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Home Other Building Blocks 1352792-74-5
1352792-74-5,MFCD28963965
Catalog No.:AA009CHU

1352792-74-5 | Verinurad

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$13.00   $9.00
- +
5mg
98+%
in stock  
$32.00   $22.00
- +
10mg
98+%
in stock  
$46.00   $32.00
- +
25mg
98+%
in stock  
$77.00   $54.00
- +
50mg
98+%
in stock  
$131.00   $92.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CHU
Chemical Name:
Verinurad
CAS Number:
1352792-74-5
Molecular Formula:
C20H16N2O2S
Molecular Weight:
348.4182
MDL Number:
MFCD28963965
SMILES:
N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
Properties
Computed Properties
 
Complexity:
541  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
4.1  

Upstream Synthesis Route

[1]Patent:WO2013/67425,2013,A1,

[2]Patent:US10047050,2018,B2,

[1]Patent:WO2013/67425,2013,A1,

[1]Patent:CN105884807,2016,A,

[1]Patent:CN106883169,2017,A,

[1]Patent:CN106883169,2017,A,

Downstream Synthesis Route
ethyl2-((3-(4-cyanonaphthalen-1-yl)pyridin-4-yl)thio)-2-methylpropanoate 
  1352792-74-5 

[1]Patent:WO2013/67425,2013,A1.Locationinpatent:Paragraph00173

[2]Patent:US10047050,2018,B2.Locationinpatent:Page/Pagecolumn41

[3]TetrahedronLetters,2020,vol.61

[1]Patent:WO2013/67425,2013,A1

[2]Patent:US10047050,2018,B2

3-bromo-4-mercaptopyridine 
  1352792-74-5 

[1]Patent:WO2013/67425,2013,A1

[2]Patent:US10047050,2018,B2

[3]TetrahedronLetters,2020,vol.61

[4]TetrahedronLetters,2020,vol.61

[5]TetrahedronLetters,2020,vol.61

[1]Patent:WO2013/67425,2013,A1

Literature

Title: Tan PK, et al. Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout. Sci Rep. 2017 Apr 6;7(1):665.

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