Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics.

Journal: Neurology 20060725

Title: A novel calcium silicate based microspheres of repaglinide: in vivo investigations.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20060628

Title: Ionization, lipophilicity and solubility properties of repaglinide.

Journal: Journal of pharmaceutical and biomedical analysis 20060607

Title: Determination of clopidogrel metabolite (SR26334) in human plasma by LC-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20060503

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Peroxisome proliferator-activated receptor gamma agonists in renal disease.

Journal: European journal of endocrinology 20060501

Title: Safety profile of repaglinide as used in general practice in England: results of a prescription-event monitoring study.

Journal: Acta diabetologica 20060501

Title: Transporters as a determinant of drug clearance and tissue distribution.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

Title: Repaglinide in the management of new-onset diabetes mellitus after renal transplantation.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060401

Title: Meglitinide analogues: a review of clinical data focused on recent trials.

Journal: Diabetes & metabolism 20060401

Title: Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide.

Journal: European journal of clinical pharmacology 20060301

Title: Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia.

Journal: International journal of clinical practice 20060301

Title: Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide.

Journal: Clinical pharmacology and therapeutics 20060301

Title: An open label comparative study of glimepiride versus repaglinide in type 2 diabetes mellitus Muslim subjects during the month of Ramadan.

Journal: The Medical journal of Malaysia 20060301

Title: Meal-induced platelet activation in Type 2 diabetes mellitus: effects of treatment with repaglinide and glibenclamide.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20060201

Title: Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101

Title: The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide.

Journal: British journal of clinical pharmacology 20060101

Title: Pioglitazone: a review of its use in type 2 diabetes mellitus.

Journal: Drugs 20060101

Title: Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

Journal: Current medicinal chemistry 20060101

Title: Effect of repaglinide on endothelial dysfunction during a glucose tolerance test in subjects with impaired glucose tolerance.

Journal: Cardiovascular diabetology 20060101

Title: Treatment of impaired glucose tolerance with acarbose and its effect on intima-media thickness: a substudy of the STOP-NIDDM trial (study to prevent non-insulin-dependent diabetes mellitus).

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101

Title: Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin.

Journal: Diabetes/metabolism research and reviews 20060101

Title: Development and validation of a new high-performance liquid chromatography method for the determination of gliclazide and repaglinide in pharmaceutical formulations.

Journal: Journal of AOAC International 20060101

Title: Spotlight on pioglitazone in type 2 diabetes mellitus.

Journal: Treatments in endocrinology 20060101

Title: Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes.

Journal: Health and quality of life outcomes 20060101

Title: Type 2 diabetes mellitus: a review of pharmacological treatment.

Journal: Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20060101

Title: Basic Management of Diabetes Mellitus: Practical guidelines.

Journal: The Libyan journal of medicine 20060101

Title: Modification of cardiac oxidative stress in alloxan-induced diabetic rabbits with repaglinide treatment.

Journal: Life sciences 20051205

Title: Oral agents in managing diabetes mellitus in children and adolescents.

Journal: Pediatric clinics of North America 20051201

Title: [Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051201

Title: Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: preparation and in vitro characterization.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20051003

Title: Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20051001

Title: Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.

Journal: Basic & clinical pharmacology & toxicology 20051001

Title: Cyclosporine markedly raises the plasma concentrations of repaglinide.

Journal: Clinical pharmacology and therapeutics 20051001

Title: [Recent oral antidiabetic therapy].

Journal: Revue medicale de Bruxelles 20050901

Title: Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals.

Journal: Pharmacological research 20050801

Title: Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide.

Journal: British journal of clinical pharmacology 20050801

Title: Repaglinide/bedtime NPH insulin is comparable to twice-daily NPH insulin.

Journal: Diabetes care 20050701

Title: Mild, reversible pancytopenia induced by rosiglitazone.

Journal: Diabetes care 20050601

Title: Oxidative stress in kidney and liver of alloxan-induced diabetic rabbits: effect of repaglinide.

Journal: Acta diabetologica 20050601

Title: Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics.

Journal: Clinical pharmacology and therapeutics 20050601

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Repaglinide has more beneficial effect on cardiovascular risk factors than glimepiride: data from meal-test study.

Journal: Diabetes & metabolism 20050601

Title: Beta-cell response during a meal test: a comparative study of incremental doses of repaglinide in type 2 diabetic patients.

Journal: Diabetes care 20050501

Title: Effects of repaglinide on oxidative stress in tissues of diabetic rabbits.

Journal: Diabetes research and clinical practice 20050501

Title: In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors.

Journal: Pharmaceutical research 20050401

Title: Cholestatic hepatitis associated with repaglinide.

Journal: Diabetes care 20050301

Title: [Comparison of efficacy between nateglinide and repaglinide in treating type 2 diabetes: a randomized controlled double-blind clinical trial].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050301

Title: Oral antihyperglycemic agents and renal disease: new agents, new concepts.

Journal: Journal of the American Society of Nephrology : JASN 20050301

Title: Repaglinide administration improves brachial reactivity in type 2 diabetic patients.

Journal: Diabetes care 20050201

Title: Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

Journal: British journal of pharmacology 20050201

Title: Clinical experience with repaglinide in patients with non-insulin-dependent diabetes mellitus.

Journal: The Israel Medical Association journal : IMAJ 20050201

Title: Sulfonylurea induced beta-cell apoptosis in cultured human islets.

Journal: The Journal of clinical endocrinology and metabolism 20050101

Title: Effect of repaglinide and gliclazide on postprandial control of endogenous glucose production.

Journal: Metabolism: clinical and experimental 20050101

Title: Examination of 209 drugs for inhibition of cytochrome P450 2C8.

Journal: Journal of clinical pharmacology 20050101

Title: Islet adaptation to insulin resistance: mechanisms and implications for intervention.

Journal: Diabetes, obesity & metabolism 20050101

Title: Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: Drug interactions of clinical importance with antihyperglycaemic agents: an update.

Journal: Drug safety 20050101

Title: Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance.

Journal: Clinical pharmacokinetics 20050101

Title: Postprandial glucose regulation: new data and new implications.

Journal: Clinical therapeutics 20050101

Title: Exubera(®) (inhaled insulin): an evidence-based review of its effectiveness in the management of diabetes.

Journal: Core evidence 20050101

Title: The impact of ATP-sensitive K+ channel subtype selectivity of insulin secretagogues for the coronary vasculature and the myocardium.

Journal: Diabetes 20041201

Title: Accuracy of continuous nocturnal glucose screening after 48 and 72 hours in type 2 diabetes patients on combined oral and insulin therapy.

Journal: Diabetes & metabolism 20041201

Title: Acute hepatotoxicity caused by repaglinide.

Journal: Annals of internal medicine 20041116

Title: Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105

Title: Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20041101

Title: Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential beta-cell imaging agent.

Journal: Bioorganic & medicinal chemistry letters 20041018

Title: Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide.

Journal: British journal of clinical pharmacology 20041001

Title: The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20041001

Title: Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes.

Journal: Biochemical pharmacology 20040901

Title: Beta-cell insulin secretory response to oral hypoglycemic agents is blunted in humans in vivo during moderate hypoglycemia.

Journal: The Journal of clinical endocrinology and metabolism 20040901

Title: Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats.

Journal: Pharmacological research 20040801

Title: Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in type 2 diabetes patients with inadequate glycaemic control: an application of the CORE Diabetes Model in type 2 diabetes.

Journal: Current medical research and opinion 20040801

Title: Treating type 2 diabetes. When diet and exercise aren't enough, a broad range of medications can help control our blood sugar.

Journal: Health news (Waltham, Mass.) 20040801

Title: Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.

Journal: Circulation 20040713

Title: Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([18F]repaglinide): a promising radioligand for quantification of pancreatic beta-cell mass with positron emission tomography (PET).

Journal: Nuclear medicine and biology 20040701

Title: Enhancement of early- and late-phase insulin secretion and insulin sensitivity by the combination of repaglinide and metformin in type 2 diabetes mellitus.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040701

Title: Repaglinide versus nateglinide monotherapy: a randomized, multicenter study.

Journal: Diabetes care 20040601

Title: Modification of beta-cell response to different postprandial blood glucose concentrations by prandial repaglinide and combined acarbose/repaglinide application.

Journal: Diabetes, nutrition & metabolism 20040601

Title: Evidence for hypothalamic K+(ATP) channels in the modulation of glucose homeostasis.

Journal: European journal of pharmacology 20040510

Title: The effects of diet, sulfonylurea, and Repaglinide therapy on clinical and metabolic parameters in type 2 diabetic patients during Ramadan.

Journal: Endocrine research 20040501

Title: Inhibitors of ATP-sensitive potassium channels in guinea pig isolated ischemic hearts.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040401

Title: The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects.

Journal: British journal of clinical pharmacology 20040401

Title: Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide.

Journal: European journal of clinical pharmacology 20040401

Title: Dose titration of repaglinide in patients with inadequately controlled type 2 diabetes.

Journal: Diabetes research and clinical practice 20040401

Title: Combination therapy for type 2 diabetes: repaglinide plus rosiglitazone.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20040401

Title: Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context.

Journal: Archives of internal medicine 20040308

Title: The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20040301

Title: Treatment of type 2 diabetes with a combination regimen of repaglinide plus pioglitazone.

Journal: Diabetes research and clinical practice 20040201

Title: Repaglinide is more efficient than glimepiride on insulin secretion and post-prandial glucose excursions in patients with type 2 diabetes. A short term study.

Journal: Diabetes & metabolism 20040201

Title: The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency.

Journal: The Journal of clinical endocrinology and metabolism 20040101

Title: Clinical pharmacokinetics of nateglinide: a rapidly-absorbed, short-acting insulinotropic agent.

Journal: Clinical pharmacokinetics 20040101

Title: Repaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus.

Journal: PharmacoEconomics 20040101

Title: Mitiglinide: KAD 1229, S 21403.

Journal: Drugs in R&D 20040101

Title: Compared to glibenclamide, repaglinide treatment results in a more rapid fall in glucose level and beta-cell secretion after glucose stimulation.

Journal: Diabetes/metabolism research and reviews 20040101

Title: Interactions between grapefruit juice and cardiovascular drugs.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

Title: Continuous glucose monitoring: physiologic and pathophysiologic significance.

Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

Title: The efficacy of repaglinide monotherapy and in combination with metformin in Indonesian type 2 diabetes mellitus patients.

Journal: Acta medica Indonesiana 20040101

Title: [Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy].

Journal: MMW Fortschritte der Medizin 20031218

Title: Glimepiride and serum adiponectin level in type 2 diabetic subjects: response to Nagasaka et al.

Journal: Diabetes care 20031201

Title: Comparison of repaglinide and nateglinide in combination with metformin: response to Raskin et al.

Journal: Diabetes care 20031201

Title: Determination of repaglinide in pharmaceutical formulations by HPLC with UV detection.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20031201

Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

Journal: British journal of cancer 20031117

Title: [Type 2 diabetes mellitus pathogenesis: new therapeutic managements?].

Journal: La Revue de medecine interne 20031101

Title: Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20031101

Title: Neuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinide.

Journal: The Biochemical journal 20031001

Title: Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide.

Journal: Clinical pharmacology and therapeutics 20031001

Title: Risk of hypoglycaemia with oral antidiabetic agents in patients with Type 2 diabetes.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20031001

Title: CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide.

Journal: British journal of clinical pharmacology 20030901

Title: Lack of effect of acute repaglinide administration on postprandial lipaemia in patients with type 2 diabetes mellitus.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030901

Title: Cardiovascular risk in type 2 diabetics and pharmacological regulation of mealtime glucose excursions.

Journal: Diabetes & metabolism 20030901

Title: Impurity profile study of repaglinide.

Journal: Journal of pharmaceutical and biomedical analysis 20030714

Title: Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin.

Journal: Diabetes care 20030701

Title: [symbol: see text] Nateglinide and [symbol: see text] repaglinide for type 2 diabetes?

Journal: Drug and therapeutics bulletin 20030701

Title: A comparison of costs for four oral antidiabetic regimens within a managed care population.

Journal: Managed care interface 20030701

Title: Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin.

Journal: Diabetes research and clinical practice 20030601

Title: The effect of prandial glucose regulation with repaglinide on treatment satisfaction, wellbeing and health status in patients with pharmacotherapy naïve Type 2 diabetes: a placebo-controlled, multicentre study.

Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20030601

Title: Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide.

Journal: Journal of clinical pharmacology 20030601

Title: [Meglitinide analogs: new insulinotropic agents for the treatment of non-insulin dependent diabetes].

Journal: Revue medicale de Bruxelles 20030601

Title: [Differences between oral antidiabetics].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20030320

Title: Safety and efficacy of repaglinide in type 2 diabetic patients with and without impaired renal function.

Journal: Diabetes care 20030301

Title: Metformin-induced hemolytic anemia in a patient with glucose-6- phosphate dehydrogenase deficiency.

Journal: Diabetes care 20030301

Title: Pharmacologic restoration of the early insulin response in pre-diabetic monkeys controls mealtime glucose excursions without peripheral hyperinsulinaemia.

Journal: Diabetologia 20030301

Title: The role of oral antidiabetic agents: why and when to use an early-phase insulin secretion agent in Type II diabetes mellitus.

Journal: Diabetologia 20030301

Title: The mechanisms underlying the unique pharmacodynamics of nateglinide.

Journal: Diabetologia 20030301

Title: Rationale and options for combination therapy in the treatment of Type 2 diabetes.

Journal: Diabetologia 20030301

Title: Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide.

Journal: Diabetologia 20030301

Title: Comparison between repaglinide and glimepiride in patients with type 2 diabetes mellitus: a one-year, randomized, double-blind assessment of metabolic parameters and cardiovascular risk factors.

Journal: Clinical therapeutics 20030201

Title: The effect of repaglinide on insulin secretion and oxidative stress in type 2 diabetic patients.

Journal: Diabetes research and clinical practice 20030101

Title: Pharmacokinetics of repaglinide in healthy caucasian and Japanese subjects.

Journal: Journal of clinical pharmacology 20030101

Title: Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions.

Journal: Journal of diabetes and its complications 20030101

Title: Economic model of first-line drug strategies to achieve recommended glycaemic control in newly diagnosed type 2 diabetes mellitus.

Journal: PharmacoEconomics 20030101

Title: [Drug safety. Notes regarding drug surveillance].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20030101

Title: Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus.

Journal: Treatments in endocrinology 20030101

Title: Effects of S 21403 on hormone secretion from isolated rat pancreas at different glucose concentrations.

Journal: European journal of pharmacology 20021205

Title: No effect of the novel antidiabetic agent nateglinide on the pharmacokinetics and anticoagulant properties of warfarin in healthy volunteers.

Journal: Journal of clinical pharmacology 20021201

Title: Sulfonylurea stimulation of insulin secretion.

Journal: Diabetes 20021201

Title: Early changes in beta-cell function and insulin pulsatility as predictors for type 2 diabetes.

Journal: Diabetes, nutrition & metabolism 20021201

Title: Repaglinide at a cellular level.

Journal: Diabetes, nutrition & metabolism 20021201

Title: Early-phase prandial insulin secretion: its role in the pathogenesis of type 2 diabetes mellitus and its modulation by repaglinide.

Journal: Diabetes, nutrition & metabolism 20021201

Title: The impact of prandial glucose regulation in practice.

Journal: Diabetes, nutrition & metabolism 20021201

Title: Repaglinide in combination therapy.

Journal: Diabetes, nutrition & metabolism 20021201

Title: High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology.

Journal: Diabetes & metabolism 20021201

Title: Hypoglycemia probably due to accidental intake of repaglinide.

Journal: Chang Gung medical journal 20021101

Title: Repaglinide versus glibenclamide treatment of Type 2 diabetes during Ramadan fasting.

Journal: Diabetes research and clinical practice 20021001

Title: Repaglinide versus metformin in combination with bedtime NPH insulin in patients with type 2 diabetes established on insulin/metformin combination therapy.

Journal: Diabetes care 20021001

Title: Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1.

Journal: Diabetes 20020901

Title: [Structures and mechanisms for non SU insulin secretagogues].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020901

Title: [Repaglinide (NN-623)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020901

Title: A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor.

Journal: Analytical biochemistry 20020815

Title: Comparison of the effects of three insulinotropic drugs on plasma insulin levels after a standard meal.

Journal: Diabetes care 20020801

Title: Response to Schmitz. Optimizing insulin secretagogue therapy in patients with type 2 diabetes: a randomized double-blind study with repaglinide.

Journal: Diabetes care 20020801

Title: [Differential type 2 diabetes therapy based on pathophysiological aspects].

Journal: Therapeutische Umschau. Revue therapeutique 20020801

Title: Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.

Journal: European journal of endocrinology 20020701

Title: Interaction of nateglinide with K(ATP) channel in beta-cells underlies its unique insulinotropic action.

Journal: European journal of pharmacology 20020503

Title: [Glinides and glitazones in diabetes treatment. Are they really effective?].

Journal: MMW Fortschritte der Medizin 20020502

Title: Current oral agents for type 2 diabetes. Many options, but which to choose when?

Journal: Postgraduate medicine 20020501

Title: Insulinotropic meglitinide analogues.

Journal: Lancet (London, England) 20020406

Title: Subclinical type 1 diabetes.

Journal: Journal of the Royal Society of Medicine 20020401

Title: [Postprandial hyperglycemia. II. Pharmacological approaches].

Journal: Revue medicale de Liege 20020401

Title: Control of post-prandial hyperglycemia--an essential part of good diabetes treatment and prevention of cardiovascular complications.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20020401

Title: Optimizing insulin secretagogue therapy in patients with type 2 diabetes: a randomized double-blind study with repaglinide.

Journal: Diabetes care 20020201

Title: Oral antihyperglycemic therapy for type 2 diabetes: scientific review.

Journal: JAMA 20020116

Title: Type 2 diabetes management.

Journal: British journal of community nursing 20020101

Title: Modeling the pharmacokinetics and pharmacodynamics of a unique oral hypoglycemic agent using neural networks.

Journal: Pharmaceutical research 20020101

Title: The pathophysiologic basis of efficacy and clinical experience with the new oral antidiabetic agents.

Journal: Journal of diabetes and its complications 20020101

Title: Type 2 diabetes management: a comprehensive clinical review of oral medications.

Journal: Comprehensive therapy 20020101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020101

Title: Clinical pharmacokinetics and pharmacodynamics of repaglinide.

Journal: Clinical pharmacokinetics 20020101

Title: Study of the insulinotropic effect of the novel antihyperglycemic agent KAD-1229 using HIT T15 cells, a hamster's insulinoma cell line.

Journal: Arzneimittel-Forschung 20020101

Title: Insulin secretagogues.

Journal: Current medical research and opinion 20020101

Title: Preventing the progressive nature of type 2 diabetes.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20020101

Title: Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection.

Journal: Clinical pharmacokinetics 20020101

Title: Repaglinide: a short acting insulin secretagogue for postprandial hyperglycaemia.

Journal: Journal of postgraduate medicine 20020101

Title: Postprandial hyperglycemia in patients with type 2 diabetes mellitus.

Journal: Treatments in endocrinology 20020101

Title: Insulinotropic meglitinide analogues.

Journal: Lancet (London, England) 20011117

Title: The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.

Journal: European journal of pharmacology 20011109

Title: Nateglinide therapy for type 2 diabetes mellitus.

Journal: The Annals of pharmacotherapy 20011101

Title: [Therapy of type 2 diabetes. Avoiding postprandial blood glucose peaks!].

Journal: MMW Fortschritte der Medizin 20011004

Title: Insulin and glucose excursion following premeal insulin lispro or repaglinide in cystic fibrosis-related diabetes.

Journal: Diabetes care 20011001

Title: Effect of repaglinide addition to NPH insulin monotherapy on glycemic control in patients with type 2 diabetes.

Journal: Diabetes care 20011001

Title: Effect of insulinotropic agent nateglinide on Kv and Ca(2+) channels in pancreatic beta-cell.

Journal: European journal of pharmacology 20010914

Title: Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control.

Journal: Current pharmaceutical design 20010901

Title: Repaglinide improves blood glucose control in sulphonylurea-naive type 2 diabetes.

Journal: Diabetes research and clinical practice 20010901

Title: [New drugs].

Journal: Revue medicale de Bruxelles 20010901

Title: [News in oral antidiabetic therapy].

Journal: Vnitrni lekarstvi 20010901

Title: [Repaglinide, potentially a therapeutic improvement for diabetes mellitus type 2].

Journal: Nederlands tijdschrift voor geneeskunde 20010811

Title: Utilization of oral hypoglycemic agents in a drug-insured U.S. population.

Journal: Diabetes care 20010801

Title: A new era in type 2 diabetes mellitus treatment?

Journal: The American journal of medicine 20010701

Title: The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide.

Journal: Clinical pharmacology and therapeutics 20010701

Title: [Objectives and therapeutic strategy in type 2 diabetes mellitus].

Journal: Anales de medicina interna (Madrid, Spain : 1984) 20010701

Title: Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels.

Journal: Diabetologia 20010601

Title: [Pharma-clinics. Medication of the month. Repaglinide (NovoNorm)].

Journal: Revue medicale de Liege 20010601

Title: [Repaglinide].

Journal: Deutsche medizinische Wochenschrift (1946) 20010511

Title: Single- and multiple-dose pharmacokinetics of repaglinide in patients with type 2 diabetes and renal impairment.

Journal: European journal of clinical pharmacology 20010501

Title: Comparison between repaglinide and glipizide in Type 2 diabetes mellitus: a 1-year multicentre study.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20010501

Title: Differential effects of short and long duration insulinotropic agents on meal-related glucose excursions.

Journal: Diabetes, obesity & metabolism 20010401

Title: [Large general practice study with repaglinide. Fewer 'anxiety eating' in diabetic patients].

Journal: MMW Fortschritte der Medizin 20010308

Title: Repaglinide-induced factitious hypoglycemia.

Journal: The Journal of clinical endocrinology and metabolism 20010201

Title: Repaglinide and diabetes: new preparation. No better than glucose-lowering sulphonamides.

Journal: Prescrire international 20010201

Title: Current understanding regarding the role of repaglinide in post-prandial hyperglycemia.

Journal: The Journal of the Association of Physicians of India 20010125

Title: The role of prandial glucose regulation with repaglinide in addressing the problem of hypoglycemia in the treatment of type 2 diabetes.

Journal: The Journal of the Association of Physicians of India 20010125

Title: Combination therapy in type 2 diabetes: the role of repaglinide.

Journal: The Journal of the Association of Physicians of India 20010125

Title: Flexible meal-related dosing with repaglinide facilitates glycemic control in therapy-naive type 2 diabetes.

Journal: Diabetes care 20010101

Title: Mealtime glucose regulation with nateglinide in healthy volunteers: comparison with repaglinide and placebo.

Journal: Diabetes care 20010101

Title: Honing type 2 diabetes treatment.

Journal: Health news (Waltham, Mass.) 20010101

Title: Oral hypoglycemic agents: insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101

Title: Repaglinide: a review of its therapeutic use in type 2 diabetes mellitus.

Journal: Drugs 20010101

Title: [New molecules].

Journal: Journal de pharmacie de Belgique 20010101

Title: Patient perceptions of prandial oral therapy for type 2 diabetes.

Journal: The Diabetes educator 20010101

Title: Glucose-dependent and glucose-sensitizing insulinotropic effect of nateglinide: comparison to sulfonylureas and repaglinide.

Journal: International journal of experimental diabetes research 20010101

Title: Effectiveness of nateglinide on in vitro insulin secretion from rat pancreatic islets desensitized to sulfonylureas.

Journal: International journal of experimental diabetes research 20010101

Title: Pharmacology and clinical experience with repaglinide.

Journal: Expert opinion on investigational drugs 20000401

Title: Wang LC, et al. Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus.Medicine (Baltimore). 2018 Sep;97(38):e12476.

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Tags:135062-02-1 Molecular Formula|135062-02-1 MDL|135062-02-1 SMILES|135062-02-1 2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid