Catalog No.:AA0012CK

136834-22-5 | Dmt-2'fluoro-da(bz) amidite

Name: Name:Dmt-2'fluoro-da(bz) amidite
Brand: AABLOCKS
SKU: AA0012CK
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

250mg

95%

in stock

$29.00 $20.00

- +

95%

in stock

$96.00 $67.00

- +

25g

95%

in stock

$1,846.00 $1,292.00

- +

Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA0012CK

Chemical Name:

Dmt-2'fluoro-da(bz) amidite

CAS Number:

136834-22-5

Molecular Formula:

C47H51FN7O7P

Molecular Weight:

875.9227

MDL Number:

MFCD12912392

SMILES:

N#CCCOP(N(C(C)C)C(C)C)O[C@@H]1[C@@H](COC(c2ccc(cc2)OC)(c2ccc(cc2)OC)c2ccccc2)O[C@H]([C@@H]1F)n1cnc2c1ncnc2NC(=O)c1ccccc1

Properties

Computed Properties

Complexity:

1420

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

XLogP3:

7.5

Downstream Synthesis Route

136834-22-5

CASUnavailable

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2017/93933,2017,A1Locationinpatent:Page/Pagecolumn89-90

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/79261,2019,A1Locationinpatent:Page/Pagecolumn76;77

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/74887,2019,A1Locationinpatent:Page/Pagecolumn87;88

136834-22-5

1834500-64-9

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2019/30057,2019,A1Locationinpatent:Paragraph1233;1257;1258

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/46498,2019,A1Locationinpatent:Page/Pagecolumn96;97

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/46496,2019,A1Locationinpatent:Page/Pagecolumn70;71

[4]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2017/93933,2017,A1

[5]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2018/92937,2018,A1Locationinpatent:Paragraph0228;0340-0344

[6]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2018/273578,2018,A1Locationinpatent:Paragraph0341-0346

[7]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/79261,2019,A1

[8]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/74887,2019,A1

464-05-1

(2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite

C38H35FN5O8P*C5H5N

[1]Patent:WO2018/98203,2018,A1.Locationinpatent:Page/Pagecolumn63

CASUnavailable

136834-22-5

2242826-20-4

[1]CurrentPatentAssignee:EISAICOLTD-WO2018/152450,2018,A1Locationinpatent:Page/Pagecolumn55;56

[2]CurrentPatentAssignee:EISAICOLTD-WO2020/36199,2020,A1Locationinpatent:Paragraph0045

CASUnavailable

136834-22-5

1427269-36-0

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/46498,2019,A1Locationinpatent:Page/Pagecolumn97

Literature

Title: Kawasaki AM, et, al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41.

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SDS