Home Other Building Blocks 1383716-40-2
1383716-40-2,MFCD28963904
Catalog No.:AA01ENQW

1383716-40-2 | PIK-III

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$16.00   $11.00
- +
5mg
98+%
in stock  
$54.00   $38.00
- +
10mg
98+%
in stock  
$82.00   $57.00
- +
25mg
98+%
in stock  
$138.00   $96.00
- +
50mg
98+%
in stock  
$232.00   $163.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01ENQW
Chemical Name:
PIK-III
CAS Number:
1383716-40-2
Molecular Formula:
C17H17N7
Molecular Weight:
319.3638
MDL Number:
MFCD28963904
SMILES:
Nc1ncc(c(n1)CC1CC1)c1ccnc(n1)Nc1ccncc1
Properties
Computed Properties
 
Complexity:
396  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2  

Upstream Synthesis Route

[1]Patent:WO2012/85815,2012,A1,.Locationinpatent:Page/Pagecolumn61

[2]ACSMedicinalChemistryLetters,2016,vol.7,#1,p.72-76

Literature

Title: Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Journal: Nature cell biology 20141101

Title: Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6.

Title: Dowdle WE, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014 Nov;16(11):1069-79.

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SDS
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Tags:1383716-40-2 Molecular Formula|1383716-40-2 MDL|1383716-40-2 SMILES|1383716-40-2 PIK-III