Home Other Building Blocks 1357389-11-7
1357389-11-7,MFCD26960954
Catalog No.:AA009BMV

1357389-11-7 | Rgfp966

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$45.00   $31.00
- +
5mg
≥98%
in stock  
$110.00   $77.00
- +
25mg
98%
in stock  
$145.00   $102.00
- +
50mg
98%
in stock  
$253.00   $178.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009BMV
Chemical Name:
Rgfp966
CAS Number:
1357389-11-7
Molecular Formula:
C21H19FN4O
Molecular Weight:
362.4002
MDL Number:
MFCD26960954
SMILES:
O=C(Nc1ccc(cc1N)F)/C=C/c1cnn(c1)C/C=C/c1ccccc1
Properties
Computed Properties
 
Complexity:
532  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Literature

Title: Malvaez M, et al. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52.

Title: Leus NG, et al. HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Biochem Pharmacol. 2016 May 15;108:58-74.

Title: Jia H, et al. The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice. PLoS One. 2016 Mar 31;11(3):e0152498.

Title: Bieszczad KM, et al. Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation. J Neurosci. 2015 Sep 23;35(38):13124-32.

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Tags:1357389-11-7 Molecular Formula|1357389-11-7 MDL|1357389-11-7 SMILES|1357389-11-7 Rgfp966