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135755-51-0,MFCD29058560
Catalog No.:AA009FKX

135755-51-0 | (R,S)Palonosetron hcl

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Purity
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10mg
> 95%
2 weeks  
$999.00   $699.00
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  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009FKX
Chemical Name:
(R,S)Palonosetron hcl
CAS Number:
135755-51-0
Molecular Formula:
C19H25ClN2O
Molecular Weight:
332.8676
MDL Number:
MFCD29058560
SMILES:
O=C1N(C[C@H]2c3c1cccc3CCC2)[C@@H]1CN2CCC1CC2.Cl
Properties
Computed Properties
 
Complexity:
456  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  

Literature

Title: Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation.

Journal: Pharmacology, biochemistry, and behavior 20150401

Title: A phase III study evaluating the safety and efficacy of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting over repeated cycles of chemotherapy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20140701

Title: Antiemetic efficacy of single-dose palonosetron and dexamethasone in patients receiving multiple cycles of multiple day-based chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20121201

Title: Palonosetron for the prevention of nausea and vomiting in children with acute lymphoblastic leukemia treated with high dose methotrexate.

Journal: Pediatric blood & cancer 20121101

Title: Acute effect of palonosetron on electrocardiographic parameters in cancer patients: a prospective study.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20121001

Title: Comparison of two dosing schedules of palonosetron for the prevention of nausea and vomiting due to interleukin-2-based biochemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20121001

Title: Efficacy and safety of palonosetron as salvage treatment in the prevention of chemotherapy-induced nausea and vomiting in patients receiving low emetogenic chemotherapy (LEC).

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20121001

Title: Prevention of delayed nausea: a University of Rochester Cancer Center Community Clinical Oncology Program study of patients receiving chemotherapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120920

Title: A randomized double blind study to evaluate efficacy of palonosetron with dexamethasone versus palonosetron alone for prevention of postoperative and postdischarge nausea and vomiting in subjects undergoing laparoscopic surgeries with high emetogenic risk.

Journal: American journal of therapeutics 20120901

Title: Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects.

Journal: European journal of pharmacology 20120815

Title: [Antiemetic effect of palonosetron in advanced colorectal cancer patients receiving mFOLFOX6 and FOLFIRI: a retrospective survey].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20120801

Title: Electrocardiographic findings of palonosetron in cancer patients.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120701

Title: A phase III open-label study to assess safety and efficacy of palonosetron for preventing chemotherapy-induced nausea and vomiting (CINV) in repeated cycles of emetogenic chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120701

Title: The role of second-generation 5-HT3 receptor antagonists in managing chemotherapy-induced nausea and vomiting in hematological malignancies.

Journal: Critical reviews in oncology/hematology 20120701

Title: Possible anaphylaxis to palonoestron.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120601

Title: Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120501

Title: Liquid chromatography-electrospray quadrupole linear ion trap mass spectrometry method for the quantitation of palonosetron in human plasma and urine: Application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization.

Journal: European review for medical and pharmacological sciences 20120401

Title: Impact of initiating antiemetic prophylaxis with palonosetron versus ondansetron on risk of uncontrolled chemotherapy-induced nausea and vomiting in patients with lung cancer receiving multi-day chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120301

Title: Aprepitant, dexamethasone, and palonosetron in the prevention of doxorubicin/cyclophosphamide-induced nausea and vomiting.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120301

Title: Gastrointestinal symptoms in cancer patients with advanced disease: new methodologies, insights, and a proposed approach.

Journal: Current opinion in supportive and palliative care 20120301

Title: Anti-emetic effect of ondansetron and palonosetron in thyroidectomy: a prospective, randomized, double-blind study.

Journal: British journal of anaesthesia 20120301

Title: Is palonosetron also effective for opioid-induced and post-discharge nausea and vomiting?

Journal: British journal of anaesthesia 20120301

Title: [Comparison of the effect of palonosetron versus tropisetron in prevention of vomiting in patients receiving high dose cisplatin-based chemotherapy].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120301

Title: Single dose palonosetron and dexamethasone in preventing nausea and vomiting induced by high emetogenic ABVD regimen in Hodgkin Lymphoma patients.

Journal: Leukemia research 20120201

Title: Determination of palonosetron in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20120105

Title: Palonosetron plus 1-day dexamethasone for the prevention of nausea and vomiting due to moderately emetogenic chemotherapy: effect of established risk factors on treatment outcome in a phase III trial.

Journal: The journal of supportive oncology 20120101

Title: Antiemetic control with palonosetron in patients with gastrointestinal cancer receiving a fluoropyrimidine-based regimen in addition to either irinotecan or oxaliplatin: a retrospective study.

Journal: Oncology 20120101

Title: Impact of 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study.

Journal: BMC health services research 20120101

Title: Palonosetron: an evidence-based choice in prevention of nausea and vomiting induced by moderately emetogenic chemotherapy.

Journal: Tumori 20120101

Title: Palonosetron for prevention of acute and delayed nausea and vomiting in non-small-cell lung carcinoma patients.

Journal: Medical oncology (Northwood, London, England) 20111201

Title: Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20111201

Title: Management of postdischarge nausea and vomiting after ambulatory surgery.

Journal: Current opinion in anaesthesiology 20111201

Title: Antiemetics: American Society of Clinical Oncology clinical practice guideline update.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111101

Title: Single-dose palonosetron for prevention of chemotherapy-induced nausea and vomiting in patients with aggressive non-Hodgkin's lymphoma receiving moderately emetogenic chemotherapy containing steroids: results of a phase II study from the Gruppo Italiano per lo Studio dei Linfomi (GISL).

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20111001

Title: A triple-drug combination to prevent nausea and vomiting following BEAM chemotherapy before autologous hematopoietic stem cell transplantation.

Journal: Transplantation proceedings 20111001

Title: [The efficacy of aprepitant and palonosetron on cisplatin doublet in lung cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20111001

Title: Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase.

Journal: Journal of pharmaceutical and biomedical analysis 20110910

Title: Comparison of healthcare resource use between patients receiving ondansetron or palonosetron as prophylaxis for chemotherapy-induced nausea and vomiting.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20110901

Title: Palonosetron plus 3-day aprepitant and dexamethasone to prevent nausea and vomiting in patients receiving highly emetogenic chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801

Title: Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following moderately emetogenic chemotherapy: a randomized, multicenter, phase III trial.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801

Title: Chemotherapy-induced nausea and vomiting and antiemetic prophylaxis with palonosetron versus other 5-HT3 receptor antagonists in patients with cancer treated with low emetogenic chemotherapy in a hospital outpatient setting in the United States.

Journal: Current medical research and opinion 20110801

Title: Impact of 5-HT(3) RA selection within triple antiemetic regimens on uncontrolled highly emetogenic chemotherapy-induced nausea/vomiting.

Journal: Expert review of pharmacoeconomics & outcomes research 20110801

Title: Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT3R) in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110601

Title: Determination of palonosetron in human urine by LC-MS/MS.

Journal: Bioanalysis 20110601

Title: Palonosetron for the prevention of chemotherapy-induced nausea and vomiting in glioblastoma patients treated with temozolomide: a phase II study.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110501

Title: Comparison of palanosetron, granisetron and ondansetron as anti-emetics for prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery.

Journal: Journal of the Indian Medical Association 20110501

Title: Three palonosetron regimens to prevent CINV in myeloma patients receiving multiple-day high-dose melphalan and hematopoietic stem cell transplantation.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110401

Title: Palonosetron versus other 5-HT(3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting in patients with cancer on chemotherapy in a hospital outpatient setting.

Journal: Clinical therapeutics 20110401

Title: Randomized, double-blind, crossover study of palonosetron compared with granisetron for the prevention of chemotherapy-induced nausea and vomiting in a Chinese population.

Journal: Medical oncology (Northwood, London, England) 20110301

Title: Different doses of palonosetron for the prevention of postoperative nausea and vomiting in children undergoing strabismus surgery.

Journal: Drugs in R&D 20110301

Title: Palonosetron-induced migraine-type headache.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20110201

Title: A systematic review and meta-analysis of intravenous palonosetron in the prevention of chemotherapy-induced nausea and vomiting in adults.

Journal: The oncologist 20110201

Title: Palonosetron versus other 5-HT₃ receptor antagonists for prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancies treated with emetogenic chemotherapy in a hospital outpatient setting in the United States.

Journal: Journal of medical economics 20110101

Title: A randomized, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery.

Journal: The Journal of international medical research 20110101

Title: Single-dose palonosetron and dexamethasone in preventing nausea and vomiting induced by moderately emetogenic chemotherapy in breast and colorectal cancer patients.

Journal: Tumori 20110101

Title: A randomized controlled trial of two different interventions for the prevention of postoperative nausea and vomiting: total intravenous anaesthesia using propofol and remifentanil versus prophylactic palonosetron with inhalational anaesthesia using sevoflurane-nitrous oxide.

Journal: The Journal of international medical research 20110101

Title: Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia.

Journal: Cancer 20101215

Title: Neurokinin-1 and novel serotonin antagonists for postoperative and postdischarge nausea and vomiting.

Journal: Current opinion in anaesthesiology 20101201

Title: Palonosetron to prevent nausea and vomiting in children undergoing BMT: efficacy and safety.

Journal: Bone marrow transplantation 20101101

Title: The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20101101

Title: Clinical evaluation of two antiemetic combinations palonosetron dexamethasone versus ondansetron dexamethasone in chemotherapy of head and neck cancer.

Journal: Singapore medical journal 20101101

Title: [Pharmacological, pharmacokinetic, and clinical profile of palonosetron hydrochloride (ALOXI I.V. Injection 0.75 mg), a novel antiemetic 5-HT3-receptor antagonist].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100801

Title: Palonosetron for the prevention of chemotherapy-induced nausea and vomiting in patients with cancer.

Journal: Future oncology (London, England) 20100701

Title: Palonosetron induced anaphylaxis in an adult female.

Journal: British journal of clinical pharmacology 20100701

Title: Double-blind, randomised, controlled study of the efficacy and tolerability of palonosetron plus dexamethasone for 1 day with or without dexamethasone on days 2 and 3 in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20100501

Title: Review of palonosetron: emerging data distinguishing it as a novel 5-HT(3) receptor antagonist for chemotherapy-induced nausea and vomiting.

Journal: Expert opinion on pharmacotherapy 20100401

Title: Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting.

Journal: Expert review of anticancer therapy 20100201

Title: Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function.

Journal: European journal of pharmacology 20100125

Title: Serotonin receptor antagonists for highly emetogenic chemotherapy in adults.

Journal: The Cochrane database of systematic reviews 20100120

Title: Palonosetron and dexamethasone for prevention of nausea and vomiting in patients receiving high-dose chemotherapy with auto-SCT.

Journal: Bone marrow transplantation 20100101

Title: Cost-utility analysis of palonosetron-based therapy in preventing emesis among breast cancer patients.

Journal: The journal of supportive oncology 20100101

Title: Single dose of palonosetron plus dexamethasone to control nausea, vomiting and to warrant an adequate food intake in patients treated with highly emetogenic chemotherapy (HEC). Preliminary results.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20091201

Title: Palonosetron: a second generation 5-hydroxytryptamine 3 receptor antagonist.

Journal: Expert opinion on drug metabolism & toxicology 20091201

Title: Palonosetron: in the prevention of nausea and vomiting.

Journal: Drugs 20091112

Title: A phase II study of palonosetron combined with dexamethasone to prevent nausea and vomiting induced by highly emetogenic chemotherapy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20091101

Title: A phase II dose-ranging study of palonosetron in Japanese patients receiving moderately emetogenic chemotherapy, including anthracycline and cyclophosphamide-based chemotherapy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20091101

Title: Enantioseparation of palonosetron hydrochloride by capillary zone electrophoresis with high-concentration beta-CD as chiral selector.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20091001

Title: Palonosetron in prevention of nausea and vomiting after highly emetogenic chemotherapy before haematopoietic stem cell transplantation-single center experience.

Journal: Transplantation proceedings 20091001

Title: Effectiveness of a single-day three-drug regimen of dexamethasone, palonosetron, and aprepitant for the prevention of acute and delayed nausea and vomiting caused by moderately emetogenic chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090501

Title: Effect of 5-HT3 antagonists and a 5-HT(1A) agonist on fluoxetine-induced conditioned gaping reactions in rats.

Journal: Psychopharmacology 20090501

Title: Palonosetron plus dexamethasone effectively prevents acute and delayed chemotherapy-induced nausea and vomiting following highly or moderately emetogenic chemotherapy in pre-treated patients who have failed to respond to a previous antiemetic treatment: comparison between elderly and non-elderly patient response.

Journal: Critical reviews in oncology/hematology 20090401

Title: Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus).

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090401

Title: [Postoperative nausea and vomiting--what's new in anti-emetic pharmacotherapy?].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20090401

Title: Seizure associated with palonosetron.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090301

Title: Antiemetic control: toward a new standard of care for emetogenic chemotherapy.

Journal: Expert opinion on pharmacotherapy 20090301

Title: Palonosetron (Aloxi) and dexamethasone for the prevention of acute and delayed nausea and vomiting in patients receiving multiple-day chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090201

Title: Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial.

Journal: The Lancet. Oncology 20090201

Title: Palonosetron: more than just another option?

Journal: The Lancet. Oncology 20090201

Title: Palonosetron--a single-dose antiemetic adjunct for hepatic artery radioembolization: a feasibility study.

Journal: Cardiovascular and interventional radiology 20090101

Title: The efficacy and safety of palonosetron compared with granisetron in preventing highly emetogenic chemotherapy-induced vomiting in the Chinese cancer patients: a phase II, multicenter, randomized, double-blind, parallel, comparative clinical trial.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20090101

Title: Physical and chemical stability of palonosetron hydrochloride with five common parenteral drugs during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080915

Title: We're tired of waiting.

Journal: Anesthesia and analgesia 20080801

Title: A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period.

Journal: Anesthesia and analgesia 20080801

Title: A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting.

Journal: Anesthesia and analgesia 20080801

Title: Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor.

Journal: Anesthesia and analgesia 20080801

Title: Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy-induced nausea and vomiting in children.

Journal: Archives of medical research 20080801

Title: Randomized, placebo-controlled, pilot study evaluating aprepitant single dose plus palonosetron and dexamethasone for the prevention of acute and delayed chemotherapy-induced nausea and vomiting.

Journal: Cancer 20080501

Title: Optimizing antiemetic therapy in multiple-day and multiple cycles of chemotherapy.

Journal: Current opinion in supportive and palliative care 20080301

Title: Early Austrian multicenter experience with palonosetron as antiemetic treatment for patients undergoing highly or moderately emetogenic chemotherapy.

Journal: Wiener medizinische Wochenschrift (1946) 20080101

Title: [Pharmacokinetic and pharmacodynamic features of palonosetron].

Journal: Tumori 20080101

Title: [Meta-analysis of phase III studies with palonosetron in the prevention of vomiting induced by moderately emetogenic chemotherapy].

Journal: Tumori 20080101

Title: [Clinical role of palonosetron for patients receiving cisplatin-based chemotherapy].

Journal: Tumori 20080101

Title: [Palonosetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) in Italy: pharmacologic, clinical and economic aspects].

Journal: Tumori 20080101

Title: Clinical update on palonosetron in the management of chemotherapy-induced nausea and vomiting.

Journal: Tumori 20080101

Title: Recent advances, trends and economic considerations in the risk assessment, prevention and treatment of postoperative nausea and vomiting.

Journal: Expert opinion on pharmacotherapy 20071201

Title: A phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier oncology group study.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20071101

Title: Palonosetron plus dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple-day cisplatin chemotherapy for germ cell cancer.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20071101

Title: [Gastrointestinal complication of cancer chemotherapy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: Antiemetic agents.

Journal: Oncology (Williston Park, N.Y.) 20070701

Title: Determination of palonosetron in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20070628

Title: Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070601

Title: [Medical treatment of chemotherapy-induced nausea and vomiting].

Journal: Ugeskrift for laeger 20070226

Title: Preventing emesis in lung cancer patients.

Journal: The journal of supportive oncology 20070201

Title: Are all 5-HT3 receptor antagonists the same?

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20070101

Title: Prevention of emesis from multiple-day and high-dose chemotherapy regimens.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20070101

Title: Radiation-induced nausea and vomiting.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20070101

Title: Enantioseparation of palonosetron hydrochloride by micellar electrokinetic chromatography with sodium cholate as chiral selector.

Journal: Journal of chromatography. A 20061103

Title: Pharmacokinetic evaluation and safety profile of a 15-minute versus 30-second infusion of palonosetron in healthy subjects.

Journal: Journal of clinical pharmacology 20061001

Title: Palonosetron: a second-generation 5-hydroxytryptamine receptor antagonist.

Journal: Future oncology (London, England) 20061001

Title: Infusion of palonosetron plus dexamethasone for the prevention of chemotherapy-induced nausea and vomiting.

Journal: The journal of supportive oncology 20061001

Title: A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060901

Title: Combination therapy for chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy: palonosetron, dexamethasone, and aprepitant.

Journal: The journal of supportive oncology 20060901

Title: Relative efficacy of ondansetron, granisetron, dolasetron and palonosetron in controlling acute nausea and vomiting associated with platinum-based chemotherapy.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20060601

Title: Emerging drugs for chemotherapy-induced emesis.

Journal: Expert opinion on emerging drugs 20060301

Title: New antiemetic drugs.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060301

Title: Chemotherapy-induced nausea and vomiting: state of the art in 2006.

Journal: The journal of supportive oncology 20060201

Title: The role of 5-HT3 receptor antagonists in preventing postoperative nausea and vomiting.

Journal: AORN journal 20060101

Title: Applying new data to manage CINV: achieving optimal outcomes through a comprehensive care model.

Journal: ONS news 20060101

Title: Update on the management of chemotherapy-induced nausea and vomiting.

Journal: Journal of infusion nursing : the official publication of the Infusion Nurses Society 20060101

Title: Compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051001

Title: 5HT3-receptor antagonists as antiemetics in cancer.

Journal: Drug and therapeutics bulletin 20050801

Title: Update on anti-emetics for chemotherapy-induced emesis.

Journal: Internal medicine journal 20050801

Title: New drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron.

Journal: Expert opinion on drug metabolism & toxicology 20050601

Title: Evaluation of safety and pharmacokinetics of consecutive multiple-day dosing of palonosetron in healthy subjects.

Journal: Journal of clinical pharmacology 20050501

Title: [Antiemetic prophylaxis in the chemotherapy of gastrointestinal tumours].

Journal: Zeitschrift fur Gastroenterologie 20050401

Title: Pharmacokinetics of palonosetron in combination with aprepitant in healthy volunteers.

Journal: Current medical research and opinion 20050401

Title: Palonosetron HCl compatibility and stability with doxorubicin HCl and epirubicin HCl during simulated Y-site administration.

Journal: The Annals of pharmacotherapy 20050201

Title: Integrating aprepitant and palonosetron into clinical practice: a role for the new antiemetics.

Journal: Clinical journal of oncology nursing 20050201

Title: Palonosetron improves prevention of chemotherapy-induced nausea and vomiting in elderly patients.

Journal: The journal of supportive oncology 20050101

Title: [Achieving optimal antiemetic management].

Journal: Krankenpflege Journal 20050101

Title: [Second generation of 5-HT3 antagonists].

Journal: Krankenpflege Journal 20050101

Title: Pharmacokinetics, metabolism and excretion of intravenous [l4C]-palonosetron in healthy human volunteers.

Journal: Biopharmaceutics & drug disposition 20041101

Title: Physical and chemical stability of palonosetron HCl in 4 infusion solutions.

Journal: The Annals of pharmacotherapy 20041001

Title: New drugs 04. Part III.

Journal: Nursing 20040901

Title: Stability of palonosetron hydrochloride with paclitaxel and docetaxel during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040801

Title: The next generation of chemotherapy-induced nausea and vomiting prevention and control: a new 5-HT3 antagonist arrives.

Journal: Clinical journal of oncology nursing 20040601

Title: Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects.

Journal: Journal of clinical pharmacology 20040501

Title: Palonosetron: a unique 5-HT3 receptor antagonist indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting.

Journal: Clinical advances in hematology & oncology : H&O 20040501

Title: Palonosetron (Aloxi) for prevention of nausea and vomiting due to cancer chemotherapy.

Journal: The Medical letter on drugs and therapeutics 20040329

Title: Efficacy, safety and pharmacokinetics of palonosetron in patients receiving highly emetogenic cisplatin-based chemotherapy: a dose-ranging clinical study.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040201

Title: Palonosetron.

Journal: Drugs 20040101

Title: Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron.

Journal: Cancer 20031201

Title: Palonosetron: a unique 5-HT3-receptor antagonist for the prevention of chemotherapy-induced emesis.

Journal: Expert opinion on pharmacotherapy 20031201

Title: Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20031001

Title: Pathogenesis-based treatment of chemotherapy-induced nausea and vomiting--two new agents.

Journal: The journal of supportive oncology 20030101

Title: Palonosetron (Helsinn).

Journal: Current opinion in investigational drugs (London, England : 2000) 20021001

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Tags:135755-51-0 Molecular Formula|135755-51-0 MDL|135755-51-0 SMILES|135755-51-0 (R,S)Palonosetron hcl