Catalog No.:AA009C8L

1380316-03-9 | EPZ004777 HCl

Name: Name:EPZ004777 HCl
Brand: AABLOCKS
SKU: AA009C8L
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

5mg

99%

1 week

$241.00 $169.00

- +

10mg

99%

1 week

$336.00 $235.00

- +

25mg

99%

1 week

$558.00 $391.00

- +

50mg

99%

1 week

$939.00 $658.00

- +

Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA009C8L

Chemical Name:

EPZ004777 HCl

CAS Number:

1380316-03-9

Molecular Formula:

C28H42ClN7O4

Molecular Weight:

576.1306

MDL Number:

MFCD27920717

SMILES:

O=C(Nc1ccc(cc1)C(C)(C)C)NCCCN(C(C)C)C[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc2c1ncnc2N.Cl

Properties

Literature

Title: Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65.

Title: Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.

Title: Deshpande AJ, et al. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.Blood. 2013 Mar 28;121(13):2533-41.

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