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139051-78-8,MFCD00672670
Catalog No.:AA006YPD

139051-78-8 | (2R,4S)-5,7-Dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

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$1,036.00   $725.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006YPD
Chemical Name:
(2R,4S)-5,7-Dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
CAS Number:
139051-78-8
Molecular Formula:
C17H15Cl2N3O3
Molecular Weight:
380.2253
MDL Number:
MFCD00672670
SMILES:
O=C(NC1CC(Nc2c1c(Cl)cc(c2)Cl)C(=O)O)Nc1ccccc1
Properties
Computed Properties
 
Complexity:
502  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
2  
XLogP3:
3.5  

Literature

Title: Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential.

Journal: Pharmacology, biochemistry, and behavior 20101101

Title: Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses.

Journal: Journal of neurochemistry 20100201

Title: The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles.

Journal: The European journal of neuroscience 20071101

Title: Medium supplementation with zinc enables detection of imipramine-induced adaptation in glycine/NMDA receptors labeled with [3H]L-689,560.

Journal: Pharmacological reports : PR 20060101

Title: Glycine binding site of the synaptic NMDA receptor in subpostremal NTS neurons.

Journal: Journal of neurophysiology 20050701

Title: In vitro and in vivo antagonistic activities of SM-31900 for the NMDA receptor glycine-binding site.

Journal: Brain research 20020719

Title: Catalytic enantioselective Reissert-type reaction: development and application to the synthesis of a potent NMDA receptor antagonist (-)-L-689,560 using a solid-supported catalyst.

Journal: Journal of the American Chemical Society 20010718

Title: Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.

Journal: Journal of medicinal chemistry 20010607

Title: Increased density of glutamate/N-methyl-D-aspartate receptors in superior temporal cortex in schizophrenia.

Journal: Neuroscience letters 20010518

Title: 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

Journal: Journal of medicinal chemistry 19940513

Title: 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.

Journal: Journal of medicinal chemistry 19920529

Title: Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017

Title: Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35.

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Tags:139051-78-8 Molecular Formula|139051-78-8 MDL|139051-78-8 SMILES|139051-78-8 (2R,4S)-5,7-Dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid