Title: Comparing the cardiovascular therapeutic indices of glycopyrronium and tiotropium in an integrated rat pharmacokinetic, pharmacodynamic and safety model.
Journal: Toxicology and applied pharmacology 20150815
Title: Olodaterol: first global approval.
Journal: Drugs 20131101
Title: Aclidinium bromide for the treatment of chronic obstructive pulmonary disease.
Journal: Expert opinion on pharmacotherapy 20130601
Title: Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases.
Journal: The Journal of pharmacology and experimental therapeutics 20130501
Title: Tiotropium increases PPARγ and decreases CREB in cells isolated from induced sputum of COPD patients.
Journal: Advances in experimental medicine and biology 20130101
Title: Effect of device design on the in vitro performance and comparability for capsule-based dry powder inhalers.
Journal: The AAPS journal 20121201
Title: Cost-utility analysis of tiotropium versus usual care in patients with COPD in the UK and Belgium.
Journal: Respiratory medicine 20121201
Title: Detrended fluctuation analysis of peak expiratory flow and exacerbation frequency in COPD.
Journal: The European respiratory journal 20121101
Title: The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium.
Journal: The Journal of pharmacology and experimental therapeutics 20121101
Title: Efficacy and safety of NVA237 versus placebo and tiotropium in patients with COPD: the GLOW2 study.
Journal: The European respiratory journal 20121101
Title: Probing biochemical mechanisms of action of muscarinic M3 receptor antagonists with label-free whole cell assays.
Journal: Analytical chemistry 20121002
Title: Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol.
Journal: British journal of pharmacology 20121001
Title: Bronchodilators modulate inflammation in chronic obstructive pulmonary disease subjects.
Journal: Pharmacological research 20121001
Title: Addition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPD.
Journal: Respiratory medicine 20121001
Title: Effect of combination treatment on lung volumes and exercise endurance time in COPD.
Journal: Respiratory medicine 20121001
Title: [Early treatment of COPD with tiotropium].
Journal: Pneumologie (Stuttgart, Germany) 20121001
Title: Which long-acting bronchodilator is most cost-effective for the treatment of COPD?
Journal: The Netherlands journal of medicine 20121001
Title: Tiotropium in asthma poorly controlled with standard combination therapy.
Journal: The New England journal of medicine 20120927
Title: Tiotropium for asthma--promise and caution.
Journal: The New England journal of medicine 20120927
Title: Tiotropium versus long-acting beta-agonists for stable chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20120912
Title: Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomised, double-blind comparison.
Journal: Thorax 20120901
Title: Computed tomography assessment of pharmacological lung volume reduction induced by bronchodilators in COPD.
Journal: COPD 20120801
Title: Four-year trial of tiotropium in chronic obstructive pulmonary disease.
Journal: Canadian family physician Medecin de famille canadien 20120801
Title: Tiotropium versus placebo for chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20120711
Title: Inhibitory effects of tiotropium on rhinovirus infection in human airway epithelial cells.
Journal: The European respiratory journal 20120701
Title: β₂ long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD.
Journal: Biochimica et biophysica acta 20120701
Title: Effect of tiotropium bromide on airway remodeling in a chronic asthma model.
Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20120701
Title: Rehospitalization risks and outcomes in COPD patients receiving maintenance pharmacotherapy.
Journal: Respiratory medicine 20120601
Title: Efficacy of tiotropium in COPD patients with FEV1 ≥ 60% participating in the UPLIFT® trial.
Journal: COPD 20120601
Title: Key observations from the NHLBI Asthma Clinical Research Network.
Journal: Thorax 20120501
Title: Cause-specific mortality adjudication in the UPLIFT® COPD trial: findings and recommendations.
Journal: Respiratory medicine 20120401
Title: Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study.
Journal: Therapeutic advances in respiratory disease 20120401
Title: A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium.
Journal: COPD 20120401
Title: In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD.
Journal: Immunobiology 20120301
Title: Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma.
Journal: British journal of pharmacology 20120301
Title: Efficacy of aclidinium bromide 400 μg twice daily compared with placebo and tiotropium in patients with moderate to severe COPD.
Journal: Chest 20120301
Title: Comparison of tiotropium plus fluticasone propionate/salmeterol with tiotropium in COPD: a randomized controlled study.
Journal: Respiratory medicine 20120301
Title: Tiotropium: what came after the UPLIFT study.
Journal: Expert opinion on pharmacotherapy 20120301
Title: Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Journal: Nature 20120223
Title: Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.
Journal: Life sciences 20120213
Title: Pharmacoeconomic evaluation of tiotropium bromide in the long-term treatment of chronic obstructive pulmonary disease (COPD) in Italy.
Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20120201
Title: Tiotropium improves walking endurance in COPD.
Journal: The European respiratory journal 20120201
Title: Tiotropium Handihaler and the risk of cardio- or cerebrovascular events and mortality in patients with COPD.
Journal: Pulmonary pharmacology & therapeutics 20120201
Title: Comparison of three combined pharmacological approaches with tiotropium monotherapy in stable moderate to severe COPD: a systematic review.
Journal: Pulmonary pharmacology & therapeutics 20120201
Title: Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids.
Journal: COPD 20120201
Title: PURLs: would this long-acting bronchodilator be better for your patient?
Journal: The Journal of family practice 20120201
Title: Tiotropium bromide inhalation powder: a review of its use in the management of chronic obstructive pulmonary disease.
Journal: Drugs 20120122
Title: The impact of tiotropium on mortality and exacerbations when added to inhaled corticosteroids and long-acting β-agonist therapy in COPD.
Journal: Chest 20120101
Title: Acute effects of indacaterol on lung hyperinflation in moderate COPD: a comparison with tiotropium.
Journal: Respiratory medicine 20120101
Title: Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD.
Journal: Respiratory medicine 20120101
Title: Assessment of combined muscarinic antagonist and fibrinolytic therapy for inhalation injury.
Journal: Journal of burn care & research : official publication of the American Burn Association 20120101
Title: Observational study on the impact of initiating tiotropium alone versus tiotropium with fluticasone propionate/salmeterol combination therapy on outcomes and costs in chronic obstructive pulmonary disease.
Journal: Respiratory research 20120101
Title: Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients.
Journal: International journal of chronic obstructive pulmonary disease 20120101
Title: Comparative health-care cost advantage of ipratropium over tiotropium in COPD patients.
Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20120101
Title: Clinical and economic outcomes in an observational study of COPD maintenance therapies: multivariable regression versus propensity score matching.
Journal: International journal of chronic obstructive pulmonary disease 20120101
Title: Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20120101
Title: [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)].
Journal: Pneumonologia i alergologia polska 20120101
Title: Effects of tiotropium on sympathetic activation during exercise in stable chronic obstructive pulmonary disease patients.
Journal: International journal of chronic obstructive pulmonary disease 20120101
Title: Clinical trial design in chronic obstructive pulmonary disease: current perspectives and considerations with regard to blinding of tiotropium.
Journal: Respiratory research 20120101
Title: [A pharmacovigilance study in chest diseases outpatient clinic].
Journal: Tuberkuloz ve toraks 20120101
Title: Effects of inhaled tiotropium on left ventricular diastolic function in chronic obstructive pulmonary disease patients after pulmonary resection.
Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20120101
Title: Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease.
Journal: Respiratory research 20120101
Title: Exacerbation frequency and course of COPD.
Journal: International journal of chronic obstructive pulmonary disease 20120101
Title: Factors associated with misdiagnosis of COPD in primary care.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20111201
Title: [Prevention in chronic obstructive pulmonary disease. POET-COPD (prevention of exacerbations with tiotropium in COPD)].
Journal: Der Internist 20111201
Title: Application of latent growth and growth mixture modeling to identify and characterize differential responders to treatment for COPD.
Journal: Contemporary clinical trials 20111101
Title: Cost-utility analysis of indacaterol in Germany: a once-daily maintenance bronchodilator for patients with COPD.
Journal: Respiratory medicine 20111101
Title: [Theoretical and clinical aspects of tiotropium application as a first line therapy in stable state of all stages of chronic obstructive pulmonary disease].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20111101
Title: [The curative effect of Fluticasone Salmeterol combined with Tiotropium Bromide for silicosis].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20111101
Title: Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
Journal: Journal of medicinal chemistry 20111013
Title: Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD.
Journal: The European respiratory journal 20111001
Title: Premature discontinuation during the UPLIFT study.
Journal: Respiratory medicine 20111001
Title: Blinded 12-week comparison of once-daily indacaterol and tiotropium in COPD.
Journal: The European respiratory journal 20111001
Title: Effects of inhaled tiotropium plus transdermal tulobuterol versus tiotropium alone on impulse oscillation system (IOS)-assessed measures of peripheral airway resistance and reactance, lung function and quality of life in patients with COPD: a randomized crossover study.
Journal: Pulmonary pharmacology & therapeutics 20111001
Title: Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111001
Title: [Evidence of pharmacotherapy in COPD--key findings from recently-conducted randomized clinical studies].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20111001
Title: Centrilobular opacities in the asthmatic lung successfully treated with inhaled ciclesonide and tiotropium: with assessment of alveolar nitric oxide levels.
Journal: Allergology international : official journal of the Japanese Society of Allergology 20110901
Title: Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoea.
Journal: Respiratory medicine 20110901
Title: Changes of clinical outcomes and health care resources in moderate and in severe COPD treated uniquely with tiotropium 18 mcg od for twenty-four months.
Journal: Pulmonary pharmacology & therapeutics 20110801
Title: Chronic obstructive pulmonary disease megatrials: taking the results into office practice.
Journal: The American journal of the medical sciences 20110801
Title: Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial.
Journal: The Journal of allergy and clinical immunology 20110801
Title: Risk of nonlower respiratory serious adverse events following COPD exacerbations in the 4-year UPLIFT® trial.
Journal: Lung 20110801
Title: Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma.
Journal: The Journal of allergy and clinical immunology 20110801
Title: Effect of tiotropium bromide on expression of CD(8) (+)CD (25) (+)FoxP (3) (+) regulatory T cells in patients with stable chronic obstructive pulmonary disease.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110801
Title: Outcomes and costs associated with initial maintenance therapy with fluticasone propionate-salmeterol xinafoate 250 microg/50 microg combination versus tiotropium in commercially insured patients with COPD.
Journal: Managed care (Langhorne, Pa.) 20110801
Title: Another plausible explanation for mist inhaler's toxicity.
Journal: BMJ (Clinical research ed.) 20110725
Title: Efficacy of tiotropium in COPD patients from Asia: a subgroup analysis from the UPLIFT trial.
Journal: Respirology (Carlton, Vic.) 20110701
Title: The epidemiology and type of medication errors reported to the National Poisons Information Centre of Ireland.
Journal: Clinical toxicology (Philadelphia, Pa.) 20110701
Title: Tiotropium versus salmeterol in COPD.
Journal: The New England journal of medicine 20110630
Title: Tiotropium versus salmeterol in COPD.
Journal: The New England journal of medicine 20110630
Title: Tiotropium versus salmeterol in COPD.
Journal: The New England journal of medicine 20110630
Title: Tiotropium versus salmeterol in COPD.
Journal: The New England journal of medicine 20110630
Title: Spiriva (Respimat) increases mortality by 52% in patients with COPD: time to take action.
Journal: The New Zealand medical journal 20110624
Title: Safety of tiotropium.
Journal: BMJ (Clinical research ed.) 20110614
Title: Short-term effects of inhalative tiotropium/formoterol/budenoside versus tiotropium/formoterol in patients with newly diagnosed chronic obstructive pulmonary disease requiring surgery for lung cancer: a prospective randomized trial.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110601
Title: Effects of formoterol and tiotropium bromide on mucus clearance in patients with COPD.
Journal: Respiratory medicine 20110601
Title: NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease.
Journal: Therapeutic advances in respiratory disease 20110601
Title: Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Journal: Bioorganic & medicinal chemistry letters 20110601
Title: Trends in health care utilization in British Columbia following public coverage for tiotropium.
Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110601
Title: Triple inhalers for obstructive airways disease: will they be useful?
Journal: Expert review of respiratory medicine 20110601
Title: Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study.
Journal: Archives of internal medicine 20110523
Title: Inhaled anticholinergics for chronic obstructive pulmonary disease: comment on 'Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease'.
Journal: Archives of internal medicine 20110523
Title: Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD.
Journal: Respiratory medicine 20110501
Title: Cost effectiveness of budesonide/formoterol added to tiotropium bromide versus placebo added to tiotropium bromide in patients with chronic obstructive pulmonary disease: Australian, Canadian and Swedish healthcare perspectives.
Journal: PharmacoEconomics 20110501
Title: Inhaled anticholinergic drugs and risk of acute urinary retention.
Journal: BJU international 20110401
Title: Cardio- and cerebrovascular safety of indacaterol vs formoterol, salmeterol, tiotropium and placebo in COPD.
Journal: Respiratory medicine 20110401
Title: Tiotropium for treatment of stable COPD: a meta-analysis of clinically relevant outcomes.
Journal: Respiratory care 20110401
Title: Tiotropium versus salmeterol for the prevention of exacerbations of COPD.
Journal: The New England journal of medicine 20110324
Title: Choice of bronchodilator therapy for patients with COPD.
Journal: The New England journal of medicine 20110324
Title: Reported pneumonia in patients with COPD: findings from the INSPIRE study.
Journal: Chest 20110301
Title: Acute bronchodilator responsiveness in bronchiolitis obliterans syndrome following hematopoietic stem cell transplantation.
Journal: Chest 20110301
Title: Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: [Phosphodiesterase-4 inhibitors: roflumilast].
Journal: Revista clinica espanola 20110301
Title: Tiotropium step-up therapy in asthma.
Journal: The New England journal of medicine 20110210
Title: Tiotropium step-up therapy in asthma.
Journal: The New England journal of medicine 20110210
Title: Combined treatment with formoterol and tiotropium is more efficacious than treatment with tiotropium alone in patients with chronic obstructive pulmonary disease, regardless of smoking status, inhaled corticosteroid use, baseline severity, or gender.
Journal: Pulmonary pharmacology & therapeutics 20110201
Title: Comparison of tiotropium plus formoterol to tiotropium alone in stable chronic obstructive pulmonary disease: a meta-analysis.
Journal: Respirology (Carlton, Vic.) 20110201
Title: [Pathogenesis, diagnosis and therapy of bronchial asthma. How can the lungs be freed?].
Journal: MMW Fortschritte der Medizin 20110127
Title: Effects of adding salmeterol/fluticasone propionate to tiotropium on airway dimensions in patients with chronic obstructive pulmonary disease.
Journal: Respirology (Carlton, Vic.) 20110101
Title: Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101
Title: Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial.
Journal: Respiratory research 20110101
Title: Community pharmacy and pharmacist staff call center: assessment of medication safety and effectiveness.
Journal: Journal of the American Pharmacists Association : JAPhA 20110101
Title: Respiratory-related medical expenditure and inpatient utilisation among COPD patients receiving long-acting bronchodilator therapy.
Journal: Journal of medical economics 20110101
Title: Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: Inhibition of granulocyte migration by tiotropium bromide.
Journal: Respiratory research 20110101
Title: Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate.
Journal: Journal of pharmacological sciences 20110101
Title: Anticholinergics may play more roles in chronic obstructive pulmonary disease.
Journal: Chinese medical journal 20110101
Title: Combination inhaled steroid and long-acting beta(2)-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20110101
Title: [The verge and the abyss: tiotropium (Spiriva) in COPD].
Journal: Harefuah 20110101
Title: Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of randomised controlled trials.
Journal: BMJ (Clinical research ed.) 20110101
Title: [Determination of clinical phenotypes of chronic obstructive pulmonary disease--a new treatment approach].
Journal: Terapevticheskii arkhiv 20110101
Title: Delivery characteristics and patients' handling of two single-dose dry-powder inhalers used in COPD.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: Tiotropium reduces risk of exacerbations irrespective of previous use of inhaled anticholinergics in placebo-controlled clinical trials.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20110101
Title: Adverse health consequences in COPD patients with rapid decline in FEV1--evidence from the UPLIFT trial.
Journal: Respiratory research 20110101
Title: Cost-effectiveness analysis of roflumilast/tiotropium therapy versus tiotropium monotherapy for treating severe-to-very severe COPD.
Journal: Journal of medical economics 20110101
Title: Suppression of IL-8 production from airway cells by tiotropium bromide in vitro.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: The discovery of new spirocyclic muscarinic M3 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist.
Journal: The Journal of pharmacology and experimental therapeutics 20101201
Title: Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep.
Journal: Critical care medicine 20101201
Title: Effect of tiotropium on quality of life in COPD: a systematic review.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20101201
Title: [Clinical profile of roflumilast].
Journal: Archivos de bronconeumologia 20101201
Title: COPD in young patients: a pre-specified analysis of the four-year trial of tiotropium (UPLIFT).
Journal: Respiratory medicine 20101101
Title: [Tiotropium bromide for treating chronic obstructive pulmonary disease].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20101101
Title: Tiotropium bromide step-up therapy for adults with uncontrolled asthma.
Journal: The New England journal of medicine 20101028
Title: Products at risk.
Journal: The New England journal of medicine 20101028
Title: Anticholinergics for patients with asthma?
Journal: The New England journal of medicine 20101028
Title: Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trial.
Journal: Respiratory medicine 20101001
Title: Energy expenditure and impact of bronchodilators in COPD patients.
Journal: Respiratory medicine 20101001
Title: Sustained 24-h efficacy of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients.
Journal: Respiratory medicine 20101001
Title: A one-year trial of tiotropium Respimat plus usual therapy in COPD patients.
Journal: Respiratory medicine 20101001
Title: Adherence to controller therapy for chronic obstructive pulmonary disease: a review.
Journal: Current medical research and opinion 20101001
Title: Onset of effect of aclidinium, a novel, long-acting muscarinic antagonist, in patients with COPD.
Journal: COPD 20101001
Title: Pooled studies can raise misleading alarm bells, regulators say.
Journal: Nature medicine 20101001
Title: Meta-analysis and moderation.
Journal: Nature reviews. Drug discovery 20101001
Title: The safety of tiotropium--the FDA's conclusions.
Journal: The New England journal of medicine 20100916
Title: Paradoxical trough effects of triple therapy with budesonide/formoterol and tiotropium bromide on pulmonary function outcomes in COPD.
Journal: Chest 20100901
Title: The cardiovascular risk of tiotropium: is it real?
Journal: Expert opinion on drug safety 20100901
Title: Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD.
Journal: Respiratory medicine 20100901
Title: Comment on tiotropium.
Journal: Respiratory medicine 20100901
Title: [Experimental inhalation therapy with nebulized tiotropium in COPD patients unable to use the Handihaler].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20100901
Title: Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100801
Title: Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD.
Journal: Pulmonary pharmacology & therapeutics 20100801
Title: Outpatient management of severe COPD.
Journal: The New England journal of medicine 20100729
Title: Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium.
Journal: American journal of respiratory and critical care medicine 20100715
Title: Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT trial.
Journal: The European respiratory journal 20100701
Title: Combining tiotropium and salmeterol in COPD: Effects on airflow obstruction and symptoms.
Journal: Respiratory medicine 20100701
Title: Family increases: UPLIFT first maintenance subgroup analysis.
Journal: The European respiratory journal 20100701
Title: Complete smoking cessation is beneficial in older and more advanced COPD patients.
Journal: The European respiratory journal 20100701
Title: [A randomized, double-blind, placebo-control study of once-daily inhaled tiotropium in chronic obstructive pulmonary disease].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20100701
Title: Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux.
Journal: The European respiratory journal 20100601
Title: Integrating indacaterol dose selection in a clinical study in COPD using an adaptive seamless design.
Journal: Pulmonary pharmacology & therapeutics 20100601
Title: Tiotropium therapy and mortality risk in COPD patients: the most severe, the most protected? Evaluation of Celli B, Decramer M, Kesten S, et al. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009; 180(10): 948-55.
Journal: Expert opinion on pharmacotherapy 20100601
Title: Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: the UPLIFT trial.
Journal: Expert review of respiratory medicine 20100601
Title: Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20100512
Title: [Safety of tiotropium therapy in chronic obstructive lung diseases (COPD)].
Journal: Orvosi hetilap 20100502
Title: Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice.
Journal: The European respiratory journal 20100501
Title: [Therapeutic effect of tiotropium bromide powder inhalation in patients with stable bronchiectasis].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100501
Title: Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry.
Journal: Journal of proteomics 20100418
Title: New evidence in pulmonary and preventive medicine.
Journal: Internal and emergency medicine 20100401
Title: Combining triple therapy and pulmonary rehabilitation in patients with advanced COPD: a pilot study.
Journal: Respiratory medicine 20100301
Title: Effects of inhaled therapy on biomarkers of systemic inflammation in stable chronic obstructive pulmonary disease.
Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20100301
Title: Long-acting anticholinergic use in chronic obstructive pulmonary disease: efficacy and safety.
Journal: Current opinion in pulmonary medicine 20100301
Title: Economic analyses comparing tiotropium with ipratropium or salmeterol in UK patients with COPD.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20100301
Title: Tiotropium and chronic obstructive pulmonary disease.
Journal: BMJ (Clinical research ed.) 20100219
Title: Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trial.
Journal: The European respiratory journal 20100201
Title: Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD.
Journal: Respiratory medicine 20100201
Title: Tiotropium 5microg via Respimat and 18microg via HandiHaler; efficacy and safety in Japanese COPD patients.
Journal: Respiratory medicine 20100201
Title: Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.
Journal: Molecular pharmaceutics 20100201
Title: Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease.
Journal: Expert opinion on investigational drugs 20100201
Title: Role of inhaled tiotropium on the perioperative outcomes of patients with lung cancer and chronic obstructive pulmonary disease.
Journal: The Thoracic and cardiovascular surgeon 20100201
Title: Accidental overdose of tiotropium in a patient with atrial fibrillation.
Journal: The Annals of pharmacotherapy 20100201
Title: [Debates surrounding COPD].
Journal: Revue des maladies respiratoires 20100201
Title: [Long-term trials assessing pharmacological treatments in COPD: lessons and limitations].
Journal: Revue des maladies respiratoires 20100201
Title: How much lift to the UPLIFT study?
Journal: Lancet (London, England) 20100116
Title: Cardiovascular safety of tiotropium in patients with COPD.
Journal: Chest 20100101
Title: [Muscarinic cholinergic receptor antagonists enhanced the expression of CD(8)(+)CD(25)(+)Foxp(3)(+) regulatory T cells in stable COPD patients].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20100101
Title: Preventing and managing exacerbations in COPD--critical appraisal of the role of tiotropium.
Journal: International journal of chronic obstructive pulmonary disease 20100101
Title: [Short-term effect of tiotropium in COPD patients being treated with a beta2 agonist].
Journal: Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 20100101
Title: Pharmacological studies of bronchial constriction inhibited by parasympatholytics and cilomilast using equine precision-cut lung slices.
Journal: Berliner und Munchener tierarztliche Wochenschrift 20100101
Title: Cost effectiveness of tiotropium for chronic obstructive pulmonary disease: a systematic review of the evidence.
Journal: Journal of medical economics 20100101
Title: Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry.
Journal: PloS one 20100101
Title: Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic agents.
Journal: Quality in primary care 20100101
Title: [Anticholinergics and their cardiovascular effects--between fear and reality].
Journal: Pneumologia (Bucharest, Romania) 20100101
Title: Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies.
Journal: International journal of chronic obstructive pulmonary disease 20100101
Title: Do we need different treatments for very elderly COPD patients?
Journal: Respiration; international review of thoracic diseases 20100101
Title: Tiotropium's cost-effectiveness for the treatment of COPD: a cost-utility analysis under real-world conditions.
Journal: BMC pulmonary medicine 20100101
Title: 'Show me the money': a fair criticism of economic studies on inhaled bronchodilators for COPD.
Journal: BMC pulmonary medicine 20100101
Title: Tiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro.
Journal: International journal of chronic obstructive pulmonary disease 20100101
Title: Does tiotropium lower exacerbation and hospitalization frequency in COPD patients: results of a meta-analysis.
Journal: BMC pulmonary medicine 20100101
Title: Indacaterol provides 24-hour bronchodilation in COPD: a placebo-controlled blinded comparison with tiotropium.
Journal: Respiratory research 20100101
Title: Tiotropium Respimat® improves physical functioning in chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20100101
Title: Development and implementation of treadmill exercise testing protocols in COPD.
Journal: International journal of chronic obstructive pulmonary disease 20100101
Title: Tiotropium increases cytosolic muscarinic M3 receptors and acetylated H3 histone proteins in induced sputum cells of COPD patients.
Journal: European journal of medical research 20100101
Title: [Triple therapy in chronic obstructive pulmonary disease].
Journal: Archivos de bronconeumologia 20100101
Title: [The efficacy of tiotropium bromide (spiriva) in the treatment of patients with chronic obstructive pulmonary disease of varying severity: results of the Russian trial].
Journal: Terapevticheskii arkhiv 20100101
Title: A pilot comparison of helium dilution and plethysmographic lung volumes to assess the impact of a long-acting bronchodilator on lung hyperinflation in COPD.
Journal: Pulmonary pharmacology & therapeutics 20091201
Title: Alternative mechanisms for tiotropium.
Journal: Pulmonary pharmacology & therapeutics 20091201
Title: Therapeutic conversion of the combination of ipratropium and albuterol to tiotropium in patients with chronic obstructive pulmonary disease.
Journal: Pulmonary pharmacology & therapeutics 20091201
Title: Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease.
Journal: American journal of respiratory and critical care medicine 20091115
Title: On comparing different devices of inhalation products.
Journal: Respiratory medicine 20091101
Title: Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
Journal: The Journal of pharmacology and experimental therapeutics 20091101
Title: Management of chronic obstructive pulmonary disease: moving beyond the asthma algorithm.
Journal: The Journal of allergy and clinical immunology 20091101
Title: Inhaled tiotropium bromide and risk of stroke.
Journal: British journal of clinical pharmacology 20091101
Title: The use of inhaled anticholinergics in chronic obstructive pulmonary disease: is there cause for concern of cardiovascular safety?
Journal: Polskie Archiwum Medycyny Wewnetrznej 20091101
Title: Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstructive pulmonary disease.
Journal: Advances in therapy 20091101
Title: Do inhaled anticholinergics increase or decrease the risk of major cardiovascular events?: a synthesis of the available evidence.
Journal: Drugs 20091022
Title: Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chronic obstructive pulmonary disease.
Journal: American journal of respiratory and critical care medicine 20091015
Title: Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial.
Journal: Lancet (London, England) 20091003
Title: UPLIFTing care for chronic obstructive pulmonary disease.
Journal: Lancet (London, England) 20091003
Title: Evaluation of withdrawal of maintenance tiotropium in COPD.
Journal: Respiratory medicine 20091001
Title: Tiotropium and risk for fatal and nonfatal cardiovascular events in patients with chronic obstructive pulmonary disease: systematic review with meta-analysis.
Journal: Respiratory medicine 20091001
Title: Combination of formoterol and tiotropium in the treatment of COPD: effects on lung function.
Journal: COPD 20091001
Title: Anticholinergic treatment in airways diseases.
Journal: Advances in therapy 20091001
Title: Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials.
Journal: Lancet (London, England) 20090829
Title: Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
Journal: Journal of medicinal chemistry 20090827
Title: Outcomes associated with tiotropium use in patients with chronic obstructive pulmonary disease.
Journal: Archives of internal medicine 20090810
Title: Preclinical evaluation of long-acting muscarinic antagonists: comparison of tiotropium and investigational drugs.
Journal: The Journal of pharmacology and experimental therapeutics 20090801
Title: Pharmacologic treatments for chronic obstructive pulmonary disease: a mixed-treatment comparison meta-analysis.
Journal: Pharmacotherapy 20090801
Title: The efficacy and safety of tiotropium in Chinese patients with stable chronic obstructive pulmonary disease: a meta-analysis.
Journal: Respirology (Carlton, Vic.) 20090701
Title: Preoperative use of inhaled tiotropium in lung cancer patients with untreated COPD.
Journal: Respirology (Carlton, Vic.) 20090701
Title: Tiotropium-lessons from recent studies.
Journal: Respirology (Carlton, Vic.) 20090701
Title: Efficacy and safety of nebulized formoterol as add-on therapy in COPD patients receiving maintenance tiotropium bromide: Results from a 6-week, randomized, placebo-controlled, clinical trial.
Journal: Drugs 20090618
Title: Acute effects of higher than standard doses of salbutamol and ipratropium on tiotropium-induced bronchodilation in patients with stable COPD.
Journal: Pulmonary pharmacology & therapeutics 20090601
Title: Tiotropium induced bronchodilation and protection from dynamic hyperinflation is independent of extent of emphysema in COPD.
Journal: Pulmonary pharmacology & therapeutics 20090601
Title: Inhaled muscarinic antagonists for COPD--does an anti-inflammatory mechanism really play a role?
Journal: Current opinion in pharmacology 20090601
Title: Patient-level pooled analysis of the effect of tiotropium on COPD exacerbations and related hospitalisations.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20090601
Title: Don't prescribe tiotropium for smokers with an FEV1 above 60% predicted.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20090601
Title: Efficacy of tiotropium in the prevention of exacerbations of COPD.
Journal: Therapeutic advances in respiratory disease 20090601
Title: How safe are anticholinergics in patients with COPD?
Journal: The Medical journal of Australia 20090504
Title: Tiotropium fumarate: an interesting pharmaceutical co-crystal.
Journal: Journal of pharmaceutical sciences 20090501
Title: Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response.
Journal: Allergy 20090501
Title: Long-term bronchodilator inhaled therapy in COPD: the role of tiotropium bromidum.
Journal: Reviews on recent clinical trials 20090501
Title: Safety and pharmacological profile of tiotropium bromide.
Journal: Expert opinion on drug safety 20090501
Title: Low frequency oscillometry parameters in COPD patients are less variable during inspiration than during expiration.
Journal: Respiratory physiology & neurobiology 20090430
Title: Relationship between improved airflow limitation and changes in airway calibre induced by inhaled anticholinergic agents in COPD.
Journal: Thorax 20090401
Title: Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD.
Journal: The European respiratory journal 20090401
Title: Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD.
Journal: Respiratory medicine 20090401
Title: Biochemical properties, pharmacokinetics and pharmacological response of tiotropium in chronic obstructive pulmonary disease patients.
Journal: Expert opinion on drug metabolism & toxicology 20090401
Title: Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.
Journal: JAMA 20090325
Title: Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.
Journal: JAMA 20090325
Title: Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.
Journal: JAMA 20090325
Title: Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease.
Journal: JAMA 20090325
Title: Changes in lung function and health status in patients with COPD treated with tiotropium or salmeterol plus fluticasone.
Journal: Respirology (Carlton, Vic.) 20090301
Title: Interventions to reduce the frequency of exacerbations of chronic obstructive pulmonary disease.
Journal: Postgraduate medical journal 20090301
Title: After UPLIFT: smoking cessation remains the best intervention in smokers with COPD.
Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20090201
Title: TORCH and UPLIFT: what has been learned from the COPD 'mega-trials'?
Journal: COPD 20090201
Title: Formoterol and tiotropium compared with tiotropium alone for treatment of COPD.
Journal: COPD 20090201
Title: Tiotropium in chronic obstructive pulmonary disease.
Journal: The New England journal of medicine 20090108
Title: Tiotropium in chronic obstructive pulmonary disease.
Journal: The New England journal of medicine 20090108
Title: Tiotropium in chronic obstructive pulmonary disease.
Journal: The New England journal of medicine 20090108
Title: Tiotropium in chronic obstructive pulmonary disease.
Journal: The New England journal of medicine 20090108
Title: Tiotropium in chronic obstructive pulmonary disease.
Journal: The New England journal of medicine 20090108
Title: The efficacy of tiotropium administered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.
Journal: Respiratory medicine 20090101
Title: The INSPIRE trial results: are they truly breathtaking?
Journal: American journal of respiratory and critical care medicine 20090101
Title: The effect of tiotropium therapy on markers of elastin degradation in COPD.
Journal: Respiratory research 20090101
Title: [The UPLIFT study (Understanding Potential Long-term Impacts on Function with Tiotropium)].
Journal: Revue medicale de Liege 20090101
Title: Validity, reliability, and responsiveness of a new short Visual Simplified Respiratory Questionnaire (VSRQ) for health-related quality of life assessment in chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20090101
Title: Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations.
Journal: International journal of chronic obstructive pulmonary disease 20090101
Title: [Thiotropium in bronchial asthma].
Journal: Terapevticheskii arkhiv 20090101
Title: Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT studies.
Journal: International journal of chronic obstructive pulmonary disease 20090101
Title: The efficacy of tiotropium as a steroid-sparing agent in severe asthma.
Journal: Canadian respiratory journal 20090101
Title: Impact of frequency of COPD exacerbations on pulmonary function, health status and clinical outcomes.
Journal: International journal of chronic obstructive pulmonary disease 20090101
Title: Healthcare costs associated with initial maintenance therapy with fluticasone propionate 250 μg/salmeterol 50 μg combination versus anticholinergic bronchodilators in elderly US Medicare-eligible beneficiaries with COPD.
Journal: Journal of medical economics 20090101
Title: Sequential comparison of tiotropium to high-dose ipratropium in patients with chronic obstructive pulmonary disease in a practice setting.
Journal: International journal of chronic obstructive pulmonary disease 20090101
Title: Tiotropium HandiHaler in the treatment of COPD: a safety review.
Journal: International journal of chronic obstructive pulmonary disease 20090101
Title: [Early diagnosis, Uplift and COPD in stage II].
Journal: Pneumologia (Bucharest, Romania) 20090101
Title: Rational timing of combination therapy with tiotropium and formoterol in moderate and severe COPD.
Journal: Respiratory medicine 20081201
Title: Uplifting times for COPD.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20081201
Title: Tiotropium does not affect lower urinary tract functions in COPD patients with benign prostatic hyperplasia.
Journal: Pulmonary pharmacology & therapeutics 20081201
Title: The role of tiotropium in the hospital management of exacerbation of chronic obstructive pulmonary disease.
Journal: Respiratory care 20081201
Title: Incorporating tiotropium into a respiratory therapist-directed bronchodilator protocol for managing in-patients with COPD exacerbations decreases bronchodilator costs.
Journal: Respiratory care 20081201
Title: New COPD medications seem okay for the heart.
Journal: Harvard heart letter : from Harvard Medical School 20081201
Title: Safety, tolerability and risk benefit analysis of tiotropium in COPD.
Journal: International journal of chronic obstructive pulmonary disease 20081201
Title: Tiotropium and exercise training in COPD patients: effects on dyspnea and exercise tolerance.
Journal: International journal of chronic obstructive pulmonary disease 20081201
Title: Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro.
Journal: International journal of chronic obstructive pulmonary disease 20081201
Title: Expected value of perfect information: an empirical example of reducing decision uncertainty by conducting additional research.
Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20081201
Title: Cost effectiveness of therapy with combinations of long acting bronchodilators and inhaled steroids for treatment of COPD.
Journal: Thorax 20081101
Title: Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study.
Journal: Respiratory medicine 20081101
Title: [Combination of inhaled salmeterol/fluticasone and tiotropium in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20081101
Title: A 4-year trial of tiotropium in chronic obstructive pulmonary disease.
Journal: The New England journal of medicine 20081009
Title: COPD and declining FEV1--time to divide and conquer?
Journal: The New England journal of medicine 20081009
Title: Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.
Journal: JAMA 20080924
Title: Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20080901
Title: The INSPIRE study: influence of prior use and discontinuation of inhaled corticosteroids.
Journal: American journal of respiratory and critical care medicine 20080901
Title: Pharmacokinetics and tolerability (Study 1) with particular reference to ocular safety (Study 2) of tiotropium Respimat soft mist inhaler: findings from two dose-ranging studies in healthy men.
Journal: International journal of chronic obstructive pulmonary disease 20080901
Title: Comparison of a combination of tiotropium plus formoterol to salmeterol plus fluticasone in moderate COPD.
Journal: Chest 20080801
Title: Inhaled steroids and COPD.
Journal: The European respiratory journal 20080801
Title: Survival with tiotropium compared to long-acting Beta-2-agonists in Chronic Obstructive Pulmonary Disease.
Journal: COPD 20080801
Title: Responses to tiotropium in African-American and Caucasian patients with chronic obstructive pulmonary disease.
Journal: Translational research : the journal of laboratory and clinical medicine 20080801
Title: Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis.
Journal: Clinical therapeutics 20080801
Title: Superiority of 'triple' therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD.
Journal: Thorax 20080701
Title: A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison.
Journal: Respiratory medicine 20080701
Title: Treatment step down should be avoided at entry in COPD therapeutic trials.
Journal: American journal of respiratory and critical care medicine 20080701
Title: Is salmeterol/fluticasone propionate equivalent to tiotropium bromide in the treatment of COPD?
Journal: American journal of respiratory and critical care medicine 20080701
Title: Management of patients with COPD: a comparison of the INSPIRE and TORCH studies.
Journal: American journal of respiratory and critical care medicine 20080701
Title: Tiotropium and salmeterol/fluticasone combination do not cause oxygen desaturation in COPD.
Journal: Respiratory medicine 20080601
Title: Comparison of tiotropium bromide and combined ipratropium/salbutamol for the treatment of COPD: a UK General Practice Research Database 12-month follow-up study.
Journal: Primary care respiratory journal : journal of the General Practice Airways Group 20080601
Title: Confirmed beta16 Arg/Arg polymorphism in a patient with uncontrolled asthma.
Journal: The Annals of pharmacotherapy 20080601
Title: Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype.
Journal: The European respiratory journal 20080601
Title: Isocapnic cold air challenge in patients with COPD: are there any predisposing factors?
Journal: COPD 20080601
Title: Comparison of the protective effect amongst anticholinergic drugs on methacholine-induced bronchoconstriction in asthma.
Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20080601
Title: Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD.
Journal: International journal of chronic obstructive pulmonary disease 20080601
Title: [Treatment of mild chronic obstructive pulmonary disease].
Journal: Medicina clinica 20080510
Title: Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD.
Journal: Respirology (Carlton, Vic.) 20080501
Title: Does tiotropium reduce hospitalizations in chronic obstructive pulmonary disease?
Journal: Annals of internal medicine 20080415
Title: Frequent mistakes in equivalence studies of generic inhalation products.
Journal: Respiratory medicine 20080401
Title: Bronchodilator responsiveness in patients with COPD.
Journal: The European respiratory journal 20080401
Title: Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trial.
Journal: Respiratory medicine 20080401
Title: Sleep-predominant lowering of ambulatory blood pressure by bedtime inhalation of a novel muscarinic M3 receptor antagonist: a new 'bronchoantihypertensive' strategy targeting the lung in hypertension with chronic obstructive pulmonary disease.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080401
Title: Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.
Journal: European journal of pharmacology 20080317
Title: Tiotropium; more knowledge leads to more questions.
Journal: International journal of chronic obstructive pulmonary disease 20080301
Title: Impairment of small airways in COPD patients with frequent exacerbations and effects of treatment with tiotropium.
Journal: International journal of chronic obstructive pulmonary disease 20080301
Title: Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients.
Journal: International journal of chronic obstructive pulmonary disease 20080301
Title: Effect of add-on therapy of tiotropium in COPD treated with theophylline.
Journal: International journal of chronic obstructive pulmonary disease 20080301
Title: Efficacy of tiotropium inhalation powder in african-american patients with chronic obstructive pulmonary disease.
Journal: COPD 20080201
Title: Comparable spirometric efficacy of tiotropium compared with salmeterol plus fluticasone in patients with COPD: a pilot study.
Journal: Pulmonary pharmacology & therapeutics 20080101
Title: Tiotropium improves FEV1 in patients with COPD irrespective of smoking status.
Journal: Pulmonary pharmacology & therapeutics 20080101
Title: The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide.
Journal: American journal of respiratory and critical care medicine 20080101
Title: Improvements with tiotropium in COPD patients with concomitant asthma.
Journal: Respiratory medicine 20080101
Title: A randomized study of tiotropium Respimat Soft Mist inhaler vs. ipratropium pMDI in COPD.
Journal: Respiratory medicine 20080101
Title: Using cost-effectiveness analysis to sharpen formulary decision-making: the example of tiotropium at the Veterans Affairs health care system.
Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101
Title: Estimating effects from randomized trials with discontinuations: the need for intent-to-treat design and G-estimation.
Journal: Clinical trials (London, England) 20080101
Title: Tiotropium ameliorates symptoms in patients with chronic airway mucus hypersecretion which is resistant to macrolide therapy.
Journal: Internal medicine (Tokyo, Japan) 20080101
Title: [Impact of new therapeutic products for the treatment of chronic obstructive pulmonary disease and asthma in primary care in Madrid between 1996 and 2005].
Journal: Gaceta sanitaria 20080101
Title: [Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].
Journal: Terapevticheskii arkhiv 20080101
Title: [Tiotropium: new about known].
Journal: Terapevticheskii arkhiv 20080101
Title: Sensitive HPLC-ESI-MS method for the determination of tiotropium in human plasma.
Journal: Journal of chromatographic science 20080101
Title: Short term effect of a single dose of formoterol or tiotropium on the isolated nocturnal hypoxemia in stable COPD patients: a double blind randomized study.
Journal: European review for medical and pharmacological sciences 20080101
Title: Tiotropium bromide attenuates respiratory syncytial virus replication in epithelial cells.
Journal: Respiration; international review of thoracic diseases 20080101
Title: Effect of tiotropium on cough reflex sensitivity in acute viral cough.
Journal: Lung 20080101
Title: [Effect of tiotropium bromide on exercise tolerance in patients with chronic obstructive pulmonary disease].
Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20080101
Title: Socioeconomic gradients in tiotropium use among adults with COPD.
Journal: International journal of chronic obstructive pulmonary disease 20080101
Title: [The UPLIFT study: future perspectives].
Journal: Archivos de bronconeumologia 20080101
Title: Tiotropium administered by a pressurized metered dose inhaler (pMDI) and spacer produces a similar bronchodilator response as that administered by a Rotahaler in adult subjects with stable moderate-to-severe COPD.
Journal: Respiratory medicine 20071201
Title: A dose-ranging study of tiotropium delivered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.
Journal: International journal of chronic obstructive pulmonary disease 20071201
Title: Small airways ventilation heterogeneity and hyperinflation in COPD: response to tiotropium bromide.
Journal: International journal of chronic obstructive pulmonary disease 20071201
Title: [Long-acting bronchodilator agents are the choice in COPD. Keeping the airways open continuously].
Journal: MMW Fortschritte der Medizin 20071122
Title: Premature discontinuation of patients: a potential bias in COPD clinical trials.
Journal: The European respiratory journal 20071101
Title: Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro.
Journal: Respiratory medicine 20071101
Title: Effects of short-acting bronchodilators added to maintenance tiotropium therapy.
Journal: Chest 20071101
Title: A patient with vanishing lung syndrome and remarkable tolerance to high altitude.
Journal: Medicine and science in sports and exercise 20071101
Title: Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison.
Journal: The European respiratory journal 20071001
Title: Lung deposition of radiolabeled tiotropium in healthy subjects and patients with chronic obstructive pulmonary disease.
Journal: Journal of clinical pharmacology 20071001
Title: The value of early diagnosis for effective management of chronic obstructive pulmonary disease.
Journal: The Journal of family practice 20071001
Title: [Calculation of morbidity, use of resources and costs of patients treated with tiotropium bromide for COPD in a Spanish population].
Journal: Atencion primaria 20071001
Title: The combination of tiotropium and budesonide in the treatment of chronic obstructive pulmonary disease.
Journal: Journal of Korean medical science 20071001
Title: The effect of tiotropium on the pulmonary diffusing capacity.
Journal: Methods and findings in experimental and clinical pharmacology 20071001
Title: [New COPD guideline. Physical training pays].
Journal: MMW Fortschritte der Medizin 20070906
Title: Effect of tiotropium bromide on the cardiovascular response to exercise in COPD.
Journal: Respiratory medicine 20070901
Title: Effect of tiotropium on sputum and serum inflammatory markers and exacerbations in COPD.
Journal: The European respiratory journal 20070901
Title: Investigating new standards for prophylaxis in reduction of exacerbations--the INSPIRE study methodology.
Journal: COPD 20070901
Title: Eppur si muove, or COPD treatment success and inflammation.
Journal: The European respiratory journal 20070901
Title: Tiotropium is less likely to induce oxygen desaturation in stable COPD patients compared to long-acting beta2-agonists.
Journal: Respiratory medicine 20070801
Title: Cross-reaction allergic pancreatitis with ketoprofen and flurbiprofen.
Journal: Pancreas 20070801
Title: Enhanced persistence with tiotropium compared with other respiratory drugs in COPD.
Journal: Respiratory medicine 20070701
Title: A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotropium in severe persistent asthma.
Journal: Respiratory medicine 20070601
Title: Modelling the 5-year cost effectiveness of tiotropium, salmeterol and ipratropium for the treatment of chronic obstructive pulmonary disease in Spain.
Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20070601
Title: Effects of tiotropium or combined therapy with salmeterol on hyperinflation in COPD.
Journal: Osaka city medical journal 20070601
Title: Role of tiotropium in the treatment of COPD.
Journal: International journal of chronic obstructive pulmonary disease 20070601
Title: Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids.
Journal: International journal of chronic obstructive pulmonary disease 20070601
Title: Which bronchodilator in COPD?
Journal: International journal of chronic obstructive pulmonary disease 20070601
Title: Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide.
Journal: Life sciences 20070530
Title: The additive effect of theophylline on a combination of formoterol and tiotropium in stable COPD: a pilot study.
Journal: Respiratory medicine 20070501
Title: Oral aphthous-like ulceration due to tiotropium bromide.
Journal: Medicina oral, patologia oral y cirugia bucal 20070501
Title: Influence of tiotropium on symptoms of chronic obstructive pulmonary disease in a patient with chronic heart failure.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20070501
Title: Cost-effectiveness of long-acting bronchodilators for chronic obstructive pulmonary disease.
Journal: Mayo Clinic proceedings 20070501
Title: Summaries for patients. Combination inhaler therapy for chronic obstructive pulmonary disease.
Journal: Annals of internal medicine 20070417
Title: Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.
Journal: Annals of internal medicine 20070417
Title: Effects of replacing oxitropium with tiotropium on pulmonary function in patients with COPD: a randomized study.
Journal: Respiratory medicine 20070301
Title: Combination inhaled bronchodilator therapy in the management of chronic obstructive pulmonary disease.
Journal: Pharmacotherapy 20070301
Title: Tiotropium and simplified detection of dynamic hyperinflation.
Journal: Chest 20070301
Title: The development of anticholinergics in the management of COPD.
Journal: International journal of chronic obstructive pulmonary disease 20070301
Title: Interfaces to connect the HandiHaler and Aerolizer powder inhalers to a tracheostomy tube.
Journal: Respiratory care 20070201
Title: [Successful lobectomy in 3 lung cancer cases with severe COPD after treatment with tiotropium bromide].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070201
Title: Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: Tiotropium for the treatment of stable chronic obstructive pulmonary disease: a systematic review with meta-analysis.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: A pilot study to assess the effects of combining fluticasone propionate/salmeterol and tiotropium on the airflow obstruction of patients with severe-to-very severe COPD.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: Acute angle-closure glaucoma precipitated by local tiotropium absorption.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: Improvement of pulmonary function and dyspnea by tiotropium in COPD patients using a transdermal beta(2)-agonist.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: Photosensitive lichenoid eruption and inhaled tiotropium bromide.
Journal: Dermatology (Basel, Switzerland) 20070101
Title: Risk indexes for exacerbations and hospitalizations due to COPD.
Journal: Chest 20070101
Title: Treatment persistence and compliance with medications for chronic obstructive pulmonary disease.
Journal: Canadian respiratory journal 20070101
Title: Cardiovascular and respiratory hospitalizations and mortality among users of tiotropium in Denmark.
Journal: European journal of epidemiology 20070101
Title: Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high-performance liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Efficacy and safety of tiotropium in COPD patients in primary care--the SPiRiva Usual CarE (SPRUCE) study.
Journal: Respiratory research 20070101
Title: Use of tiotropium bromide for pre-operative treatment in chronic obstructive pulmonary disease patients: comparison with oxitropium bromide.
Journal: Internal medicine (Tokyo, Japan) 20070101
Title: [Tiotropium bromide (Spiriva) in stablechronic obstructive pulmonary disease].
Journal: Georgian medical news 20070101
Title: [Tiotropium--an antiinflammatory drug?].
Journal: Pneumologia (Bucharest, Romania) 20070101
Title: Comparative safety of long-acting inhaled bronchodilators: a cohort study using the UK THIN primary care database.
Journal: Drug safety 20070101
Title: A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease.
Journal: Canadian respiratory journal 20070101
Title: Tiotropium and the treatment of chronic obstructive pulmonary disease.
Journal: Canadian respiratory journal 20070101
Title: Evaluating the pharmacoeconomic effect of adding tiotropium bromide to the management of chronic obstructive pulmonary disease patients in Singapore.
Journal: Respiratory medicine 20061201
Title: Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20061201
Title: Pooled clinical trial analysis of tiotropium safety.
Journal: Chest 20061201
Title: Effect of formoterol, tiotropium, and their combination in patients with acute exacerbation of chronic obstructive pulmonary disease: a pilot study.
Journal: Respiratory medicine 20061101
Title: Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20061001
Title: Tiotropium for stable chronic obstructive pulmonary disease: A meta-analysis.
Journal: Thorax 20061001
Title: The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function.
Journal: The American journal of medicine 20061001
Title: The impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary disease.
Journal: The American journal of medicine 20061001
Title: Clinical course of chronic obstructive pulmonary disease: review of therapeutic interventions.
Journal: The American journal of medicine 20061001
Title: The role of patient-centered outcomes in the course of chronic obstructive pulmonary disease: how long-term studies contribute to our understanding.
Journal: The American journal of medicine 20061001
Title: Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages?
Journal: Chest 20061001
Title: Tiotropium in COPD patients not previously receiving maintenance respiratory medications.
Journal: Respiratory medicine 20060901
Title: Additive benefits of tiotropium in COPD patients treated with long-acting beta agonists and corticosteroids.
Journal: Respirology (Carlton, Vic.) 20060901
Title: Double-blind randomized parallel group study comparing the efficacy and safety of tiotropium and ipratropium in the treatment of COPD patients in Taiwan.
Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20060901
Title: Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor.
Journal: British journal of pharmacology 20060801
Title: Economic evaluation of tiotropium and salmeterol in the treatment of chronic obstructive pulmonary disease (COPD) in Greece.
Journal: Current medical research and opinion 20060801
Title: [Can tiotropium bromide favorably influence the course of disease?].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20060801
Title: Comparison of the acute effect of tiotropium versus a combination therapy with single inhaler budesonide/formoterol on the degree of resting pulmonary hyperinflation.
Journal: Respiratory medicine 20060701
Title: [Tiotropium, a long-acting bronchodilating agent for the treatment of COPD].
Journal: Nederlands tijdschrift voor geneeskunde 20060603
Title: Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium and ipratropium in guinea-pig and human airways.
Journal: British journal of pharmacology 20060601
Title: [Efficacy of tiotropium bromide (Spiriva) in patients with chronic-obstructive pulmonary disease (COPD) of different severities].
Journal: Pneumologie (Stuttgart, Germany) 20060601
Title: Cost reduction strategies used by elderly patients with chronic obstructive pulmonary disease to cope with a generic-only pharmacy benefit.
Journal: Journal of managed care pharmacy : JMCP 20060601
Title: [Comparison of tiotropium inhalation capsules and ipratropium metered dose inhaler in a randomized, double-blind, double-dummy, efficacy and safety study in patients with chronic obstructive pulmonary disease].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20060601
Title: Tiotropium bromide.
Journal: International journal of chronic obstructive pulmonary disease 20060601
Title: [Tiotropium].
Journal: Deutsche medizinische Wochenschrift (1946) 20060526
Title: Improving dyspnea in chronic obstructive pulmonary disease: optimal treatment strategies.
Journal: Proceedings of the American Thoracic Society 20060501
Title: What's new in clinical pharmacology and therapeutics.
Journal: WMJ : official publication of the State Medical Society of Wisconsin 20060501
Title: [A case of bronchiolitis obliterans syndrome successfully treated by Tiotropium bromide].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060501
Title: COPDX: an update of guidelines for the management of chronic obstructive pulmonary disease with a review of recent evidence.
Journal: The Medical journal of Australia 20060403
Title: Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects.
Journal: British journal of clinical pharmacology 20060401
Title: Comparative costs of tiotropium and ipratropium.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060315
Title: Anticholinergic agents in asthma and COPD.
Journal: European journal of pharmacology 20060308
Title: The effect of tiotropium on exacerbations and airflow in patients with COPD.
Journal: The European respiratory journal 20060301
Title: Is sustained pharmacologic lung volume reduction now possible in COPD?
Journal: Chest 20060301
Title: Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD.
Journal: Chest 20060301
Title: Something old, something new, something borrowed. COPD treatment today.
Journal: Advance for nurse practitioners 20060201
Title: Chronic obstructive pulmonary disease: the evidence for use of tiotropium.
Journal: British journal of hospital medicine (London, England : 2005) 20060201
Title: Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium.
Journal: Annals of internal medicine 20060117
Title: Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium.
Journal: Annals of internal medicine 20060117
Title: Effects of tiotropium and other long acting bronchodilators in chronic obstructive pulmonary disease.
Journal: Pulmonary pharmacology & therapeutics 20060101
Title: Health outcomes following treatment for 6 months with once daily tiotropium compared with twice daily salmeterol in patients with COPD.
Journal: Thorax 20060101
Title: The effect of tiotropium on hyperinflation and exercise capacity in chronic obstructive pulmonary disease.
Journal: Respiration; international review of thoracic diseases 20060101
Title: Onset and duration of action of formoterol and tiotropium in patients with moderate to severe COPD.
Journal: Respiration; international review of thoracic diseases 20060101
Title: [Tiotropium as new quality medication in the COPD management].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060101
Title: Muscarinic receptor signaling in the pathophysiology of asthma and COPD.
Journal: Respiratory research 20060101
Title: [Experience of practical use of sustained-release M-cholinolytic agent thiotropium bromide (Spiriva) in patients with chronic obstructive lung disease].
Journal: Problemy tuberkuleza i boleznei legkikh 20060101
Title: Single dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary disease.
Journal: Lung 20060101
Title: [Spiriva (thiotropium bromide)--an effective drug for chronic obstructive pulmonary disease].
Journal: Terapevticheskii arkhiv 20060101
Title: Absence of electrocardiographic findings and improved function with once-daily tiotropium in patients with chronic obstructive pulmonary disease.
Journal: Pharmacotherapy 20051201
Title: Does pulmonary rehabilitation give additional benefit over tiotropium therapy in primary care management of chronic obstructive pulmonary disease? Randomized controlled clinical trial in Hong Kong Chinese.
Journal: Journal of clinical pharmacy and therapeutics 20051201
Title: Tiotropium effective in treatment of COPD.
Journal: American family physician 20051201
Title: [Economic value of tiotropium in the treatment of chronic obstructive pulmonary disease].
Journal: Praxis 20051116
Title: PHARMAC responds on long-acting inhalers for COPD.
Journal: The New Zealand medical journal 20051111
Title: [Bronchodilators reduce air-trapping in COPD patients].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20051015
Title: [Laudatio. On the presentation of the 2005 Robert Koch Award to the drug tiotropium bromide (spiriva)].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20051015
Title: [Gratitude].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20051015
Title: Long-acting inhaled bronchodilators for COPD--lack of logic continues.
Journal: The New Zealand medical journal 20050916
Title: Summaries for patients. Tiotropium and the treatment of chronic obstructive lung disease.
Journal: Annals of internal medicine 20050906
Title: Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial.
Journal: Annals of internal medicine 20050906
Title: Therapeutic gains of prolonged bronchial dilatation in chronic obstructive pulmonary disease.
Journal: Annals of internal medicine 20050906
Title: Tiotropium: a bronchodilator for chronic obstructive pulmonary disease.
Journal: The Annals of pharmacotherapy 20050901
Title: Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD.
Journal: Chest 20050901
Title: [Tiotropium: a new therapeutic option in chronic obstructive pulmonary disease].
Journal: Revue medicale suisse 20050824
Title: Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD.
Journal: The European respiratory journal 20050801
Title: Inhalation route inducing subacute cutaneous lupus erythematosus with tiotropium.
Journal: Archives of dermatology 20050701
Title: Tiotropium: an inhaled anticholinergic for chronic obstructive pulmonary disease.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050615
Title: Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling.
Journal: American journal of respiratory and critical care medicine 20050515
Title: [Therapy of COPD. Reducing air trapping in the lung--improving physical capacity].
Journal: MMW Fortschritte der Medizin 20050512
Title: [2005 Robert Koch Award for tiotropium. Quality leap in therapy of COPD].
Journal: MMW Fortschritte der Medizin 20050512
Title: Bronchodilator response to formoterol after regular tiotropium or to tiotropium after regular formoterol in COPD patients.
Journal: Respiratory medicine 20050501
Title: [Cost-effectiveness analysis of tiotropium compared to ipratropium and salmeterol].
Journal: Archivos de bronconeumologia 20050501
Title: [Pharmacological and clinical profile of tiotropium bromide (Spiriva), a new long-acting anticholinergic bronchodilator for COPD treatment].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20050501
Title: Managing chronic diseases: combination of inhaler treatment in India has shown good results.
Journal: BMJ (Clinical research ed.) 20050423
Title: Inhaled tiotropium for stable chronic obstructive pulmonary disease.
Journal: The Cochrane database of systematic reviews 20050418
Title: [New Development in inhalation therapy for COPD].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050410
Title: [Postoperative intestinal paralysis caused by the muscarinic receptor blocker tiotropium bromide].
Journal: Der Urologe. Ausg. A 20050401
Title: Tiotropium bromide: a new long-acting bronchodilator for the treatment of chronic obstructive pulmonary disease.
Journal: Clinical therapeutics 20050401
Title: Is a long-acting inhaled bronchodilator the first agent to use in stable chronic obstructive pulmonary disease?
Journal: Current opinion in pulmonary medicine 20050301
Title: Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD.
Journal: Chest 20050301
Title: [Bronchodilator efficacy of combined salmeterol and tiotropium in patients with chronic obstructive pulmonary disease].
Journal: Archivos de bronconeumologia 20050301
Title: Spending decisions for tobacco-related disease treatment and tobacco control: an example and a solution.
Journal: The New Zealand medical journal 20050225
Title: 2004 drug approval highlights: FDA update.
Journal: The Nurse practitioner 20050201
Title: [Effectiveness of treatment with tiotropium in patients who suffer from COPD].
Journal: Medicina clinica 20050115
Title: One-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium.
Journal: Pulmonary pharmacology & therapeutics 20050101
Title: Probabilistic Markov model to assess the cost-effectiveness of bronchodilator therapy in COPD patients in different countries.
Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20050101
Title: The role of tiotropium bromide, a long-acting anticholinergic bronchodilator, in the management of COPD.
Journal: Treatments in respiratory medicine 20050101
Title: [Comparative efficacy of choline antagonists in chronic obstructive lung disease].
Journal: Problemy tuberkuleza i boleznei legkikh 20050101
Title: [Air trapping in COPD].
Journal: Krankenpflege Journal 20050101
Title: Improved daytime spirometric efficacy of tiotropium compared with salmeterol in patients with COPD.
Journal: Pulmonary pharmacology & therapeutics 20050101
Title: An acute bronchodilator test with tiotropium or salmeterol does not allow a subdivision of patients according to responses.
Journal: Respiration; international review of thoracic diseases 20050101
Title: [Long-acting m-cholinolytic thiotropium bromide (spiriva) in therapy of patients with chronic obstructive pulmonary disease (stage 3)].
Journal: Terapevticheskii arkhiv 20050101
Title: The role of anticholinergics in chronic obstructive pulmonary disease.
Journal: The American journal of medicine 20041220
Title: Lung function improvements with once-daily tiotropium in chronic obstructive pulmonary disease.
Journal: The American journal of medicine 20041220
Title: The functional impact of adding salmeterol and tiotropium in patients with stable COPD.
Journal: Respiratory medicine 20041201
Title: Tiotropium bromide.
Journal: Chest 20041201
Title: [Spiriva].
Journal: Revue medicale de Liege 20040901
Title: Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease.
Journal: Expert opinion on pharmacotherapy 20040801
Title: Tiotropium bromide.
Journal: Nature reviews. Drug discovery 20040801
Title: Tiotropium (Spiriva) for COPD.
Journal: American family physician 20040615
Title: Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD.
Journal: The European respiratory journal 20040601
Title: Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD.
Journal: The European respiratory journal 20040601
Title: Tiotropium (Spiriva) for COPD.
Journal: The Medical letter on drugs and therapeutics 20040524
Title: The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD.
Journal: Chest 20040501
Title: [Tiotropium as a controller of bronchoconstriction].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20040501
Title: Management of chronic obstructive pulmonary disease.
Journal: JAMA 20040303
Title: [Other forms of bronchodilation].
Journal: Archivos de bronconeumologia 20040301
Title: Pharmacokinetics of intravenous, single-dose tiotropium in subjects with different degrees of renal impairment.
Journal: Journal of clinical pharmacology 20040201
Title: One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease.
Journal: The European respiratory journal 20040201
Title: The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD.
Journal: Pulmonary pharmacology & therapeutics 20040101
Title: The role of long-acting bronchodilators in the management of stable COPD.
Journal: Chest 20040101
Title: [Tiotropium bromide: the role in the treatment of chronic obstructive pulmonary diseases].
Journal: Terapevticheskii arkhiv 20040101
Title: Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD).
Journal: PharmacoEconomics 20040101
Title: Tiotropium: a new, long-acting agent for the management of COPD--a clinical review.
Journal: Director (Cincinnati, Ohio) 20040101
Title: Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD.
Journal: Treatments in respiratory medicine 20040101
Title: The Canadian Optimal Therapy of COPD Trial: design, organization and patient recruitment.
Journal: Canadian respiratory journal 20040101
Title: Early protective effects of tiotropium bromide in patients with airways hyperresponsiveness.
Journal: European review for medical and pharmacological sciences 20040101
Title: [Tiotropium--the 'surgical' drug].
Journal: Pneumologia (Bucharest, Romania) 20040101
Title: Eletrocardiographic monitoring in COPD patients receiving tiotropium.
Journal: COPD 20040101
Title: Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial.
Journal: COPD 20040101
Title: Tiotropium bromide: a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease.
Journal: International journal of clinical practice 20031201
Title: Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes.
Journal: Chest 20031101
Title: [No medication for COPD patients who do not stop smoking? 'Fat diabetics are treated, too'].
Journal: MMW Fortschritte der Medizin 20031030
Title: [Early detection of COPD and erectile dysfunction. Here your communication talent is needed].
Journal: MMW Fortschritte der Medizin 20031016
Title: Effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease.
Journal: Thorax 20031001
Title: Assessment of patient performance of the HandiHaler compared with the metered dose inhaler four weeks after instruction.
Journal: Respiratory medicine 20031001
Title: Pharmacologic treatment of chronic obstructive pulmonary disease: past, present, and future.
Journal: Pharmacotherapy 20031001
Title: [Tiotropium (Spiriva) - a long-acting inhaled anticholinergic for the treatment of chronic obstructive pulmonary disease (COPD)].
Journal: Pneumologie (Stuttgart, Germany) 20030901
Title: Tolerance to bronchodilating effects of salmeterol in COPD.
Journal: Respiratory medicine 20030901
Title: Long-acting beta 2-adrenoceptor agonists or tiotropium bromide for patients with COPD: is combination therapy justified?
Journal: Current opinion in pharmacology 20030601
Title: [Tiotropium. A new anti-cholinergic agent for treatment of chronic obstructive pulmonary disease].
Journal: Ugeskrift for laeger 20030526
Title: [Often test the lungs of your patients! 'Each patient should know his FEV1 value'].
Journal: MMW Fortschritte der Medizin 20030508
Title: Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD.
Journal: Thorax 20030501
Title: Outcome measurements in COPD: are we schizophrenic?
Journal: Chest 20030501
Title: Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses.
Journal: Chest 20030501
Title: [Regulation of bronchial tone in chronic obstructive pulmonary disease (COPD): role of muscarinic receptors].
Journal: Anales de medicina interna (Madrid, Spain : 1984) 20030401
Title: Meaningful effect size and patterns of response of the transition dyspnea index.
Journal: Journal of clinical epidemiology 20030301
Title: Tiotropium: an inhaled, long-acting anticholinergic drug for chronic obstructive pulmonary disease.
Journal: Pharmacotherapy 20030201
Title: Minimal important difference of the transition dyspnoea index in a multinational clinical trial.
Journal: The European respiratory journal 20030201
Title: Tiotropium for chronic obstructive pulmonary disease.
Journal: Drug and therapeutics bulletin 20030201
Title: [Clinical pharmacology of thiotropium bromide].
Journal: Terapevticheskii arkhiv 20030101
Title: Methods to analyse cost data of patients who withdraw in a clinical trial setting.
Journal: PharmacoEconomics 20030101
Title: [Tiotropium].
Journal: Revista de medicina de la Universidad de Navarra 20030101
Title: [Tiotropium bromide in the treatment of chronic obstructive lung disease].
Journal: Terapevticheskii arkhiv 20030101
Title: [Milestones in inhalation therapy of airway diseases].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20021215
Title: [Clinical benefits of tiotropium, a new anticholinergic bronchodilator].
Journal: Anales de medicina interna (Madrid, Spain : 1984) 20021201
Title: [After diagnosis 11 more years remain. COPD alarm in Europe!].
Journal: MMW Fortschritte der Medizin 20021031
Title: [Dyspnea and quality of life in chronic obstructive pulmonary disease].
Journal: Archivos de bronconeumologia 20021001
Title: [Recent therapeutic strategies and new drugs].
Journal: Revue medicale de Bruxelles 20020901
Title: Tiotropium bromide: a novel once-daily anticholinergic bronchodilator for the treatment of COPD.
Journal: Drugs of today (Barcelona, Spain : 1998) 20020901
Title: A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol.
Journal: Chest 20020701
Title: [The first long-acting anticholinergic drug. COPD drug with 24-hour effect].
Journal: MMW Fortschritte der Medizin 20020627
Title: Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease.
Journal: The European respiratory journal 20020401
Title: New therapeutic drugs in the management of chronic obstructive pulmonary disease.
Journal: Current opinion in pulmonary medicine 20020301
Title: Tiotropium in the management of chronic obstructive pulmonary disease.
Journal: The European respiratory journal 20020201
Title: A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease.
Journal: The European respiratory journal 20020201
Title: Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium.
Journal: The European respiratory journal 20020201
Title: Tiotropium bromide.
Journal: Drugs 20020101
Title: Anticholinergics in the treatment of chronic obstructive pulmonary disease.
Journal: Respiration; international review of thoracic diseases 20020101
Title: [New cholinergic drugs in asthma and COPD].
Journal: Pneumonologia i alergologia polska 20020101
Title: Future treatment of chronic obstructive pulmonary disease.
Journal: Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20020101
Title: Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog.
Journal: Biopharmaceutics & drug disposition 20010701
Title: Antimuscarinic treatment for lung diseases from research to clinical practice.
Journal: Life sciences 20010427
Title: Tiotropium bromide.
Journal: Expert opinion on investigational drugs 20010401
Title: Inhaled anticholinergic therapy: applied pharmacology and interesting developments.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010101
Title: Ba 679 BR, a novel long-acting anticholinergic bronchodilator.
Journal: Life sciences 19930101
