Home Amines 139264-24-7
139264-24-7,MFCD12546349
Catalog No.:AA001AIF

139264-24-7 | 2-Oxazolidinone, 4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-, (4R)-

Pack Size
Purity
Availability
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Quantity
  
1g
≥ 95 %
2 weeks  
$474.00   $332.00
- +
5g
≥ 95 %
2 weeks  
$1,183.00   $828.00
- +
10g
≥ 95 %
2 weeks  
$1,926.00   $1,348.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001AIF
Chemical Name:
2-Oxazolidinone, 4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-, (4R)-
CAS Number:
139264-24-7
Molecular Formula:
C16H21N3O2
Molecular Weight:
287.3568
MDL Number:
MFCD12546349
SMILES:
CN(CCc1c[nH]c2c1cc(C[C@@H]1COC(=O)N1)cc2)C
Properties
Computed Properties
 
Complexity:
375  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Literature

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Title: Frovatriptan versus zolmitriptan for the acute treatment of migraine with aura: a subgroup analysis of a double-blind, randomized, multicenter, Italian study.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20120501

Title: Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20120501

Title: Antidromic vasodilatation and the migraine mechanism.

Journal: The journal of headache and pain 20120301

Title: Effect of CGRP and sumatriptan on the BOLD response in visual cortex.

Journal: The journal of headache and pain 20120301

Title: [Pediatric poisoning with triptans: review of cases in the Lille poison center between 2000 and 2010].

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Title: A case of cluster headache accompanied by myoclonus and hemiparesis.

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Journal: Patient preference and adherence 20120101

Title: Zolmitriptan-induced acute myocardial infarction.

Journal: Cardiology journal 20120101

Title: Preparation and evaluation of zolmitriptan submicron emulsion for rapid and effective nasal absorption in beagle dogs.

Journal: Drug development and industrial pharmacy 20111201

Title: Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study versus rizatriptan.

Journal: The journal of headache and pain 20111201

Title: Suggested randomised, controlled trial with frovatriptan.

Journal: The journal of headache and pain 20111201

Title: Surface thermodynamics of mucoadhesive dry powder formulation of zolmitriptan.

Journal: AAPS PharmSciTech 20111201

Title: Evaluation of submicron emulsion as vehicles for rapid-onset intranasal delivery and improvement in brain targeting of zolmitriptan.

Journal: Drug delivery 20111101

Title: Influence of formulation variables in transdermal drug delivery system containing zolmitriptan.

Journal: International journal of pharmaceutics 20111031

Title: CONSORT recommendations in abstracts of randomised, controlled trials on migraine and headache.

Journal: The journal of headache and pain 20111001

Title: Zolmitriptan induced acute coronary syndrome: a unique case.

Journal: American journal of therapeutics 20110901

Title: Formulation of zolmitriptan sublingual tablets prepared by direct compression with different polymers: in vitro and in vivo evaluation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

Title: Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.

Journal: Journal of neurophysiology 20110801

Title: Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus.

Journal: Journal of neurology 20110701

Title: Guidelines on the diagnosis and the current management of headache and related disorders.

Journal: Annals of Indian Academy of Neurology 20110701

Title: Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment.

Journal: The journal of headache and pain 20110601

Title: A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine.

Journal: The journal of headache and pain 20110601

Title: When to use frovatriptan in migraine?

Journal: The journal of headache and pain 20110601

Title: Evolution of paediatric off-label use after new significant medicines become available for adults: a study on triptans in Finnish children 1994-2007.

Journal: British journal of clinical pharmacology 20110601

Title: Triptan overuse in the Dutch general population: a nationwide pharmaco-epidemiology database analysis in 6.7 million people.

Journal: Cephalalgia : an international journal of headache 20110601

Title: N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain.

Journal: European journal of pain (London, England) 20110501

Title: Frovatriptan versus other triptans in the acute treatment of migraine: pooled analysis of three double-blind, randomized, cross-over, multicenter, Italian studies.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20110501

Title: Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, multicenter, Italian, comparative study versus zolmitriptan.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20110501

Title: A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine.

Journal: The journal of headache and pain 20110401

Title: Cardiac safety in cluster headache patients using the very high dose of verapamil (≥720 mg/day).

Journal: The journal of headache and pain 20110401

Title: Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice.

Journal: Diabetes 20110401

Title: Triptans other than sumatriptan in child and adolescent migraine: literature review.

Journal: Expert review of neurotherapeutics 20110301

Title: Why pharmacokinetic differences among oral triptans have little clinical importance: a comment.

Journal: The journal of headache and pain 20110201

Title: Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan.

Journal: Cephalalgia : an international journal of headache 20110201

Title: Acute migraine therapy: new drugs and new approaches.

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Title: Overview of diagnosis and management of paediatric headache. Part II: therapeutic management.

Journal: The journal of headache and pain 20110201

Title: Treatment of acute migraine headache.

Journal: American family physician 20110201

Title: Almotriptan 12.5 mg in menstrually related migraine: a randomized, double-blind, placebo-controlled study.

Journal: Cephalalgia : an international journal of headache 20110101

Title: Antimigraine efficacy of telcagepant based on patient's historical triptan response.

Journal: Headache 20110101

Title: Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine.

Journal: Headache 20110101

Title: IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells.

Journal: PloS one 20110101

Title: Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: in vivo pharmacodynamic studies using rat electroshock model.

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Title: Autoradiographic Mapping of 5-HT(1B/1D) Binding Sites in the Rhesus Monkey Brain Using [carbonyl-C]zolmitriptan.

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Title: New directions in migraine.

Journal: BMC medicine 20110101

Title: Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level.

Journal: BMC neuroscience 20110101

Title: A large pharmacy claims-based descriptive analysis of patients with migraine and associated pharmacologic treatment patterns.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Identification of major degradation products of ketoconazole.

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Title: Patients' preference for olanzapine orodispersible tablet compared with conventional oral tablet in a multinational, randomized, crossover study.

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Journal: Expert opinion on pharmacotherapy 20100901

Title: Characterization of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) in human isolated coronary arteries.

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Title: Triptans for the management of migraine.

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Title: Acute and preventive pharmacologic treatment of cluster headache.

Journal: Neurology 20100803

Title: Nitroglycerin provocation in normal subjects is not a useful human migraine model?

Journal: Cephalalgia : an international journal of headache 20100801

Title: Early responses in randomized clinical trials of triptans in acute migraine treatment. Are they clinically relevant? A comment.

Journal: Headache 20100701

Title: Zolmitriptan and human aggression: interaction with alcohol.

Journal: Psychopharmacology 20100701

Title: Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601

Title: Evolution of migraine-associated symptoms in menstrually related migraine following symptomatic treatment with almotriptan.

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Title: New acute treatments for headache.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601

Title: Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries.

Journal: Journal of cardiovascular pharmacology 20100501

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Journal: European journal of clinical pharmacology 20100401

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Title: Anodic voltammetry of zolmitriptan at boron-doped diamond electrode and its analytical applications.

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Title: Prinzmetal-variant angina in a patient using zolmitriptan and citalopram.

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Title: Cluster headache.

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Title: Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets.

Journal: Indian journal of pharmaceutical sciences 20100101

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Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20091101

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Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091008

Title: Zolmitriptan nasal spray in the acute treatment of cluster headache: a meta-analysis of two studies.

Journal: Headache 20091001

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Title: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

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Title: Zolmitriptan compared to propranolol in the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study.

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Title: Controlled non-invasive transdermal iontophoretic delivery of zolmitriptan hydrochloride in vitro and in vivo.

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Title: 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.

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Title: A study of the interaction between enantiomers of zolmitriptan and hydroxypropyl-beta-cyclodextrin by capillary electrophoresis.

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Title: Alcohol and cluster headaches.

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Title: Individual triptan selection in migraine attack therapy.

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Title: [Cluster headache].

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Title: Triptans and troponin: a case report.

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Title: Migraine pathogenesis and state of pharmacological treatment options.

Journal: BMC medicine 20090101

Title: Rizatriptan for the acute treatment of migraine: Consistency, preference, satisfaction, and quality of life.

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Title: Pediatric migraine.

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Title: Recent advances in the pharmacological management of migraine.

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Title: Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial.

Journal: Lancet (London, England) 20081220

Title: CGRP-receptor antagonism in migraine treatment.

Journal: Lancet (London, England) 20081220

Title: Male-specific induction of CYP3A2 in rats by zolmitriptan.

Journal: The Journal of pharmacy and pharmacology 20081201

Title: Treatment satisfaction and efficacy of the rapid release formulation of sumatriptan 100 mg tablets utilising an early intervention paradigm in patients previously unsatisfied with sumatriptan.

Journal: International journal of clinical practice 20081201

Title: Prophylaxis of migraine: general principles and patient acceptance.

Journal: Neuropsychiatric disease and treatment 20081201

Title: Difference in triptan effect in patients with migraine and early allodynia.

Journal: Cephalalgia : an international journal of headache 20081001

Title: Optimizing prophylactic treatment of migraine: Subtypes and patient matching.

Journal: Therapeutics and clinical risk management 20081001

Title: In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions.

Journal: Basic & clinical pharmacology & toxicology 20080801

Title: Tactile-induced ultrasonic vocalization in the rat: a novel assay to assess anti-migraine therapies in vivo.

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Title: Treatment of children with migraine in the emergency department: a qualitative systematic review.

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Title: Effectiveness of zolmitriptan nasal spray for the acute treatment of cluster headache: study 1.

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Title: Effectiveness of zolmitriptan nasal spray for the acute treatment of cluster headache: study 2.

Journal: Current neurology and neuroscience reports 20080301

Title: Cluster headache.

Journal: BMJ clinical evidence 20080215

Title: Meta-analysis of the efficacy and safety of zolmitriptan in the acute treatment of migraine.

Journal: Headache 20080201

Title: Fabrication of molecularly imprinted hybrid monoliths via a room temperature ionic liquid-mediated nonhydrolytic sol-gel route for chiral separation of zolmitriptan by capillary electrochromatography.

Journal: Electrophoresis 20080201

Title: Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system.

Journal: The journal of headache and pain 20080201

Title: Triptans in pregnancy.

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Title: Review of frovatriptan in the treatment of migraine.

Journal: Neuropsychiatric disease and treatment 20080201

Title: Acute treatment of paediatric migraine: a meta-analysis of efficacy.

Journal: Journal of paediatrics and child health 20080101

Title: Almotriptan, an antimigraine agent, and its malate salt.

Journal: Acta crystallographica. Section C, Crystal structure communications 20080101

Title: Gender differences in sex life issues - a population-based study of migraine sufferers.

Journal: BMC family practice 20080101

Title: A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements.

Journal: BMC medical physics 20080101

Title: Cluster headache.

Journal: Orphanet journal of rare diseases 20080101

Title: Oral zolmitriptan in the short-term prevention of menstrual migraine: a randomized, placebo-controlled study.

Journal: CNS drugs 20080101

Title: Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.

Journal: Molecular pain 20080101

Title: The treatment of migraine headaches in children and adolescents.

Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20080101

Title: Clinical pharmacology of the serotonin receptor agonist, zolmitriptan.

Journal: Expert opinion on drug metabolism & toxicology 20071201

Title: Almotriptan in the treatment of migraine.

Journal: Neuropsychiatric disease and treatment 20071201

Title: Renal ischaemic injuries during the use of zolmitriptan for treatment of migraines in a transplanted patient under tacrolimus therapy.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071101

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Journal: Revista de neurologia 20071101

Title: Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment.

Journal: Cephalalgia : an international journal of headache 20071001

Title: Use of almotriptan in triptan-experienced and triptan-naïve patients.

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Title: [Trigeminal autonomic cephalgias: diagnostic and therapeutic implications].

Journal: MMW Fortschritte der Medizin 20070906

Title: Patterns of triptans use: a study based on the records of a community pharmaceutical department.

Journal: Cephalalgia : an international journal of headache 20070901

Title: Patient preference for triptan formulations: a prospective study with zolmitriptan.

Journal: Headache 20070901

Title: Marketed oral triptans in the acute treatment of migraine: a systematic review on efficacy and tolerability.

Journal: Headache 20070901

Title: Meta-analysis examining the efficacy and safety of almotriptan in the acute treatment of migraine.

Journal: Headache 20070901

Title: Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study.

Journal: Neurology 20070828

Title: Acute renal failure in a 17-year-old female with ALL receiving escalating intravenous methotrexate without leukovorin.

Journal: Pediatric blood & cancer 20070801

Title: Economic analysis of triptan therapy for acute migraine: a Medicaid perspective.

Journal: Pharmacotherapy 20070801

Title: Efficacy of zolmitriptan nasal spray in adolescent migraine.

Journal: Pediatrics 20070801

Title: The impact of migraine: a case study.

Journal: The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20070801

Title: Times to pain relief and pain freedom with rizatriptan 10 mg and other oral triptans.

Journal: International journal of clinical practice 20070701

Title: The 1:1 inclusion compounds zolmitriptan-benzene and zolmitriptan-phenol.

Journal: Acta crystallographica. Section C, Crystal structure communications 20070701

Title: Characterization of the human basilar artery contractile response to 5-HT and triptans.

Journal: Fundamental & clinical pharmacology 20070601

Title: Acute migraine: Current treatment and emerging therapies.

Journal: Therapeutics and clinical risk management 20070601

Title: Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2.

Journal: The Journal of pharmacy and pharmacology 20070501

Title: Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.

Journal: Neurology 20070424

Title: [Intranasal zolmitriptan acts quickly].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20070301

Title: Almotriptan and zolmitriptan in the acute treatment of migraine.

Journal: Acta neurologica Scandinavica 20070101

Title: Effectiveness and satisfaction with zolmitriptan 5 mg nasal spray for treatment of migraine in real-life practice: results of a postmarketing surveillance study.

Journal: Clinical drug investigation 20070101

Title: Use of the sustained pain-free plus no adverse events endpoint in clinical trials of triptans in acute migraine.

Journal: CNS drugs 20070101

Title: Hemifacial spasm and cluster headache.

Journal: Cephalalgia : an international journal of headache 20070101

Title: Extractive spectrophotometric methods for determination of zolmitriptan in tablets.

Journal: Journal of AOAC International 20070101

Title: Improved migraine management in primary care: results of a patient treatment experience study using zolmitriptan orally disintegrating tablet.

Journal: International journal of clinical practice 20061201

Title: Pharmacokinetics and interactions of headache medications, part I: introduction, pharmacokinetics, metabolism and acute treatments.

Journal: Expert opinion on drug metabolism & toxicology 20061201

Title: Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study.

Journal: Archives of neurology 20061101

Title: Nasal delivery of antimigraine drugs: clinical rationale and evidence base.

Journal: Headache 20061101

Title: Tailoring management strategies for the patient with menstrual migraine: focus on prevention and treatment.

Journal: Headache 20061001

Title: Zolmitriptan uptake by human intestinal epithelial Caco-2 cells.

Journal: Die Pharmazie 20061001

Title: Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine.

Journal: Therapeutics and clinical risk management 20060901

Title: Rizatriptan in the treatment of migraine.

Journal: Neuropsychiatric disease and treatment 20060901

Title: Topiramate in the prevention of migraine: a review of its efficacy, tolerability, and acceptability.

Journal: Neuropsychiatric disease and treatment 20060901

Title: Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.

Journal: Neurology 20060808

Title: The impact of different antimigraine compounds on platelet and erythrocyte aggregation.

Journal: Cephalalgia : an international journal of headache 20060801

Title: Daily morning hemifacial spasm in a patient with cluster headache.

Journal: Cephalalgia : an international journal of headache 20060601

Title: Efficacy and tolerability of almotriptan versus zolmitriptan for the acute treatment of menstrual migraine.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060501

Title: [Symptomatic treatment of migraine with zolmitriptan: experience with 82 patients].

Journal: Neurologia (Barcelona, Spain) 20060501

Title: The pharmacological treatment options for pediatric migraine: an evidence-based appraisal.

Journal: NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 20060401

Title: [Experience with intranasal zolmitriptan in cluster headache].

Journal: Neurologia (Barcelona, Spain) 20060401

Title: Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060217

Title: Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data.

Journal: Journal of pharmacokinetics and pharmacodynamics 20060201

Title: Zolmitriptan oral tablet in migraine treatment: high placebo responses in adolescents.

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Title: Zolmitriptan intranasal: a review of the pharmacokinetics and clinical efficacy.

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Title: Antimigraine drug, zolmitriptan, inhibits high-voltage activated calcium currents in a population of acutely dissociated rat trigeminal sensory neurons.

Journal: Molecular pain 20060101

Title: Renal infarction during the use of rizatriptan and zolmitriptan: two case reports.

Journal: Clinical toxicology (Philadelphia, Pa.) 20060101

Title: Eletriptan: a review of its use in the acute treatment of migraine.

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Title: [Clinical use of triptans in the management of migraine].

Journal: CNS drugs 20060101

Title: Spotlight on eletriptan in migraine.

Journal: CNS drugs 20060101

Title: Efficacy and tolerability of zolmitriptan oral tablet in the acute treatment of menstrual migraine.

Journal: CNS drugs 20060101

Title: A comparative study on the cost of new antibiotics and drugs of other therapeutic categories.

Journal: PloS one 20060101

Title: Distribution of intranasal C-zolmitriptan assessed by positron emission tomography.

Journal: Cephalalgia : an international journal of headache 20051201

Title: The study of enantioseparation of zolmitriptan on vancomycin-bonded chiral stationary phase.

Journal: Journal of separation science 20051201

Title: Over-the-counter triptans--making the switch.

Journal: The Lancet. Neurology 20051001

Title: [The role of triptans and analgesics for primary headache treatment].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20051001

Title: A stability indicating LC method for zolmitriptan.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: A validated chiral LC method for the enantiomeric separation of Zolmitriptan key intermediate, ZTR-5.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: The use of multiattribute decision models in evaluating triptan treatment options in migraine.

Journal: Journal of neurology 20050901

Title: [Extrahepatic cholestasia during therapy with Zolmitriptan (AscoTop)].

Journal: Zeitschrift fur Gastroenterologie 20050901

Title: Sumatriptan and zolmitriptan.

Journal: Nursing times 20050901

Title: Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder.

Journal: Neuropsychiatric disease and treatment 20050901

Title: Multiple attack study on the available triptans in Italy versus placebo.

Journal: European journal of neurology 20050701

Title: Intranasal zolmitriptan.

Journal: Expert opinion on pharmacotherapy 20050601

Title: The treatment of pediatric migraine.

Journal: Pediatric annals 20050601

Title: Intranasal mucoadhesive microemulsions of zolmitriptan: preliminary studies on brain-targeting.

Journal: Journal of drug targeting 20050601

Title: Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

Title: Triptans induce vasoconstriction of human arteries and veins from the thoracic wall.

Journal: Journal of cardiovascular pharmacology 20050501

Title: Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors.

Journal: Pain 20050501

Title: Myocardial infarction after taking zolmitriptan.

Journal: The Yale journal of biology and medicine 20050501

Title: Determination of zolmitriptan enantiomers in rat liver microsomes by chiral high performance liquid chromatography with fl uorescence detection.

Journal: Biomedical chromatography : BMC 20050401

Title: [Economic evaluation of acute migraine attack treatment with triptans in Spain].

Journal: Neurologia (Barcelona, Spain) 20050401

Title: Pediatric migraine: recognition and treatment.

Journal: The Journal of the American Osteopathic Association 20050401

Title: Eletriptan review.

Journal: Expert opinion on pharmacotherapy 20050401

Title: A validated chiral LC method for the determination of zolmitriptan and its potential impurities.

Journal: Journal of pharmaceutical and biomedical analysis 20050309

Title: Pain-free rates with zolmitriptan 2.5 mg ODT in the acute treatment of migraine: results of a large double-blind placebo- controlled trial.

Journal: Current medical research and opinion 20050301

Title: Triptan nonresponder studies: implications for clinical practice.

Journal: Headache 20050201

Title: The 5-HT1D receptor agonist zolmitriptan for neuroleptic-induced akathisia: an open label preliminary study.

Journal: International clinical psychopharmacology 20050101

Title: Correlation between lipophilicity and triptan outcomes.

Journal: Headache 20050101

Title: Zolmitriptan 5 mg nasal spray: efficacy and onset of action in the acute treatment of migraine--results from phase 1 of the REALIZE Study.

Journal: Headache 20050101

Title: Zolmitriptan nasal spray exhibits good long-term safety and tolerability in migraine: results of the INDEX trial.

Journal: Headache 20050101

Title: Speed of onset, efficacy and tolerability of zolmitriptan nasal spray in the acute treatment of migraine: a randomised, double-blind, placebo-controlled study.

Journal: CNS drugs 20050101

Title: Distribution of zolmitriptan into the CNS in healthy volunteers: a positron emission tomography study.

Journal: Drugs in R&D 20050101

Title: [Management costs of chest and CNS-related adverse events associated with the treatment of acute migraine attacks with oral triptans].

Journal: Neurologia (Barcelona, Spain) 20050101

Title: Part II: clinical efficacy and tolerability of zolmitriptan orally disintegrating tablet in the acute treatment of migraine.

Journal: Current medical research and opinion 20050101

Title: Part III: the convenience of, and patient preference for, zolmitriptan orally disintegrating tablet.

Journal: Current medical research and opinion 20050101

Title: Part IV: effects of zolmitriptan orally disintegrating tablet on migraine symptoms and ability to perform normal activities: a post-marketing surveillance study in Germany.

Journal: Current medical research and opinion 20050101

Title: An economic evaluation of rizatriptan in the treatment of migraine.

Journal: PharmacoEconomics 20050101

Title: [Probabilistic cost-effectiveness analysis of oral eletriptan in the treatment of acute migraine in Portugal].

Journal: Acta medica portuguesa 20050101

Title: Myalgia and cramps associated with zolmitriptan.

Journal: Clinical neuropharmacology 20050101

Title: The use of triptans in the management of menstrual migraine.

Journal: CNS drugs 20050101

Title: Rizatriptan: a pharmacoeconomic review of its use in the acute treatment of migraine.

Journal: PharmacoEconomics 20050101

Title: Treatment satisfaction with zolmitriptan nasal spray for migraine in a real life setting: results from phase two of the REALIZE study.

Journal: The journal of headache and pain 20050101

Title: Bioequivalence and rapid absorption of zolmitriptan nasal spray compared with oral tablets in healthy Japanese subjects.

Journal: Clinical drug investigation 20050101

Title: Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society.

Journal: Neurology 20041228

Title: Quantification of zolmitriptan in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

Title: [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041201

Title: Role of alcohol consumption in escalation to violence.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Benefits of treating highly disabled migraine patients with zolmitriptan while pain is mild.

Journal: Cephalalgia : an international journal of headache 20041101

Title: Migraine treatment strategies: the global Migraine And Zolmitriptan Evaluation (MAZE) survey--phase IV.

Journal: Current medical research and opinion 20041101

Title: Acute myocardial infarction following the use of antimigraine therapy.

Journal: The Journal of invasive cardiology 20041001

Title: Cluster headache: symptomatic treatment.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

Title: [Triptans in migraine: a comparative review of pharmacology, pharmacokinetics].

Journal: No to shinkei = Brain and nerve 20040901

Title: [Triptans in migraine: from clinical view].

Journal: No to shinkei = Brain and nerve 20040901

Title: [Meta-analysis of triptan treatment in migraine].

Journal: No to shinkei = Brain and nerve 20040901

Title: [Side effects of triptans].

Journal: No to shinkei = Brain and nerve 20040901

Title: Differences of anti-nociceptive mechanisms of migraine drugs on the trigeminal pain processing during and outside acute migraine attacks.

Journal: Cephalalgia : an international journal of headache 20040801

Title: The therapeutic profile of zolmitriptan in clinical practice.

Journal: International journal of clinical practice 20040801

Title: Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040701

Title: Impact of migraine on patients and their families: the Migraine And Zolmitriptan Evaluation (MAZE) survey--Phase III.

Journal: Current medical research and opinion 20040701

Title: Triptans and CNS side-effects: pharmacokinetic and metabolic mechanisms.

Journal: Cephalalgia : an international journal of headache 20040601

Title: Transformed migraine and medication overuse in a tertiary headache centre--clinical characteristics and treatment outcomes.

Journal: Cephalalgia : an international journal of headache 20040601

Title: Migraine headache.

Journal: Clinical evidence 20040601

Title: High-performance liquid chromatographic analysis of zolmitriptan in human plasma using fluorescence detection.

Journal: Journal of pharmaceutical and biomedical analysis 20040528

Title: Double-blind clinical trials of oral triptans vs other classes of acute migraine medication - a review.

Journal: Cephalalgia : an international journal of headache 20040501

Title: Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats.

Journal: Cephalalgia : an international journal of headache 20040501

Title: [Unstable angina in relationship to intake of zolmitriptan].

Journal: Neurologia (Barcelona, Spain) 20040501

Title: Patients with migraine prefer zolmitriptan orally disintegrating tablet to sumatriptan conventional oral tablet.

Journal: International journal of clinical practice 20040301

Title: Efficacy and tolerability of oral zolmitriptan in menstrually associated migraine: a randomized, prospective, parallel-group, double-blind, placebo-controlled study.

Journal: Headache 20040201

Title: Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials.

Journal: Pharmacoepidemiology and drug safety 20040201

Title: Managing migraines. New treatments focus on relieving pain fast--or heading off these headaches before they begin.

Journal: Health news (Waltham, Mass.) 20040201

Title: Zolmitriptan (Zomig) nasal spray for migraine.

Journal: The Medical letter on drugs and therapeutics 20040119

Title: Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain.

Journal: Cephalalgia : an international journal of headache 20040101

Title: Defeating migraine pain with triptans: a race against the development of cutaneous allodynia.

Journal: Annals of neurology 20040101

Title: [HPLC determination of zolmitriptan and its related substances].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040101

Title: Fixed drug eruption of the penis due to zolmitriptan.

Journal: Dermatology (Basel, Switzerland) 20040101

Title: Patterns of use of triptans and reasons for switching them in a tertiary care migraine population.

Journal: Headache 20040101

Title: Determining triptan preference for the individual patient.

Journal: Headache 20040101

Title: Rizatriptan versus rizatriptan plus rofecoxib versus rizatriptan plus tolfenamic acid in the acute treatment of migraine.

Journal: BMC neurology 20040101

Title: Intranasal medications for the treatment of migraine and cluster headache.

Journal: CNS drugs 20040101

Title: [Treatment of migraine].

Journal: Medicinski arhiv 20040101

Title: Acute treatment of migraine with zolmitriptan 5 mg orally disintegrating tablet.

Journal: CNS drugs 20040101

Title: Zolmitriptan (Zomig).

Journal: Expert review of neurotherapeutics 20040101

Title: In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan.

Journal: Chemico-biological interactions 20031215

Title: [Zolmitriptan-induced hepatotoxicity].

Journal: Gastroenterologia y hepatologia 20031201

Title: Comparative efficacy of eletriptan and zolmitriptan in the acute treatment of migraine.

Journal: Cephalalgia : an international journal of headache 20031201

Title: Migraine headache.

Journal: Clinical evidence 20031201

Title: Zolmitriptan nasal spray: advances in migraine treatment.

Journal: Neurology 20031028

Title: Clinical applications of new therapeutic deliveries in migraine.

Journal: Neurology 20031028

Title: Abnormal habituation of 'nociceptive' blink reflex in migraine--evidence for increased excitability of trigeminal nociception.

Journal: Cephalalgia : an international journal of headache 20031001

Title: Patients with migraine prefer zolmitriptan orally disintegrating tablet to sumatriptan conventional oral tablet.

Journal: International journal of clinical practice 20030901

Title: Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701

Title: The evolving management of migraine.

Journal: Current opinion in neurology 20030601

Title: [Improved pharmacokinetics. Fast tryptan with sustained response].

Journal: MMW Fortschritte der Medizin 20030526

Title: [Highly selective beginning. Associated symptoms and side effects in retrospect].

Journal: MMW Fortschritte der Medizin 20030526

Title: Topical agents in the treatment of cluster headache.

Journal: Current pain and headache reports 20030401

Title: Zolmitriptan for treatment of migrainous vertigo: a pilot randomized placebo-controlled trial.

Journal: Neurology 20030311

Title: Safety profile of the triptans.

Journal: Expert opinion on drug safety 20030301

Title: Migraine: pathophysiology, pharmacology, treatment and future trends.

Journal: Current vascular pharmacology 20030301

Title: [Zolmitriptan as fast-melt tablet in the acute treatment of patients with migraine attacks: the ZORO study].

Journal: Praxis 20030226

Title: Reassessing the contraindication of zolmitriptan and serotonin reuptake inhibitors: an evidence-based pharmacotherapeutic case report.

Journal: Journal of clinical pharmacy and therapeutics 20030201

Title: [Triptane. Zolmitriptan--fast and effective in migraine].

Journal: Schmerz (Berlin, Germany) 20030101

Title: Speed of onset and efficacy of zolmitriptan nasal spray in the acute treatment of migraine: a randomised, double-blind, placebo-controlled, dose-ranging study versus zolmitriptan tablet.

Journal: CNS drugs 20030101

Title: Pharmacological approaches to migraine.

Journal: Journal of neural transmission. Supplementum 20030101

Title: Migraine prevalence and treatment patterns: the global Migraine and Zolmitriptan Evaluation survey.

Journal: Headache 20030101

Title: Coprescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients.

Journal: Headache 20030101

Title: Transcranial Doppler in migraine attacks before and after treatment with oral zolmitriptan or sumatriptan.

Journal: Headache 20030101

Title: Management of trigeminal autonomic cephalgias and hemicrania continua.

Journal: Drugs 20030101

Title: Tolerability and consistency of effect of zolmitriptan nasal spray in a long-term migraine treatment trial.

Journal: CNS drugs 20030101

Title: Migraine: diagnosis and management.

Journal: Internal medicine journal 20030101

Title: Newer formulations of the triptans: advances in migraine management.

Journal: Drugs 20030101

Title: Meta-analysis of oral triptan therapy for migraine: number needed to treat and relative cost to achieve relief within 2 hours.

Journal: Journal of managed care pharmacy : JMCP 20030101

Title: Impact of antimigraine compounds on cognitive processing: a placebo-controlled crossover study.

Journal: Headache 20030101

Title: The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.

Journal: British journal of pharmacology 20021201

Title: Ergot and triptan overuse in Austria--an evaluation of clinical data and cost.

Journal: Cephalalgia : an international journal of headache 20021201

Title: Preliminary studies of the pharmacokinetics and tolerability of zolmitriptan nasal spray in healthy volunteers.

Journal: Journal of clinical pharmacology 20021101

Title: Pharmacokinetics, dose proportionality, and tolerability of single and repeat doses of a nasal spray formulation of zolmitriptan in healthy volunteers.

Journal: Journal of clinical pharmacology 20021101

Title: Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems.

Journal: Psychopharmacology 20021001

Title: Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials.

Journal: Cephalalgia : an international journal of headache 20021001

Title: Cerebral vasoconstriction and stroke after use of serotonergic drugs.

Journal: Neurology 20020827

Title: Triptans reduce the inflammatory response in bacterial meningitis.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020801

Title: Selegiline: a second look. Six years later: too risky in Parkinson's disease.

Journal: Prescrire international 20020801

Title: Review of zolmitriptan and its clinical applications in migraine.

Journal: Expert opinion on pharmacotherapy 20020701

Title: Mechanisms of action of the 5-HT1B/1D receptor agonists.

Journal: Archives of neurology 20020701

Title: The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects.

Journal: European journal of clinical pharmacology 20020701

Title: Efficacy of oral ketoprofen in acute migraine: a double-blind randomized clinical trial.

Journal: Neurology 20020611

Title: Zolmitriptan is effective and well tolerated in Japanese patients with migraine: a dose-response study.

Journal: Cephalalgia : an international journal of headache 20020601

Title: Gateways to Clinical Trials. June 2002.

Journal: Methods and findings in experimental and clinical pharmacology 20020601

Title: Acute migraine headache: possible sensitization of neurons in the spinal trigeminal nucleus?

Journal: Neurology 20020423

Title: Zolmitriptan orally disintegrating tablet is effective in the acute treatment of migraine.

Journal: Cephalalgia : an international journal of headache 20020301

Title: [Splenic infarction associated with Zolmitriptan use].

Journal: Gastroenterologie clinique et biologique 20020301

Title: Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor.

Journal: European journal of pharmacology 20020201

Title: Re: Zakrzewska JM. Cluster headache: review of the literature. Br J Oral Maxillofac Surg 2001; 39: 103-113.

Journal: The British journal of oral & maxillofacial surgery 20020201

Title: Comparison of triptan tablet consumption per attack: a prospective study of migraineurs in Spain.

Journal: Headache 20020201

Title: Simultaneous measurement of zolmitriptan and its major metabolites N-desmethylzolmitriptan and zolmitriptan N-oxide in human plasma by high-performance liquid chromatography with coulometric detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020125

Title: [Treatment of migraine in patients with hypertension and ischemic heart disease].

Journal: Ideggyogyaszati szemle 20020120

Title: Zolmitriptan versus a combination of acetylsalicylic acid and metoclopramide in the acute oral treatment of migraine: a double-blind, randomised, three-attack study.

Journal: European neurology 20020101

Title: [Migraine: a disease, not a symptom].

Journal: La Revue du praticien 20020101

Title: Cost-effectiveness analysis of stratified versus stepped care strategies for acute treatment of migraine: The Disability in Strategies for Care (DISC) Study.

Journal: PharmacoEconomics 20020101

Title: Rizatriptan: an update of its use in the management of migraine.

Journal: Drugs 20020101

Title: Patient perceptions and treatment preferences in migraine management.

Journal: CNS drugs 20020101

Title: Spotlight on rizatriptan in migraine.

Journal: CNS drugs 20020101

Title: Restoring migraine sufferers' ability to function normally: a comparison of rizatriptan and other triptans in randomized trials.

Journal: European neurology 20020101

Title: An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy.

Journal: Proceedings of the Western Pharmacology Society 20020101

Title: [The problems of migraine headache treatment].

Journal: Medicina (Kaunas, Lithuania) 20020101

Title: A comparison of familial and sporadic migraine in a headache clinic population.

Journal: Functional neurology 20020101

Title: Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials.

Journal: Lancet (London, England) 20011117

Title: Clinical features of withdrawal headache following overuse of triptans and other headache drugs.

Journal: Neurology 20011113

Title: [Cost effectiveness of treatment with triptanes in Spain].

Journal: Revista de neurologia 20011101

Title: Comparison of rizatriptan and other triptans on stringent measures of efficacy.

Journal: Neurology 20011023

Title: Patient satisfaction with rizatriptan versus other triptans: direct head-to-head comparisons.

Journal: International journal of clinical practice 20011001

Title: Assessing patient preference in migraine treatment.

Journal: Cephalalgia : an international journal of headache 20011001

Title: Advances in pharmacological treatment of migraine.

Journal: Expert opinion on investigational drugs 20011001

Title: Have the triptans fulfilled their promise?

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20010901

Title: Triptans are all different.

Journal: Archives of neurology 20010901

Title: What matters is not the differences between triptans, but the differences between patients.

Journal: Archives of neurology 20010901

Title: Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis.

Journal: Headache 20010901

Title: Dexamethasone decreases migraine recurrence observed after treatment with a triptan combined with a nonsteroidal anti-inflammatory drug.

Journal: Arquivos de neuro-psiquiatria 20010901

Title: Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice.

Journal: Psychopharmacology 20010901

Title: Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain.

Journal: European journal of pharmacology 20010817

Title: Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).

Journal: Archives of neurology 20010701

Title: Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor.

Journal: British journal of pharmacology 20010701

Title: Safety and rational use of the triptans.

Journal: The Medical clinics of North America 20010701

Title: An open preference study with sumatriptan 50 mg and zolmitriptan 2.5 mg in 100 migraine patients.

Journal: Cephalalgia : an international journal of headache 20010701

Title: Recent development in paediatric headache.

Journal: Current opinion in neurology 20010601

Title: Current options for the prevention and treatment of migraine.

Journal: Clinical therapeutics 20010601

Title: Migraine treatment outcomes with rizatriptan in triptan-naive patients: a naturalistic study.

Journal: Clinical therapeutics 20010601

Title: Zolmitriptan versus sumatriptan for the acute oral treatment of migraine: a randomized, double-blind, international study.

Journal: European journal of neurology 20010501

Title: Decreased sensitivity of 5-HT(1D) receptors in melancholic depression.

Journal: The British journal of psychiatry : the journal of mental science 20010501

Title: Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans.

Journal: British journal of clinical pharmacology 20010501

Title: [Current topics: expectation for new triptans].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410

Title: Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010401

Title: 4991W93 inhibits release of calcitonin gene-related peptide in the cat but only at doses with 5HT(1B/1D) receptor agonist activity?

Journal: Neuropharmacology 20010301

Title: Zolmitriptan versus sumatriptan comparison trial.

Journal: Headache 20010301

Title: Donitriptan (Pierre Fabre).

Journal: Current opinion in investigational drugs (London, England : 2000) 20010301

Title: Acute treatment of migraine and the role of triptans.

Journal: Current neurology and neuroscience reports 20010301

Title: What is the optimal strategy for managing acute migraine headaches?

Journal: The Journal of family practice 20010201

Title: A systematic review of the use of triptans in acute migraine.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20010201

Title: New abortive agents for the treatment of migraine.

Journal: Advances in internal medicine 20010101

Title: NMR studies on three optical active drug molecules.

Journal: Acta poloniae pharmaceutica 20010101

Title: The cost effectiveness of stratified care in the management of migraine.

Journal: PharmacoEconomics 20010101

Title: Triptans in the treatment of basilar migraine and migraine with prolonged aura.

Journal: Headache 20010101

Title: Sumatriptan: pharmacological basis and clinical results.

Journal: Current medical research and opinion 20010101

Title: Zolmitriptan: differences from sumatriptan.

Journal: Current medical research and opinion 20010101

Title: Comparative aspects of triptans in treating migraine.

Journal: Clinical cornerstone 20010101

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Tags:139264-24-7 Molecular Formula|139264-24-7 MDL|139264-24-7 SMILES|139264-24-7 2-Oxazolidinone, 4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-, (4R)-