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135911-02-3,MFCD00903364
Catalog No.:AA00725U

135911-02-3 | RP 67580

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10mg
≥97%(HPLC)
in stock  
$454.00   $318.00
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50mg
≥97%(HPLC)
in stock  
$1,674.00   $1,172.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00725U
Chemical Name:
RP 67580
CAS Number:
135911-02-3
Molecular Formula:
C29H30N2O2
Molecular Weight:
438.5607
MDL Number:
MFCD00903364
SMILES:
COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1
Properties
Computed Properties
 
Complexity:
676  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.7  

Literature

Title: Substance P promotes hepatic stellate cell proliferation and activation via the TGF-β1/Smad-3 signaling pathway.

Journal: Toxicology and applied pharmacology 20170815

Title: Microvascular dysfunction with increased vascular leakage response in mice systemically exposed to arsenic.

Journal: Cardiovascular toxicology 20140901

Title: Tonic postganglionic sympathetic inhibition induced by afferent renal nerves?

Journal: Hypertension (Dallas, Tex. : 1979) 20120201

Title: Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia.

Journal: Journal of neuroinflammation 20120101

Title: State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616

Title: The mechanisms underlying the generation of the colonic migrating motor complex in both wild-type and nNOS knockout mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100201

Title: Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats.

Journal: British journal of pharmacology 20100201

Title: Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091201

Title: Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.

Journal: Biochemical pharmacology 20091015

Title: Neurokinin 1 receptor activates transient receptor potential-like currents in noradrenergic A7 neurons in rats.

Journal: Molecular and cellular neurosciences 20090901

Title: Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus.

Journal: The European journal of neuroscience 20090601

Title: Neurokinin1 antagonists potentiate antidepressant properties of serotonin reuptake inhibitors, yet blunt their anxiogenic actions: a neurochemical, electrophysiological, and behavioral characterization.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090301

Title: Role of the neurokinin-1 receptors in ejaculation in anesthetized rats.

Journal: The journal of sexual medicine 20090101

Title: Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation.

Journal: Respiratory research 20090101

Title: NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin.

Journal: Pain 20080930

Title: N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.

Journal: American journal of physiology. Heart and circulatory physiology 20080801

Title: Physiological and morphological properties of, and effect of substance P on, neurons in the A7 catecholamine cell group in rats.

Journal: Neuroscience 20080602

Title: Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20080601

Title: TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080501

Title: Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis.

Journal: Scandinavian journal of gastroenterology 20080301

Title: Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

Journal: Neuron 20071108

Title: TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.

Journal: American journal of physiology. Heart and circulatory physiology 20070901

Title: Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070401

Title: Involvement of substance P and neurogenic inflammation in arsenic-induced early vascular dysfunction.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070101

Title: TRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis.

Journal: American journal of nephrology 20070101

Title: Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice.

Journal: European journal of pharmacology 20061024

Title: Neuroanatomical and pharmacological assessment of Fos expression induced in the rat brain by the phosphodiesterase-4 inhibitor 6-(4-pyridylmethyl)-8-(3-nitrophenyl) quinoline.

Journal: Neuropharmacology 20061001

Title: Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.

Journal: Neuroscience research 20060901

Title: Activation of central neurokinin-1 receptors induces reinstatement of cocaine-seeking behavior.

Journal: Neuroscience letters 20051216

Title: Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.

Journal: Regulatory peptides 20050915

Title: Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs.

Journal: Peptides 20050801

Title: Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040401

Title: Hypothalamic response to experimental allergic encephalomyelitis: role of substance P.

Journal: Neuroimmunomodulation 20040101

Title: Role of tachykinin NK1, NK2 and NK3 receptors in the modulation of visceral hypersensitivity in the rat.

Journal: Neuroscience letters 20031113

Title: The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness.

Journal: European journal of pharmacology 20030829

Title: Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.

Journal: Neuropharmacology 20030801

Title: Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.

Journal: Pharmacology, biochemistry, and behavior 20030101

Title: Modulation of somatostatin receptors, somatostatin content and Gi proteins by substance P in the rat frontoparietal cortex and hippocampus.

Journal: Journal of neurochemistry 20030101

Title: Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with N-methyl-D-aspartate and GABA(B) receptors.

Journal: Neuroscience 20030101

Title: Modulation of cardiac activity by tachykinins in the rat substantia nigra.

Journal: British journal of pharmacology 20011201

Title: Substance P and its transglutaminase-synthesized spermine derivative elicit yawning behavior via nitric oxide in rats.

Journal: Peptides 20010901

Title: Influence of capsaicin cream in rats with peripheral neuropathy.

Journal: Pharmacological research 20010801

Title: Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue.

Journal: European journal of pharmacology 20010706

Title: Influence of painful chronic neuropathy on neurogenic inflammation.

Journal: Pain 20010501

Title: Role of supraspinal tachykinins for volume- and L-dopa-induced bladder activity in normal conscious rats.

Journal: Neurourology and urodynamics 20000101

Title: Effect of tachykinin receptor antagonists in experimental neuropathic pain.

Journal: European journal of pharmacology 19981120

Title: Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from Clostridium histolyticum.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970501

Title: Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19961101

Title: Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors.

Journal: British journal of pharmacology 19960801

Title: Prostaglandin E2-induced bladder hyperactivity in normal, conscious rats: involvement of tachykinins?

Journal: The Journal of urology 19950601

Title: An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.

Journal: British journal of pharmacology 19950201

Title: Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction.

Journal: British journal of pharmacology 19940901

Title: Capsaicin-induced bladder hyperactivity in normal conscious rats.

Journal: The Journal of urology 19940801

Title: Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats.

Journal: European journal of pharmacology 19940701

Title: Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder.

Journal: British journal of pharmacology 19940401

Title: RP 67580, a selective antagonist of neurokinin-1 receptors, modifies some of the naloxone-precipitated morphine withdrawal signs in rats.

Journal: Neuroscience letters 19930625

Title: Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

Journal: The Journal of biological chemistry 19921225

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