[1]Ren,Long;Nan,Guanglei;Wang,Yongcheng;Xiao,Zhiyan[JournalofOrganicChemistry,2018,vol.83,#23,p.14472-14488]
Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
Journal: Chemical research in toxicology 20150518
Title: Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry 20140615
Title: Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach.
Journal: European journal of medicinal chemistry 20140610
Title: Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry 20140415
Title: Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.
Journal: European journal of medicinal chemistry 20140409
Title: Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.
Journal: Bioorganic & medicinal chemistry 20140401
Title: Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.
Journal: Bioorganic & medicinal chemistry 20140315
Title: Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.
Journal: Bioorganic & medicinal chemistry 20140101
Title: Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20131215
Title: Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies.
Journal: Bioorganic & medicinal chemistry 20131101
Title: Discovery of piperidine-linked pyridine analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: ChemMedChem 20130701
Title: Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.
Journal: Bioorganic & medicinal chemistry 20130401
Title: Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.
Journal: Bioorganic & medicinal chemistry 20121201
Title: Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity.
Journal: Bioorganic & medicinal chemistry letters 20121201
Title: Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors.
Journal: European journal of medicinal chemistry 20121201
Title: Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.
Journal: Bioorganic & medicinal chemistry 20120915
Title: Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.
Journal: European journal of medicinal chemistry 20120701
Title: Overall benefit of antiretroviral treatment on the risk of fracture in HIV: nested case-control analysis in a health-insured population.
Journal: AIDS (London, England) 20120601
Title: Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal: European journal of medicinal chemistry 20120501
Title: Nanotechnology and the treatment of HIV infection.
Journal: Viruses 20120401
Title: Exploring the complexity of the HIV-1 fitness landscape.
Journal: PLoS genetics 20120301
Title: Methylmethacrylate-sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood-brain barrier.
Journal: Colloids and surfaces. B, Biointerfaces 20120201
Title: Sudden death of cardiac origin and psychotropic drugs.
Journal: Frontiers in pharmacology 20120101
Title: Malaria and hiv in adults: when the parasite runs into the virus.
Journal: Mediterranean journal of hematology and infectious diseases 20120101
Title: Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, delavirdine and saquinavir.
Journal: Colloids and surfaces. B, Biointerfaces 20111201
Title: Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.
Journal: Bioorganic & medicinal chemistry 20111201
Title: Emerging trends of drug-resistant HIV-1 among drug-treated patients in former blood donors in Hubei, China: a three-year surveillance from 2004 to 2006.
Journal: Virologica Sinica 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors.
Journal: Antiviral research 20111101
Title: Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.
Journal: Bioorganic & medicinal chemistry 20110901
Title: A computational study of CYP3A4 mediated drug interaction profiles for anti-HIV drugs.
Journal: Journal of molecular modeling 20110801
Title: Rilpivirine: a step forward in tailored HIV treatment.
Journal: Lancet (London, England) 20110716
Title: Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry 20110715
Title: Clinical management of HIV drug resistance.
Journal: Viruses 20110401
Title: Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: The home as an appropriate setting for women undertaking cervical ripening before the induction of labour.
Journal: Midwifery 20110201
Title: Novel HIV-1 recombinant forms in antenatal cohort, Montreal, Quebec, Canada.
Journal: Emerging infectious diseases 20110201
Title: 'Dynamic range' of inferred phenotypic HIV drug resistance values in clinical practice.
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Title: Machine learning on normalized protein sequences.
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Title: Ixabepilone as monotherapy or in combination with capecitabine for the treatment of advanced breast cancer.
Journal: Breast cancer : basic and clinical research 20110101
Title: Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition.
Journal: BMC biochemistry 20110101
Title: Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors.
Journal: Virology journal 20110101
Title: Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects.
Journal: PloS one 20110101
Title: Safety and tolerability of antiretrovirals during pregnancy.
Journal: Infectious diseases in obstetrics and gynecology 20110101
Title: Clinical predictors of immune reconstitution following combination antiretroviral therapy in patients from the Australian HIV Observational Database.
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Title: Efficacy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice.
Journal: International journal of nanomedicine 20110101
Title: Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones.
Journal: Scientia pharmaceutica 20110101
Title: HIV-Associated Venous Thromboembolism.
Journal: Mediterranean journal of hematology and infectious diseases 20110101
Title: Human immunodeficiency virus endocrinopathy.
Journal: Indian journal of endocrinology and metabolism 20110101
Title: Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
Journal: PloS one 20110101
Title: Impact of comorbidities and drug therapy on development of renal impairment in a predominantly African American and Hispanic HIV clinic population.
Journal: HIV/AIDS (Auckland, N.Z.) 20110101
Title: National prevalence and trends of HIV transmitted drug resistance in Mexico.
Journal: PloS one 20110101
Title: Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.
Journal: PloS one 20110101
Title: Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort study.
Journal: BMC pulmonary medicine 20110101
Title: Nanomedicine as an emerging approach against intracellular pathogens.
Journal: International journal of nanomedicine 20110101
Title: Optimizing ixabepilone treatment schedules in patients with advanced or metastatic breast cancer.
Journal: Cancer chemotherapy and pharmacology 20101101
Title: Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism-Importance of slow dissociation and relaxation rates for antiviral efficacy.
Journal: Biochemical pharmacology 20101015
Title: Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.
Journal: Antimicrobial agents and chemotherapy 20101001
Title: Methadone, buprenorphine, and street drug interactions with antiretroviral medications.
Journal: Current HIV/AIDS reports 20100801
Title: Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.
Journal: Bioorganic & medicinal chemistry 20100715
Title: Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry 20100701
Title: Colloid formation by drugs in simulated intestinal fluid.
Journal: Journal of medicinal chemistry 20100527
Title: Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.
Journal: Bioorganic & medicinal chemistry 20100401
Title: HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate.
Journal: Viruses 20100401
Title: Profile of etravirine for the treatment of HIV infection.
Journal: Therapeutics and clinical risk management 20100101
Title: Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging.
Journal: Particle and fibre toxicology 20100101
Title: Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1).
Journal: Mini reviews in medicinal chemistry 20100101
Title: Clinical, virological and immunological responses in Danish HIV patients receiving raltegravir as part of a salvage regimen.
Journal: Clinical epidemiology 20100101
Title: Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.
Journal: Retrovirology 20100101
Title: Progress in antiretroviral drug delivery using nanotechnology.
Journal: International journal of nanomedicine 20100101
Title: Case report: delirium due to a diltiazem-fentanyl CYP3A4 drug interaction.
Journal: General hospital psychiatry 20100101
Title: Beyond the black box: drug- and device-associated hypersensitivity events.
Journal: Drug, healthcare and patient safety 20100101
Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091201
Title: Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
Journal: Bioorganic & medicinal chemistry 20091115
Title: Predicting new molecular targets for known drugs.
Journal: Nature 20091112
Title: Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: European journal of medicinal chemistry 20091101
Title: A comparison of HIV-1 drug susceptibility as provided by conventional phenotyping and by a phenotype prediction tool based on viral genotype.
Journal: Journal of medical virology 20091001
Title: The in vivo response of novel buprenorphine metabolites, M1 and M3, to antiretroviral inducers and inhibitors of buprenorphine metabolism.
Journal: Basic & clinical pharmacology & toxicology 20090901
Title: Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal: ChemMedChem 20090901
Title: 1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.
Journal: Bioorganic & medicinal chemistry 20090901
Title: The history of antiretrovirals: key discoveries over the past 25 years.
Journal: Reviews in medical virology 20090901
Title: Changes in cognition during antiretroviral therapy: comparison of 2 different ranking systems to measure antiretroviral drug efficacy on HIV-associated neurocognitive disorders.
Journal: Journal of acquired immune deficiency syndromes (1999) 20090901
Title: Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.
Journal: Bioorganic & medicinal chemistry 20090815
Title: Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry 20090815
Title: Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus.
Journal: Medical microbiology and immunology 20090801
Title: The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research.
Journal: Antiviral research 20090501
Title: Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda.
Journal: AIDS (London, England) 20090427
Title: Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.
Journal: International journal of antimicrobial agents 20090401
Title: [Establishment of pharmacological evaluation system for non-nucleoside reverse-transcriptase inhibitors resistant HIV-1].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090401
Title: Systematic review: Helicobacter pylori infection and impaired drug absorption.
Journal: Alimentary pharmacology & therapeutics 20090215
Title: Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor.
Journal: Antimicrobial agents and chemotherapy 20090201
Title: Structural modifications of DAPY analogues with potent anti-HIV-1 activity.
Journal: ChemMedChem 20090201
Title: Warfarin-antiretroviral interactions.
Journal: The Annals of pharmacotherapy 20090201
Title: Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update.
Journal: PloS one 20090101
Title: The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.
Journal: Retrovirology 20090101
Title: Developments of indoles as anti-HIV-1 inhibitors.
Journal: Current pharmaceutical design 20090101
Title: A study of 3-substituted benzylidene-1,3-dihydro-indoline derivatives as antimicrobial and antiviral agents.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101
Title: Pharmacotherapy of pediatric and adolescent HIV infection.
Journal: Therapeutics and clinical risk management 20090101
Title: The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review.
Journal: BMC public health 20090101
Title: A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome.
Journal: Bioinformatics and biology insights 20090101
Title: Etravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection.
Journal: Core evidence 20090101
Title: Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy.
Journal: HIV/AIDS (Auckland, N.Z.) 20090101
Title: 1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20081015
Title: Lopinavir/ritonavir in the treatment of HIV-1 infection: a review.
Journal: Therapeutics and clinical risk management 20081001
Title: Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: Journal of medicinal chemistry 20080828
Title: A study of seven rule-based algorithms for the interpretation of HIV-1 genotypic resistance data in Thailand.
Journal: Journal of virological methods 20080701
Title: Atorvastatin and cardiovascular risk in the elderly--patient considerations.
Journal: Clinical interventions in aging 20080601
Title: Quantification of the HIV-integrase inhibitor raltegravir (MK-0518) in human plasma by high-performance liquid chromatography with fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080515
Title: Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry 20080401
Title: Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: introducing a diketoacid functionality into delavirdine.
Journal: Bioorganic & medicinal chemistry 20080401
Title: New approaches in the treatment of HIV/AIDS - focus on maraviroc and other CCR5 antagonists.
Journal: Therapeutics and clinical risk management 20080401
Title: Monitoring the development of non-nucleoside reverse transcriptase inhibitor-associated resistant HIV-1 using an electrochemiluminescence-based reverse transcriptase polymerase assay.
Journal: Analytical biochemistry 20080301
Title: Addressing ceiling effects in health status measures: a comparison of techniques applied to measures for people with HIV disease.
Journal: Health services research 20080201
Title: Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors.
Journal: European journal of pharmacology 20080128
Title: Mechanism of inhibition of HIV-1 reverse transcriptase by the novel broad-range DNA polymerase inhibitor N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide.
Journal: Biochemistry 20080108
Title: The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001-2006) in Portugal.
Journal: Retrovirology 20080101
Title: Community-based randomised controlled trial evaluating falls and osteoporosis risk management strategies.
Journal: Trials 20080101
Title: [HIV-1 genotypic resistance profiles in children failing highly active antiretroviral therapy].
Journal: Zhonghua yi xue za zhi 20071211
Title: Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.
Journal: Therapeutic drug monitoring 20071201
Title: Characterization of HIV-1 subtypes and viral antiretroviral drug resistance in men who have sex with men in Beijing, China.
Journal: AIDS (London, England) 20071201
Title: US and UK versions of the EQ-5D preference weights: does choice of preference weights make a difference?
Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20070801
Title: Transport of stavudine, delavirdine, and saquinavir across the blood-brain barrier by polybutylcyanoacrylate, methylmethacrylate-sulfopropylmethacrylate, and solid lipid nanoparticles.
Journal: International journal of pharmaceutics 20070801
Title: Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses.
Journal: Protein science : a publication of the Protein Society 20070801
Title: Teratogenicity risk of antiretroviral therapy in pregnancy.
Journal: Current HIV/AIDS reports 20070801
Title: Review of tipranavir in the treatment of drug-resistant HIV.
Journal: Therapeutics and clinical risk management 20070801
Title: Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701
Title: Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.
Journal: The Biochemical journal 20070515
Title: Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains.
Journal: European journal of medicinal chemistry 20070501
Title: Emergence of NNRTI drug resistance mutations after single-dose nevirapine exposure in HIV type 1 subtype C-infected infants in India.
Journal: AIDS research and human retroviruses 20070501
Title: Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301
Title: Modulation of human BCRP (ABCG2) activity by anti-HIV drugs.
Journal: The Journal of antimicrobial chemotherapy 20070201
Title: Non-nucleoside phenotypic hypersusceptibility cut-point determination from ACTG 359.
Journal: HIV clinical trials 20070101
Title: AIDS in the Third World: how to stop the HIV infection?
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20070101
Title: Anti-HIV drugs.
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20070101
Title: Electrospray tandem mass spectroscopic characterisation of 18 antiretroviral drugs and simultaneous quantification of 12 antiretrovirals in plasma.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Clinical implications of mutations at reverse transcriptase codon 135 on response to NNRTI-based therapy.
Journal: The open virology journal 20070101
Title: Interactions between buprenorphine and antiretrovirals. I. The nonnucleoside reverse-transcriptase inhibitors efavirenz and delavirdine.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061215
Title: Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.
Journal: PLoS pathogens 20061101
Title: Initial highly-active antiretroviral therapy with a protease inhibitor versus a non-nucleoside reverse transcriptase inhibitor: discrepancies between direct and indirect meta-analyses.
Journal: Lancet (London, England) 20061028
Title: Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile.
Journal: Antiviral research 20060801
Title: Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission.
Journal: Current HIV research 20060701
Title: A randomised trial comparing genotypic and virtual phenotypic interpretation of HIV drug resistance: the CREST study.
Journal: PLoS clinical trials 20060701
Title: Natural polymorphism in protease and reverse transcriptase genes and in vitro antiretroviral drug susceptibilities of non-B HIV-1 strains from treatment-naive patients.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060501
Title: Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors.
Journal: AIDS (London, England) 20060424
Title: Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors.
Journal: Journal of medicinal chemistry 20060420
Title: Remission from Kaposi's sarcoma on HAART is associated with suppression of HIV replication and is independent of protease inhibitor therapy.
Journal: British journal of cancer 20060410
Title: Effect of buprenorphine and antiretroviral agents on the QT interval in opioid-dependent patients.
Journal: The Annals of pharmacotherapy 20060301
Title: Phenotypic drug resistance patterns in subtype A HIV-1 clones with nonnucleoside reverse transcriptase resistance mutations.
Journal: AIDS research and human retroviruses 20060301
Title: Short communication: low prevalence of genotypic drug resistance mutations among antiretroviral-naive HIV type 1 patients in Malaysia.
Journal: AIDS research and human retroviruses 20060201
Title: Drug interactions between opioids and antiretroviral medications: interaction between methadone, LAAM, and delavirdine.
Journal: The American journal on addictions 20060101
Title: DR_SEQAN: a PC/Windows-based software to evaluate drug resistance using human immunodeficiency virus type 1 genotypes.
Journal: BMC infectious diseases 20060101
Title: Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.
Journal: American journal of therapeutics 20060101
Title: A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.
Journal: PloS one 20060101
Title: Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.
Journal: Antimicrobial agents and chemotherapy 20051101
Title: Drug-resistance mutations in antiretroviral-naïve patients with established HIV-1 infection in Mexico.
Journal: HIV medicine 20051101
Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Journal: Current drug metabolism 20051001
Title: Pharmacokinetic drug interactions with non-nucleoside reverse transcriptase inhibitors.
Journal: Expert opinion on drug metabolism & toxicology 20051001
Title: The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.
Journal: Molecular pharmacology 20050901
Title: Emerging anti-HIV drugs.
Journal: Expert opinion on emerging drugs 20050501
Title: The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs.
Journal: FEBS letters 20050425
Title: From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal: Journal of medicinal chemistry 20050324
Title: Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
Journal: Journal of medicinal chemistry 20050324
Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.
Journal: Therapeutics and clinical risk management 20050301
Title: HIV-reverse transcriptase inhibition: inclusion of ligand-induced fit by cross-docking studies.
Journal: Journal of medicinal chemistry 20050113
Title: Population pharmacokinetics of delavirdine and N-delavirdine in HIV-infected individuals.
Journal: Clinical pharmacokinetics 20050101
Title: Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.
Journal: Clinical pharmacokinetics 20050101
Title: The HIV protease inhibitors nelfinavir and saquinavir, but not a variety of HIV reverse transcriptase inhibitors, adversely affect human proteasome function.
Journal: Antiviral therapy 20050101
Title: The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life.
Journal: Health and quality of life outcomes 20050101
Title: HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors.
Journal: AIDS research and therapy 20050101
Title: Phenotypic susceptibility to nonnucleoside inhibitors of virion-associated reverse transcriptase from different HIV types and groups.
Journal: Journal of acquired immune deficiency syndromes (1999) 20041215
Title: PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide.
Journal: Biology of reproduction 20041201
Title: Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides.
Journal: Bioorganic & medicinal chemistry 20041201
Title: TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.
Journal: Antimicrobial agents and chemotherapy 20041201
Title: Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
Journal: Journal of medicinal chemistry 20041118
Title: CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro.
Journal: AIDS (London, England) 20041105
Title: Effects of the G190A substitution of HIV reverse transcriptase on phenotypic susceptibility of patient isolates to delavirdine.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20041101
Title: Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
Journal: Therapeutic drug monitoring 20041001
Title: Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives.
Journal: Farmaco (Societa chimica italiana : 1989) 20041001
Title: Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4.
Journal: Current drug metabolism 20041001
Title: Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds.
Journal: Bioorganic & medicinal chemistry 20040801
Title: [Progress in HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040801
Title: Long-term pharmacokinetics of amprenavir in combination with delavirdine in HIV-infected children.
Journal: AIDS (London, England) 20040702
Title: Dose-dependent pharmacokinetics of delavirdine in combination with amprenavir in healthy volunteers.
Journal: The Journal of antimicrobial chemotherapy 20040701
Title: High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040615
Title: Antiviral drugs in current clinical use.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040601
Title: New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.
Journal: Journal of natural products 20040601
Title: Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.
Journal: Biochemical pharmacology 20040515
Title: Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
Journal: Journal of medicinal chemistry 20040506
Title: Clinical utility of current NNRTIs and perspectives of new agents in this class under development.
Journal: Antiviral chemistry & chemotherapy 20040501
Title: Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359.
Journal: The Journal of infectious diseases 20040401
Title: In vivo dynamics of the 103N mutation following the withdrawal of non-nucleoside reverse transcriptase inhibitors in HIV-infected patients: preliminary results.
Journal: The new microbiologica 20040401
Title: Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Journal: Journal of medicinal chemistry 20040226
Title: Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis.
Journal: Antiviral therapy 20040201
Title: Clinical efficacy of antiretroviral combination therapy based on protease inhibitors or non-nucleoside analogue reverse transcriptase inhibitors: indirect comparison of controlled trials.
Journal: BMJ (Clinical research ed.) 20040131
Title: Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
Journal: Current topics in medicinal chemistry 20040101
Title: Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors.
Journal: Current topics in medicinal chemistry 20040101
Title: Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors).
Journal: Psychosomatics 20040101
Title: Pharmacokinetics of antiretrovirals in pregnant women.
Journal: Clinical pharmacokinetics 20040101
Title: Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future.
Journal: Chemistry & biodiversity 20040101
Title: 3-iodo-4-phenoxypyridinones (IOPY's), a new family of highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal: Bioorganic & medicinal chemistry letters 20031215
Title: Provider bias in the selection of non-nucleoside reverse transcriptase inhibitor and protease inhibitor-based highly active antiretroviral therapy and HIV treatment outcomes in observational studies.
Journal: AIDS (London, England) 20031205
Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
Journal: British journal of cancer 20031117
Title: Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Journal: Journal of medicinal chemistry 20031009
Title: Modest decreases in NNRTI susceptibility do not influence virological outcome in patients receiving initial NNRTI-containing triple therapy.
Journal: Antiviral therapy 20031001
Title: Drug resistance profiles of recombinant reverse transcriptases from human immunodeficiency virus type 1 subtypes A/E, B, and C.
Journal: AIDS research and human retroviruses 20030901
Title: Pfizer announces free drug program.
Journal: AIDS patient care and STDs 20030901
Title: Use of HIV-1 reverse transcriptase recovered from human plasma for phenotypic drug susceptibility testing.
Journal: AIDS (London, England) 20030704
Title: Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1.
Journal: AIDS (London, England) 20030613
Title: Comparison of nine resistance interpretation systems for HIV-1 genotyping.
Journal: Antiviral therapy 20030601
Title: Protease inhibitor-sparing regimens: new evidence strengthens position.
Journal: Journal of acquired immune deficiency syndromes (1999) 20030601
Title: Toxicity of non-nucleoside analogue reverse transcriptase inhibitors.
Journal: Seminars in liver disease 20030501
Title: Pharmacia pilots patent share for HIV drug.
Journal: Nature reviews. Drug discovery 20030401
Title: Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030205
Title: Delavirdine malabsorption in HIV-infected subjects with spontaneous gastric hypoacidity.
Journal: Journal of clinical pharmacology 20030201
Title: A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors.
Journal: AIDS (London, England) 20030103
Title: Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication.
Journal: Journal of virology 20030101
Title: Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers.
Journal: British journal of clinical pharmacology 20030101
Title: Effect of Food on the Steady-State Pharmacokinetics of Delavirdine in Patients with HIV Infection.
Journal: Clinical drug investigation 20030101
Title: Multiple-Dose Pharmacokinetics of Delavirdine Mesylate and Didanosine in HIV-Infected Patients.
Journal: Clinical drug investigation 20030101
Title: Nelfinavir and non-nucleoside reverse transcriptase inhibitor-based salvage regimens in heavily HIV pretreated patients.
Journal: The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses 20030101
Title: Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.
Journal: Journal of medicinal chemistry 20021219
Title: Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal: Biology of reproduction 20021201
Title: Pharmacokinetic interaction between amprenavir and delavirdine: evidence of induced clearance by amprenavir.
Journal: Clinical pharmacology and therapeutics 20021201
Title: Genotypic and phenotypic resistance patterns in early-stage HIV-1-infected patients failing initial therapy with stavudine, didanosine and nevirapine.
Journal: Antiviral therapy 20021201
Title: Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance.
Journal: Antiviral research 20021101
Title: New anti-HIV agents and targets.
Journal: Medicinal research reviews 20021101
Title: Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates.
Journal: AIDS (London, England) 20021018
Title: Effect of delavirdine on plasma lipids and lipoproteins in patients receiving antiretroviral therapy.
Journal: AIDS (London, England) 20020906
Title: Durability of response to treatment among antiretroviral-experienced subjects: 48-week results from AIDS Clinical Trials Group Protocol 359.
Journal: The Journal of infectious diseases 20020901
Title: New developments in anti-HIV chemotherapy.
Journal: Biochimica et biophysica acta 20020718
Title: Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020705
Title: Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT.
Journal: Antimicrobial agents and chemotherapy 20020701
Title: Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture.
Journal: Pharmaceutical research 20020701
Title: Rifampin and rifabutin drug interactions: an update.
Journal: Archives of internal medicine 20020513
Title: Rhabdomyolysis with acute renal failure probably related to the interaction of atorvastatin and delavirdine.
Journal: The American journal of medicine 20020415
Title: Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.
Journal: Journal of medicinal chemistry 20020411
Title: Determination of delavirdine in very small volumes of plasma by high-performance liquid chromatography with fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020405
Title: Lack of hepatotoxicity associated with nonnucleoside reverse transcriptase inhibitors.
Journal: Journal of acquired immune deficiency syndromes (1999) 20020401
Title: Delavirdine increases drug exposure of ritonavir-boosted protease inhibitors.
Journal: AIDS (London, England) 20020329
Title: Nelfinavir urinary stones.
Journal: The Journal of urology 20020301
Title: Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives.
Journal: Current pharmaceutical design 20020101
Title: Delavirdine in rescue regimens.
Journal: TreatmentUpdate 20020101
Title: Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection.
Journal: Clinical pharmacokinetics 20020101
Title: [Therapeutic aspects of HIV/AIDS infected patients and evaluation of therapeutic protocols].
Journal: Acta pharmaceutica Hungarica 20011201
Title: The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.
Journal: The Journal of biological chemistry 20011130
Title: Drugs for HIV infection.
Journal: The Medical letter on drugs and therapeutics 20011126
Title: Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo.
Journal: The Journal of infectious diseases 20011115
Title: New developments in anti-HIV chemotherapy.
Journal: Current medicinal chemistry 20011101
Title: Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties.
Journal: Chemical & pharmaceutical bulletin 20011101
Title: HIV-protease inhibitors alter retinoic acid synthesis.
Journal: AIDS (London, England) 20011019
Title: Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).
Journal: Bioorganic & medicinal chemistry letters 20010903
Title: Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Journal: Bioorganic & medicinal chemistry letters 20010903
Title: Mismatched double-stranded RNA (polyI-polyC(12)U) is synergistic with multiple anti-HIV drugs and is active against drug-sensitive and drug-resistant HIV-1 in vitro.
Journal: Antiviral research 20010901
Title: Antiviral drugs: current state of the art.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20010801
Title: Antiretrovirals: simultaneous determination of five protease inhibitors and three nonnucleoside transcriptase inhibitors in human plasma by a rapid high-performance liquid chromatography--mass spectrometry assay.
Journal: Therapeutic drug monitoring 20010801
Title: Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants.
Journal: Virology 20010705
Title: Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy.
Journal: AIDS (London, England) 20010615
Title: Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.
Journal: Journal of medicinal chemistry 20010607
Title: High prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients receiving antiretroviral therapy in Abidjan, Côte d'Ivoire.
Journal: Journal of acquired immune deficiency syndromes (1999) 20010415
Title: Determination of serum levels of thirteen human immunodeficiency virus-suppressing drugs by high-performance liquid chromatography.
Journal: Journal of chromatography. A 20010413
Title: Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles.
Journal: Journal of virology 20010401
Title: International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance.
Journal: Journal of acquired immune deficiency syndromes (1999) 20010301
Title: Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.
Journal: Bioorganic & medicinal chemistry letters 20010226
Title: Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010201
Title: Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.
Journal: Virology 20010201
Title: Use of HIV protease inhibitors as pharmacoenhancers.
Journal: The AIDS reader 20010201
Title: Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101
Title: The emerging roles of non-nucleoside reverse transcriptase inhibitors in antiretroviral therapy.
Journal: Drugs 20010101
Title: Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors.
Journal: Journal of clinical pharmacology 20010101
Title: Delavirdine: clinical pharmacokinetics and drug interactions.
Journal: Clinical pharmacokinetics 20010101
Title: Saquinavir soft gelatin capsule: a comparative safety review.
Journal: Drug safety 20010101
Title: New developments in anti-HIV chemotherapy.
Journal: Farmaco (Societa chimica italiana : 1989) 20010101
Title: A single amino acid change at Leu-188 in the reverse transcriptase of HIV-2 and SIV renders them sensitive to non-nucleoside reverse transcriptase inhibitors.
Journal: Archives of virology 20010101
Title: A randomized trial of nelfinavir, ritonavir, or delavirdine in combination with saquinavir-SGC and stavudine in treatment-experienced HIV-1-infected patients.
Journal: HIV clinical trials 20010101
Title: Combination therapy with indinavir, ritonavir, and delavirdine and nucleoside reverse transcriptase inhibitors in patients with HIV/AIDS who have failed multiple antiretroviral combinations.
Journal: HIV clinical trials 20010101
Title: Clinical pharmacokinetics of non-nucleoside reverse transcriptase inhibitors.
Journal: Clinical pharmacokinetics 20010101
Title: Baseline antiretroviral drug susceptibility influences treatment response in patients receiving saquinavir-enhancing therapy.
Journal: HIV clinical trials 20010101
Title: Can delavirdine substitute for ritonavir?
Journal: TreatmentUpdate 20010101
Title: Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Journal: Bioorganic & medicinal chemistry letters 20000918
Title: Piperidinylethyl, phenoxyethyl and fluoroethyl bromopyridyl thiourea compounds with potent anti-HIV activity.
Journal: Antiviral chemistry & chemotherapy 20000901
Title: Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.
Journal: Antimicrobial agents and chemotherapy 20000801
Title: Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5'-(4'-amino-1',2'-oxath iole-2',2'-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.
Journal: AIDS research and human retroviruses 20000610
Title: Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Journal: Journal of medicinal chemistry 20000518
Title: Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine.
Journal: Antimicrobial agents and chemotherapy 20000501
Title: Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors.
Journal: Molecular pharmacology 20000501
Title: Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
Journal: AIDS research and human retroviruses 20000410
Title: Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.
Journal: Journal of medicinal chemistry 20000309
Title: Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260).
Journal: Antimicrobial agents and chemotherapy 20000301
Title: Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20000117
Title: N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Journal: Bioorganic & medicinal chemistry letters 19991220
Title: Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.
Journal: Antimicrobial agents and chemotherapy 19991201
Title: Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.
Journal: Journal of medicinal chemistry 19991007
Title: Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
Journal: Journal of medicinal chemistry 19991007
Title: N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.
Journal: Bioorganic & medicinal chemistry letters 19990920
Title: Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.
Journal: Antiviral chemistry & chemotherapy 19990901
Title: Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV.
Journal: AIDS (London, England) 19990820
Title: Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
Journal: Bioorganic & medicinal chemistry letters 19990607
Title: Argentine plant extracts active against polymerase and ribonuclease H activities of HIV-1 reverse transcriptase.
Journal: Phytotherapy research : PTR 19990501
Title: Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride.
Journal: Antimicrobial agents and chemotherapy 19981201
Title: Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptase.
Journal: Antimicrobial agents and chemotherapy 19981201
Title: Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries.
Journal: AIDS (London, England) 19981022
Title: Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV.
Journal: Journal of medicinal chemistry 19980924
Title: Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.
Journal: Journal of medicinal chemistry 19980730
Title: Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent.
Journal: AIDS (London, England) 19980709
Title: S-1153 inhibits replication of known drug-resistant strains of human immunodeficiency virus type 1.
Journal: Antimicrobial agents and chemotherapy 19980601
Title: A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152.
Journal: The Journal of general virology 19980601
Title: Human immunodeficiency virus type 1 subtype F reverse transcriptase sequence and drug susceptibility.
Journal: Journal of virology 19980501
Title: (-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.
Journal: Journal of medicinal chemistry 19980423
Title: Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-dideoxy-3'-thiacytidine (lamivudine).
Journal: Biochemical pharmacology 19980301
Title: 1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.
Journal: Antimicrobial agents and chemotherapy 19980301
Title: Colorimetric assays for evaluation of the mode of action of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors.
Journal: Antiviral chemistry & chemotherapy 19980301
Title: A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781.
Journal: AIDS research and human retroviruses 19980210
Title: In-vitro selection of HIV-1 variants resistant to non-nucleoside reverse transcriptase inhibitors in monocyte-derived macrophages.
Journal: The Journal of antimicrobial chemotherapy 19971201
Title: Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.
Journal: Journal of virology 19971101
Title: Susceptibility of human immunodeficiency virus type 1 group O isolates to antiretroviral agents: in vitro phenotypic and genotypic analyses.
Journal: Journal of virology 19971101
Title: Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine.
Journal: The Journal of infectious diseases 19971101
Title: Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor.
Journal: Antimicrobial agents and chemotherapy 19970501
Title: In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097.
Journal: Virology 19970428
Title: Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives.
Journal: Drug design and discovery 19970401
Title: Inhibition of human immunodeficiency virus type 1 infection in vitro by combination of delavirdine, zidovudine and didanosine.
Journal: Antiviral research 19970301
Title: Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.
Journal: Journal of medicinal chemistry 19961220
Title: Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal: Journal of medicinal chemistry 19960913
Title: Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.
Journal: Biochemical and biophysical research communications 19960814
Title: Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.
Journal: Molecular pharmacology 19960801
Title: The nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors.
Journal: Antimicrobial agents and chemotherapy 19960701
Title: (Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.
Journal: Journal of virology 19960601
Title: Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine.
Journal: Molecular pharmacology 19960501
Title: Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19960109
Title: Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s.
Journal: FEBS letters 19950814
Title: Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives).
Journal: Proceedings of the National Academy of Sciences of the United States of America 19950606
Title: Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal: FEBS letters 19950213
Title: In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha.
Journal: The Journal of infectious diseases 19950101
Title: Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.
Journal: Journal of virology 19941201
Title: Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E.
Journal: Biochemical pharmacology 19940601
Title: Anti-human immunodeficiency virus type 1 activities of novel non-nucleoside reverse transcriptase inhibitors.
Journal: The Journal of antimicrobial chemotherapy 19940201
Title: Bisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3'-azido-3'-deoxythymidine or 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 replication in vitro.
Journal: Antimicrobial agents and chemotherapy 19940201
Title: A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930515
Title: Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate.
Journal: Journal of medicinal chemistry 19930514
Title: U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.
Journal: Antimicrobial agents and chemotherapy 19930501
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