Catalog No.:AA01EN2Q

1354690-24-6 | Leniolisib

Name: Name:Leniolisib
Brand: AABLOCKS
SKU: AA01EN2Q
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

1mg

98%

in stock

$19.00 $14.00

- +

5mg

98%

in stock

$47.00 $33.00

- +

25mg

98%

in stock

$119.00 $83.00

- +

Technical Information
Properties
Downstream Synthesis Route
Literature
Request for Quotation
Download SDS

Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01EN2Q

Chemical Name:

Leniolisib

CAS Number:

1354690-24-6

Molecular Formula:

C21H25F3N6O2

Molecular Weight:

450.4574

MDL Number:

MFCD30470232

SMILES:

CCC(=O)N1CC[C@@H](C1)Nc1ncnc2c1CN(CC2)c1cnc(c(c1)C(F)(F)F)OC

Properties

Computed Properties

Complexity:

654

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.5

Downstream Synthesis Route

1354692-00-4

79-03-8

1354690-24-6

[1]Patent:WO2012/4299,2012,A1.Locationinpatent:Page/Pagecolumn145

[2]ACSMedicinalChemistryLetters,2017,vol.8,p.975-980

495-69-2

1354690-24-6

1354691-99-8

[1]Patent:WO2012/4299,2012,A1.Locationinpatent:Page/Pagecolumn148-149

[2]Patent:WO2013/1445,2013,A1.Locationinpatent:Page/Pagecolumn62

[3]Patent:WO2013/88404,2013,A1.Locationinpatent:Page/Pagecolumn163

[4]Patent:US2015/342951,2015,A1.Locationinpatent:Paragraph0944

121643-44-5

1354690-24-6

[1]Patent:WO2013/1445,2013,A1

[2]Patent:WO2013/88404,2013,A1

[3]Patent:US2015/342951,2015,A1

[4]Patent:WO2012/4299,2012,A1

914612-23-0

1354690-24-6

[1]Patent:WO2013/1445,2013,A1

[2]Patent:WO2013/88404,2013,A1

[3]Patent:US2015/342951,2015,A1

[4]ACSMedicinalChemistryLetters,2017,vol.8,p.975-980

[5]Patent:WO2012/4299,2012,A1

1354690-24-6

1354691-97-6

[1]Patent:WO2012/4299,2012,A1.Locationinpatent:Page/Pagecolumn146-147

[2]Patent:US2015/342951,2015,A1.Locationinpatent:Paragraph0940

Literature

Title: Effective 'activated PI3Kδ syndrome'-targeted therapy with the PI3Kδ inhibitor leniolisib.

Journal: Blood 20171123

Title: Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.

Journal: ACS medicinal chemistry letters 20170914

Title: Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections.

Journal: Clinical immunology (Orlando, Fla.) 20170301

Title: Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Journal: Nature immunology 20140101

Title: Rao V, et al. Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine: NEJM. ISSN 0028-4793; 1533-4406

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SDS

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Tags:1354690-24-6 Molecular Formula|1354690-24-6 MDL|1354690-24-6 SMILES|1354690-24-6 Leniolisib