Title: Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice.
Journal: Pharmacology, biochemistry, and behavior 20121001
Title: Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies.
Journal: European journal of medicinal chemistry 20120901
Title: Nutraceuticals in the management of osteoarthritis : a critical review.
Journal: Drugs & aging 20120901
Title: Diacerein: a potential therapeutic drug for periodontal disease.
Journal: Medical hypotheses 20120801
Title: [Clinical study of Qianggu granule and diacerein capsule in treating knee osteoarthritis].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120601
Title: [Management of osteoarthritis: oral therapies].
Journal: La Revue du praticien 20120501
Title: Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.
Journal: Diabetes care 20120201
Title: Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.
Journal: International journal of rheumatic diseases 20120201
Title: [Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201
Title: A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.
Journal: Current medical research and opinion 20120101
Title: Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.
Journal: Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT 20120101
Title: Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.
Journal: International journal of molecular sciences 20120101
Title: Fast-dissolving and high-drug-loaded, Fatty Acid-based self-emulsifying solid dispersions of diacerein.
Journal: PDA journal of pharmaceutical science and technology 20120101
Title: Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.
Journal: TheScientificWorldJournal 20120101
Title: Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
Journal: Medical hypotheses 20111201
Title: Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
Journal: Endocrinology 20111101
Title: Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000.
Journal: Drug development and industrial pharmacy 20111001
Title: Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial.
Journal: Diabetes care 20110701
Title: Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.
Journal: Annals of the rheumatic diseases 20110601
Title: Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.
Journal: Drug testing and analysis 20110401
Title: Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110301
Title: Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study.
Journal: Yonsei medical journal 20110301
Title: Lyprinol-is it a useful anti-inflammatory agent?
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Comparison of general practitioners and rheumatologists' prescription patterns for patients with knee osteoarthritis.
Journal: BMC musculoskeletal disorders 20110101
Title: Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis.
Journal: BMC medicine 20110101
Title: A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis.
Journal: Arthritis research & therapy 20110101
Title: T'ai chi for the treatment of osteoarthritis: a systematic review and meta-analysis.
Journal: BMJ open 20110101
Title: [Pharmacological therapies for osteoarthritis].
Journal: Therapie 20110101
Title: Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form.
Journal: Indian journal of pharmaceutical sciences 20110101
Title: Improvement in the dissolution profile of diacerein using a surfactant-based solid dispersion technique.
Journal: Drug discoveries & therapeutics 20101201
Title: Effects of diacerein at the molecular level in the osteoarthritis disease process.
Journal: Therapeutic advances in musculoskeletal disease 20100401
Title: Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100301
Title: Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.
Journal: Osteoarthritis and cartilage 20100301
Title: Effects of risedronate on osteoarthritis of the knee.
Journal: Yonsei medical journal 20100301
Title: A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.
Journal: Arthritis research & therapy 20100101
Title: Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment.
Journal: Arthritis research & therapy 20100101
Title: Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment.
Journal: Arthritis research & therapy 20100101
Title: Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study.
Journal: BMJ (Clinical research ed.) 20100101
Title: Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms.
Journal: Journal of young pharmacists : JYP 20100101
Title: Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial.
Journal: Clinical rheumatology 20091001
Title: Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation.
Journal: Fundamental & clinical pharmacology 20090801
Title: Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study).
Journal: Joint, bone, spine : revue du rhumatisme 20090701
Title: Physico-chemical and structural characterization of diacerhein.
Journal: Journal of pharmaceutical and biomedical analysis 20090501
Title: PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition.
Journal: Journal of molecular biology 20090424
Title: Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415
Title: Isolation and structural elucidation of two impurities from a diacerein bulk drug.
Journal: Journal of pharmaceutical and biomedical analysis 20090220
Title: Comment on: comparison between chondroprotective effects of glucosamine, curcumin and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.
Journal: Osteoarthritis and cartilage 20090101
Title: [Non-surgical treatment of osteoarthritis of large joints - new aspects].
Journal: Wiener medizinische Wochenschrift (1946) 20090101
Title: Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.
Journal: Scandinavian journal of rheumatology 20090101
Title: The effects of excluding patients from the analysis in randomised controlled trials: meta-epidemiological study.
Journal: BMJ (Clinical research ed.) 20090101
Title: Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Journal: Arthritis research & therapy 20090101
Title: Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.
Journal: International journal of medical sciences 20090101
Title: A stability-indicating high performance liquid chromatographic method for the determination of diacerein in capsules.
Journal: Indian journal of pharmaceutical sciences 20090101
Title: A modified method for isolation of rhein from senna.
Journal: Indian journal of pharmaceutical sciences 20090101
Title: [Treatment of osteoarthritis with drugs and other modalities].
Journal: Der Internist 20081201
Title: Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.
Journal: Osteoarthritis and cartilage 20081001
Title: Immune system and inflammation.
Journal: Indian journal of pharmacology 20081001
Title: Prize sessions.
Journal: Indian journal of pharmacology 20081001
Title: The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
Journal: Pharmacological research 20080701
Title: Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice.
Journal: International immunopharmacology 20080601
Title: Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.
Journal: Rheumatology (Oxford, England) 20080501
Title: [Effectiveness of drugs used in degenerative joint diseases (arthroses)].
Journal: Medicina clinica 20080405
Title: OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.
Journal: Osteoarthritis and cartilage 20080201
Title: Intra-articular hyaluronic acid for treatment of osteoarthritis: a nationwide study among the older population of Taiwan.
Journal: BMC health services research 20080101
Title: The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial.
Journal: BMC musculoskeletal disorders 20080101
Title: In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators.
Journal: Bio-medical materials and engineering 20080101
Title: Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
Journal: Arthritis research & therapy 20080101
Title: Clinical review of chondroitin sulfate in osteoarthritis.
Journal: Osteoarthritis and cartilage 20080101
Title: Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis.
Journal: Arthritis research & therapy 20080101
Title: An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK).
Journal: Journal of the Indian Medical Association 20080101
Title: Bioequivalence study of two capsule formulations containing diacerein 50 mg in healthy human subjects.
Journal: Arzneimittel-Forschung 20080101
Title: In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties.
Journal: Biorheology 20080101
Title: P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis.
Journal: Journal of inflammation (London, England) 20080101
Title: Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
Journal: BMC musculoskeletal disorders 20080101
Title: The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period.
Journal: Arthritis and rheumatism 20071201
Title: [Review of the evidence about drugs used as SYSADOA].
Journal: Medicina clinica 20071103
Title: Nutraceuticals in the management of osteoarthritis.
Journal: Orthopedics 20070801
Title: The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study.
Journal: Osteoarthritis and cartilage 20070601
Title: Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis.
Journal: Evidence-based medicine 20070601
Title: Selection of reliable reference genes for qPCR studies on chondroprotective action.
Journal: BMC molecular biology 20070101
Title: DMOAD developments: present and future.
Journal: Bulletin of the NYU hospital for joint diseases 20070101
Title: A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria.
Journal: Arthritis research & therapy 20070101
Title: Diacerhein versus glucosamine in a rat model of osteoarthritis.
Journal: Clinics (Sao Paulo, Brazil) 20061001
Title: A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis.
Journal: Archives of internal medicine 20060925
Title: Effect of oral diacerein (DAR) in an experimental hip chondrolysis model.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060601
Title: Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients.
Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060601
Title: [Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort.
Journal: Annals of the rheumatic diseases 20060301
Title: Diacerein for osteoarthritis.
Journal: The Cochrane database of systematic reviews 20060125
Title: Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.
Journal: Arthritis research & therapy 20060101
Title: Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis.
Journal: Biorheology 20060101
Title: IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein.
Journal: Biorheology 20060101
Title: The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Journal: Anesthesia and analgesia 20051201
Title: Osteoarthritis: an overview of the disease and its treatment strategies.
Journal: Seminars in arthritis and rheumatism 20050801
Title: [Pharmacological treatment of osteoarthritis. Expectations and reality].
Journal: Revista clinica espanola 20050401
Title: Future treatment of osteoarthritis.
Journal: Orthopedics 20050201
Title: Subjective impact of osteoarthritis flare-ups on patients' quality of life.
Journal: Health and quality of life outcomes 20050101
Title: Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.
Journal: Arthritis research & therapy 20050101
Title: Expedient total syntheses of rhein and diacerhein via Fries rearrangement.
Journal: The Journal of organic chemistry 20041210
Title: Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis.
Journal: Annals of the rheumatic diseases 20041201
Title: [Total hip arthroplasty indication, evaluation criteria for structure modifying trials. Lessons from the ECHODIAH and PHARE studies].
Journal: Presse medicale (Paris, France : 1983) 20040522
Title: [Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis].
Journal: Presse medicale (Paris, France : 1983) 20040522
Title: Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis.
Journal: Osteoarthritis and cartilage 20040401
Title: [Chondromodulation in 2003: dream or reality?].
Journal: Revue medicale de la Suisse romande 20040201
Title: Measurement of structure (disease) modification in osteoarthritis.
Journal: Osteoarthritis and cartilage 20040101
Title: Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.
Journal: Arthritis research & therapy 20040101
Title: Similar group mean scores, but large individual variations, in patient-relevant outcomes over 2 years in meniscectomized subjects with and without radiographic knee osteoarthritis.
Journal: Health and quality of life outcomes 20040101
Title: Diacerein has a structure/disease-modifying effect on hip osteoarthritis.
Journal: Clinical and experimental rheumatology 20040101
Title: New perspectives in the management of osteoarthritis. structure modification: facts or fantasy?
Journal: The Journal of rheumatology. Supplement 20030801
Title: The true results of the ECHODIAH study with diacerein.
Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20030501
Title: Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.
Journal: Clinical and experimental rheumatology 20030101
Title: Long-term treatment with diacerein has a structure/disease modifying effect on hip osteoarthritis.
Journal: Clinical and experimental rheumatology 20030101
Title: [Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].
Journal: Presse medicale (Paris, France : 1983) 20021207
Title: [Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model].
Journal: Presse medicale (Paris, France : 1983) 20021207
Title: [Clinical and radiographic status of patients in the ECHODIAH study who underwent THA Pertinence of the pain-function index for operative decision making].
Journal: Presse medicale (Paris, France : 1983) 20021207
Title: Oral and intra-articular remedies: Review of papers published from March 2001 to February 2002.
Journal: Current opinion in rheumatology 20020901
Title: Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects.
Journal: Matrix biology : journal of the International Society for Matrix Biology 20020801
Title: Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption.
Journal: European journal of pharmacology 20020712
Title: Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.
Journal: Pharmacology & toxicology 20020701
Title: [Current therapeutic possibilities in the treatment of arthrosis].
Journal: La Revue du praticien 20020301
Title: [Current medical possibilities in the treatment of arthrosis].
Journal: Presse medicale (Paris, France : 1983) 20020112
Title: [Results of the ECHODIAH clinical trial on hip arthrosis].
Journal: Presse medicale (Paris, France : 1983) 20020112
Title: In vitro study of intracellular IL-1beta production and beta1 integrins expression in stimulated chondrocytes--effect of rhein.
Journal: Biorheology 20020101
Title: Diacerein as a disease-modulating agent in osteoarthritis.
Journal: Current rheumatology reports 20011201
Title: Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.
Journal: Arthritis and rheumatism 20011101
Title: Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.
Journal: Immunopharmacology and immunotoxicology 20011101
Title: Pharmacological therapy of osteoarthritis.
Journal: Best practice & research. Clinical rheumatology 20011001
Title: Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis.
Journal: European journal of pharmacology 20010511
Title: A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis.
Journal: Osteoarthritis and cartilage 20010401
Title: Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.
Journal: Osteoarthritis and cartilage 20010401
Title: Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
Journal: The Journal of rheumatology 20010401
Title: The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.
Journal: The Journal of rheumatology 20010401
Title: Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects.
Journal: The Clinical journal of pain 20010301
Title: Reports of equivalence trials should not mask negative or mediocre results.
Journal: Joint, bone, spine : revue du rhumatisme 20010301
Title: [Pharmacy clinics. How I treat...Osteoarthritis. 2nd part: new therapeutic perspectives].
Journal: Revue medicale de Liege 20010301
Title: Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.
Journal: Japanese journal of pharmacology 20010101
Title: [Case report of fatal hepatitis from diacerein].
Journal: Therapie 20010101
Title: Effects of diacerein on indomethacin-induced gastric ulceration.
Journal: Pharmacology 20010101
Title: Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Journal: Osteoarthritis and cartilage 20000501
Title: Sleep attacks and Parkinson's disease treatment.
Journal: Lancet (London, England) 20000415
Title: Clinical pharmacokinetics of diacerein.
Journal: Clinical pharmacokinetics 19981101
Title: Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat.
Journal: The Journal of pharmacy and pharmacology 19880901
Title: http://en.wikipedia.org/wiki/Diacerein
