+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
1401090-53-6,MFCD28502073
Catalog No.:AA001BYD

1401090-53-6 | Ibiglustat

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$108.00   $76.00
- +
25mg
≥98%
in stock  
$183.00   $128.00
- +
50mg
95%
in stock  
$331.00   $232.00
- +
100mg
98%
in stock  
$497.00   $348.00
- +
250mg
95%
in stock  
$728.00   $510.00
- +
1g
98%
in stock  
$2,172.00   $1,520.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001BYD
Chemical Name:
Ibiglustat
CAS Number:
1401090-53-6
Molecular Formula:
C20H24FN3O2S
Molecular Weight:
389.4869
MDL Number:
MFCD28502073
SMILES:
O=C(NC(c1csc(n1)c1ccc(cc1)F)(C)C)O[C@@H]1CN2CCC1CC2
Properties
Computed Properties
 
Complexity:
533  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.5  

Downstream Synthesis Route
97-67-6    1401090-53-6   
(S)-quinuclidin-3-yl(2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamatemalate 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1Locationinpatent:Page/Pagecolumn48;49

C13H11FN2OS 
 
(S)-quinuclidin-3-ol 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-US9126993,2015,B2Locationinpatent:Page/Pagecolumn92

[2]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1Locationinpatent:Page/Pagecolumn46;47

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1Locationinpatent:Page/Pagecolumn26

[4]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[5]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1Locationinpatent:Page/Pagecolumn95;96

[6]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1Locationinpatent:Page/Pagecolumn88;92-94

[7]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1Locationinpatent:Page/Pagecolumn76;80-81

[8]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1Locationinpatent:Page/Pagecolumn114-115

ethyl2-(2-(4-fluorophenyl)thiazol-4-yl)-2-methylpropanoate 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1

[2]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[4]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[5]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[6]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[7]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[8]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[9]CurrentPatentAssignee:SANOFI-US9126993,2015,B2

[10]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[11]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[12]CurrentPatentAssignee:SANOFI-US2017/334903,2017,A1

[13]CurrentPatentAssignee:SANOFI-US2017/334903,2017,A1

[14]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[15]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[16]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[17]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[18]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

[19]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

2-(2-(4-fluorophenyl)thiazol-4-yl)-2-methylpropanoicacid 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1

[2]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[4]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[5]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[6]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[7]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[8]CurrentPatentAssignee:SANOFI-US9126993,2015,B2

[9]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[10]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[11]CurrentPatentAssignee:SANOFI-US2017/334903,2017,A1

[12]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[13]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[14]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

2-(2-(4-fluorophenyl)thiazol-4-yl)-N-hydroxy-2-methylpropanamide 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1

[2]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[4]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[5]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[6]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[7]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[8]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[9]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

Literature

Title: Viel C, et al. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Sci Rep. 2021;11(1):20945. Published 2021 Oct 22.

Title: Peterschmitt MJ, et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021;10(1):86-98.

Title: Stojkovska I, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2018;373(1):51-60. doi:10.1007/s00441-017-2704-y

Title: Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 1401090-53-6
1629063-78-0

1629063-78-0
Building Blocks
More >
Historical Records
927802-96-8

927802-96-8
Tags:1401090-53-6 Molecular Formula|1401090-53-6 MDL|1401090-53-6 SMILES|1401090-53-6 Ibiglustat
Catalog No.: AA001BYD
1401090-53-6,MFCD28502073
1401090-53-6 | Ibiglustat
Pack Size： 5mg
Purity： 98%
in stock
$108.00 $76.00
Pack Size： 25mg
Purity： ≥98%
in stock
$183.00 $128.00
Pack Size： 50mg
Purity： 95%
in stock
$331.00 $232.00
Pack Size： 100mg
Purity： 98%
in stock
$497.00 $348.00
Pack Size： 250mg
Purity： 95%
in stock
$728.00 $510.00
Pack Size： 1g
Purity： 98%
in stock
$2,172.00 $1,520.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001BYD
Chemical Name: Ibiglustat
CAS Number: 1401090-53-6
Molecular Formula: C20H24FN3O2S
Molecular Weight: 389.4869
MDL Number: MFCD28502073
SMILES: O=C(NC(c1csc(n1)c1ccc(cc1)F)(C)C)O[C@@H]1CN2CCC1CC2
Properties
Complexity: 533  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.5  
Downstream Synthesis Route
97-67-6    1401090-53-6   
(S)-quinuclidin-3-yl(2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamatemalate 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1Locationinpatent:Page/Pagecolumn48;49

C13H11FN2OS 
 
(S)-quinuclidin-3-ol 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-US9126993,2015,B2Locationinpatent:Page/Pagecolumn92

[2]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1Locationinpatent:Page/Pagecolumn46;47

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1Locationinpatent:Page/Pagecolumn26

[4]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[5]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1Locationinpatent:Page/Pagecolumn95;96

[6]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1Locationinpatent:Page/Pagecolumn88;92-94

[7]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1Locationinpatent:Page/Pagecolumn76;80-81

[8]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1Locationinpatent:Page/Pagecolumn114-115

ethyl2-(2-(4-fluorophenyl)thiazol-4-yl)-2-methylpropanoate 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1

[2]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[4]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[5]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[6]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[7]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[8]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[9]CurrentPatentAssignee:SANOFI-US9126993,2015,B2

[10]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[11]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[12]CurrentPatentAssignee:SANOFI-US2017/334903,2017,A1

[13]CurrentPatentAssignee:SANOFI-US2017/334903,2017,A1

[14]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[15]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[16]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[17]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[18]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

[19]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

2-(2-(4-fluorophenyl)thiazol-4-yl)-2-methylpropanoicacid 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1

[2]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[4]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[5]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[6]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[7]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[8]CurrentPatentAssignee:SANOFI-US9126993,2015,B2

[9]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[10]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[11]CurrentPatentAssignee:SANOFI-US2017/334903,2017,A1

[12]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[13]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[14]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

2-(2-(4-fluorophenyl)thiazol-4-yl)-N-hydroxy-2-methylpropanamide 
  1401090-53-6 

[1]CurrentPatentAssignee:SANOFI-WO2014/152215,2014,A1

[2]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[3]CurrentPatentAssignee:SANOFI-WO2014/151291,2014,A1

[4]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[5]Zhao,Jin;Gimi,Rayomand;Katti,Sanjeev;Reardon,Michael;Nivorozhkin,Vitaly;Konowicz,Paul;Lee,Edward;Sole,Lynne;Green,Jerome;Siegel,CraigS.[OrganicProcessResearchandDevelopment,2015,vol.19,#5,p.576-581]

[6]CurrentPatentAssignee:SANOFI-WO2016/145046,2016,A1

[7]CurrentPatentAssignee:SANOFI-WO2020/163337,2020,A1

[8]CurrentPatentAssignee:SANOFI-WO2020/163244,2020,A1

[9]CurrentPatentAssignee:SANOFI-WO2021/156769,2021,A1

Related Products of of 1401090-53-6
1629063-78-0
1629063-78-0
Building Blocks More >
140480-96-2
140480-96-2
1-[(4-Methoxyphenyl)methyl]pyrrole-2,5-dione
AA001CG6 | MFCD00113970
1408074-64-5
1408074-64-5
Methyl 5-bromo-7-azaindole-6-carboxylate
AA001CQD | MFCD21606695
1454843-77-6
1454843-77-6
5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid
AA001D0Q | MFCD24390705
1458-16-8
1458-16-8
Methyl 3-amino-6-iodopyrazine-2-carboxylate
AA001DCQ | MFCD09909640
1461-96-7
1461-96-7
Cis-cyclopentane-1,2-dicarboxylic acid
AA001DMT | MFCD01311172
1464091-45-9
1464091-45-9
Methyl 4-((1-cyclobutyl-4-oxo-4,5,6,7,8,9-hexahydro-3h-pyrazolo[3,4-c]quinolin-3-yl)methyl)picolinate
AA001DWS | MFCD26406740
14678-95-6
14678-95-6
5-Amino-1-(4-methoxyphenyl)-1h-pyrazole-4-carboxylic acid
AA001E9B | MFCD00973939
147128-77-6
147128-77-6
(4R,6S)-5,6-Dihydro-4-hydroxy-6-methylthieno[2,3-b]thiopyran-7,7-dioxide
AA001EJP | MFCD11035925
1475-13-4
1475-13-4
2,4-Dichloro-alpha-methylbenzyl alcohol
AA001EVB | MFCD00004511
147782-19-2
147782-19-2
1,2-Cyclopropanedicarboxylic acid, 3-[(S)-aminocarboxymethyl]-, (1R,2R)-
AA001F4G | MFCD00673968
Historical Records
927802-96-8
927802-96-8
Submit
© 2017 AA BLOCKS, INC. All rights reserved.