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140678-14-4,MFCD01939723
Catalog No.:AA009CG7

140678-14-4 | Mangafodipir trisodium

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1mg
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$241.00   $169.00
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5mg
99%
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$606.00   $424.00
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10mg
99%
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$924.00   $647.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CG7
Chemical Name:
Mangafodipir trisodium
CAS Number:
140678-14-4
Molecular Formula:
C22H27MnN4Na3O14P2
Molecular Weight:
757.3231
MDL Number:
MFCD01939723
SMILES:
O=C1[O-][Mn+2]2345[N](C1)(CC[N]5(CC(=O)[O-]2)Cc1c([O-]4)c(C)ncc1COP(=O)(O)O)Cc1c([O-]3)c(C)ncc1COP(=O)(O)[O-].[Na+].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
873  
Covalently-Bonded Unit Count:
8  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
13  

Literature

Title: Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers.

Journal: The British journal of radiology 20120901

Title: Preoperative detection of colorectal liver metastases in fatty liver: MDCT or MRI?

Journal: European journal of radiology 20110801

Title: Mangafodipir protects against hepatic ischemia-reperfusion injury in mice.

Journal: PloS one 20110101

Title: Magnetic resonance cholangiography with mangafodipir trisodium in Caroli's disease with pancreas involvement.

Journal: JOP : Journal of the pancreas 20100906

Title: Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways.

Journal: European journal of pharmacology 20100825

Title: In vitro neurotoxicity of magnetic resonance imaging (MRI) contrast agents: influence of the molecular structure and paramagnetic ion.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100801

Title: Toward clinical application of manganese-enhanced MRI of retinal function.

Journal: Brain research bulletin 20100215

Title: Secretin-stimulated multi-detector CT versus mangafodipir trisodium-enhanced MR imaging plus MRCP in characterization of non-metastatic solid pancreatic lesions.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20091101

Title: Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis.

Journal: Therapeutic drug monitoring 20091001

Title: Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree.

Journal: Radiographics : a review publication of the Radiological Society of North America, Inc 20091001

Title: Tumor models and specific contrast agents for small animal imaging in oncology.

Journal: Methods (San Diego, Calif.) 20090601

Title: Detection of neuroendocrine liver metastases with MnDPDP-enhanced MRI.

Journal: Neuroendocrinology 20090101

Title: Mangafodipir as a cytoprotective adjunct to chemotherapy--a case report.

Journal: Acta oncologica (Stockholm, Sweden) 20090101

Title: [Imaging of the postoperative biliary tract].

Journal: Journal de radiologie 20090101

Title: Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP.

Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20090101

Title: Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics.

Journal: Clinical radiology 20081101

Title: The use of 18F-FDG PET/CT in colorectal liver metastases--comparison with CT and liver MRI.

Journal: European journal of nuclear medicine and molecular imaging 20080701

Title: Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination.

Journal: European radiology 20080501

Title: Axon tracing in the adult rat optic nerve and tract after intravitreal injection of MnDPDP using a semiautomatic segmentation technique.

Journal: Journal of magnetic resonance imaging : JMRI 20080101

Title: [Value of MRCP with Mangafodipir Trisodium (Teslascan) injection in the diagnosis and management of bile leaks].

Journal: Journal de radiologie 20071201

Title: Mangafodipir-DPDP enhanced MRI visualization of a pancreatic adenocarcinoma previously undetected by extracellular contrast enhanced CT and MRI.

Journal: Acta bio-medica : Atenei Parmensis 20071201

Title: Manganese dipyridoxyl-diphosphate (MnDPDP) as a viability marker in patients with myocardial infarction.

Journal: Journal of magnetic resonance imaging : JMRI 20070901

Title: Re: diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.

Journal: Clinical radiology 20070801

Title: Contrast enhanced cartilage imaging: Comparison of ionic and non-ionic contrast agents.

Journal: European journal of radiology 20070701

Title: [New possibilities to study biliary tree and gallbladder: functional magnetic resonance cholangiography contrast-enhanced with mangafodipir trisodium (Mn DPDP)].

Journal: Journal de radiologie 20070401

Title: Diagnostic accuracy of rim and segmental MRI enhancement of colorectal hepatic metastasis after administration of mangafodipir trisodium.

Journal: AJR. American journal of roentgenology 20070201

Title: An apparent unidirectional influx constant for manganese as a measure of myocardial calcium channel activity.

Journal: Journal of magnetic resonance imaging : JMRI 20061101

Title: Detection of hepatic metastasis: manganese- and ferucarbotran-enhanced MR imaging.

Journal: European journal of radiology 20061001

Title: Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images.

Journal: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20060901

Title: Imaging liver metastases: review and update.

Journal: European journal of radiology 20060501

Title: Mangafodipir trisodium-enhanced MR imaging of pancreatic disease.

Journal: European radiology 20060501

Title: Mangafodipir trisodium-enhanced MRI for the detection and characterization of focal hepatic lesions: is delayed imaging useful?

Journal: Journal of magnetic resonance imaging : JMRI 20060501

Title: Diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.

Journal: Clinical radiology 20060401

Title: Comparison of mangafodipir trisodium- and ferucarbotran-enhanced MRI for detection and characterization of hepatic metastases in colorectal cancer patients.

Journal: AJR. American journal of roentgenology 20060401

Title: Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions.

Journal: World journal of gastroenterology 20060314

Title: Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity.

Journal: Journal of the National Cancer Institute 20060215

Title: Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.

Journal: Journal of the National Cancer Institute 20060215

Title: The magnetic resonance imaging contrast agent mangafodipir exerts antitumor activity via a previously described superoxide dismutase mimetic activity.

Journal: Cancer research 20060101

Title: [Mangafodipir trisodium-enhanced magnetic resonance cholangiography for detection of bile leaks].

Journal: Journal de radiologie 20060101

Title: [MR and biliary tract].

Journal: Ugeskrift for laeger 20050829

Title: Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET.

Journal: AJR. American journal of roentgenology 20050701

Title: MR cholangiography with manganese dipyridoxyl diphosphate in the evaluation of biliary-enteric anastomoses: preliminary experience.

Journal: AJR. American journal of roentgenology 20050501

Title: Functional MR cholangiography: diagnosis of functional abnormalities of the gallbladder and biliary tree.

Journal: AJR. American journal of roentgenology 20050501

Title: On the AJR viewbox. Intrapancreatic accessory spleen: diagnosis with RES-specific contrast-enhanced MRI.

Journal: AJR. American journal of roentgenology 20050501

Title: Detection of liver metastases from gastrointestinal cancer: comparision of high resolution MnDPDP enhanced MRI and FDG-PET.

Journal: Academic radiology 20050501

Title: Biliary atresia: feasibility of mangafodipir trisodium-enhanced MR cholangiography for evaluation.

Journal: Radiology 20050401

Title: Double gallbladder diagnosed on contrast-enhanced MR cholangiography with mangafodipir trisodium.

Journal: AJR. American journal of roentgenology 20050301

Title: Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.

Journal: Investigative radiology 20050101

Title: Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part II: comparison with cine magnetic resonance imaging.

Journal: Investigative radiology 20050101

Title: Bile duct leaks after laparoscopic cholecystectomy: value of contrast-enhanced MRCP.

Journal: Abdominal imaging 20050101

Title: Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging.

Journal: Journal of computer assisted tomography 20050101

Title: Hepatocyte-targeted MR contrast agents: contrast enhanced detection of liver cancer in diffusely damaged liver.

Journal: Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 20050101

Title: Gadobenate dimeglumine as an intrabiliary contrast agent: comparison with mangafodipir trisodium with respect to non-dilated biliary tree depiction.

Journal: Korean journal of radiology 20050101

Title: Defining intrahepatic biliary anatomy in living liver transplant donor candidates at mangafodipir trisodium-enhanced MR cholangiography versus conventional T2-weighted MR cholangiography.

Journal: Radiology 20041201

Title: Early biliary complications of laparoscopic cholecystectomy: evaluation on T2-weighted MR cholangiography in conjunction with mangafodipir trisodium-enhanced 3D T1-weighted MR cholangiography.

Journal: AJR. American journal of roentgenology 20041201

Title: [MRT of the liver. Clinical significance of nonspecific and liver-specific MRT contrast agents].

Journal: Der Radiologe 20041201

Title: Relaxation enhancing properties of MnDPDP in human myocardium.

Journal: Journal of magnetic resonance imaging : JMRI 20041201

Title: Manganese toxicity upon overexposure.

Journal: NMR in biomedicine 20041201

Title: Preoperative evaluation of biliary anatomy in adult live liver donors with volumetric mangafodipir trisodium enhanced magnetic resonance cholangiography.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20041101

Title: MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents.

Journal: AJR. American journal of roentgenology 20041001

Title: Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging.

Journal: Journal of magnetic resonance imaging : JMRI 20041001

Title: Magnetic resonance with manganese-DPDP (mangafodipir) of focal solid pancreatic lesions.

Journal: La Radiologia medica 20040901

Title: Contrast-enhanced magnetic resonance cholangiography using mangafodipir compared with standard T2W MRC sequences: a pictorial essay.

Journal: Journal of magnetic resonance imaging : JMRI 20040801

Title: MR imaging of the stomach: potential use for mangafodipir trisodium--a study in swine.

Journal: Radiology 20040701

Title: Diagnosing biliary complications of orthotopic liver transplantation with mangafodipir trisodium-enhanced MR cholangiography: comparison with conventional MR cholangiography.

Journal: AJR. American journal of roentgenology 20040601

Title: Mangafodipir-enhanced magnetic resonance cholangiography for the diagnosis of bile duct leaks.

Journal: Gastrointestinal endoscopy 20040601

Title: Identification and staging of pancreatic tumours using computed tomography, endoscopic ultrasound and mangafodipir trisodium-enhanced magnetic resonance imaging.

Journal: Australasian radiology 20040601

Title: Mangan-enhanced MR imaging for the detection and localisation of small pancreatic insulinoma.

Journal: European radiology 20040501

Title: Assessment of sequential enhancement patterns of focal nodular hyperplasia and hepatocellular carcinoma on mangafodipir trisodium enhanced MR imaging.

Journal: Investigative radiology 20040501

Title: Antioxidant activity of mangafodipir is not a new finding.

Journal: Journal of hepatology 20040501

Title: Small (<or= 2 cm) hepatic lesions in colorectal cancer patients: detection and characterization on mangafodipir trisodium-enhanced MRI.

Journal: AJR. American journal of roentgenology 20040501

Title: Uptake of MnCl2 and mangafodipir trisodium in the myocardium: a magnetic resonance imaging study in pigs.

Journal: Journal of magnetic resonance imaging : JMRI 20040501

Title: Mn-DPDP-enhanced 24-h delayed-scan MRI of hepatocellular carcinoma is correlated with histology.

Journal: European radiology 20040401

Title: Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications.

Journal: European radiology 20040401

Title: Biliary tract depiction in living potential liver donors: comparison of conventional MR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography--initial experience.

Journal: Radiology 20040301

Title: [Detection of liver metastases in colorectal cancer on chemotherapy. Comparative study between MRI with teslascan and computed tomography with intravenous contrast media].

Journal: Journal de radiologie 20040301

Title: Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT.

Journal: European radiology 20040101

Title: [Contribution of MR cholangiography after Teslascan infusion for the diagnosis of post-traumatic biliary injury].

Journal: Gastroenterologie clinique et biologique 20040101

Title: Magnetic resonance cholangiography with mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after T-tube removal in liver transplantation.

Journal: Journal of computer assisted tomography 20040101

Title: Mangafodipir prevents liver injury induced by acetaminophen in the mouse.

Journal: Journal of hepatology 20031101

Title: Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast-enhanced magnetic resonance cholangiography.

Journal: Journal of magnetic resonance imaging : JMRI 20031001

Title: [Comparative study of four GRE sequences in MnDPDP-enhanced magnetic resonance imaging for primary hepatocellular carcinoma].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030901

Title: Intraoperative contrast-enhanced MR-imaging as predictor of tissue damage during cryoablation of porcine liver.

Journal: Magnetic resonance imaging 20030901

Title: Safety and efficacy of Mangafodipir trisodium in patients with liver lesions and cirrhosis.

Journal: European radiology 20030701

Title: Improved image contrast with mangafodipir trisodium (MnDPDP) during MR-guided percutaneous cryosurgery of the liver.

Journal: Magnetic resonance imaging 20030701

Title: Noninvasive preoperative evaluation of biliary anatomy in right-lobe living donors with mangafodipir trisodium-enhanced MR cholangiography.

Journal: Transplantation proceedings 20030601

Title: Acute cholecystitis at T2-weighted and manganese-enhanced T1-weighted MR cholangiography: preliminary study.

Journal: Radiology 20030501

Title: MnDPDP-enhanced magnetization transfer MR imaging: implications for effective liver imaging.

Journal: Magnetic resonance imaging 20030101

Title: Atypical focal nodular hyperplasia of the liver: imaging features of nonspecific and liver-specific MR contrast agents.

Journal: AJR. American journal of roentgenology 20021201

Title: Evaluation of focal pancreatic masses: comparison of mangafodipir-enhanced MR imaging and contrast-enhanced helical CT.

Journal: European radiology 20021201

Title: T1 efficacy of EVP-ABD: a potential manganese-based MR contrast agent for hepatic vascular and tissue phase imaging.

Journal: Journal of magnetic resonance imaging : JMRI 20021201

Title: Breast carcinoma metastases to the liver simulating cirrhosis.

Journal: Radiology 20021201

Title: MnDPDP enhanced magnetic resonance imaging of focal liver lesions.

Journal: Clinical radiology 20021201

Title: Intrahepatic biliary anatomy of living adult liver donors: correlation of mangafodipir trisodium-enhanced MR cholangiography and intraoperative cholangiography.

Journal: AJR. American journal of roentgenology 20021101

Title: [Focal secondary malignant liver lesions: MnDPDP-enhanced MRT at 0.2 tesla vs. helical CT-arterioportography].

Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20021101

Title: [MnDPDP--contrast medium with protective effect in acute myocardial infarction].

Journal: Lakartidningen 20021003

Title: Diagnosis and staging of pancreatic cancer: comparison of mangafodipir trisodium-enhanced MR imaging and contrast-enhanced helical hydro-CT.

Journal: AJR. American journal of roentgenology 20020901

Title: Preoperative detection of hepatocellular carcinoma: ferumoxides-enhanced versus mangafodipir trisodium-enhanced MR imaging.

Journal: AJR. American journal of roentgenology 20020901

Title: Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging.

Journal: Chinese medical journal 20020901

Title: Using contrast-enhanced MR cholangiography with IV mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after cholecystectomy: a prospective study of 11 patients.

Journal: AJR. American journal of roentgenology 20020801

Title: Liver lesion detection and characterization with sequential use of hepatobiliary contrast agent mangafodipir trisodium and gadolinium-DTPA in a single imaging protocol.

Journal: Academic radiology 20020801

Title: Exploring multifunctional features of necrosis avid contrast agents.

Journal: Academic radiology 20020801

Title: [MR imaging of pancreatic lesions with Mn-DPDP. A histopathologic correlation].

Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20020701

Title: Development of contrast-enhanced virtual MR cholangioscopy: a feasibility study.

Journal: European radiology 20020601

Title: Characterization of liver lesions with mangafodipir trisodium-enhanced MR imaging: multicenter study comparing MR and dual-phase spiral CT.

Journal: Radiology 20020501

Title: Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis.

Journal: Radiology 20020501

Title: Thallium-like test for myocardial viability with MnDPDP-enhanced MRI.

Journal: Academic radiology 20020501

Title: Multimodality diagnosis of liver tumors: feature analysis with CT, liver-specific and contrast-enhanced MR, and a computer model.

Journal: Academic radiology 20020301

Title: Stability and transmetallation of the magnetic resonance contrast agent MnDPDP measured by EPR.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020301

Title: Multifocal inflammatory pseudotumor of the liver: dynamic gadolinium-enhanced, ferumoxides-enhanced, and mangafodipir trisodium-enhanced MR imaging findings.

Journal: European radiology 20020201

Title: Functioning acinar cell pancreatic carcinoma: diagnosis on mangafodipir trisodium (Mn-DPDP)-enhanced MRI.

Journal: Journal of computer assisted tomography 20020101

Title: MRI characteristics in focal hepatic disease before and after administration of MnDPDP: discriminant analysis as a diagnostic tool.

Journal: European radiology 20020101

Title: Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results.

Journal: Journal of computer assisted tomography 20020101

Title: [Organ specific MRI contrast media in general practice].

Journal: Wiener medizinische Wochenschrift. Supplement 20020101

Title: Contrast-enhanced magnetic resonance cholangiography versus heavily T2-weighted magnetic resonance cholangiography.

Journal: Investigative radiology 20011101

Title: New contrast agents for imaging the liver.

Journal: Magnetic resonance imaging clinics of North America 20011101

Title: Contrast-enhanced MR imaging in the diagnosis and preservation of cardiac viability.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 20011101

Title: Cardioprotective effects of the MR contrast agent MnDPDP and its metabolite MnPLED upon reperfusion of the ischemic porcine myocardium.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 20011101

Title: [Magnetic resonance imaging of the liver: what kind of contrast agents?].

Journal: La Radiologia medica 20010901

Title: Clinical and cost effectiveness of a new hepatocellular MRI contrast agent, mangafodipir trisodium, in the preoperative assessment of liver resectability.

Journal: Annals of surgical oncology 20010801

Title: Dephosphorylation of MnDPDP and related compounds by acid and alkaline phosphatase.

Journal: Journal of pharmaceutical and biomedical analysis 20010601

Title: Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy.

Journal: AJR. American journal of roentgenology 20010401

Title: Determination of mangafodipir trisodium and related impurities in bulk substance and pharmaceutical formulation by ion-pair high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20010401

Title: [Comparison of biphasic spiral CT and MnDPDP-enhanced MRI in the detection and characterization of liver lesions].

Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20010301

Title: Technical report: lymph node enhancement at MRI with MnDPDP in primary hepatic carcinoma.

Journal: Clinical radiology 20010101

Title: The value of MnDPDP enhancement during MR guided laser interstitial thermoablation of liver tumors.

Journal: Journal of magnetic resonance imaging : JMRI 20010101

Title: Detection of bile duct leaks using MR cholangiography with mangfodipir trisodium (Teslascan).

Journal: Journal of computer assisted tomography 20010101

Title: Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma.

Journal: European radiology 20010101

Title: Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety).

Journal: Journal of magnetic resonance imaging : JMRI 20000701

Title: Mechanisms of action of liver contrast agents: impact for clinical use.

Journal: Journal of computer assisted tomography 19991101

Title: Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas.

Journal: Acta radiologica. Supplementum 19980101

Title: Dynamic evaluation of the hepatic uptake and clearance of manganese-based MRI contrast agents: a 31P NMR study on the isolated and perfused rat liver.

Journal: Journal of magnetic resonance imaging : JMRI 19980101

Title: Metabolism and pharmacokinetics of MnDPDP in man.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 19970701

Title: Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 19970701

Title: Karlsson JOG, et al. Mangafodipir a Selective Cytoprotectant - with Special Reference to Oxaliplatin and Its Association to Chemotherapy-Induced Peripheral Neuropathy (CIPN). Transl Oncol. 2017 Aug;10(4):641-649.

Title: Wang C. Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas. Acta Radiol Suppl. 1998;415:1-31.

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