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Home Amines 1404456-53-6
1404456-53-6,MFCD28009442
Catalog No.:AA001CD7

1404456-53-6 | 2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$143.00   $100.00
- +
10mg
in stock  
$232.00   $162.00
- +
25mg
in stock  
$419.00   $293.00
- +
50mg
in stock  
$668.00   $468.00
- +
100mg
in stock  
$1,109.00   $777.00
- +
500mg
in stock  
$3,439.00   $2,407.00
- +
1000mg
in stock  
$5,464.00   $3,825.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001CD7
Chemical Name:
2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-
CAS Number:
1404456-53-6
Molecular Formula:
C23H29ClN4O2S
Molecular Weight:
461.0200
MDL Number:
MFCD28009442
SMILES:
O=C([C@@H](NC(=O)c1ccc(s1)CNc1cc(Cl)cnc1C)CC1CCCC1)NC1CC1
Properties
Computed Properties
 
Complexity:
629  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
5.2  

Downstream Synthesis Route
(S)-2-((tert-butoxycarbonyl)amino)-3-cyclopentylpropanoicacid 
  1404456-53-6 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2012/149102,2012,A1

[1]Patent:WO2012/149102,2012,A1

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2012/149102,2012,A1

1404456-63-8   
(S)-2-amino-3-cyclopentyl-N-(2-cyclopropyl)propanamidebis-hydrochloride 
  1404456-53-6 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2012/149102,2012,A1Locationinpatent:Page/Pagecolumn79;80

[1]Patent:WO2012/149102,2012,A1

Literature

Title: Gilmartin AG, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014 Mar;10(3):181-7.

Title: Esfandiari A, et al. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Mol Cancer Ther. 2016 Mar;15(3):379-91.

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Tags:1404456-53-6 Molecular Formula|1404456-53-6 MDL|1404456-53-6 SMILES|1404456-53-6 2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-