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Home Other Building Blocks 1370468-36-2
1370468-36-2,MFCD28124343
Catalog No.:AA0012OL

1370468-36-2 | Elbasvir

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$139.00   $97.00
- +
2mg
98%
in stock  
$243.00   $170.00
- +
5mg
98%
in stock  
$313.00   $219.00
- +
10mg
98%
in stock  
$407.00   $285.00
- +
50mg
98%
in stock  
$1,200.00   $840.00
- +
100mg
98%
in stock  
$2,040.00   $1,428.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0012OL
Chemical Name:
Elbasvir
CAS Number:
1370468-36-2
Molecular Formula:
C49H55N9O7
Molecular Weight:
882.0171
MDL Number:
MFCD28124343
SMILES:
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc([nH]1)c1ccc2c(c1)O[C@H](n1c2cc2c1ccc(c2)c1cnc([nH]1)C1CCCN1C(=O)[C@H](C(C)C)NC(=O)OC)c1ccccc1)C(C)C
Properties
Computed Properties
 
Complexity:
1680  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
13  
XLogP3:
6.7  

Downstream Synthesis Route

[1]Patent:WO2012/40923,2012,A1

[1]Patent:WO2012/41014,2012,A1.Locationinpatent:Page/Pagecolumn139

[2]Patent:WO2012/40923,2012,A1.Locationinpatent:Page/Pagecolumn117

[1]Patent:WO2012/40923,2012,A1

[1]Patent:WO2012/40923,2012,A1

[1]Patent:WO2012/40923,2012,A1

Literature

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs 20170701

Title: Elbasvir/Grazoprevir: A Review of the Latest Agent in the Fight against Hepatitis C.

Journal: International journal of hepatology 20160101

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology 20150101

Title: Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity.

Journal: ChemMedChem 20131201

Title: Liu R, et al. Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor Elbasvir. Antimicrob Agents Chemother. 2015 Nov;59(11):6922-6929.

Title: Lahser FC, et al. The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons. Antimicrob Agents Chemother. 2016 A

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SDS
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