Home Other Building Blocks 1354235-96-3
1354235-96-3,MFCD20926336
Catalog No.:AA009FU6

1354235-96-3 | trans-Ned 19

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
98% by HPLC
in stock  
$213.00   $149.00
- +
10mg
98% by HPLC
in stock  
$315.00   $221.00
- +
25mg
98% by HPLC
in stock  
$596.00   $417.00
- +
50mg
98% by HPLC
in stock  
$970.00   $679.00
- +
100mg
98% by HPLC
in stock  
$1,632.00   $1,142.00
- +
500mg
98% by HPLC
in stock  
$5,126.00   $3,588.00
- +
1000mg
98% by HPLC
in stock  
$8,164.00   $5,715.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009FU6
Chemical Name:
trans-Ned 19
CAS Number:
1354235-96-3
Molecular Formula:
C30H31FN4O3
Molecular Weight:
514.5905
MDL Number:
MFCD20926336
SMILES:
COc1ccc(cc1CN1CCN(CC1)c1ccccc1F)[C@H]1N[C@@H](Cc2c1[nH]c1c2cccc1)C(=O)O
Properties
Computed Properties
 
Complexity:
810  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
2  

Literature

Title: Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes.

Journal: Journal of cellular and molecular medicine 20141101

Title: Cross talk among calcium, hydrogen peroxide, and nitric oxide and activation of gene expression involving calmodulins and calcium-dependent protein kinases in Ulva compressa exposed to copper excess.

Journal: Plant physiology 20120301

Title: NAADP regulates human platelet function.

Journal: The Biochemical journal 20120101

Title: Intracellular angiotensin II activates rat myometrium.

Journal: American journal of physiology. Cell physiology 20110901

Title: NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells.

Journal: Blood 20110505

Title: TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.

Journal: The Journal of biological chemistry 20101105

Title: A functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat.

Journal: The Journal of pharmacology and experimental therapeutics 20100601

Title: Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.

Journal: The Journal of biological chemistry 20091211

Title: NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.

Journal: American journal of physiology. Renal physiology 20090801

Title: Identification of a chemical probe for NAADP by virtual screening.

Journal: Nature chemical biology 20090401

Title: Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438.

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Tags:1354235-96-3 Molecular Formula|1354235-96-3 MDL|1354235-96-3 SMILES|1354235-96-3 trans-Ned 19