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139026-66-7,MFCD00214124
Catalog No.:AA009BA9

139026-66-7 | JMV 449

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥95% by HPLC
2 weeks  
$1,568.00   $1,098.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009BA9
Chemical Name:
JMV 449
CAS Number:
139026-66-7
Molecular Formula:
C38H66N8O7
Molecular Weight:
746.9800
MDL Number:
MFCD00214124
SMILES:
NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@H](CC)C)Cc1ccc(cc1)O)NC[C@H](CCCCN)N
Properties
Computed Properties
 
Complexity:
1140  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
53  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
9  
Isotope Atom Count:
0  
Rotatable Bond Count:
25  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.3  

Literature

Title: Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways.

Journal: Neurochemical research 20120901

Title: Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.

Journal: The European journal of neuroscience 20111001

Title: NT agonist regulates expression of nuclear high-affinity neurotensin receptors.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20040301

Title: Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia.

Journal: Neuroscience letters 20031120

Title: Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.

Journal: Molecular pharmacology 20030801

Title: Neurotensin induces tyrosine hydroxylase gene activation through nitric oxide and protein kinase C signaling pathways.

Journal: Molecular pharmacology 20020901

Title: Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells.

Journal: Metabolic brain disease 20011201

Title: Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

Title: Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.

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SDS
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Tags:139026-66-7 Molecular Formula|139026-66-7 MDL|139026-66-7 SMILES|139026-66-7 JMV 449
Catalog No.: AA009BA9
139026-66-7,MFCD00214124
139026-66-7 | JMV 449
Pack Size： 10mg
Purity： ≥95% by HPLC
2 weeks
$1,568.00 $1,098.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA009BA9
Chemical Name: JMV 449
CAS Number: 139026-66-7
Molecular Formula: C38H66N8O7
Molecular Weight: 746.9800
MDL Number: MFCD00214124
SMILES: NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)[C@H](CC)C)Cc1ccc(cc1)O)NC[C@H](CCCCN)N
Properties
Complexity: 1140  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 7  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 53  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 9  
Isotope Atom Count: 0  
Rotatable Bond Count: 25  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.3  
Literature fold

Title: Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways.

Journal: Neurochemical research20120901

Title: Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.

Journal: The European journal of neuroscience20111001

Title: NT agonist regulates expression of nuclear high-affinity neurotensin receptors.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society20040301

Title: Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia.

Journal: Neuroscience letters20031120

Title: Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus.

Journal: Molecular pharmacology20030801

Title: Neurotensin induces tyrosine hydroxylase gene activation through nitric oxide and protein kinase C signaling pathways.

Journal: Molecular pharmacology20020901

Title: Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells.

Journal: Metabolic brain disease20011201

Title: Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

Title: Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.

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