Home Fluorides 1371569-69-5
1371569-69-5,MFCD23143626
Catalog No.:AA009EKT

1371569-69-5 | (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$15.00   $11.00
- +
5mg
97%
in stock  
$37.00   $26.00
- +
100mg
97%
in stock  
$269.00   $188.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009EKT
Chemical Name:
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
CAS Number:
1371569-69-5
Molecular Formula:
C20H17F3N2O2S
Molecular Weight:
406.4214
MDL Number:
MFCD23143626
SMILES:
CCS(=O)c1nc(cc(n1)C(F)(F)F)c1cccc(c1)OCc1ccccc1
Properties
Computed Properties
 
Complexity:
514  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4  

Downstream Synthesis Route

[1]Eng,Heather;Sharma,Raman;McDonald,ThomasS.;Edmonds,DavidJ.;Fortin,Jean-Philippe;Li,Xianping;Stevens,BenjaminD.;Griffith,DavidA.;Limberakis,Chris;Nolte,WhitneyM.;Price,DavidA.;Jackson,Margaret;Kalgutkar,AmitS.[DrugMetabolismandDisposition,2013,vol.41,#8,p.1470-1479]

70-18-8    1371569-69-5   
C28H28F3N5O7S 

[1]Eng,Heather;Sharma,Raman;McDonald,ThomasS.;Edmonds,DavidJ.;Fortin,Jean-Philippe;Li,Xianping;Stevens,BenjaminD.;Griffith,DavidA.;Limberakis,Chris;Nolte,WhitneyM.;Price,DavidA.;Jackson,Margaret;Kalgutkar,AmitS.[DrugMetabolismandDisposition,2013,vol.41,#8,p.1470-1479]

[1]DrugMetabolismandDisposition,2013,vol.41,p.1470-1479

[1]Eng,Heather;Sharma,Raman;McDonald,ThomasS.;Edmonds,DavidJ.;Fortin,Jean-Philippe;Li,Xianping;Stevens,BenjaminD.;Griffith,DavidA.;Limberakis,Chris;Nolte,WhitneyM.;Price,DavidA.;Jackson,Margaret;Kalgutkar,AmitS.[DrugMetabolismandDisposition,2013,vol.41,#8,p.1470-1479]

4-(3-(benzyloxy)phenyl)-2-(methylthio)-6-(trifluoromethyl)pyrimidine 
  1371569-69-5 

[1]Eng,Heather;Sharma,Raman;McDonald,ThomasS.;Edmonds,DavidJ.;Fortin,Jean-Philippe;Li,Xianping;Stevens,BenjaminD.;Griffith,DavidA.;Limberakis,Chris;Nolte,WhitneyM.;Price,DavidA.;Jackson,Margaret;Kalgutkar,AmitS.[DrugMetabolismandDisposition,2013,vol.41,#8,p.1470-1479]

Literature

Title: A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

Journal: Nature chemical biology 20140801

Title: Small molecule drug discovery at the glucagon-like peptide-1 receptor.

Journal: Experimental diabetes research 20120101

Title: Sloop KW, et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes. 2010 Dec;59(12):3099-107.

Title: Willard FS, et al. Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol Pharmacol. 2012 Dec;82(6):1066-73.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1371569-69-5
Tags:1371569-69-5 Molecular Formula|1371569-69-5 MDL|1371569-69-5 SMILES|1371569-69-5 (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine