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135459-87-9,MFCD12031997
Catalog No.:AA00HU2Q

135459-87-9 | 2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile

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5g
98%
in stock  
$21.00   $15.00
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10g
98%
in stock  
$29.00   $21.00
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25g
95%
in stock  
$62.00   $44.00
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100g
98%
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$96.00   $68.00
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500g
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$469.00   $328.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00HU2Q
Chemical Name:
2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile
CAS Number:
135459-87-9
Molecular Formula:
C12H6N2O8SSr2
Molecular Weight:
513.4896
MDL Number:
MFCD12031997
SMILES:
N#Cc1c(sc(c1CC(=O)[O-])C(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Sr+2].[Sr+2]
Properties
Computed Properties
 
Complexity:
533  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
11  
Rotatable Bond Count:
4  

Literature

Title: Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats.

Journal: Clinical oral implants research 20120901

Title: Strontium is incorporated in different levels into bones and teeth of rats treated with strontium ranelate.

Journal: Calcified tissue international 20120901

Title: Repeated supratherapeutic dosing of strontium ranelate over 15 days does not prolong QT(c) interval in healthy volunteers.

Journal: British journal of clinical pharmacology 20120801

Title: Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation.

Journal: Osteoarthritis and cartilage 20120701

Title: Potential anti-catabolic and anabolic properties of strontium ranelate.

Journal: Current molecular pharmacology 20120601

Title: Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling.

Journal: Aging cell 20120601

Title: Strontium ranelate--a promising therapeutic principle in osteoporosis.

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20120601

Title: Osteoporosis treatment in postmenopausal women with pre-existing fracture.

Journal: Taiwanese journal of obstetrics & gynecology 20120601

Title: Persistence and compliance of medications used in the treatment of osteoporosis--analysis using a large scale, representative, longitudinal German database.

Journal: International journal of clinical pharmacology and therapeutics 20120501

Title: Effects of strontium ranelate on cortical bone collagen integrity.

Journal: Saudi medical journal 20120501

Title: Oral bisphosphonate use increases the risk for inflammatory jaw disease: a cohort study.

Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120401

Title: Adherence to therapeutic and diagnostic recommendations in patients with femur fracture and at risk of re-fracture or death: results of an analysis of administrative databases.

Journal: Reumatismo 20120316

Title: Osteoporosis, osteopenia and fracture risk: widening the therapeutic horizons.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20120308

Title: [Alopecia areata universalis due to strontium ranelate].

Journal: Medicina clinica 20120303

Title: Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120301

Title: Individualizing osteoporosis therapy.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120301

Title: Strontium ranelate prevents bone loss in a rat model of localized muscle paralysis.

Journal: Annals of biomedical engineering 20120301

Title: Long-term treatment of osteoporosis in postmenopausal women: a review from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).

Journal: Current medical research and opinion 20120301

Title: Strontium ranelate: too many adverse effects.

Journal: Prescrire international 20120301

Title: Effects of strontium on proliferation and differentiation of rat bone marrow mesenchymal stem cells.

Journal: Biochemical and biophysical research communications 20120224

Title: Possible benefits of strontium ranelate in complicated long bone fractures.

Journal: Rheumatology international 20120201

Title: The use of combination therapy in the treatment of postmenopausal osteoporosis.

Journal: Endocrine 20120201

Title: Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial.

Journal: Current medical research and opinion 20120201

Title: EMAS clinical guide: selective estrogen receptor modulators for postmenopausal osteoporosis.

Journal: Maturitas 20120201

Title: Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201

Title: Hemorheological changes with strontium ranelate treatment do not seem to be related to its claimed prothrombotic effects.

Journal: Archives of gerontology and geriatrics 20120101

Title: The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101

Title: Microarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goats.

Journal: Biological trace element research 20120101

Title: The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation.

Journal: Molecular and cellular biochemistry 20120101

Title: Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101

Title: Persistence with osteoporosis medications among postmenopausal women in the UK General Practice Research Database.

Journal: Menopause (New York, N.Y.) 20120101

Title: Weak effect of strontium on early implant fixation in rat tibia.

Journal: Bone 20120101

Title: Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention.

Journal: Journal of environmental and public health 20120101

Title: Hip cortical thickness assessment in postmenopausal women with osteoporosis and strontium ranelate effect on hip geometry.

Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20120101

Title: Strontium ranelate treatment improves oxidative damage in osteoporotic rat model.

Journal: Pharmacological reports : PR 20120101

Title: Sequential osteoporosis treatments.

Journal: Joint, bone, spine : revue du rhumatisme 20111201

Title: Prevention of osteoporosis: one step forward, two steps back.

Journal: Menopause international 20111201

Title: A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption.

Journal: Clinical chemistry and laboratory medicine 20111114

Title: Current options for the management of postmenopausal osteoporosis.

Journal: Expert opinion on pharmacotherapy 20111101

Title: Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride.

Journal: Journal of synchrotron radiation 20111101

Title: [Strontium ranelate promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells by increasing bone morphogenetic protein-7 expression].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111101

Title: Stevens-Johnson syndrome due to strontium ranelate.

Journal: Annals of the Academy of Medicine, Singapore 20111101

Title: The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats.

Journal: Biological trace element research 20111001

Title: [Adverse drug reactions of strontium ranelate(Protelos(®) in France].

Journal: Presse medicale (Paris, France : 1983) 20111001

Title: [Strontium ranelate(Protelos®): who really benefits of the doubt?].

Journal: Presse medicale (Paris, France : 1983) 20111001

Title: The action of Strontium ranelate: myth or reality.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20111001

Title: The effect of PTH(1-84) or strontium ranelate on bone formation markers in postmenopausal women with primary osteoporosis: results of a randomized, open-label clinical trial.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110901

Title: Distribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate.

Journal: European journal of endocrinology 20110901

Title: Gastrointestinal tolerability and patterns of switching in patients treated for primary osteoporosis: the Swedish Adherence Register Analysis (SARA).

Journal: Calcified tissue international 20110901

Title: Effects of anti-osteoporosis medications on fracture healing.

Journal: Current osteoporosis reports 20110901

Title: Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts.

Journal: Bone 20110901

Title: Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide.

Journal: The Journal of clinical endocrinology and metabolism 20110901

Title: Uses and misuses of statistics: the case of strontium ranelate and the number needed to treat.

Journal: Journal of endocrinological investigation 20110901

Title: Vertebral fractures.

Journal: The New England journal of medicine 20110818

Title: [Pharmacologic treatment of osteoporosis--2011].

Journal: Orvosi hetilap 20110814

Title: Anabolic agents and bone quality.

Journal: Clinical orthopaedics and related research 20110801

Title: A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX(®).

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110801

Title: Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis.

Journal: Calcified tissue international 20110801

Title: An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts.

Journal: The Journal of biological chemistry 20110708

Title: [Osteoporosis].

Journal: Praxis 20110706

Title: How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110601

Title: Strontium ranelate: too many adverse effects.

Journal: Prescrire international 20110601

Title: Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis.

Journal: Bone 20110501

Title: Increased bone strength is associated with improved bone microarchitecture in intact female rats treated with strontium ranelate: a finite element analysis study.

Journal: Bone 20110501

Title: Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats.

Journal: Endocrinology 20110501

Title: Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis.

Journal: Climacteric : the journal of the International Menopause Society 20110401

Title: The possible introduction of anti-osteoporosis drugs as an integrated treatment in total hip arthroplasty.

Journal: Aging clinical and experimental research 20110401

Title: Cost-effectiveness of Denosumab for the treatment of postmenopausal osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110301

Title: Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110301

Title: Strontium ranelate-induced DRESS syndrome with persistent autoimmune hepatitis.

Journal: Acta dermato-venereologica 20110301

Title: The treatment of symptomatic osteoporotic spinal compression fractures.

Journal: The Journal of the American Academy of Orthopaedic Surgeons 20110301

Title: [Incidence of hip fractures due to osteoporosis in relation to the prescription of drugs for their prevention and treatment in Galicia, Spain].

Journal: Atencion primaria 20110201

Title: Strontium ranelate and risk of vertebral fractures in frail osteoporotic women.

Journal: Bone 20110201

Title: Strontium is incorporated into the fracture callus but does not influence the mechanical strength of healing rat fractures.

Journal: Calcified tissue international 20110201

Title: [Strontium ranelate-induced DRESS syndrome].

Journal: Annales de dermatologie et de venereologie 20110201

Title: Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110101

Title: Effect of strontium ranelate on fracture healing in the osteoporotic rats.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110101

Title: Strontium ranelate in post-menopausal osteoporosis.

Journal: Endokrynologia Polska 20110101

Title: Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.

Journal: PloS one 20110101

Title: [Strontium ranelate in post-menopausal osteoporosis].

Journal: Endokrynologia Polska 20110101

Title: How to manage postmenopausal osteoporosis?

Journal: Acta clinica Belgica 20110101

Title: Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101201

Title: Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure.

Journal: Acta biomaterialia 20101201

Title: Impact of treatments for postmenopausal osteoporosis (bisphosphonates, parathyroid hormone, strontium ranelate, and denosumab) on bone quality: a systematic review.

Journal: Calcified tissue international 20101201

Title: Strontium ranelate: a look back at its use for osteoporosis.

Journal: Expert opinion on pharmacotherapy 20101201

Title: Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101101

Title: Sustained vertebral antifracture efficacy of oral anti-osteoporotic therapies in postmenopausal osteoporosis.

Journal: Current medical research and opinion 20101101

Title: How to prevent glucocorticoid-induced osteoporosis.

Journal: Cleveland Clinic journal of medicine 20101101

Title: Evidence-based guidelines for the pharmacological treatment of postmenopausal osteoporosis: a consensus document by the Belgian Bone Club.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101001

Title: Strontium ranelate decreases receptor activator of nuclear factor-ΚB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor.

Journal: Molecular pharmacology 20101001

Title: Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology.

Journal: Molecular interventions 20101001

Title: Use of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolism.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100901

Title: Spotlight on strontium ranelate: in postmenopausal osteoporosis.

Journal: Drugs & aging 20100901

Title: Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate.

Journal: The Journal of biological chemistry 20100813

Title: Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis.

Journal: Rheumatology international 20100801

Title: The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100801

Title: The relationship of inflammation to systemic diseases and chronic periodontitis.

Journal: International journal of dental hygiene 20100801

Title: Cost-effectiveness of strontium ranelate for the prevention and treatment of osteoporosis.

Journal: Expert review of pharmacoeconomics & outcomes research 20100801

Title: Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100701

Title: Bladder rupture following osteoporotic pubic ramus and sacral insufficiency fractures.

Journal: Age and ageing 20100701

Title: Incidence of venous thromboembolism in users of strontium ranelate: an analysis of data from a prescription-event monitoring study in England.

Journal: Drug safety 20100701

Title: Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601

Title: The effects of strontium ranelate on biochemical markers of bone turnover and their relationship with bone mineral density.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601

Title: Effects of alendronate and strontium ranelate on cancellous and cortical bone mass in glucocorticoid-treated adult rats.

Journal: Calcified tissue international 20100601

Title: Addressing the age-related needs of osteoporotic patients with strontium ranelate.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601

Title: Strontium ranelate: an effective solution for diverse fracture risks.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601

Title: Comparing and contrasting the effects of strontium ranelate and other osteoporosis drugs on microarchitecture.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601

Title: Strontium is incorporated into mineral crystals only in newly formed bone during strontium ranelate treatment.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100501

Title: Strontium ranelate treatment enhances hydroxyapatite-coated titanium screws fixation in osteoporotic rats.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100501

Title: Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat.

Journal: Rheumatology international 20100501

Title: Strontium ranelate improves implant osseointegration.

Journal: Bone 20100501

Title: The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro.

Journal: Biomaterials 20100501

Title: Severe exfoliative dermatitis caused by strontium ranelate: two cases of a new drug reaction.

Journal: Age and ageing 20100501

Title: Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis.

Journal: Drugs 20100416

Title: In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100401

Title: Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age.

Journal: Bone 20100401

Title: [Preventive and therapeutic effect of strontium ranelate on osteoporosis in rats subjected to simulated weightlessness].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100401

Title: Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100401

Title: Effect of osteoporosis treatment on mortality: a meta-analysis.

Journal: The Journal of clinical endocrinology and metabolism 20100301

Title: The effect of prior bisphosphonate therapy on the subsequent BMD and bone turnover response to strontium ranelate.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100301

Title: Short-term bone marker responses to teriparatide and strontium ranelate in patients with osteoporosis previously treated with bisphosphonates.

Journal: Arquivos brasileiros de endocrinologia e metabologia 20100301

Title: Vertebral anti-fracture efficacy of strontium ranelate according to pre-treatment bone turnover.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100201

Title: The cost-effectiveness of strontium ranelate in the UK for the management of osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100201

Title: Prospective assessment of thoracic kyphosis in postmenopausal women with osteoporosis.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100201

Title: Cost-effectiveness of strontium ranelate versus risedronate in the treatment of postmenopausal osteoporotic women aged over 75 years.

Journal: Bone 20100201

Title: [Rash and renal failure secondary to strontium ranelate].

Journal: Medicina clinica 20100130

Title: Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100101

Title: Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing.

Journal: Calcified tissue international 20100101

Title: [Impact of a health safety warning on strontium ranelate utilization].

Journal: Gaceta sanitaria 20100101

Title: [Diagnosis and treatment of osteoporosis in persons aged more than 75 years].

Journal: Revista espanola de geriatria y gerontologia 20100101

Title: Therapeutic options in osteoporosis.

Journal: Acta bio-medica : Atenei Parmensis 20100101

Title: Efficacy of strontium ranelate on bone mineral density in men with osteoporosis.

Journal: Arzneimittel-Forschung 20100101

Title: A comparison between bisphosphonates and other treatments for osteoporosis.

Journal: Current pharmaceutical design 20100101

Title: Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss.

Journal: Clinical interventions in aging 20100101

Title: Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary.

Journal: Clinical interventions in aging 20100101

Title: Long-term treatment of postmenopausal osteoporosis with strontium ranelate: results at 8 years.

Journal: Bone 20091201

Title: Effects of strontium ranelate, raloxifene and misoprostol on bone mineral density in ovariectomized rats.

Journal: European journal of obstetrics, gynecology, and reproductive biology 20091201

Title: About the comparison of two anabolic agents, teriparatide and strontium ranelate, in treated osteoporotic women.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20091201

Title: Re: 'Effect of long-term treatment with strontium ranelate on bone strontium content' by Bärenholdt et al. (Bone, 2009).

Journal: Bone 20091101

Title: Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20091001

Title: Bullous DRESS in a patient on strontium ranelate.

Journal: Clinical and experimental dermatology 20091001

Title: Strontium ranelate: new perspectives for the management of osteoporosis.

Journal: Rheumatology (Oxford, England) 20091001

Title: Osteoporosis: from early fracture prevention to better bone health with strontium ranelate.

Journal: Rheumatology (Oxford, England) 20091001

Title: Continuous broad protection against osteoporotic fractures with strontium ranelate.

Journal: Rheumatology (Oxford, England) 20091001

Title: Strontium ranelate improves bone microarchitecture in osteoporosis.

Journal: Rheumatology (Oxford, England) 20091001

Title: Strontium: confusion and hallucinations. Do not use strontium.

Journal: Prescrire international 20091001

Title: Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis.

Journal: Bone 20090901

Title: Strontium ranelate as a cause of acute renal failure and dress syndrome.

Journal: Nephrology (Carlton, Vic.) 20090901

Title: Strontium ranelate: new data on fracture prevention and mechanisms of action.

Journal: Current osteoporosis reports 20090901

Title: Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090801

Title: Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosis.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090801

Title: Effect of long-term treatment with strontium ranelate on bone strontium content.

Journal: Bone 20090801

Title: The new frontier of bone formation: a breakthrough in postmenopausal osteoporosis?

Journal: Climacteric : the journal of the International Menopause Society 20090801

Title: Could strontium ranelate have a synergistic role in the treatment of osteoporosis?

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090801

Title: Osteoblasts play key roles in the mechanisms of action of strontium ranelate.

Journal: British journal of pharmacology 20090801

Title: Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate.

Journal: Journal of cellular and molecular medicine 20090801

Title: Effect of strontium ranelate on lumbar spine bone mineral density in women with established osteoporosis previously treated with teriparatide.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090701

Title: Monitoring strontium ranelate therapy in patients with osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090701

Title: Effects of bone anabolic agents on bone ultrastructure.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090601

Title: Synthesis, characterization of strontium-bile acid salts and their bioactivity vs. the anti-osteoporosis drug strontium ranelate.

Journal: Journal of inorganic biochemistry 20090601

Title: Efficacy and safety of pharmacological agents in managing osteoporosis in the old old: review of the evidence.

Journal: Bone 20090501

Title: [Drugs under development for osteoporosis ].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20090501

Title: [Efficacy of strontium ranelate for the mineralization of bone in postmenopausal women].

Journal: Ginecologia y obstetricia de Mexico 20090501

Title: Strontium ranelate may cause alopecia.

Journal: BMJ (Clinical research ed.) 20090422

Title: No difference between strontium ranelate (SR) and calcium/vitamin D on bone turnover markers in women with established osteoporosis previously treated with teriparatide: a randomized controlled trial.

Journal: Clinical endocrinology 20090401

Title: Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090401

Title: Pregnancy- and lactation-associated osteoporosis with severe vertebral deformities: can strontium ranelate be a new alternative for the treatment?

Journal: The spine journal : official journal of the North American Spine Society 20090401

Title: Strontium ranelate-induced DRESS syndrome: first two case reports.

Journal: Allergy 20090401

Title: Generalized cutaneous drug eruption due to strontium ranelate.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20090301

Title: New findings with old drugs for osteoporosis.

Journal: Expert opinion on pharmacotherapy 20090201

Title: The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways.

Journal: The Journal of biological chemistry 20090102

Title: Strontium ranelate-induced toxic epidermal necrolysis in a patient with post-menopausal osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090101

Title: Strontium ranelate decreases plasma homocysteine levels in postmenopausal osteoporotic women.

Journal: Rheumatology international 20090101

Title: [How to prevent early postmenopausal fracture risk? Proposition of a strategy].

Journal: Gynecologie, obstetrique & fertilite 20090101

Title: [Current approaches to the diagnosis and treatment of postmenopausal osteoporosis].

Journal: Terapevticheskii arkhiv 20090101

Title: Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis.

Journal: Annals of the rheumatic diseases 20081201

Title: Effective doses for strontium ranelate.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20081201

Title: Rash, strontium ranelate and DRESS syndrome put into perspective. European Medicine Agency on the alert.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20081201

Title: Strontium ranelate: the first agent of a new therapeutic class in osteoporosis.

Journal: Advances in therapy 20081201

Title: The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study.

Journal: Archives of gynecology and obstetrics 20081101

Title: Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions.

Journal: British journal of clinical pharmacology 20081101

Title: The effects of strontium ranelate in Asian women with postmenopausal osteoporosis.

Journal: Calcified tissue international 20081101

Title: [Newly developed drugs for osteoporosis in overseas and their future roles for the therapy].

Journal: Clinical calcium 20081001

Title: Bone-forming agents in the management of osteoporosis.

Journal: Best practice & research. Clinical endocrinology & metabolism 20081001

Title: Strontium ranelate does not stimulate bone formation in ovariectomized rats.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080901

Title: Treatment of osteoporosis: all the questions we still cannot answer.

Journal: The American journal of medicine 20080901

Title: Cytotoxicity analysis of strontium ranelate on cultured human periodontal ligament fibroblasts: a preliminary report.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20080801

Title: Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength.

Journal: Rheumatology (Oxford, England) 20080701

Title: Strontium ranelate: short- and long-term benefits for post-menopausal women with osteoporosis.

Journal: Rheumatology (Oxford, England) 20080701

Title: Strontium ranelate for the management of osteoporosis.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080701

Title: Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms.

Journal: Bone 20080601

Title: Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial.

Journal: Arthritis and rheumatism 20080601

Title: Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080401

Title: Effect of strontium ranelate on hydrogen peroxide-induced apoptosis of CRL-11372 cells.

Journal: Biochemical genetics 20080401

Title: Osteoporosis: overview in disease, epidemiology, treatment and health economy.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080401

Title: Effects of strontium ranelate on spinal osteoarthritis progression.

Journal: Annals of the rheumatic diseases 20080301

Title: Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080301

Title: [Assessment of bone quality. Drug developments for restoring bone mass and quality in the treatment of osteoporosis].

Journal: Clinical calcium 20080301

Title: Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080201

Title: Interstitial granulomatous reaction to strontium ranelate.

Journal: Archives of dermatology 20080201

Title: Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro.

Journal: Bone 20080101

Title: [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. Results of Russian multicenter trial].

Journal: Terapevticheskii arkhiv 20080101

Title: [Osteoporosis: from cost-effect characteristics to clinical efficacy and safety of strontium ranelate (bivalos)].

Journal: Terapevticheskii arkhiv 20080101

Title: [Strontium ranelate's (Osseor) dual mode of action: increasing bone mass and decreasing bone resorption].

Journal: Reumatizam 20080101

Title: [The efficacy of strontium ranelate (Osseor) on fractures in osteoporosis].

Journal: Reumatizam 20080101

Title: Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.

Journal: BMC musculoskeletal disorders 20080101

Title: Relationship between change in femoral neck bone mineral density and hip fracture incidence during treatment with strontium ranelate.

Journal: Current medical research and opinion 20071201

Title: Effect of strontium ranelate on fracture healing in rat tibia.

Journal: Joint, bone, spine : revue du rhumatisme 20071201

Title: Evidence based medicine and effective interventions of pharmacological therapy for the prevention of osteoporotic fractures.

Journal: Minerva endocrinologica 20071201

Title: [Therapeutics issues in osteoporosis].

Journal: Medicina clinica 20071201

Title: [New bone density conservation agents for osteoporosis under research and development: Strontium ranelate].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071128

Title: [Strontium ranlelate (Protelos)].

Journal: Revue medicale de Liege 20071101

Title: [Advances in the field of osteoporosis].

Journal: La Revue du praticien 20071015

Title: Osteoporosis: non-hormonal treatment.

Journal: Climacteric : the journal of the International Menopause Society 20071001

Title: Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070901

Title: [Current and future prospects for anti-osteoporotic drugs].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070901

Title: The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation.

Journal: Biochemical pharmacology 20070801

Title: Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate.

Journal: The Journal of clinical endocrinology and metabolism 20070801

Title: Strontium ranelate--does it affect the management of postmenopausal osteoporosis?

Journal: Australian family physician 20070801

Title: By the way, doctor. What can you tell me about the mineral strontium, which is advertised for treating osteoporosis?

Journal: Harvard women's health watch 20070801

Title: Strontium ranelate normalizes bone mineral density in osteopenic patients.

Journal: Aging clinical and experimental research 20070801

Title: Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070701

Title: [The necessity of cost-effectiveness analysis in osteoporosis].

Journal: Revue medicale suisse 20070613

Title: Pharmacological treatment of osteoporosis for people over 70.

Journal: Aging clinical and experimental research 20070601

Title: Induction of a program gene expression during osteoblast differentiation with strontium ranelate.

Journal: Biochemical and biophysical research communications 20070406

Title: Strontium ranelate in the prevention of osteoporotic fractures.

Journal: International journal of clinical practice 20070201

Title: The clinical effectiveness and cost-effectiveness of strontium ranelate for the prevention of osteoporotic fragility fractures in postmenopausal women.

Journal: Health technology assessment (Winchester, England) 20070201

Title: An analysis of which anti-osteoporosis therapeutic regimen would improve compliance in a population of elderly adults.

Journal: Current medical research and opinion 20070201

Title: Osteoporosis: strategies for prevention and management.

Journal: Best practice & research. Clinical rheumatology 20070201

Title: Osteoporosis.

Journal: Rheumatic diseases clinics of North America 20070201

Title: [Osteoporosis: basics and pitfalls].

Journal: Praxis 20070124

Title: Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women.

Journal: Bone 20070101

Title: Short-term hemostatic safety of strontium ranelate treatment in elderly women with osteoporosis.

Journal: The Annals of pharmacotherapy 20070101

Title: [Therapeutic agents for disorders of bone and calcium metabolism. Osteoporotic fracture prevention by strontium ranelate].

Journal: Clinical calcium 20070101

Title: How long should patients take medications for postmenopausal osteoporosis?

Journal: Joint, bone, spine : revue du rhumatisme 20070101

Title: Effect of bone strontium on BMD measurements.

Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20070101

Title: A review of strontium ranelate and its effect on DXA scans.

Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20070101

Title: The correction of BMD measurements for bone strontium content.

Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20070101

Title: Improvement in bone strength parameters. The role of strontium ranelate.

Journal: Journal of musculoskeletal & neuronal interactions 20070101

Title: Treatment and prevention of osteoporosis.

Journal: Wiener medizinische Wochenschrift (1946) 20070101

Title: [Strontium ranelate (Osseor)--unique double mechanism--physiologic bone treatment as live tissue].

Journal: Reumatizam 20070101

Title: Osteoporosis prevention and therapy: preserving and building strength through bone quality.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20061201

Title: An economic evaluation of strontium ranelate in the treatment of osteoporosis in a Swedish setting: based on the results of the SOTI and TROPOS trials.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20061201

Title: Strontium ranelate: a novel treatment in postmenopausal osteoporosis.

Journal: Annals of the New York Academy of Sciences 20061201

Title: Strontium ranelate: a novel treatment for postmenopausal osteoporosis: a review of safety and efficacy.

Journal: Clinical interventions in aging 20061201

Title: Strontium ranelate for preventing and treating postmenopausal osteoporosis.

Journal: The Cochrane database of systematic reviews 20061018

Title: [Osteoporosis priority: Reduce the number of fractures].

Journal: Presse medicale (Paris, France : 1983) 20061001

Title: [Drug treatment of postmenopausal osteoporosis. What's New in 2006].

Journal: Presse medicale (Paris, France : 1983) 20061001

Title: [Osteoporosis in the elderly].

Journal: Presse medicale (Paris, France : 1983) 20061001

Title: Theoretical model for the interpretation of BMD scans in patients stopping strontium ranelate treatment.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060901

Title: [DVO guideline 2006. What changes have there been in the diagnosis, prevention and treatment of osteoporosis?].

Journal: Zeitschrift fur Rheumatologie 20060901

Title: [Anabolic treatment for osteoporosis: PTH treatment].

Journal: Clinical calcium 20060901

Title: Developments in the pharmacotherapeutic management of osteoporosis.

Journal: Expert opinion on pharmacotherapy 20060801

Title: Anabolic skeletal therapy for osteoporosis.

Journal: Arquivos brasileiros de endocrinologia e metabologia 20060801

Title: Strontium ranelate for preventing and treating postmenopausal osteoporosis.

Journal: The Cochrane database of systematic reviews 20060719

Title: [Strontium ranelate and non-vertebral fracture in postmenopausal osteoporosis].

Journal: Medicina clinica 20060715

Title: Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060701

Title: Boning up on osteoporosis--current thinking on management. Interview by Emma Buchanan.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20060701

Title: Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation.

Journal: Current opinion in rheumatology 20060601

Title: Strontium ranelate: vertebral and non-vertebral fracture risk reduction.

Journal: Current opinion in rheumatology 20060601

Title: Addressing and meeting the needs of osteoporotic patients with strontium ranelate: a review.

Journal: Current opinion in rheumatology 20060601

Title: Preclinical assessment of gastrooesophageal tolerance of the new antiosteoporotic drug strontium ranelate: an endoscopic study in monkeys.

Journal: Basic & clinical pharmacology & toxicology 20060501

Title: Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060401

Title: Strontium ranelate for osteoporosis?

Journal: Drug and therapeutics bulletin 20060401

Title: Strontium ranelate--data on vertebral and nonvertebral fracture efficacy and safety: mechanism of action.

Journal: Current osteoporosis reports 20060301

Title: [Up-to-date treatments for osteoporosis].

Journal: Orvosi hetilap 20060219

Title: Protelos: nonvertebral and hip antifracture efficacy in postmenopausal osteoporosis.

Journal: Bone 20060201

Title: Strontium ranelate: a physiological approach for optimizing bone formation and resorption.

Journal: Bone 20060201

Title: Fighting osteoporosis on two fronts.

Journal: Bone 20060201

Title: Strontium ranelate: a physiological approach for an improved bone quality.

Journal: Bone 20060201

Title: Strontium ranelate: an increased bone quality leading to vertebral antifracture efficacy at all stages.

Journal: Bone 20060201

Title: Strontium ranelate: the first dual acting treatment for postmenopausal osteoporosis.

Journal: Clinical orthopaedics and related research 20060201

Title: Anabolic agents: a new chapter in the management of osteoporosis.

Journal: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20060201

Title: [The latest developments in endocrinology 2004/2005].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20060115

Title: [Strontium ranelate].

Journal: Clinical calcium 20060101

Title: Selective alpha7 nicotinic acetylcholine receptor ligands.

Journal: Current medicinal chemistry 20060101

Title: Comprehensive therapy in osteoporosis using a single drug: from ADFR to strontium ranelate.

Journal: Current medicinal chemistry 20060101

Title: [Strontium ranelate--new paradigm in the treatment of postmenopausal osteoporosis].

Journal: Lijecnicki vjesnik 20060101

Title: Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls.

Journal: Drugs 20060101

Title: Strontium as therapy for osteoporosis.

Journal: Current opinion in pharmacology 20051201

Title: Newer drug treatments: their effects on fracture prevention.

Journal: Best practice & research. Clinical rheumatology 20051201

Title: Long-term effect of strontium ranelate treatment on BMD.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20051101

Title: [How to take charge of osteoporosis in women in 2005].

Journal: Revue de l'infirmiere 20051101

Title: [Strontium ranelate: a novel concept for the treatment of osteoporosis].

Journal: Wiener klinische Wochenschrift 20051101

Title: Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20051001

Title: [Strontium ranelate: a new therapeutic principle for postmenopausal osteoporosis].

Journal: Ugeskrift for laeger 20050912

Title: Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050901

Title: On some osteoporosis analyses.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050801

Title: Osteoporosis.

Journal: Clinics in geriatric medicine 20050801

Title: Strontium ranelate for the treatment of osteoporosis.

Journal: BMJ (Clinical research ed.) 20050618

Title: Postmenopausal osteoporosis: therapeutic options.

Journal: Climacteric : the journal of the International Menopause Society 20050601

Title: Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study.

Journal: The Journal of clinical endocrinology and metabolism 20050501

Title: Where now for the management of osteoporosis?

Journal: Hospital medicine (London, England : 1998) 20050501

Title: Strontium ranelate (Fujisawa/Servier).

Journal: Current opinion in investigational drugs (London, England : 2000) 20050401

Title: Strontium ranelate: a new treatment for postmenopausal osteoporosis with a dual mode of action.

Journal: Current osteoporosis reports 20050301

Title: Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050201

Title: Prevention of vertebral fractures by strontium ranelate in postmenopausal women with osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050101

Title: Strontium ranelate: a novel mode of action leading to renewed bone quality.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050101

Title: Clinical effects of strontium ranelate in women with postmenopausal osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050101

Title: Strontium ranelate: a novel mode of action optimizing bone formation and resorption.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050101

Title: [Strontium Ranelate as a new therapeutic agent for osteoporosis].

Journal: Clinical calcium 20050101

Title: Management of bone health in postmenopausal women.

Journal: Hormone research 20050101

Title: A new treatment for post-menopausal osteoporosis: strontium ranelate.

Journal: Journal of endocrinological investigation 20050101

Title: Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20041201

Title: [New treatments in osteoporosis].

Journal: La Revue de medecine interne 20041201

Title: Guidelines for the management of postmenopausal osteoporosis for GPs.

Journal: Australian family physician 20041101

Title: [Treatment of postmenopausal osteoporosis in 2004].

Journal: Revue medicale de Liege 20041101

Title: In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor.

Journal: Biochemical and biophysical research communications 20041029

Title: Recent important clinical trials of drugs in osteoporosis.

Journal: Expert opinion on pharmacotherapy 20040701

Title: Strontium ranelate: a new paradigm in the treatment of osteoporosis.

Journal: Expert opinion on investigational drugs 20040701

Title: Bone anabolic agents: the unanswered queries.

Journal: Basic & clinical pharmacology & toxicology 20040601

Title: Postmenopausal osteoporosis and strontium ranelate.

Journal: The New England journal of medicine 20040506

Title: Postmenopausal osteoporosis and strontium ranelate.

Journal: The New England journal of medicine 20040506

Title: Normal matrix mineralization induced by strontium ranelate in MC3T3-E1 osteogenic cells.

Journal: Metabolism: clinical and experimental 20040401

Title: [New medication combines osteo-anabolic and anti-resorptive effects. Double strategy against osteoporosis].

Journal: MMW Fortschritte der Medizin 20040401

Title: Strontium strengthens some bones.

Journal: Health news (Waltham, Mass.) 20040301

Title: [Preclinical evaluation of strontium ranelate in bone quality].

Journal: Revue medicale de la Suisse romande 20040201

Title: The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis.

Journal: The New England journal of medicine 20040129

Title: Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same?

Journal: The New England journal of medicine 20040129

Title: [Strontium ranelate: new therapeutic agent for postmenopausal osteoporosis].

Journal: Medecine sciences : M/S 20040101

Title: [Therapy of osteoporosis: bisphosphonates, SERM's, teriparatide and strontium].

Journal: Zeitschrift fur Rheumatologie 20031201

Title: New anabolic agents in the treatment of osteoporosis.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20031001

Title: S12911-2 reduces bone loss induced by short-term immobilization in rats.

Journal: Bone 20030701

Title: S 12911-2 inhibits osteoclastic bone resorption in vitro.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030601

Title: [Prevention of hip fractures in the elderly: where are we in 2003?].

Journal: Revue medicale de Liege 20030401

Title: Strontium and osteoporosis.

Journal: The journal of the British Menopause Society 20030301

Title: Strontium ranelate: a new paradigm in the treatment of osteoporosis.

Journal: Drugs of today (Barcelona, Spain : 1998) 20030201

Title: Management of post-menopausal osteoporosis: something new on the horizon?

Journal: Journal of endocrinological investigation 20030201

Title: Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030101

Title: Is the calcium receptor a molecular target for the actions of strontium on bone?

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030101

Title: Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030101

Title: The mineralization of bone tissue: a forgotten dimension in osteoporosis research.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030101

Title: Optimizing bone metabolism in osteoporosis: insight into the pharmacologic profile of strontium ranelate.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030101

Title: [Bone mineralization and mineral status].

Journal: Therapie 20030101

Title: [Large clinical trials for osteoporosis].

Journal: Therapie 20030101

Title: Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial.

Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20021201

Title: In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation.

Journal: European journal of pharmacology 20020816

Title: Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice.

Journal: Metabolism: clinical and experimental 20020701

Title: Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial.

Journal: The Journal of clinical endocrinology and metabolism 20020501

Title: Strontium ranelate in osteoporosis.

Journal: Current pharmaceutical design 20020101

Title: Anabolic agents for treating postmenopausal osteoporosis.

Journal: Joint, bone, spine : revue du rhumatisme 20011201

Title: Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis).

Journal: Bone 20010801

Title: Strontium ranelate increases cartilage matrix formation.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010201

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Tags:135459-87-9 Molecular Formula|135459-87-9 MDL|135459-87-9 SMILES|135459-87-9 2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile