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Home Other Building Blocks 1370256-78-2
1370256-78-2,MFCD28900746
Catalog No.:AA0012N8

1370256-78-2 | 1-(5-((7-(3-Morpholinopropoxy)quinazolin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(p-tolyl)urea

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$349.00   $244.00
- +
10mg
98%
in stock  
$499.00   $349.00
- +
25mg
98%
in stock  
$941.00   $659.00
- +
50mg
98%
in stock  
$1,472.00   $1,030.00
- +
100mg
98%
in stock  
$2,179.00   $1,525.00
- +
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Technical Information
Catalog Number:
AA0012N8
Chemical Name:
1-(5-((7-(3-Morpholinopropoxy)quinazolin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(p-tolyl)urea
CAS Number:
1370256-78-2
Molecular Formula:
C25H27N7O3S2
Molecular Weight:
537.6570
MDL Number:
MFCD28900746
SMILES:
O=C(Nc1nnc(s1)Sc1ncnc2c1ccc(c2)OCCCN1CCOCC1)Nc1ccc(cc1)C
Properties
Computed Properties
 
Complexity:
712  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
4  

Literature

Title: Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Journal: Journal of medicinal chemistry 20120426

Title: Li WW, et al. Discovery of the novel potent and selective FLT3 inhibitor 1-{5--(3- morpholinopropoxy)quinazolin-4-ylthio-,3,4thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo. J Med Chem. 2012 Apr 26;55(8):3852-66.

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Tags:1370256-78-2 Molecular Formula|1370256-78-2 MDL|1370256-78-2 SMILES|1370256-78-2 1-(5-((7-(3-Morpholinopropoxy)quinazolin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(p-tolyl)urea