Home Amines 138614-30-9
138614-30-9,MFCD04112967
Catalog No.:AA0018T0

138614-30-9 | (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propan

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1mg
≥98%
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$205.00   $143.00
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5mg
in stock  
$334.00   $234.00
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50mg
98%
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$593.00   $415.00
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0018T0
Chemical Name:
(2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propan
CAS Number:
138614-30-9
Molecular Formula:
C59H89N19O13S
Molecular Weight:
1304.5225
MDL Number:
MFCD04112967
SMILES:
OC[C@@H](C(=O)N1Cc2ccccc2CC1C(=O)N1[C@H]2CCCC[C@H]2CC1C(=O)N[C@H](C(=O)O)CCCN=C(N)N)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)C1C[C@H](CN1C(=O)C1CCCN1C(=O)C(NC(=O)[C@@H](CCCN=C(N)N)N)CCCN=C(N)N)O
Properties
Computed Properties
 
Complexity:
2720  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
92  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
15  
Rotatable Bond Count:
30  
Undefined Atom Stereocenter Count:
5  
XLogP3:
-6.4  

Literature

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Title: Icatibant for the treatment of hereditary angioedema.

Journal: The Annals of pharmacotherapy 20130101

Title: Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells.

Journal: American journal of physiology. Cell physiology 20121215

Title: The high glucose-induced stimulation of B1R and B2R expression via CB(1)R activation is involved in rat podocyte apoptosis.

Journal: Life sciences 20121102

Title: Icatibant: a novel approach to the treatment of angioedema related to the use of angiotensin-converting enzyme inhibitors.

Journal: The American journal of emergency medicine 20121001

Title: An update on hereditary angioedema.

Journal: Current opinion in pediatrics 20121001

Title: Icatibant , the bradykinin B2 receptor antagonist with target to the interconnected kinin systems.

Journal: Expert opinion on pharmacotherapy 20121001

Title: [Several new treatment possibilities of hereditary angio-oedema].

Journal: Ugeskrift for laeger 20120820

Title: Icatibant treatment for acquired C1-inhibitor deficiency: a real-world observational study.

Journal: Allergy 20120801

Title: Current management options for hereditary angioedema.

Journal: Current allergy and asthma reports 20120801

Title: Gangliosides stimulate bradykinin B2 receptors to promote calmodulin kinase II-mediated neuronal differentiation.

Journal: Journal of biochemistry 20120701

Title: New drugs 2012, part 2.

Journal: Nursing 20120701

Title: Safety and efficacy of icatibant self-administration for acute hereditary angioedema.

Journal: Clinical and experimental immunology 20120601

Title: Renin-angiotensin system inhibitors and angioedema: anesthetic implications.

Journal: Current opinion in anaesthesiology 20120601

Title: Treatment of idiopathic nonhistaminergic angioedema with bradykinin B2 receptor antagonist icatibant.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20120601

Title: Update on treatment of hereditary angioedema.

Journal: Asian Pacific journal of allergy and immunology 20120601

Title: Successful perioperative management of a patient with C1 esterase inhibitor deficiency with a novel bradykinin receptor B2 antagonist.

Journal: Anaesthesia and intensive care 20120501

Title: Progress in the emergency management of hereditary angioedema: focus on new treatment options in the United States.

Journal: Postgraduate medicine 20120501

Title: Immunotherapy for primary immunodeficiency diseases.

Journal: The Medical clinics of North America 20120501

Title: [Upper airway obstruction caused by ACE inhibitor-induced angioedema].

Journal: Lakartidningen 20120401

Title: Home treatment of hereditary angioedema with icatibant administered by health care professionals.

Journal: The Journal of allergy and clinical immunology 20120301

Title: Hereditary angioedema therapies in the United States: movement toward an international treatment consensus.

Journal: Clinical therapeutics 20120301

Title: Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group.

Journal: Allergy 20120201

Title: Inflammatory skin responses induced by icatibant injection are mast cell mediated and attenuated by H(1)-antihistamines.

Journal: Experimental dermatology 20120201

Title: [Hereditary angioedema].

Journal: La Revue du praticien 20120101

Title: Switch to icatibant in a patient affected by hereditary angioedema with high disease activity: a case report.

Journal: International journal of immunopathology and pharmacology 20120101

Title: Bradykinin receptor 2 extends inflammatory cell recruitment in a model of acute gouty arthritis.

Journal: Biochemical and biophysical research communications 20111216

Title: [Angiotensin-converting enzyme inhibitor induced angioedema : new therapy options].

Journal: Der Anaesthesist 20111201

Title: Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts.

Journal: Cardiovascular drugs and therapy 20111201

Title: Randomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20111201

Title: In brief: icatibant (Firazyr) for hereditary angioedema.

Journal: The Medical letter on drugs and therapeutics 20111128

Title: New topics in bradykinin research.

Journal: Allergy 20111101

Title: Bradykinin does not mediate remote ischaemic preconditioning or ischaemia-reperfusion injury in vivo in man.

Journal: Heart (British Cardiac Society) 20111101

Title: Cardiovascular and vasoconstrictive actions of skate bradykinin in the little skate, Leucoraja erinacea (Elasmobranchii).

Journal: General and comparative endocrinology 20111101

Title: The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis.

Journal: Shock (Augusta, Ga.) 20111101

Title: [Bradykinin-mediated angioedema secondary to angiotensin converting enzyme: initiate treatment from the prehospital phase].

Journal: Annales francaises d'anesthesie et de reanimation 20111101

Title: Insurers will find icatibant lifesaving but expensive treatment. Managed care once again faces the all-too-familiar debate about cost and benefit.

Journal: Managed care (Langhorne, Pa.) 20111101

Title: [Conestat alpha: effective but not practical].

Journal: La Revue du praticien 20111101

Title: [Icatibant is a new treatment option in life-threatening angioedema triggered by angiotensin-converting enzyme inhibitor].

Journal: Ugeskrift for laeger 20111010

Title: Successful long-term treatment with the bradykinin B2 receptor antagonist icatibant in a patient with hereditary angioedema.

Journal: International journal of dermatology 20111001

Title: Anti-nociceptive effect of kinin B₁ and B₂ receptor antagonists on peripheral neuropathy induced by paclitaxel in mice.

Journal: British journal of pharmacology 20110901

Title: Therapeutic approaches in hereditary angioedema.

Journal: Clinical reviews in allergy & immunology 20110801

Title: Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Management of adult patients with icatibant in hereditary angioedema.

Journal: Emergency medicine journal : EMJ 20110801

Title: One hypovolaemic shock…two kinin pathway abnormalities.

Journal: Intensive care medicine 20110701

Title: Treatment of acquired angioedema with icatibant: a case report.

Journal: Internal and emergency medicine 20110601

Title: Efficacy of icatibant treatment in patients with hereditary angio-oedema type I resistant to treatment with C1 inhibitor concentrate.

Journal: The British journal of dermatology 20110601

Title: Oversulfated chondroitin sulfate and OSCS-contaminated heparin cause dose- and route-dependent hemodynamic effects in the rat.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110601

Title: Icatibant in hereditary angioedema: news and challenges.

Journal: Expert review of clinical immunology 20110501

Title: Tissue kallikrein protects cortical neurons against hypoxia/reoxygenation injury via the ERK1/2 pathway.

Journal: Biochemical and biophysical research communications 20110408

Title: Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B₂ receptor.

Journal: British journal of pharmacology 20110301

Title: Rapid resolution of erythema marginatum after icatibant in acquired angioedema.

Journal: Acta dermato-venereologica 20110301

Title: The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling.

Journal: Regulatory peptides 20110225

Title: Acute NADPH oxidase activation potentiates cerebrovascular permeability response to bradykinin in ischemia-reperfusion.

Journal: Free radical biology & medicine 20110215

Title: Bradykinin and B₂ receptor antagonism in rat and human articular chondrocytes.

Journal: British journal of pharmacology 20110201

Title: Long-term prophylaxis of hereditary angioedema with androgen derivates: a critical appraisal and potential alternatives.

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20110201

Title: [Allergy-immunology. New therapies for acute attacks in hereditary angioedema].

Journal: Revue medicale suisse 20110119

Title: Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20110101

Title: Hereditary angioedema: long-term treatment with one or more injections of C1 inhibitor concentrate per week.

Journal: International archives of allergy and immunology 20110101

Title: Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy.

Journal: Cardiovascular diabetology 20110101

Title: Update on the acute treatment of hereditary angioedema.

Journal: Allergy and asthma proceedings 20110101

Title: Bradykinin promotes migration and invasion of human immortalized trophoblasts.

Journal: Reproductive biology and endocrinology : RB&E 20110101

Title: Hereditary angioedema: management of laryngeal attacks.

Journal: American journal of rhinology & allergy 20110101

Title: Alteration in airway microvascular leakage induced by sensorineural stimulation in rats exposed to inhaled formaldehyde.

Journal: Toxicology letters 20101215

Title: Angioedema due to C1 inhibitor deficiency in 2010.

Journal: Internal and emergency medicine 20101201

Title: Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101201

Title: An overview of novel therapies for acute hereditary angioedema.

Journal: American journal of clinical dermatology 20101201

Title: Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.

Journal: Pancreas 20101101

Title: Treatment of angiotensin-converting enzyme inhibitor-related angioedema with the bradykinin B2 receptor antagonist icatibant.

Journal: Journal of the American Academy of Dermatology 20101101

Title: Icatibant. Attacks of hereditary angioedema: continue to use C1 esterase inhibitor.

Journal: Prescrire international 20101101

Title: Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: a case series.

Journal: Annals of emergency medicine 20100901

Title: Contribution of bradykinin B2 receptors to the inhibition by valsartan of systemic and renal effects of exogenous angiotensin II in salt-repleted humans.

Journal: The Journal of pharmacology and experimental therapeutics 20100901

Title: Hereditary angioedema: an update on available therapeutic options.

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20100901

Title: Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema.

Journal: The New England journal of medicine 20100805

Title: Hereditary angioedema--therapies old and new.

Journal: The New England journal of medicine 20100805

Title: Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor.

Journal: Investigative ophthalmology & visual science 20100701

Title: Successful treatment of acquired C1 inhibitor deficiency with icatibant.

Journal: Clinical and experimental dermatology 20100701

Title: Tissue kallikrein promotes prostate cancer cell migration and invasion via a protease-activated receptor-1-dependent signaling pathway.

Journal: Biological chemistry 20100701

Title: Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.

Journal: Peptides 20100501

Title: Bradykinin receptor blockade reduces sympathetic nerve response to muscle contraction in rats with ischemic heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20100501

Title: [Emergency management of acute angioedema].

Journal: Deutsche medizinische Wochenschrift (1946) 20100501

Title: Icatibant.

Journal: British journal of clinical pharmacology 20100501

Title: Successful treatment of hereditary angioedema with bradykinin B2-receptor antagonist icatibant.

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20100401

Title: Kinin B(1) and B(2) receptors contribute to orofacial heat hyperalgesia induced by infraorbital nerve constriction injury in mice and rats.

Journal: Neuropeptides 20100401

Title: Comparison of the peripheral mediator background of heat injury- and plantar incision-induced drop of the noxious heat threshold in the rat.

Journal: Life sciences 20100213

Title: Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells.

Journal: Peptides 20100201

Title: The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice.

Journal: British journal of pharmacology 20100201

Title: Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism.

Journal: Journal of neurophysiology 20100101

Title: Icatibant.

Journal: Drugs 20100101

Title: Short-term prophylactic treatment of hereditary angioedema with icatibant.

Journal: Allergy 20100101

Title: Management of acute attacks of hereditary angioedema: potential role of icatibant.

Journal: Vascular health and risk management 20100101

Title: Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.

Journal: Journal of cellular physiology 20091201

Title: Effect of Intra-articular 4-(S)-amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.

Journal: The Journal of allergy and clinical immunology 20091201

Title: Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts.

Journal: British journal of pharmacology 20091201

Title: Icatibant for hereditary angioedema.

Journal: Drugs of today (Barcelona, Spain : 1998) 20091201

Title: Bradykinin receptor 2 antagonist (icatibant) for hereditary angioedema type III attacks.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20091101

Title: Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis.

Journal: Journal of the American Society of Nephrology : JASN 20091001

Title: Involvement of the kallikrein-kinin system in a model of hyperalgesia in low kallikrein rats.

Journal: Veterinary research communications 20090901

Title: Differential fading of inhibitory and excitatory B2 bradykinin receptor responses in rat sympathetic neurons: a role for protein kinase C.

Journal: Journal of neurochemistry 20090901

Title: B(2) kinin receptors mediate the Indian red scorpion venom-induced augmentation of visceral reflexes via the nitric oxide cyclic guanosine monophosphate pathway.

Journal: Acta physiologica (Oxford, England) 20090801

Title: Cardioprotective effect of sasanquasaponin preconditioning via bradykinin-NO pathway in isolated rat heart.

Journal: Phytotherapy research : PTR 20090801

Title: Scorpion toxin of Androctonus australis garzonii induces neuropeptide Y release via bradykinin stimulation in rat atria and kidneys.

Journal: Peptides 20090801

Title: Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.

Journal: European journal of pharmacology 20090801

Title: Bradykinin receptor antagonists--a review of the patent literature 2005-2008.

Journal: Expert opinion on therapeutic patents 20090701

Title: When is prophylaxis for hereditary angioedema necessary?

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090501

Title: Effects of bradykinin on venous capacitance in health and treated chronic heart failure.

Journal: Clinical science (London, England : 1979) 20090301

Title: Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.

Journal: Arthritis and rheumatism 20090301

Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.

Journal: Neuro endocrinology letters 20090301

Title: Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090201

Title: Bradykinin protects against oxidative stress-induced endothelial cell senescence.

Journal: Hypertension (Dallas, Tex. : 1979) 20090201

Title: The bradykinin B2 receptor mediates hypoxia/reoxygenation induced neuronal cell apoptosis through the ERK1/2 pathway.

Journal: Neuroscience letters 20090123

Title: Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI.

Journal: Annals of the rheumatic diseases 20090101

Title: Angiotensin II-mediated vasodilation is reduced in adult spontaneously hypertensive rats despite enhanced expression of AT2 receptors.

Journal: Clinical and experimental pharmacology & physiology 20090101

Title: Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema.

Journal: Stroke 20090101

Title: Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.

Journal: Journal of vascular research 20090101

Title: [Hereditary angioedema: a case series and bibliographic update].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20090101

Title: Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine- and streptozotocin-induced hyperalgesia.

Journal: Pharmacological reports : PR 20090101

Title: Update on therapeutic developments for hereditary angioedema.

Journal: Allergy and asthma proceedings 20090101

Title: The protein therapy of kallikrein in cerebral ischemic reperfusion injury.

Journal: Current medicinal chemistry 20090101

Title: Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin.

Journal: Hepato-gastroenterology 20090101

Title: Hereditary angioedema: new hopes for an orphan disease.

Journal: The Israel Medical Association journal : IMAJ 20081201

Title: Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential.

Journal: Circulation research 20081121

Title: Vascular B1 kinin receptors in patients with congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20081101

Title: Blockade of renal medullary bradykinin B2 receptors increases tubular sodium reabsorption in rats fed a normal-salt diet.

Journal: American journal of physiology. Renal physiology 20080901

Title: Therapeutic potential of icatibant (HOE-140, JE-049).

Journal: Expert opinion on pharmacotherapy 20080901

Title: Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.

Journal: Journal of cardiovascular pharmacology 20080801

Title: Knee osteoarthritis: a role for bradykinin?

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080801

Title: B2 kinin receptor activation is the predominant mechanism by which trypsin mediates endothelium-dependent relaxation in bovine coronary arteries.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080701

Title: Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.

Journal: Pancreas 20080701

Title: [Hereditary angioedema--treatment].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20080701

Title: Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors.

Journal: British journal of pharmacology 20080501

Title: Pharmacological blockade of B2-kinin receptor reduces renal protective effect of angiotensin-converting enzyme inhibition in db/db mice model.

Journal: American journal of physiology. Renal physiology 20080501

Title: Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080401

Title: Antihypertensive effects of crude extracts from leaves of Echinodorus grandiflorus.

Journal: Fundamental & clinical pharmacology 20080401

Title: ACE activity is modulated by kinin B2 receptor.

Journal: Hypertension (Dallas, Tex. : 1979) 20080301

Title: Analysis of the vasorelaxant action of angiotensin II in the isolated rat renal artery.

Journal: Journal of pharmacological sciences 20080301

Title: Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw.

Journal: Journal of neuroscience methods 20080215

Title: Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease.

Journal: Neuroscience 20080206

Title: Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis.

Journal: Hypertension (Dallas, Tex. : 1979) 20080201

Title: MEN16132, a kinin B2 receptor antagonist, prevents the endogenous bradykinin effects in guinea-pig airways.

Journal: European journal of pharmacology 20080128

Title: Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion.

Journal: Life sciences 20080116

Title: Negative inotropic effect of selective AT2 receptor stimulation and its modulation by the endocardial endothelium.

Journal: European journal of pharmacology 20080114

Title: Effect of bradykinin receptor antagonists on vincristine- and streptozotocin-induced hyperalgesia in a rat model of chemotherapy-induced and diabetic neuropathy.

Journal: Pharmacology 20080101

Title: New therapies for hereditary angioedema: disease outlook changes dramatically.

Journal: The Journal of allergy and clinical immunology 20080101

Title: Hereditary angioedema: a current state-of-the-art review, II: historical perspective of non-histamine-induced angioedema.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101

Title: Hereditary angiodema: a current state-of-the-art review, VI: novel therapies for hereditary angioedema.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101

Title: Hereditary angioedema: a current state-of-the-art review, VIII: current status of emerging therapies.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080101

Title: Effects of the bradykinin B2 receptor antagonist icatibant on microvascular permeability after thermal injury in sheep.

Journal: Shock (Augusta, Ga.) 20071201

Title: [ACE-inhibitor induced angioedema].

Journal: Laryngo- rhino- otologie 20071101

Title: ACE inhibitor reduces growth factor receptor expression and signaling but also albuminuria through B2-kinin glomerular receptor activation in diabetic rats.

Journal: American journal of physiology. Renal physiology 20071001

Title: Endoplasmic reticulum is a key organella in bradykinin-triggered ATP release from cultured smooth muscle cells.

Journal: Journal of pharmacological sciences 20070901

Title: Bradykinin into amygdala induces thermal hyperalgesia in rats.

Journal: Neuropeptides 20070801

Title: Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling.

Journal: Cardiovascular research 20070701

Title: C1-inhibitor deficiencies (hereditary angioedema): where are we with therapies?

Journal: Current allergy and asthma reports 20070701

Title: Peripheral kinin B(1) and B(2) receptor-operated mechanisms are implicated in neuropathic nociception induced by spinal nerve ligation in rats.

Journal: Neuropharmacology 20070701

Title: Pharmacological and biochemical characterization of bradykinin B2 receptors in the mouse colon: influence of the TNBS-induced colitis.

Journal: Regulatory peptides 20070607

Title: Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant).

Journal: The Journal of allergy and clinical immunology 20070601

Title: On the mechanism of coronary vasodilation induced by angiotensin-(1-7) in the isolated guinea pig heart.

Journal: Basic & clinical pharmacology & toxicology 20070601

Title: Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin.

Journal: Investigative ophthalmology & visual science 20070501

Title: [Practical management of C1 inhibitor deficiency].

Journal: Actas dermo-sifiliograficas 20070501

Title: Functional characterization of the mechanisms underlying bradykinin-induced relaxation in the isolated rat carotid artery.

Journal: Life sciences 20070417

Title: Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction.

Journal: Regulatory peptides 20070405

Title: Bradykinin B(2) receptor does not contribute to blood pressure lowering during AT(1) receptor blockade.

Journal: The Journal of pharmacology and experimental therapeutics 20070301

Title: Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20070301

Title: Angiotensin-converting enzyme inhibitor enhances liver regeneration following partial hepatectomy: involvement of bradykinin B2 and angiotensin AT1 receptors.

Journal: Biological & pharmaceutical bulletin 20070301

Title: Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload.

Journal: Journal of the American College of Cardiology 20070220

Title: Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.

Journal: Vascular pharmacology 20070201

Title: Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Journal: British journal of pharmacology 20070101

Title: Bradykinin is a mediator, but unlikely a trigger, of antiarrhythmic effects of ischemic preconditioning.

Journal: Journal of cardiovascular electrophysiology 20070101

Title: The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.

Journal: European journal of pharmacology 20061203

Title: Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation.

Journal: Journal of leukocyte biology 20061201

Title: Novel pharmacotherapy of acute hereditary angioedema with bradykinin B2-receptor antagonist icatibant.

Journal: Allergy 20061201

Title: Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat).

Journal: American journal of physiology. Renal physiology 20061101

Title: Angiotensin-(1-7) potentiates responses to bradykinin but does not change responses to angiotensin I.

Journal: Canadian journal of physiology and pharmacology 20061101

Title: Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.

Journal: The EMBO journal 20061018

Title: Kinin modulation of conventional outflow facility in the bovine eye.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

Title: AT1 receptor blockade prevents microvascular dysfunction induced by ischemia/reperfusion injury.

Journal: Journal of atherosclerosis and thrombosis 20061001

Title: Kinins and neuroinflammation: dual effect on prostaglandin synthesis.

Journal: European journal of pharmacology 20060928

Title: Angiotensin-converting enzyme inhibitor-related angioedema: how to deal with it.

Journal: Expert opinion on drug safety 20060901

Title: Inhibition of angiotensin-converting enzyme reduces rat liver reperfusion injury via bradykinin-2-receptor.

Journal: The Journal of surgical research 20060801

Title: Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway.

Journal: Journal of cardiovascular pharmacology 20060701

Title: Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum.

Journal: European journal of pharmacology 20060606

Title: Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20060601

Title: Bradykinin mediates phosphorylation of eNOS in odontoblasts.

Journal: Journal of dental research 20060601

Title: Experimental therapy with tissue kallikrein against cerebral ischemia.

Journal: Frontiers in bioscience : a journal and virtual library 20060501

Title: Bradykinin antagonists modified with dipeptide mimetic beta-turn inducers.

Journal: Bioorganic & medicinal chemistry letters 20060501

Title: Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease.

Journal: European journal of pharmacology 20060308

Title: Potentiation of nicotinic currents by bradykinin in the paratracheal ganglia neurons of rats.

Journal: European journal of pharmacology 20060215

Title: B(2)-receptor modulation of the reactivity to phenylephrine and angiotensin II in the carotid artery of normotensive rats after trandolapril treatment.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20060201

Title: Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kinin-dependent mechanism.

Journal: Journal of hypertension 20060101

Title: Modulation of renal kallikrein by a high potassium diet in rats with intense proteinuria.

Journal: Kidney international 20060101

Title: Mechanism of non-capacitative Ca2+ influx in response to bradykinin in vascular endothelial cells.

Journal: Journal of vascular research 20060101

Title: Pharmacological enhancement of the kallikrein-kinin system promotes anti-fibrotic responses in human mesangial cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

Title: MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.

Journal: European journal of pharmacology 20051228

Title: [Mechanism of cardioprotection against ischemia/reperfusion injury by valsartan: an experiment with isolated rat hearts].

Journal: Zhonghua yi xue za zhi 20051214

Title: Activation of splanchnic and pelvic colonic afferents by bradykinin in mice.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051201

Title: Bradykinin B2 receptor antagonism attenuates inflammation, mast cell infiltration and fibrosis in remote myocardium after infarction in rats.

Journal: Clinical and experimental pharmacology & physiology 20051201

Title: Optical biosensor provides insights for bradykinin B(2) receptor signaling in A431 cells.

Journal: FEBS letters 20051121

Title: Does insulin release kinins in rats?

Journal: European journal of pharmacology 20051121

Title: MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass.

Journal: Clinical pharmacology and therapeutics 20051101

Title: Antagonistic effects of novel non-peptide chlorobenzhydryl piperazine compounds on contractile response to bradykinin in the guinea-pig ileum.

Journal: European journal of pharmacology 20051031

Title: Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.

Journal: Pain 20050901

Title: The kallikrein-kinin system: current and future pharmacological targets.

Journal: Journal of pharmacological sciences 20050901

Title: Kinin and opioid receptors in the paratrigeminal nucleus modulate the somatosensory reflex to rat sciatic nerve stimulation.

Journal: Peptides 20050801

Title: Bradykinin B2 type receptor activation regulates fluid and electrolyte transport in the rabbit kidney.

Journal: Peptides 20050801

Title: Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: A possible alternative mechanism of kinin generation in vivo by cathepsin L.

Journal: Biological chemistry 20050701

Title: Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats.

Journal: European journal of pharmacology 20050615

Title: Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function.

Journal: The Journal of biological chemistry 20050520

Title: Bradykinin potentiates 5-HT3 receptor-mediated current in rat trigeminal ganglion neurons.

Journal: Acta pharmacologica Sinica 20050401

Title: Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha.

Journal: Regulatory peptides 20050330

Title: Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways.

Journal: The Journal of biological chemistry 20050304

Title: Fate of bradykinin on the rat liver when administered by the venous or arterial route.

Journal: Journal of gastroenterology and hepatology 20050301

Title: Hit to Lead Success Stories--IBC Conference: Effective chemistry strategies for reducing attrition rates and speeding lead compounds into the pipeline. 31 January-1 February 2005, San Diego, CA, USA.

Journal: IDrugs : the investigational drugs journal 20050301

Title: Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene.

Journal: Regulatory peptides 20050115

Title: Icatibant: HOE 140, JE 049, JE049.

Journal: Drugs in R&D 20050101

Title: ACE inhibition lowers angiotensin-II-induced monocyte adhesion to HUVEC by reduction of p65 translocation and AT 1 expression.

Journal: Journal of vascular research 20050101

Title: Effects of bradykinin on cardiovascular remodeling in renovascular hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20041101

Title: Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1.

Journal: Cellular signalling 20041001

Title: Bradykinin antagonists have no analgesic effect on incisional pain.

Journal: Anesthesia and analgesia 20041001

Title: Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice.

Journal: Journal of cardiovascular pharmacology 20041001

Title: Nephroprotection in Zucker diabetic fatty rats by vasopeptidase inhibition is partly bradykinin B2 receptor dependent.

Journal: British journal of pharmacology 20040901

Title: Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.

Journal: Journal of cardiovascular pharmacology 20040901

Title: Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040701

Title: Flow-dependent dilation mediated by endogenous kinins requires angiotensin AT2 receptors.

Journal: Circulation research 20040625

Title: Stimulation of cyclic GMP production via AT2 and B2 receptors in the pressure-overloaded aorta after banding.

Journal: Hypertension (Dallas, Tex. : 1979) 20040601

Title: Hoe 140 abolishes the blood pressure lowering effect of taurine in high fructose-fed rats.

Journal: Amino acids 20040601

Title: The N-terminal of icatibant and bradykinin interact with the same Asp residues in the human B2 receptor.

Journal: European journal of pharmacology 20040503

Title: Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats.

Journal: British journal of pharmacology 20040501

Title: Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501

Title: Pharmacological characterization of canine bradykinin receptors in prostatic culture and in isolated prostate.

Journal: British journal of pharmacology 20040501

Title: BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2.

Journal: Methods and findings in experimental and clinical pharmacology 20040501

Title: Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats.

Journal: Regulatory peptides 20040415

Title: Action of bradykinin in the submucosal plexus of guinea pig small intestine.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats.

Journal: British journal of pharmacology 20040401

Title: The role of bradykinin in the antifibrotic actions of perindoprilat on human mesangial cells.

Journal: Kidney international 20040401

Title: Cell survival signalling in heart derived myofibroblasts induced by preconditioning and bradykinin: the role of p38 MAP kinase.

Journal: Molecular and cellular biochemistry 20040401

Title: Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP.

Journal: Journal of hypertension 20040401

Title: Role of bradykinin B2 and B1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040215

Title: Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor.

Journal: British journal of pharmacology 20040201

Title: Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040201

Title: Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction.

Journal: Pharmacological research 20040101

Title: Changes in vascular distensibility during angiotensin-converting enzyme inhibition involve bradykinin type 2 receptors.

Journal: Journal of vascular research 20040101

Title: Potential role of kinins in the effects of taurine in high-fructose-fed rats.

Journal: Canadian journal of physiology and pharmacology 20040101

Title: Icatibant: HOE 140, JE 049, JE049.

Journal: Drugs in R&D 20040101

Title: Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction.

Journal: Pharmacological research 20031201

Title: Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation.

Journal: Journal of cardiovascular pharmacology 20031201

Title: Protective effect of bradykinin antagonist Hoe-140 during in vivo myocardial ischemic-reperfusion injury in the cat.

Journal: Regulatory peptides 20031015

Title: Autoradiographic localization of [125I-Tyr0]bradykinin binding sites in brains of Wistar-Kyoto and spontaneously hypertensive rats.

Journal: Cellular and molecular neurobiology 20031001

Title: Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495.

Journal: Cardiovascular research 20031001

Title: Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030901

Title: Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.

Journal: European journal of pharmacology 20030829

Title: Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.

Journal: Gastroenterology 20030701

Title: Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: AT1-receptor antagonism improves endothelial function in coronary artery disease by a bradykinin/B2-receptor-dependent mechanism.

Journal: Hypertension (Dallas, Tex. : 1979) 20030501

Title: Transactivation of KDR/Flk-1 by the B2 receptor induces tube formation in human coronary endothelial cells.

Journal: Hypertension (Dallas, Tex. : 1979) 20030501

Title: Enalaprilat, losartan and LU 135252 in coronary blood flow regulation.

Journal: European journal of clinical investigation 20030501

Title: Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.

Journal: Toxicon : official journal of the International Society on Toxinology 20030501

Title: Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury.

Journal: British journal of pharmacology 20030501

Title: Effect of a kinin B2 receptor antagonist on LPS- and cytokine-induced neutrophil migration in rats.

Journal: British journal of pharmacology 20030501

Title: Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation.

Journal: British journal of pharmacology 20030501

Title: Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker.

Journal: Circulation 20030415

Title: Modulation of cutaneous inflammation by angiotensin-converting enzyme.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030401

Title: Amelioration of hyperalgesia by kinin receptor antagonists or kininogen deficiency in chronic constriction nerve injury in rats.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030401

Title: Kinins are involved in the antiproteinuric effect of angiotensin-converting enzyme inhibition in experimental diabetic nephropathy.

Journal: International immunopharmacology 20030301

Title: Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.

Journal: European journal of pharmacology 20030221

Title: Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin.

Journal: Circulation 20030204

Title: Angiotensin II and renal medullary blood flow in Lyon rats.

Journal: American journal of physiology. Renal physiology 20030201

Title: B2 bradykinin receptor mediates the stimulatory effect of bradykinin on rat germ cell proliferation in vitro.

Journal: Andrologia 20030201

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Journal: European journal of pharmacology 20030126

Title: Characterisation of bradykinin B1 and B2 receptors using rat isolated vas deferens.

Journal: European journal of pharmacology 20030105

Title: Bradykinin B1 and B2 receptors differentially regulate cardiac Na+-H+ exchanger, Na+-Ca2+ exchanger and Na+-HCO3- symporter.

Journal: European journal of pharmacology 20030101

Title: Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.

Journal: European journal of pharmacology 20030101

Title: Renoprotective effects of omapatrilat are mediated partially by bradykinin.

Journal: American journal of nephrology 20030101

Title: Effect of neutral endopeptidase inhibition on vascular response induced by exogenous angiotensin I in the isolated rat lung.

Journal: Polish journal of pharmacology 20030101

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Journal: Pharmacology 20021001

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Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20021001

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Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20021001

Title: Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform.

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Title: Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I.

Journal: Pharmacology 20020801

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Journal: Neuropeptides 20020801

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Journal: Journal of the American College of Cardiology 20020703

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Journal: Biomaterials 20020701

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Journal: The journal of peptide research : official journal of the American Peptide Society 20020401

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Journal: Canadian journal of physiology and pharmacology 20020401

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Journal: International journal of cancer 20020301

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Journal: British journal of pharmacology 20020101

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Journal: Biochemistry 20011225

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Journal: British journal of pharmacology 20011201

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Journal: Japanese journal of pharmacology 20011201

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Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

Title: Changes in blood glucose and plasma insulin levels induced by bradykinin in anaesthetized rats.

Journal: British journal of pharmacology 20011101

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Journal: Clinical and experimental pharmacology & physiology 20011001

Title: Bradykinin receptor antagonists attenuate neointimal proliferation postangioplasty.

Journal: American journal of physiology. Heart and circulatory physiology 20011001

Title: Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.

Journal: American journal of physiology. Lung cellular and molecular physiology 20011001

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Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011001

Title: Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia.

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Journal: Hypertension (Dallas, Tex. : 1979) 20011001

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Journal: Canadian journal of physiology and pharmacology 20011001

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Journal: Journal of medical and dental sciences 20010901

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Journal: Toxicon : official journal of the International Society on Toxinology 20010801

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Journal: British journal of pharmacology 20010801

Title: Bradykinin B2, but not B1, receptor antagonism has a neuroprotective effect after brain injury.

Journal: Journal of neurotrauma 20010801

Title: Bradykinin B2 receptor is involved in the late phase of preconditioning in rabbit heart.

Journal: Journal of molecular and cellular cardiology 20010701

Title: Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat.

Journal: British journal of pharmacology 20010601

Title: Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.

Journal: Mediators of inflammation 20010601

Title: Bradykinin mediates the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats.

Journal: Stroke 20010501

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Journal: Hypertension (Dallas, Tex. : 1979) 20010501

Title: Different potentiating effects of imidapril and enalapril on kaolin-induced writhing reaction in mice.

Journal: Life sciences 20010413

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Journal: Journal of cardiovascular pharmacology 20010401

Title: Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.

Journal: Japanese journal of cancer research : Gann 20010401

Title: Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice.

Journal: Circulation research 20010330

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Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010301

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Journal: Journal of molecular and cellular cardiology 20010301

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Journal: The Journal of pharmacology and experimental therapeutics 20010301

Title: Effects of icatibant on the ramipril-induced decreased in renal lithium clearance in the rat.

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Title: Bradykinin evokes a Ca2+-activated chloride current in non-neuronal cells isolated from neonatal rat dorsal root ganglia.

Journal: The Journal of physiology 20010201

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Title: Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs.

Journal: Fundamental & clinical pharmacology 20010201

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Journal: American journal of physiology. Heart and circulatory physiology 20010101

Title: Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen.

Journal: The Journal of allergy and clinical immunology 20010101

Title: Effect of bradykinin on cultured bovine corneal endothelial cells.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

Title: Enalaprilat attenuates ischemic rises in intracellular sodium in the isolated rat heart via the bradykinin receptor.

Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20010101

Title: The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro.

Journal: Journal of submicroscopic cytology and pathology 20010101

Title: Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-dependent mechanisms in canine hearts.

Journal: Cardiovascular drugs and therapy 20010101

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Journal: European journal of pharmacology 20001208

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Journal: British journal of pharmacology 20001201

Title: Endogenous bradykinin and the renin and pressor responses to furosemide in humans.

Journal: The Journal of pharmacology and experimental therapeutics 20001101

Title: Comparison of enalapril and valsartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet.

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Tags:138614-30-9 Molecular Formula|138614-30-9 MDL|138614-30-9 SMILES|138614-30-9 (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propan