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Home Other Building Blocks 1365888-06-7
1365888-06-7,MFCD28902190
Catalog No.:AA00120R

1365888-06-7 | Gdc-0810

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$27.00   $19.00
- +
5mg
98+%
in stock  
$70.00   $49.00
- +
10mg
98+%
in stock  
$102.00   $71.00
- +
25mg
98+%
in stock  
$172.00   $121.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00120R
Chemical Name:
Gdc-0810
CAS Number:
1365888-06-7
Molecular Formula:
C26H20ClFN2O2
Molecular Weight:
446.9006
MDL Number:
MFCD28902190
SMILES:
CC/C(=C(\c1ccc2c(c1)cn[nH]2)/c1ccc(cc1)/C=C/C(=O)O)/c1ccc(cc1Cl)F
Properties
Computed Properties
 
Complexity:
719  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
7.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[2]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[4]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[5]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[6]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[7]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[8]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 
  1365888-06-7 

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[2]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[3]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[4]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[5]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[6]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[7]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[8]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

[9]Savage,Scott;McClory,Andrew;Zhang,Haiming;Cravillion,Theresa;Lim,Ngiap-Kie;Masui,Colin;Robinson,SarahJ.;Han,Chong;Ochs,Christoph;Rege,PankajD.;Gosselin,Francis[JournalofOrganicChemistry,2018,vol.83,#19,p.11571-11576]

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[1]CurrentPatentAssignee:JOHNSON&JOHNSONINC-US2012/71535,2012,A1

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2017/60326,2017,A1

Literature

Title: By Lai, et al. Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. J Med Chem. 2015 Jun 25;58(12):4888-904.

Title: Joseph JD, et al. The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. Elife. 2016 Jul 13;5. pii: e15828. doi: 10.7554/eLife.15828

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SDS
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