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14008-44-7,MFCD00837528
Catalog No.:AA001BY8

14008-44-7 | 4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-

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5mg
98%
1 week  
$463.00   $324.00
- +
10mg
98%
1 week  
$654.00   $458.00
- +
25mg
98%
1 week  
$1,320.00   $924.00
- +
50mg
98%
1 week  
$2,082.00   $1,458.00
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100mg
98%
1 week  
$3,384.00   $2,369.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001BY8
Chemical Name:
4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-
CAS Number:
14008-44-7
Molecular Formula:
C22H27N3O3S2
Molecular Weight:
445.5981
MDL Number:
MFCD00837528
SMILES:
NC(=O)C1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)C
Properties
Computed Properties
 
Complexity:
703  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.1  

Literature

Title: Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20111001

Title: Fragmentation pathways of metopimazine and its metabolite using ESI-MS(n), HR-MS and H/D exchange.

Journal: Journal of mass spectrometry : JMS 20101001

Title: Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination.

Journal: European journal of medicinal chemistry 20100901

Title: Investigational use of metomidate hydrochloride as a shipping additive for two ornamental fishes.

Journal: Journal of aquatic animal health 20090901

Title: Effect of iontophoresis and penetration enhancers on transdermal absorption of metopimazine.

Journal: Journal of dermatological science 20081201

Title: Percutaneous absorption of metopimazine and effect of cyclodextrins.

Journal: Drug development and industrial pharmacy 20080501

Title: Optimizing antiemetic therapy in multiple-day and multiple cycles of chemotherapy.

Journal: Current opinion in supportive and palliative care 20080301

Title: [Tolerance and efficacy of mefloquine as the first line treatment of uncomplicated P. falciparum malaria in children].

Journal: Pathologie-biologie 20080201

Title: Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier.

Journal: Pharmacological research 20070701

Title: Randomized, double-blind trial comparing the antiemetic effect of tropisetron plus metopimazine with tropisetron plus placebo in patients receiving multiple cycles of multiple-day cisplatin-based chemotherapy.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20070401

Title: Differential pulse cathodic voltammetric determination of floctafenine and metopimazine.

Journal: Journal of pharmaceutical and biomedical analysis 20070312

Title: Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal.

Journal: Malaria journal 20070101

Title: Aprepitant: the evidence for its place in the prevention of chemotherapy-induced nausea and vomiting.

Journal: Core evidence 20070101

Title: A pilot study of ondansetron plus metopimazine vs. ondansetron monotherapy in children receiving highly emetogenic chemotherapy: a Bayesian randomized serial N-of-1 trials design.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060301

Title: A randomized, double-blind trial assessing the efficacy and safety of sublingual metopimazine and ondansetron in the prophylaxis of chemotherapy-induced delayed emesis.

Journal: Anti-cancer drugs 20060201

Title: Comparison of the efficacy and safety of combinations of metopimazine or ondansetron with methylprednisolone in the prevention of delayed emesis in patients receiving chemotherapy.

Journal: Current medical research and opinion 20051101

Title: Options for the prevention and management of acute chemotherapy-induced nausea and vomiting in children.

Journal: Paediatric drugs 20030101

Title: Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy.

Journal: Health and quality of life outcomes 20030101

Title: Ondansetron plus metopimazine compared with ondansetron plus metopimazine plus prednisolone as antiemetic prophylaxis in patients receiving multiple cycles of moderately emetogenic chemotherapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010401

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SDS
Tags:14008-44-7 Molecular Formula|14008-44-7 MDL|14008-44-7 SMILES|14008-44-7 4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-