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14028-44-5,MFCD00069210
Catalog No.:AA001C5F

14028-44-5 | Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-

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100mg
≥95%
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250mg
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$80.00   $56.00
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500mg
≥95%
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1g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001C5F
Chemical Name:
Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-
CAS Number:
14028-44-5
Molecular Formula:
C17H16ClN3O
Molecular Weight:
313.7814
MDL Number:
MFCD00069210
SMILES:
Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1
NSC Number:
759559
Properties
Computed Properties
 
Complexity:
424  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.6  

Literature

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Journal: Journal of biomolecular screening 20120801

Title: New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.

Journal: Journal of medicinal chemistry 20120223

Title: Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20120125

Title: A literature review to explore the link between treatment satisfaction and adherence, compliance, and persistence.

Journal: Patient preference and adherence 20120101

Title: Inhibitory action of antidepressants on mouse Betaine/GABA transporter (BGT1) heterologously expressed in cell cultures.

Journal: International journal of molecular sciences 20120101

Title: Heart rate-corrected QT interval helps predict mortality after intentional organophosphate poisoning.

Journal: PloS one 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials.

Journal: The Journal of clinical psychiatry 20111201

Title: In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine.

Journal: Biopharmaceutics & drug disposition 20111001

Title: DPP-IV inhibitor may affect spermatogenesis.

Journal: Diabetes research and clinical practice 20110801

Title: New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors.

Journal: Chemical biology & drug design 20110701

Title: Efficacy of antidepressants for dysthymia: a meta-analysis of placebo-controlled randomized trials.

Journal: The Journal of clinical psychiatry 20110401

Title: Evaluation of the interaction between β-cyclodextrin and psychotropic drugs by surface plasmon resonance assay with a Biacore ® system.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Antidepressant use and colorectal cancer risk: a Danish population-based case-control study.

Journal: British journal of cancer 20110104

Title: Pharmacotherapy for treatment-resistant schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Selective serotonin reuptake inhibitors and gastrointestinal bleeding: a case-control study.

Journal: PloS one 20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Review of the safety, efficacy, and side effect profile of asenapine in the treatment of bipolar 1 disorder.

Journal: Patient preference and adherence 20110101

Title: Amoxapine inhibits delayed outward rectifier K(+) currents in cerebellar granule cells via dopamine receptor and protein kinase A activation.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.

Journal: PloS one 20110101

Title: Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants.

Journal: PloS one 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Determination of amoxapine and nortriptyline in blood plasma and serum by salt-assisted liquid-liquid microextraction and high-performance liquid chromatography.

Journal: Journal of separation science 20101201

Title: Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma.

Journal: Bioanalysis 20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Refractory hypotension during general anaesthesia caused by the long-term use of amoxapine.

Journal: Anaesthesia and intensive care 20100901

Title: Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100501

Title: Syndrome of inappropriate secretion of anti-diuretic hormone in an elderly depressive patient receiving paroxetine: a case report.

Journal: International journal of geriatric psychiatry 20100401

Title: Seizure risk associated with neuroactive drugs: data from the WHO adverse drug reactions database.

Journal: Seizure 20100301

Title: A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20100223

Title: Amoxapine inhibits the delayed rectifier outward K+ current in mouse cortical neurons via cAMP/protein kinase A pathways.

Journal: The Journal of pharmacology and experimental therapeutics 20100201

Title: Evaluation and performance of desorption electrospray ionization using a triple quadrupole mass spectrometer for quantitation of pharmaceuticals in plasma.

Journal: Rapid communications in mass spectrometry : RCM 20100201

Title: Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect.

Journal: Journal of pharmaceutical sciences 20100101

Title: Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data.

Journal: BMC bioinformatics 20100101

Title: Tricyclic antidepressants and headaches: systematic review and meta-analysis.

Journal: BMJ (Clinical research ed.) 20100101

Title: Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray.

Journal: BMC neuroscience 20100101

Title: A new strategy for antidepressant prescription.

Journal: Frontiers in neuroscience 20100101

Title: Hallucinations: Clinical aspects and management.

Journal: Industrial psychiatry journal 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Accuracy of Veterans Affairs databases for diagnoses of chronic diseases.

Journal: Preventing chronic disease 20091001

Title: 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.

Journal: Journal of clinical medicine research 20090601

Title: Persistence and compliance to antidepressant treatment in patients with depression: a chart review.

Journal: BMC psychiatry 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

Journal: PloS one 20090101

Title: Amoxapine-induced tardive dyskinesia.

Journal: Indian journal of psychiatry 20090101

Title: Depression following thrombotic cardiovascular events in elderly medicare beneficiaries: risk of morbidity and mortality.

Journal: Cardiology research and practice 20090101

Title: Suicidal antidepressant overdoses: a comparative analysis by antidepressant type.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20081201

Title: Functional expression of the glycine transporter 1 on bullfrog retinal cones.

Journal: Neuroreport 20081119

Title: Effectiveness of a multifactorial cardiovascular risk reduction clinic for diabetes patients with depression.

Journal: Preventing chronic disease 20081001

Title: Effects of different antidepressant treatments on the core of depression.

Journal: Dialogues in clinical neuroscience 20080901

Title: Determination of tricyclic antidepressants in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry.

Journal: Journal of separation science 20080701

Title: An autopsy case of poisoning with ethanol and psychotropic drugs.

Journal: Soudni lekarstvi 20080401

Title: Amoxapine-associated acute respiratory distress.

Journal: Respirology (Carlton, Vic.) 20080101

Title: Amoxapine as an antipsychotic: comparative study versus haloperidol.

Journal: Journal of clinical psychopharmacology 20071201

Title: Detection and treatment of akathisia in advanced cancer patients during adjuvant analgesic therapy with tricyclic antidepressants: case reports and review of the literature.

Journal: Palliative & supportive care 20071201

Title: Pharmacological causes of hyperprolactinemia.

Journal: Therapeutics and clinical risk management 20071001

Title: Prevalence and predictors of antidepressant use in a cohort of pregnant women.

Journal: BJOG : an international journal of obstetrics and gynaecology 20070901

Title: Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood.

Journal: Journal of analytical toxicology 20070501

Title: A fatal case of amoxapine poisoning under the influence of chronic use of psychotropic drugs.

Journal: Legal medicine (Tokyo, Japan) 20070301

Title: Differential distribution of glycine transporters in Müller cells and neurons in amphibian retinas.

Journal: Visual neuroscience 20070101

Title: Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis.

Journal: Orphanet journal of rare diseases 20070101

Title: Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method.

Journal: Forensic science international 20061016

Title: [Case of amoxapine-induced refractory status epilepticus which was successfully treated with propofol].

Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20061001

Title: Pharmacological properties of glycine uptake in the developing rat retina.

Journal: Neurochemistry international 20060901

Title: [Treatment for irritable bowel syndrome--psychotropic drugs, antidepressants and so on].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060801

Title: Novel two-stage screening procedure leads to the identification of a new class of transfection enhancers.

Journal: The journal of gene medicine 20060601

Title: Risperidone in the treatment of psychotic depression.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060601

Title: Treatments in depression.

Journal: Dialogues in clinical neuroscience 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Use of antidepressant medications in relation to the incidence of breast cancer.

Journal: British journal of cancer 20060410

Title: Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection.

Journal: Biomedical chromatography : BMC 20060201

Title: A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum.

Journal: Therapeutic drug monitoring 20060201

Title: Amoxapine as an atypical antipsychotic: a comparative study vs risperidone.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20051201

Title: Submissive behavior in mice as a test for antidepressant drug activity.

Journal: Pharmacology, biochemistry, and behavior 20051001

Title: The pharmacological management of depression.

Journal: Dialogues in clinical neuroscience 20050901

Title: Facilitation of spontaneous glutamate release by antidepressant drugs in rat locus coeruleus.

Journal: Neuroscience letters 20050210

Title: Remarkable effect of selegiline (L-deprenyl), a selective monoamine oxidase type-B inhibitor, in a patient with severe refractory depression: a case report.

Journal: Clinical neuropharmacology 20050101

Title: Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices.

Journal: The Journal of physiology 20041101

Title: Intrathecal tri-cyclic antidepressants produce spinal anesthesia.

Journal: Pain 20041101

Title: Risk of fetal exposure to tricyclic antidepressants.

Journal: Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20041001

Title: A novel physiological mechanism of glycine-induced immunomodulation: Na+-coupled amino acid transporter currents in cultured brain macrophages.

Journal: The Journal of physiology 20040815

Title: Amoxapine in schizophrenia: a negative double-blind controlled trial.

Journal: Journal of clinical psychopharmacology 20040801

Title: Possible serotonin syndrome arising from an interaction between caffeine and serotonergic antidepressants.

Journal: Human psychopharmacology 20040701

Title: Photo-distributed neutrophilic drug eruption and adult respiratory distress syndrome associated with antidepressant therapy.

Journal: Journal of cutaneous pathology 20040201

Title: Pharmacological properties of glycine transport in the frog retina.

Journal: Neurochemical research 20040101

Title: Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns.

Journal: BMC psychiatry 20040101

Title: Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction.

Journal: Drug safety 20040101

Title: Biological pathophysiology of mood disorders special reference to the neurotransmitter receptors.

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20040101

Title: Effects of some antidepressant drugs on tryptaminergic responses of the rat jejunum.

Journal: Pharmacology 20031001

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Amoxapine treatment of interfering behaviors in autistic disorder.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry 20030501

Title: New approaches to augment fungal biotransformation.

Journal: Journal of industrial microbiology & biotechnology 20030501

Title: Challenges in the treatment of depression with psychotic features.

Journal: Biological psychiatry 20030415

Title: Amoxapine shows atypical antipsychotic effects in patients with schizophrenia: results from a prospective open-label study.

Journal: Schizophrenia research 20030101

Title: [Case of prolonged recovery from serotonin syndrome caused by paroxetine].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20030101

Title: [Depression and epilepsy].

Journal: Revista de neurologia 20020901

Title: Painful ejaculation and urinary hesitancy in association with antidepressant therapy: relief with tamsulosin.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Depressive disorders preceding temporal lobe epilepsy.

Journal: Epilepsy research 20020401

Title: The role of substance P in depression: therapeutic implications.

Journal: Dialogues in clinical neuroscience 20020301

Title: The clinical pharmacology of depressive states.

Journal: Dialogues in clinical neuroscience 20020301

Title: [Unexpected drug-interaction].

Journal: Rinsho byori. The Japanese journal of clinical pathology 20020201

Title: The effects of tricyclic antidepressants on breast cancer risk.

Journal: British journal of cancer 20020107

Title: Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection.

Journal: Journal of analytical toxicology 20020101

Title: [Depression in epilepsy: symptom or syndrome?].

Journal: La Clinica terapeutica 20020101

Title: Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine.

Journal: Brain research 20011227

Title: [Delusional depression].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20010801

Title: Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA.

Journal: Journal of neurochemistry 20010301

Title: Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants.

Journal: Neurochemical research 20010301

Title: Amoxapine shows an antipsychotic effect but worsens motor function in patients with Parkinson's disease and psychosis.

Journal: Clinical neuropharmacology 20010101

Title: Availability of learned helplessness test as a model of depression compared to a forced swimming test in rats.

Journal: Pharmacology 20010101

Title: Meta-analytical studies on new antidepressants.

Journal: British medical bulletin 20010101

Title: Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice.

Journal: Biopharmaceutics & drug disposition 20000501

Title: [A case of amoxapine-induced tardive dystonia successfully treated with a low dose anti-cholinergic agent].

Journal: Rinsho shinkeigaku = Clinical neurology 20000401

Title: A case of neuroleptic malignant syndrome in a patient with hemodialysis.

Journal: International journal of urology : official journal of the Japanese Urological Association 20000201

Title: Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat.

Journal: Brain research 19961111

Title: Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.

Journal: Psychopharmacology 19960801

Title: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

Journal: Journal of neurochemistry 19960101

Title: Successful treatment of amoxapine-induced refractory status epilepticus with propofol (diprivan).

Journal: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 19950201

Title: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19940301

Title: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

Journal: Molecular pharmacology 19930301

Title: [Acute cytolytic hepatitis caused by amoxapine].

Journal: Gastroenterologie clinique et biologique 19930101

Title: A comparison of the effects of single doses of amoxapine and amitriptyline on autonomic functions in healthy volunteers.

Journal: European journal of clinical pharmacology 19930101

Title: Simultaneous quantitation of loxapine, amoxapine and their 7- and 8-hydroxy metabolites in plasma by high-performance liquid chromatography.

Journal: Journal of chromatography 19910308

Title: A possible mechanism of toxicity by the antidepressant amoxapine based on its effects in three in vitro models.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 19890101

Title: Biochemical evidence that high concentrations of the antidepressant amoxapine may cause inhibition of mitochondrial electron transport.

Journal: Toxicology and applied pharmacology 19880330

Title: Acute myocardial failure following amoxapine intoxication.

Journal: Journal of clinical psychopharmacology 19880201

Title: Amoxapine-induced cognitive impairment in two patients.

Journal: The Journal of clinical psychiatry 19870401

Title: Amoxapine-induced extrapyramidal effects.

Journal: Psychosomatics 19860601

Title: Serum neuroleptic levels and extrapyramidal side effects in patients treated with amoxapine.

Journal: The Journal of clinical psychiatry 19851001

Title: Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats.

Journal: Neuropharmacology 19851001

Title: Amoxapine-associated acute renal failure.

Journal: Southern medical journal 19850601

Title: Amoxapine for the treatment of psychotically depressed subjects. A pilot study.

Journal: The Journal of nervous and mental disease 19850201

Title: Amoxapine-induced seizures: case reports.

Journal: The Journal of clinical psychiatry 19840801

Title: Case report of tardive dyskinesia and parkinsonism associated with amoxapine therapy.

Journal: The American journal of psychiatry 19840501

Title: [Parkinsonian syndrome secondary to amoxapine].

Journal: Presse medicale (Paris, France : 1983) 19840414

Title: Convulsions associated with amoxapine.

Journal: JAMA 19840203

Title: Double-blind comparison of amoxapine and imipramine in the treatment of depressed patients.

Journal: The Journal of clinical psychiatry 19840201

Title: A case of akinesia induced by amoxapine.

Journal: The American journal of psychiatry 19840201

Title: Amoxapine and extrapyramidal symptoms.

Journal: Southern medical journal 19840101

Title: Undiagnosed dystonic reaction secondary to amoxapine.

Journal: Psychosomatics 19840101

Title: Case report of withdrawal dyskinesia associated with amoxapine.

Journal: The American journal of psychiatry 19831101

Title: Case report of withdrawal dyskinesia associated with amoxapine.

Journal: The American journal of psychiatry 19831001

Title: Amoxapine and neuroleptic side effects: a case report.

Journal: The American journal of psychiatry 19830901

Title: Psychotropic-induced ejaculatory disturbances and alpha-adrenergic antagonists.

Journal: The American journal of psychiatry 19830901

Title: Amoxapine-associated acute renal failure.

Journal: Archives of internal medicine 19830801

Title: Amoxapine-induced chorea.

Journal: Southern medical journal 19830801

Title: Akathisia induced by amoxapine.

Journal: The American journal of psychiatry 19830101

Title: Adverse reactions suggesting amoxapine-induced dopamine blockade.

Journal: The American journal of psychiatry 19821101

Title: Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants.

Journal: The American journal of psychiatry 19820901

Title: Seizures associated with amoxapine.

Journal: The American journal of psychiatry 19820601

Title: Precipitation of mania and visual hallucinations by Amoxapine Hydrochloride.

Journal: Comprehensive psychiatry 19820101

Title: Atrial flutter with amoxapine: a case report.

Journal: The American journal of psychiatry 19811101

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Tags:14028-44-5 Molecular Formula|14028-44-5 MDL|14028-44-5 SMILES|14028-44-5 Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)- |Heterocyclic_Building_Blocks