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1418013-75-8,MFCD28009371
Catalog No.:AA009CB2

1418013-75-8 | Nms-873

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Purity
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Price(USD)
Quantity
  
1mg
≥98%
in stock  
$55.00   $38.00
- +
5mg
≥98%
in stock  
$159.00   $111.00
- +
25mg
98%
in stock  
$180.00   $126.00
- +
100mg
98%
in stock  
$466.00   $326.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CB2
Chemical Name:
Nms-873
CAS Number:
1418013-75-8
Molecular Formula:
C27H28N4O3S2
Molecular Weight:
520.6662
MDL Number:
MFCD28009371
SMILES:
Cc1cc(OCc2nnc(n2c2cccnc2)SC2CCCC2)ccc1c1ccc(cc1)S(=O)(=O)C
Properties
Computed Properties
 
Complexity:
795  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
8  
XLogP3:
4.9  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.437-450

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.437-450

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.437-450

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.437-450

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.437-450

Literature

Title: Interleukin-6 induced overexpression of valosin-containing protein (VCP)/p97 is associated with androgen-independent prostate cancer (AIPC) progression.

Journal: Journal of cellular physiology 20181001

Title: Essential function of VCP/p97 in infection cycle of the nucleopolyhedrovirus AcMNPV in Spodoptera frugiperda Sf9 cells.

Journal: Virus research 20180715

Title: The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication.

Journal: PLoS pathogens 20170501

Title: Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells.

Journal: Breast cancer research and treatment 20170401

Title: p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism that Increases the Enzyme's ATPase Activity.

Journal: Cell chemical biology 20160421

Title: Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression.

Journal: PloS one 20160101

Title: Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Journal: Journal of molecular biology 20140729

Title: Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

Journal: Nature chemical biology 20130901

Title: Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313.

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SDS
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Tags:1418013-75-8 Molecular Formula|1418013-75-8 MDL|1418013-75-8 SMILES|1418013-75-8 Nms-873