Catalog No.:AA0019HA

138786-67-1 | 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methane]sulfinyl}-1-sodio-1H-1,3-benzodiazole

Name: Name:5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methane]sulfinyl}-1-sodio-1H-1,3-benzodiazole
Brand: AABLOCKS
SKU: AA0019HA
Availability: InStock
Rating: 90 (10 reviews)

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1mg

98%

in stock

$7.00 $5.00

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100mg

98%

in stock

$39.00 $28.00

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250mg

98%

in stock

$56.00 $39.00

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98%

in stock

$114.00 $80.00

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98%

in stock

$249.00 $174.00

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA0019HA

Chemical Name:

5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methane]sulfinyl}-1-sodio-1H-1,3-benzodiazole

CAS Number:

138786-67-1

Molecular Formula:

C16H15F2N3NaO4S

Molecular Weight:

406.3596

MDL Number:

MFCD08704580

SMILES:

COc1c(OC)ccnc1CS(=O)c1nc2c([nH]1)cc(cc2)OC(F)F.[Na]

Properties

Computed Properties

Complexity:

497

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

Upstream Synthesis Route

102625-70-7

138786-67-1

[1]Patent:WO2004/111029,2004,A2,.Locationinpatent:Page24

[2]Patent:CN107011252,2017,A,.Locationinpatent:Paragraph0101;0103

[3]Patent:WO2004/111029,2004,A2,.Locationinpatent:Page24

[4]Patent:WO2009/75516,2009,A2,.Locationinpatent:Page/Pagecolumn5

[5]Patent:WO2004/111029,2004,A2,.Locationinpatent:Page24

[6]Patent:WO2004/111029,2004,A2,.Locationinpatent:Page25

[7]Patent:WO2004/56804,2004,A2,.Locationinpatent:Page35

[8]Patent:WO2004/99183,2004,A1,.Locationinpatent:Page4

[9]Patent:WO2004/99183,2004,A1,.Locationinpatent:Page5

[10]Patent:WO2005/77936,2005,A1,.Locationinpatent:Page/Pagecolumn19-20

[11]Patent:WO2009/10937,2009,A1,.Locationinpatent:Page/Pagecolumn11

[12]Patent:WO2009/116072,2009,A2,.Locationinpatent:Page/Pagecolumn16

[13]Patent:CN108503622,2018,A,.Locationinpatent:Paragraph0033;0036;0037;0038;0041;0042;0043;0046

102625-64-9

138786-67-1

[1]Patent:WO2009/66317,2009,A2,.Locationinpatent:Page/Pagecolumn8

[2]Patent:CN104262326,2016,B,.Locationinpatent:Paragraph0034-0036

[3]Patent:US2010/210847,2010,A1,.Locationinpatent:Page/Pagecolumn4

[4]Patent:WO2013/108068,2013,A1,.Locationinpatent:Page/Pagecolumn18;19

[5]Patent:CN108341800,2018,A,.Locationinpatent:Paragraph0007;0008;0009

409098-86-8

138786-67-1

[1]Patent:US2005/96352,2005,A1,.Locationinpatent:Page/Pagecolumn4

97963-62-7

72830-09-2

138786-67-1

[1]Patent:WO2006/64249,2006,A2,.Locationinpatent:Page/Pagecolumn8;10

97963-62-7

138786-67-1

[1]Patent:WO2006/64249,2006,A2,.Locationinpatent:Page/Pagecolumn8;10-11

Downstream Synthesis Route

138786-67-1

magnesiumbis5-difluoromethoxy-2-3,4-dimethoxy-2-pyridinyl-methylsulfinyl-1H-benzimidazolide

[1]Patent:WO2005/107721,2005,A2.Locationinpatent:Page/Pagecolumn14

138786-67-1

pantoprazolesodium

[1]Patent:WO2004/56804,2004,A2.Locationinpatent:Page36

[2]Patent:WO2004/56804,2004,A2.Locationinpatent:Page36

[3]Patent:WO2004/56804,2004,A2.Locationinpatent:Page36

102625-70-7

138786-67-1

[1]Patent:WO2004/111029,2004,A2.Locationinpatent:Page24

[2]Patent:CN107011252,2017,A.Locationinpatent:Paragraph0101;0103

[3]Patent:WO2004/111029,2004,A2.Locationinpatent:Page24

[4]Patent:WO2009/75516,2009,A2.Locationinpatent:Page/Pagecolumn5

[5]Patent:WO2004/111029,2004,A2.Locationinpatent:Page24

[6]Patent:WO2004/111029,2004,A2.Locationinpatent:Page25

[7]Patent:WO2004/56804,2004,A2.Locationinpatent:Page35

[8]Patent:WO2004/99183,2004,A1.Locationinpatent:Page4

[9]Patent:WO2004/99183,2004,A1.Locationinpatent:Page5

[10]Patent:WO2005/77936,2005,A1.Locationinpatent:Page/Pagecolumn19-20

[11]Patent:WO2009/10937,2009,A1.Locationinpatent:Page/Pagecolumn11

[12]Patent:WO2009/116072,2009,A2.Locationinpatent:Page/Pagecolumn16

[13]Patent:CN108503622,2018,A.Locationinpatent:Paragraph0033;0036;0037;0038;0041;0042;0043;0046

[14]Patent:CN109354587,2019,A.Locationinpatent:Paragraph0228-0236

[15]Patent:CN111057044,2020,A.Locationinpatent:Paragraph0032-0034

651728-72-2

138786-67-1

3-5-difluoromethoxy-2-{(3,4-dimethoxy-pyridin-2-yl)-methanesulfinyl}-benzimidazole-1-sulfonylbenzoicacid2-(toluene-4-sulfonyl)ethylester

651728-78-8

[1]Patent:WO2004/9583,2004,A2.Locationinpatent:Page108

Literature

Title: Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity.

Journal: Chemico-biological interactions 20170105

Title: The influence of flavonoids on the binding of pantoprazole to bovine serum albumin by spectroscopic methods: with the viewpoint of food/drug interference.

Journal: Food chemistry 20121201

Title: Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.

Journal: International journal of pharmaceutics 20121115

Title: Method development and validation study for quantitative determination of 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride a genotoxic impurity in pantoprazole active pharmaceutical ingredient (API) by LC/MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: Prolonged coagulopathy related to coumarin rodenticide in a young patient: superwarfarin poisoning.

Journal: Cardiovascular journal of Africa 20121023

Title: Partial symptom-response to proton pump inhibitors in patients with non-erosive reflux disease or reflux oesophagitis - a post hoc analysis of 5796 patients.

Journal: Alimentary pharmacology & therapeutics 20121001

Title: Validation of a chiral liquid chromatography-tandem mass spectrometry method for the determination of pantoprazole in dog plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121001

Title: CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers.

Journal: European journal of clinical pharmacology 20120901

Title: Evaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450: focus on cytochrome P450 2C19.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120901

Title: Quadruple therapy with moxifloxacin and bismuth for first-line treatment of Helicobacter pylori.

Journal: World journal of gastroenterology 20120828

Title: Allergic reaction to proton pump ınhibitor: pantoprazole induced Kounis syndrome.

Journal: International journal of cardiology 20120823

Title: Regulated endocrine-specific protein 18 (RESP18) is localized to and regulated in A-like cells and G-cells in rat stomach.

Journal: Regulatory peptides 20120820

Title: A modified bismuth-containing quadruple therapy including a short course of furazolidone for Helicobacter pylori eradication after sequential therapy failure.

Journal: Helicobacter 20120801

Title: Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo.

Journal: Journal of cellular biochemistry 20120701

Title: Effect of gastric acid suppression with pantoprazole on the efficacy of calcium carbonate as a phosphate binder in haemodialysis patients.

Journal: Nephrology (Carlton, Vic.) 20120701

Title: Long-term, open-label trial: safety and efficacy of continuous maintenance treatment with pantoprazole for up to 15 years in severe acid-peptic disease.

Journal: Alimentary pharmacology & therapeutics 20120701

Title: [Clinical signs of Cushing's syndrome after long-term local application of steroid in the oral cavity].

Journal: Ugeskrift for laeger 20120625

Title: The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers.

Journal: Kidney international 20120601

Title: Randomised clinical trial: sustained response to PPI treatment of symptoms resembling functional dyspepsia and irritable bowel syndrome in patients suffering from an overlap with erosive gastro-oesophageal reflux disease.

Journal: Alimentary pharmacology & therapeutics 20120601

Title: Oral pantoprazole-induced acute pancreatitis in an 11-year-old child.

Journal: Therapeutic drug monitoring 20120601

Title: Pantoprazole, a proton pump inhibitor, delays fracture healing in mice.

Journal: Calcified tissue international 20120601

Title: Optimization and validation of a new CE method for the determination of pantoprazole enantiomers.

Journal: Electrophoresis 20120601

Title: Reflux symptom index and reflux finding score in otolaryngologic practice.

Journal: Journal of voice : official journal of the Voice Foundation 20120501

Title: Effect of gastric acid suppression with pantoprazole on the efficacy of sevelamer hydrochloride as a phosphate binder in haemodialysis patients: a pilot study.

Journal: Nephrology (Carlton, Vic.) 20120501

Title: Stereoselective interaction of pantoprazole with ABCG2. I. Drug accumulation in rat milk.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120501

Title: Stereoselective interaction of pantoprazole with ABCG2. II. In vitro flux analysis.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120501

Title: Dysphagia, oral telangiectasia, and Raynaud syndrome.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20120401

Title: Enantioselective disposition of omeprazole, pantoprazole, and lansoprazole in a same Brazilian subjects group.

Journal: Chirality 20120401

Title: Randomised clinical trial: high-dose vs. standard-dose proton pump inhibitors for the prevention of recurrent haemorrhage after combined endoscopic haemostasis of bleeding peptic ulcers.

Journal: Alimentary pharmacology & therapeutics 20120401

Title: Sequential therapy achieves a higher eradication rate than standard triple therapy in Taiwan.

Journal: Journal of gastroenterology and hepatology 20120301

Title: In vitro evaluation of phototoxic properties of proton pump inhibitors, H2-receptor antagonists and statins.

Journal: Acta dermato-venereologica 20120301

Title: Randomized controlled trial of high dose bolus versus continuous intravenous infusion pantoprazole as an adjunct therapy to therapeutic endoscopy in massive bleeding peptic ulcer.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20120301

Title: A comparison between sequential therapy and a modified bismuth-based quadruple therapy for Helicobacter pylori eradication in Iran: a randomized clinical trial.

Journal: Helicobacter 20120201

Title: 33-year-old woman with epigastric pain and hematemesis.

Journal: Mayo Clinic proceedings 20120201

Title: Exfoliative erythrodermia induced by pantoprazole.

Journal: Allergologia et immunopathologia 20120101

Title: CYP2C19 genotypes determine the efficacy of on-demand therapy of pantoprazole for reflux esophagitis as Los-Angeles grades C and D.

Journal: Journal of gastroenterology and hepatology 20120101

Title: Prediction of clopidogrel low responders by a rapid CYP2C19 activity test.

Journal: Journal of atherosclerosis and thrombosis 20120101

Title: Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells.

Journal: Neoplasma 20120101

Title: Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: a randomized, open-labeled, two-way crossover study.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: Intravenous non-high-dose pantoprazole is equally effective as high-dose pantoprazole in preventing rebleeding among low risk patients with a bleeding peptic ulcer after initial endoscopic hemostasis.

Journal: BMC gastroenterology 20120101

Title: Bone remodeling after administration of proton pump (H+/K+-ATPase) inhibitors and alendronate in ovariectomized rats.

Journal: Acta poloniae pharmaceutica 20120101

Title: Effects of pantoprazole on dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention.

Journal: Pharmacological reports : PR 20120101

Title: Predictors of high on-treatment platelet reactivity early after clopidogrel loading in ST-elevation myocardial infarction.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: Nine cases of allergy to omeprazole.

Journal: Journal of investigational allergology & clinical immunology 20120101

Title: [Factors affecting efficacy of gastroesophageal reflux disease treatment with proton pump inhibitors].

Journal: Terapevticheskii arkhiv 20120101

Title: Proton pump (H+/K+-ATPase) inhibitors weaken the protective effect of alendronate on bone mechanical properties in estrogen-deficient rats.

Journal: Pharmacological reports : PR 20120101

Title: [Prevention of stress-induced damage of the upper gastrointestinal mucosa in patients during early postoperative period].

Journal: Anesteziologiia i reanimatologiia 20120101

Title: The efficacy of PPI after endoscopic hemostasis in patients with bleeding peptic ulcer and role of Helicobacter pylori.

Journal: Medical archives (Sarajevo, Bosnia and Herzegovina) 20120101

Title: Differential effects of Cu(II) and Fe(III) on the binding of omeprazole and pantoprazole to bovine serum albumin: toxic effect of metal ions on drugs.

Journal: Journal of pharmaceutical and biomedical analysis 20111215

Title: Antiprotozoal activity of proton-pump inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20111215

Title: In vitro effect of pantoprazole on lower esophageal sphincter tone in rats.

Journal: World journal of gastroenterology 20111214

Title: [Primary antibiotic resistance of Helicobacter pylori strains and eradication rate according to gastroduodenal disease in Korea].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20111201

Title: Effective administration method of intravenous proton pump inhibitor: a novel testing using a BRAVO catheterless pH monitoring system.

Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20111201

Title: Prevalence of and impact of pantoprazole on nocturnal heartburn and associated sleep complaints in patients with erosive esophagitis.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20111101

Title: The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20111101

Title: Randomised clinical trial: the efficacy of a 10-day sequential therapy vs. a 14-day standard proton pump inhibitor-based triple therapy for Helicobacter pylori in Korea.

Journal: Alimentary pharmacology & therapeutics 20111101

Title: [Asymptomatic hypomagnesemic hypoparathyroidism induced by pantoprazol].

Journal: Medicina clinica 20111022

Title: Augmentation of myelopoiesis in a murine host bearing a T cell lymphoma following in vivo administration of proton pump inhibitor pantoprazole.

Journal: Biochimie 20111001

Title: Proton-pump inhibitors in sleep-related breathing disorders: clinical response and predictive factors.

Journal: European journal of gastroenterology & hepatology 20111001

Title: Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter.

Journal: The Journal of pharmacy and pharmacology 20111001

Title: Recurrent hypomagnesemia with proton-pump inhibitor rechallenge.

Journal: Annals of internal medicine 20110920

Title: Somatostatin adjunctive therapy for non-variceal upper gastrointestinal rebleeding after endoscopic therapy.

Journal: World journal of gastroenterology 20110807

Title: Pantoprazole for the prevention of gastrointestinal bleeding in high-risk patients with acute coronary syndromes.

Journal: Journal of critical care 20110801

Title: Anaphylaxis to pantoprazole during general anesthesia.

Journal: Journal of anesthesia 20110801

Title: Randomized, open-label, multicentre pharmacokinetic studies of two dose levels of pantoprazole granules in infants and children aged 1 month through <6 years with gastro-oesophageal reflux disease.

Journal: Clinical pharmacokinetics 20110801

Title: Quadruple therapy with medications containing either rufloxacin or furazolidone as a rescue regimen in the treatment of Helicobacter pylori-infected dyspepsia patients: a randomized pilot study.

Journal: Helicobacter 20110801

Title: Second-line Helicobacter pylori eradication: a randomized comparison of 1-week or 2-week bismuth-containing quadruple therapy.

Journal: Helicobacter 20110801

Title: Twice-a-day bismuth-containing quadruple therapy for Helicobacter pylori eradication: a randomized trial of 10 and 14 days.

Journal: Helicobacter 20110801

Title: Toxicology and toxicokinetics of oral pantoprazole in neonatal and juvenile dogs.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20110801

Title: [Efficacy of sequential therapy with pantoprazole in gastro esophageal reflux disease].

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20110801

Title: Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease.

Journal: World journal of gastroenterology 20110721

Title: Endoscopic grading of gastroesophageal flap valve helps predict proton pump inhibitor response in patients with gastroesophageal reflux disease.

Journal: Scandinavian journal of gastroenterology 20110701

Title: A multicenter, randomized, open-label, pharmacokinetics and safety study of pantoprazole tablets in children and adolescents aged 6 through 16 years with gastroesophageal reflux disease.

Journal: Journal of clinical pharmacology 20110601

Title: Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study.

Journal: Circulation. Cardiovascular interventions 20110601

Title: Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium.

Journal: The Journal of cardiovascular surgery 20110601

Title: Direct injection of native aqueous matrices by achiral-chiral chromatography ion trap mass spectrometry for simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions.

Journal: Journal of chromatography. A 20110520

Title: The proton pump inhibitor pantoprazole and its interaction with enteric-coated mycophenolate sodium in transplant recipients.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110501

Title: Empirical treatment with pantoprazole as a diagnostic tool for symptomatic adult laryngopharyngeal reflux.

Journal: The Journal of laryngology and otology 20110501

Title: Randomised clinical trial: twice daily esomeprazole 40 mg vs. pantoprazole 40 mg in Barrett's oesophagus for 1 year.

Journal: Alimentary pharmacology & therapeutics 20110501

Title: Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: a systematic review.

Journal: Pediatrics 20110501

Title: Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction.

Journal: European journal of gastroenterology & hepatology 20110501

Title: Esomeprazole but not pantoprazole is associated with lower plasma concentrations of clopidogrel's active metabolite.

Journal: The Annals of pharmacotherapy 20110401

Title: False elevation of chromogranin A due to proton pump inhibitors.

Journal: The Netherlands journal of medicine 20110401

Title: Population pharmacokinetic modeling of pantoprazole in pediatric patients from birth to 16 years.

Journal: Journal of clinical pharmacology 20110301

Title: [A case of Menetrier's disease showing mucus bridge observed during endoscopy].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20110301

Title: Clopidogrel with or without omeprazole in coronary disease.

Journal: The New England journal of medicine 20110217

Title: Pharmacodynamics and safety of pantoprazole in neonates, preterm infants, and infants aged 1 through 11 months with a clinical diagnosis of gastroesophageal reflux disease.

Journal: Digestive diseases and sciences 20110201

Title: Effect of Helicobacter pylori infection on symptoms of gastroenteritis due to enteropathogenic Escherichia coli in adults.

Journal: Digestive diseases and sciences 20110201

Title: Mechanisms of tumor growth retardation by modulation of pH regulation in the tumor-microenvironment of a murine T cell lymphoma.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201

Title: Pantoprazole induces severe acute hepatitis.

Journal: Zeitschrift fur Gastroenterologie 20110201

Title: It is difficult to discontinue PPI treatment in patients with GERD.

Journal: The American journal of gastroenterology 20110201

Title: Pancreaticogastrostomy for high-risk gland after pancreaticoduodenectomy: an eligible choice?

Journal: World journal of surgery 20110101

Title: Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies.

Journal: Clinical pharmacology and therapeutics 20110101

Title: Occupational airborne contact dermatitis caused by pantoprazole.

Journal: Contact dermatitis 20110101

Title: Quantification of pantoprazole in human plasma using LC-MS/MS for pharmacokinetics and bioequivalence study.

Journal: European journal of drug metabolism and pharmacokinetics 20110101

Title: Pharmacodynamic interaction between pantoprazole and vecuronium at neuromuscular junction.

Journal: Autonomic & autacoid pharmacology 20110101

Title: [Preparation of pantoprazole sodium enteric-coated pellets-type tablets].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110101

Title: Prediction of response to PPI therapy and factors influencing treatment outcome in patients with GORD: a prospective pragmatic trial using pantoprazole.

Journal: BMC gastroenterology 20110101

Title: Suspicion of drug-drug interaction between high-dose methotrexate and proton pump inhibitors: a case report - should the practice be changed?

Journal: Chemotherapy 20110101

Title: Comparison of the efficacy and safety of pantoprazole magnesium and pantoprazole sodium in the treatment of gastro-oesophageal reflux disease: a randomized, double-blind, controlled, multicentre trial.

Journal: Clinical drug investigation 20110101

Title: [Panum (pantoprazole) effectiveness in the treatment of patients with GERD].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: Improvement of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms during proton pump inhibitor treatment: are G-protein β3 subunit genotype, Helicobacter pylori status, and environmental factors response modifiers?

Journal: Digestion 20110101

Title: Pantoprazole provides myocardial protection similar to ischemic preconditioning: experimental study of isolated hearts of rats.

Journal: Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular 20110101

Title: [Enterofuril eradication therapy in chronic inflammatory diseases of the upper digestive tract].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: [Prevention of acute stress ulcer and gastrointestinal bleeding in patients with acute necrotizing pancreatitis].

Journal: Anesteziologiia i reanimatologiia 20110101

Title: Opportunistic streptococcal gastritis in a patient with ulcerative colitis mimicking gastric involvement by inflammatory bowel disease.

Journal: Inflammatory bowel diseases 20101201

Title: Novel approaches to inhibition of gastric acid secretion.

Journal: Current gastroenterology reports 20101201

Title: Erlotinib and pantoprazole: a relevant interaction or not?

Journal: British journal of clinical pharmacology 20101201

Title: Immunopotentiating effect of proton pump inhibitor pantoprazole in a lymphoma-bearing murine host: Implication in antitumor activation of tumor-associated macrophages.

Journal: Immunology letters 20101130

Title: Proton pump inhibitors interfere with the immunosuppressive potency of mycophenolate mofetil.

Journal: Rheumatology (Oxford, England) 20101101

Title: Effects of pantoprazole in experimental acute pancreatitis.

Journal: Life sciences 20101023

Title: A purging procedure for pantoprazole and 4-lumen catheters to prevent IV drug incompatibilities.

Journal: Pharmacy world & science : PWS 20101001

Title: Effect of sequential treatment as a first-line therapy for Helicobacter pylori eradication in patients with diabetes mellitus.

Journal: Southern medical journal 20101001

Title: Pantoprazole for symptoms of infant GERD: the emperor has no clothes!

Journal: Journal of pediatric gastroenterology and nutrition 20101001

Title: Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole.

Journal: The Netherlands journal of medicine 20101001

Title: [Microdialysis and HPLC method for determination of concentration of pantoprazole in rat striatum aftercombined administration with borneol].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

Title: Clinical results from a randomized, double-blind, dose-ranging study of pantoprazole in children aged 1 through 5 years with symptomatic histologic or erosive esophagitis.

Journal: Clinical pediatrics 20100901

Title: Sequential therapy for Helicobacter pylori eradication.

Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20100901

Title: Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: is it still effective 10 years on?

Journal: Journal of digestive diseases 20100801

Title: [Impact of different proton pump inhibitors on the antiplatelet activity of clopidogrel in combination with aspirin for patients undergoing coronary stent implantation].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100801

Title: Dyspeptic symptom development after discontinuation of a proton pump inhibitor: a double-blind placebo-controlled trial.

Journal: The American journal of gastroenterology 20100701

Title: Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole.

Journal: European journal of clinical pharmacology 20100701

Title: Pantoprazole does not influence the antiplatelet effect of clopidogrel-a whole blood aggregometry study after coronary stenting.

Journal: Journal of cardiovascular pharmacology 20100701

Title: Clinical trial: gastric acid suppression in Hispanic adults with symptomatic gastro-oesophageal reflux disease - comparator study of esomeprazole, lansoprazole and pantoprazole.

Journal: Alimentary pharmacology & therapeutics 20100701

Title: Education and imaging. Gastrointestinal: Scrub typhus induced acute gastric ulceration.

Journal: Journal of gastroenterology and hepatology 20100701

Title: Editorial: just how 'difficult' is it to withdraw PPI treatment?

Journal: The American journal of gastroenterology 20100701

Title: Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100601

Title: Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD).

Journal: European journal of clinical pharmacology 20100601

Title: Effect of the mucolytic erdosteine on the success rate of PPI-based first-line triple therapy for Helicobacter pylori eradication: a prospective, double-blind, randomized, placebo-controlled study.

Journal: Scandinavian journal of gastroenterology 20100601

Title: Efficacy and safety of pantoprazole delayed-release granules for oral suspension in a placebo-controlled treatment-withdrawal study in infants 1-11 months old with symptomatic GERD.

Journal: Journal of pediatric gastroenterology and nutrition 20100601

Title: Development and validation of a sensitive bioanalytical method for the quantitative estimation of pantoprazole in human plasma samples by LC-MS/MS: application to bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Title: [Prevalence of rebleeding from peptic ulcer in patients treated with proton pump inhibitors].

Journal: Medicina clinica 20100508

Title: [Efficacy and tolerability of pantoprazole in the treatment of gastroesophageal reflux disease].

Journal: MMW Fortschritte der Medizin 20100506

Title: Double-dosed pantoprazole accelerates the sustained symptomatic response in overweight and obese patients with reflux esophagitis in Los Angeles grades A and B.

Journal: The American journal of gastroenterology 20100501

Title: Effect of pantoprazole in patients with chronic laryngitis and pharyngitis related to gastroesophageal reflux disease: clinical, proximal, and distal pH monitoring results.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20100501

Title: Impact of oesophagitis classification in evaluating healing of erosive oesophagitis after therapy with proton pump inhibitors: a pooled analysis.

Journal: European journal of gastroenterology & hepatology 20100501

Title: Effect of corticosteroids during ongoing drug exposure in pantoprazole-induced interstitial nephritis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100501

Title: Effects of a single dose of rabeprazole 20 mg and pantoprazole 40 mg on 24-h intragastric acidity and oesophageal acid exposure: a randomized study in gastro-oesophageal reflux disease patients with a history of nocturnal heartburn.

Journal: Alimentary pharmacology & therapeutics 20100501

Title: Inappropriate utilization of intravenous proton pump inhibitors in hospital practice--a prospective study of the extent of the problem and predictive factors.

Journal: QJM : monthly journal of the Association of Physicians 20100501

Title: [13C]pantoprazole breath test as a predictor of the anti-platelet function of clopidogrel.

Journal: European journal of clinical pharmacology 20100501

Title: [Efficacy and tolerability of pantoprazole in the treatment of gastroesophageal reflux disease].

Journal: MMW Fortschritte der Medizin 20100408

Title: The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis.

Journal: Critical care medicine 20100401

Title: Comparison of the efficacy of the two tetracycline-containing sequential therapy regimens for the eradication of Helicobacter pylori: 5 days versus 14 days amoxicillin.

Journal: Helicobacter 20100401

Title: Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily.

Journal: Clinical therapeutics 20100401

Title: Influence of efflux pump inhibitors on the multidrug resistance of Helicobacter pylori.

Journal: World journal of gastroenterology 20100314

Title: The effect of mastic gum on Helicobacter pylori: a randomized pilot study.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100301

Title: Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation.

Journal: Southern medical journal 20100301

Title: The prognosis of patients having received optimal therapy for nonvariceal upper gastrointestinal bleeding might be worse in daily practice than in randomized clinical trials.

Journal: European journal of gastroenterology & hepatology 20100301

Title: A randomized controlled trial comparing two different dosages of infusional pantoprazole in peptic ulcer bleeding.

Journal: British journal of clinical pharmacology 20100301

Title: Recurrence of acute myocardial infarction in patients discharged on clopidogrel and a proton pump inhibitor after stent placement for acute myocardial infarction.

Journal: Clinical cardiology 20100301

Title: Oral sulfasalazine as a clinical BCRP probe substrate: pharmacokinetic effects of genetic variation (C421A) and pantoprazole coadministration.

Journal: Journal of pharmaceutical sciences 20100201

Title: Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100201

Title: Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial.

Journal: Annals of internal medicine 20100105

Title: Summaries for patients. Benefits and risks of continuing aspirin in patients with peptic ulcer bleeding.

Journal: Annals of internal medicine 20100105

Title: Rapidly progressing glomerulonephritis secondary to henoch-schonlein purpura treated with mycophenolate mofetil: a case report with atypical etiology and presentation.

Journal: American journal of therapeutics 20100101

Title: A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole in relation to pharmacokinetics and CYP2C19 polymorphism.

Journal: Alimentary pharmacology & therapeutics 20100101

Title: Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.

Journal: Gastroenterology 20100101

Title: Oral buffered esomeprazole is superior to i.v. pantoprazole for rapid rise of intragastric pH: a wireless pH metry analysis.

Journal: Journal of gastroenterology and hepatology 20100101

Title: Pharmacological dependency in chronic treatment of gastroesophageal reflux disease: a randomized controlled clinical trial.

Journal: Digestion 20100101

Title: Immediate-release oral proton pump inhibitors: Panacea or a flash in the pan?

Journal: Journal of gastroenterology and hepatology 20100101

Title: Evaluation of pantoprazole formulations in different dissolution apparatus using biorelevant medium.

Journal: Arzneimittel-Forschung 20100101

Title: Efficacy and pharmacokinetics of pantoprazole in alpacas.

Journal: Journal of veterinary internal medicine 20100101

Title: Bismuth-based first-line therapy for Helicobacter pylori eradication in type 2 diabetes mellitus patients.

Journal: Digestion 20100101

Title: Improved HPLC method for determination of four PPIs, omeprazole, pantoprazole, lansoprazole and rabeprazole in human plasma.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

Title: Ichthyotic-appearing skin changes associated with childhood morphea, systemic sclerosis, and systemic lupus erythematosus/scleroderma overlap.

Journal: Pediatric dermatology 20100101

Title: Proton pump inhibitor-induced neutropenia: possible cross-reactivity between omeprazole and pantoprazole.

Journal: Clinical drug investigation 20100101

Title: [Acute psychosis induced by a Helicobacter pylori (H. pylori)-eradication treatment with amoxicillin, clarithromycin and pantoprazole].

Journal: Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20100101

Title: Effects of multiple-dose esomeprazole and pantoprazole on diazepam pharmacokinetic profile and pharmacodynamic effects on cognitive and psychomotor function in healthy volunteers.

Journal: Arzneimittel-Forschung 20100101

Title: Spectrophotometric determination of peptic ulcer sulfur-containing drugs in bulk form and in tablets.

Journal: Drug testing and analysis 20100101

Title: High-performance liquid chromatographic determination of pantoprazole and its main impurities in pharmaceuticals.

Journal: Journal of AOAC International 20100101

Title: Validation of a novel, fully automated high throughput high-performance liquid chromatographic/tandem mass Spectrometric method for quantification of pantoprazole in human plasma.

Journal: Journal of AOAC International 20100101

Title: [Pharmacokinetics of the proton pump inhibitors and psychological status in patients as factors that influence the efficiency of treatment of GERD with pantoprazole].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20100101

Title: Complete remission of gastric Burkitt's lymphoma after eradication of Helicobacter pylori.

Journal: World journal of gastroenterology 20091207

Title: Efficacy of two different Helicobacter pylori eradication regimens in patients with type 2 diabetes and the effect of Helicobacter pylori eradication on dyspeptic symptoms in patients with diabetes: a randomized controlled study.

Journal: The American journal of the medical sciences 20091201

Title: [Prevention of GI bleeding due to antiplatelet agents: a labyrinth!].

Journal: Presse medicale (Paris, France : 1983) 20091201

Title: Ranitidine is unable to maintain gastric pH levels above 4 in septic patients.

Journal: Journal of critical care 20091201

Title: Pantoprazole-induced thrombocytopenia.

Journal: Indian journal of pediatrics 20091201

Title: Pantoprazole available without a prescription: new status. Better than H2 receptor agonists, but not for pregnant women.

Journal: Prescrire international 20091201

Title: Bioequivalence among three methods of administering pantoprazole granules in healthy subjects.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091101

Title: Clarithromycin resistance and efficacy of clarithromycin-containing triple eradication therapy for Helicobacter pylori infection in type 2 diabetes mellitus patients.

Journal: Southern medical journal 20091101

Title: (13)C breath tests in personalized medicine: fiction or reality?

Journal: Expert review of molecular diagnostics 20091101

Title: A rare cause of hyponatraemia?

Journal: British journal of hospital medicine (London, England : 2005) 20091101

Title: Optimal dose of intravenous pantoprazole in patients with peptic ulcer bleeding requiring endoscopic hemostasis in Korea.

Journal: Journal of gastroenterology and hepatology 20091001

Title: Bioavailability of mycophenolate mofetil and enteric-coated mycophenolate sodium is differentially affected by pantoprazole in healthy volunteers.

Journal: Journal of clinical pharmacology 20091001

Title: Periodontal therapy improves gastric Helicobacter pylori eradication.

Journal: Journal of dental research 20091001

Title: Preparation and characterization of superporous hydrogels as pH-sensitive drug delivery system for Pantoprazole sodium.

Journal: Current drug delivery 20091001

Title: Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study.

Journal: Journal of the American College of Cardiology 20090922

Title: Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma.

Journal: The Journal of allergy and clinical immunology 20090901

Title: Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients.

Journal: Chest 20090801

Title: [13C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole.

Journal: Alimentary pharmacology & therapeutics 20090801

Title: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090801

Title: Degree of healing and healing-associated factors of endoscopic submucosal dissection-induced ulcers after pantoprazole therapy for 4 weeks.

Journal: Digestive diseases and sciences 20090701

Title: Simultaneous estimation of four proton pump inhibitors--lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20090701

Title: Drug-drug interaction between clopidogrel and the proton pump inhibitors.

Journal: The Annals of pharmacotherapy 20090701

Title: Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment.

Journal: Journal of gastroenterology and hepatology 20090701

Title: Proton pump inhibitors reduce mycophenolate exposure in heart transplant recipients-a prospective case-controlled study.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20090701

Title: Do the association of cytochrome P450 interacting drugs, influence clopidogrel efficacity?

Journal: American heart journal 20090701

Title: Management of acute peptic ulcers: how ethnicity, different proton pump inhibitors and mechanism of delivery alter the equation.

Journal: Journal of gastroenterology and hepatology 20090701

Title: Comparison of p.o. or i.v. proton pump inhibitors on 72-h intragastric pH in bleeding peptic ulcer.

Journal: Journal of gastroenterology and hepatology 20090701

Title: Interaction between clopidogrel and proton pump inhibitors.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20090609

Title: Clinical trial: factors associated with freedom from relapse of heartburn in patients with healed reflux oesophagitis--results from the maintenance phase of the EXPO study.

Journal: Alimentary pharmacology & therapeutics 20090601

Title: Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20090601

Title: Agglomerates containing pantoprazole microparticles: modulating the drug release.

Journal: AAPS PharmSciTech 20090601

Title: Proton pump inhibitors and clopidogrel: a difficult dilemma.

Journal: American heart journal 20090601

Title: Proton pump inhibitor co-medication reduces mycophenolate acid drug exposure in heart transplant recipients.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090601

Title: The impact of normalization of esophageal acid profile by incremental protein pump inhibitors dosing in difficult asthma patients with proven gastro-esophageal acid reflux.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20090601

Title: Effect of preoperative intravenous pantoprazole in elective-surgery patients: a pilot study.

Journal: Digestive diseases and sciences 20090501

Title: Clinical trial: factors associated with resolution of heartburn in patients with reflux oesophagitis--results from the EXPO study.

Journal: Alimentary pharmacology & therapeutics 20090501

Title: Control of 24-hour intragastric acidity with morning dosing of immediate-release and delayed-release proton pump inhibitors in patients with GERD.

Journal: Journal of clinical gastroenterology 20090401

Title: Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: Clopidogrel and proton pump inhibitors: gastric protection at expense of vascular benefit?

Journal: Thrombosis and haemostasis 20090401

Title: Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel.

Journal: Thrombosis and haemostasis 20090401

Title: Intravenous pantoprazole as an adjuvant therapy following successful endoscopic treatment for peptic ulcer bleeding.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20090401

Title: Use of gastrointestinal proton pump inhibitors to regulate osteoclast-mediated resorption of calcium phosphate cements in vivo.

Journal: Current drug delivery 20090401

Title: International validation of a health-related quality of life questionnaire in patients with erosive gastro-oesophageal reflux disease.

Journal: Alimentary pharmacology & therapeutics 20090315

Title: Acute allergic interstitial nephritis after use of pantoprazole.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20090303

Title: Effects of pantoprazole on ulcer healing delay associated with NSAID treatment.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090301

Title: Clinical trial: intravenous pantoprazole vs. ranitidine for the prevention of peptic ulcer rebleeding: a multicentre, multinational, randomized trial.

Journal: Alimentary pharmacology & therapeutics 20090301

Title: Continuous infusion of pantoprazole with octreotide does not improve management of variceal hemorrhage.

Journal: Pharmacotherapy 20090301

Title: Impact of pantoprazole on duodeno-gastro-esophageal reflux (DGER).

Journal: Zeitschrift fur Gastroenterologie 20090301

Title: Cardiac left bundle branch block and pancytopenia in anorexia nervosa: higher risk with mirtazapine and pantoprazole? Case report.

Journal: Pharmacopsychiatry 20090301

Title: Esophageal cell proliferation in gastroesophageal reflux disease: clinical-morphological data before and after pantoprazole.

Journal: World journal of gastroenterology 20090227

Title: Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis.

Journal: World journal of gastroenterology 20090227

Title: The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.

Journal: Investigational new drugs 20090201

Title: Effects of CYP2C19 and MDR1 genotype on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxycillin and clarithromycin.

Journal: Journal of gastroenterology and hepatology 20090201

Title: Nefopam hydrochloride compatibility and stability with selected proton pump inhibitors in bionolyte G5 injection for intravenous infusion.

Journal: Journal of clinical pharmacy and therapeutics 20090201

Title: Population pharmacokinetics of intravenous pantoprazole in paediatric intensive care patients.

Journal: British journal of clinical pharmacology 20090201

Title: Blood concentration of pantoprazole sodium is significantly high in hepatogenic peptic ulcer patients, especially those with a poor CYP2C19 metabolism.

Journal: Journal of digestive diseases 20090201

Title: [Therapy of gastric acid-induced illnesses in general practice. The first pantoprazole generic drug has arrived].

Journal: MMW Fortschritte der Medizin 20090129

Title: [Taking metabolic pathways into consideration. Approved drug against problematic interactions ].

Journal: MMW Fortschritte der Medizin 20090129

Title: Intravenous proton pump inhibition utilization and prescribing patterns escalation: a comparison between early and current trends in use.

Journal: Gastrointestinal endoscopy 20090101

Title: Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel.

Journal: American heart journal 20090101

Title: Pharmacokinetic study of S-1.

Journal: International journal of clinical pharmacology and therapeutics 20090101

Title: A comparative study of proton-pump inhibitor tests for Chinese reflux patients in relation to the CYP2C19 genotypes.

Journal: Journal of clinical gastroenterology 20090101

Title: Comparison of hemostatic efficacy for argon plasma coagulation and distilled water injection in treating high-risk bleeding ulcers.

Journal: Journal of clinical gastroenterology 20090101

Title: Proton pump inhibitors exert anti-allergic effects by reducing TCTP secretion.

Journal: PloS one 20090101

Title: [Why some proton pump inhibitors are more equal than others].

Journal: Nederlands tijdschrift voor geneeskunde 20090101

Title: Negative chronotropic effect of proton pump inhibitors on frog-heart preparation.

Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20090101

Title: Pantoprazole: a proton pump inhibitor.