Home Amines 137403-12-4
137403-12-4,MFCD00924342
Catalog No.:AA00135V

137403-12-4 | N-(4-((5-(3-(2-Aminoethyl)-1H-indol-5-yl)-1,2,4-oxadiazol-3-yl)methyl)phenyl)methanesulfonamide

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1mg
≥98%
in stock  
$43.00   $30.00
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5mg
≥98%
in stock  
$159.00   $111.00
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10mg
≥98%
in stock  
$272.00   $190.00
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25mg
≥98%
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$523.00   $366.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00135V
Chemical Name:
N-(4-((5-(3-(2-Aminoethyl)-1H-indol-5-yl)-1,2,4-oxadiazol-3-yl)methyl)phenyl)methanesulfonamide
CAS Number:
137403-12-4
Molecular Formula:
C20H21N5O3S
Molecular Weight:
411.4774
MDL Number:
MFCD00924342
SMILES:
NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C
Properties
Computed Properties
 
Complexity:
635  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
2.2  

Literature

Title: Serotonin modulates glutamatergic transmission in the rat olfactory tubercle.

Journal: The European journal of neuroscience 20100201

Title: Peripheral 5-HT1A and 5-HT7 serotonergic receptors modulate parasympathetic neurotransmission in long-term diabetic rats.

Journal: Experimental diabetes research 20100101

Title: Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.

Journal: Molecular pain 20080101

Title: Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart.

Journal: Clinical and experimental pharmacology & physiology 20071101

Title: The nitric oxide synthesis/pathway mediates the inhibitory serotoninergic responses of the pressor effect elicited by sympathetic stimulation in diabetic pithed rats.

Journal: European journal of pharmacology 20060510

Title: 5-HT-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding as an assay for functional activation of G proteins coupled with 5-HT1B receptors in rat striatal membranes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060201

Title: Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.

Journal: Clinical and experimental pharmacology & physiology 20051001

Title: In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking.

Journal: Brain research 20050510

Title: Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor.

Journal: European journal of pharmacology 20020201

Title: The proliferation of human T lymphoblastic cells induced by 5-HT1B receptors activation is regulated by 5-HT-moduline.

Journal: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie 20010401

Title: Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.

Journal: European journal of pharmacology 19990910

Title: Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding.

Journal: Molecular pharmacology 19981201

Title: Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970601

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Tags:137403-12-4 Molecular Formula|137403-12-4 MDL|137403-12-4 SMILES|137403-12-4 N-(4-((5-(3-(2-Aminoethyl)-1H-indol-5-yl)-1,2,4-oxadiazol-3-yl)methyl)phenyl)methanesulfonamide