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Home Other Building Blocks 141636-65-9
141636-65-9,MFCD18072793
Catalog No.:AA001GOK

141636-65-9 | L-Norleucinamide, N-benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-

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  • Technical Information
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Technical Information
Catalog Number:
AA001GOK
Chemical Name:
L-Norleucinamide, N-benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-
CAS Number:
141636-65-9
Molecular Formula:
C49H61N9O8
Molecular Weight:
904.0641
MDL Number:
MFCD18072793
SMILES:
CCCC[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1ccccc1)C)C
Properties
Computed Properties
 
Complexity:
1720  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
66  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
20  
XLogP3:
4.4  

Literature

Title: Effects of excitatory and inhibitory neurotransmission on motor patterns of human sigmoid colon in vitro.

Journal: British journal of pharmacology 20081201

Title: Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin.

Journal: Journal of neurophysiology 19941001

Title: Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor.

Journal: Journal of medicinal chemistry 19940624

Title: Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor.

Journal: Journal of medicinal chemistry 19920710

Title: A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.

Title: M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

Title: Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9.

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Tags:141636-65-9 Molecular Formula|141636-65-9 MDL|141636-65-9 SMILES|141636-65-9 L-Norleucinamide, N-benzoyl-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-