Catalog No.:AA009C8M

1396772-26-1 | Epz005687

Name: Name:Epz005687
Brand: AABLOCKS
SKU: AA009C8M
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

1mg

98+%

in stock

$14.00 $10.00

- +

5mg

98+%

in stock

$34.00 $24.00

- +

10mg

98+%

in stock

$50.00 $35.00

- +

25mg

98+%

in stock

$84.00 $59.00

- +

Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA009C8M

Chemical Name:

Epz005687

CAS Number:

1396772-26-1

Molecular Formula:

C32H37N5O3

Molecular Weight:

539.6679

MDL Number:

MFCD25372029

SMILES:

O=C(c1cc(cc2c1cnn2C1CCCC1)c1ccc(cc1)CN1CCOCC1)NCc1c(C)cc([nH]c1=O)C

Properties

Computed Properties

Complexity:

991

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

3.7

Downstream Synthesis Route

1396779-50-2

364794-79-6

1396772-26-1

[1]Patent:WO2012/118812,2012,A2.Locationinpatent:Page/Pagecolumn314-315

771579-27-2

1396772-26-1

[1]CurrentPatentAssignee:EPIZYME,INC.-WO2012/118812,2012,A2

3-cyano-2,4-dimethyl-2-hydroxypyridine

1396772-26-1

[1]CurrentPatentAssignee:EPIZYME,INC.-WO2012/118812,2012,A2

Literature

Title: Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.

Journal: Journal of medicinal chemistry 20141126

Title: A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.

Journal: Nature chemical biology 20121101

Title: Knutson SK, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012;8(11):890-6.

Title: Tang SH, et al. Effects of H3K27 methylation inhibitor EPZ005687 on apoptosis, proliferation and cell cycle of U937 cells and normal CD34 positive cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Dec;22(6):1561-6.

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SDS