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Home Other Building Blocks 1418033-25-6
1418033-25-6,MFCD26522892
Catalog No.:AA009CG1

1418033-25-6 | Lmk-235

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$25.00   $18.00
- +
5mg
98%
in stock  
$62.00   $43.00
- +
10mg
98%
in stock  
$81.00   $57.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CG1
Chemical Name:
Lmk-235
CAS Number:
1418033-25-6
Molecular Formula:
C15H22N2O4
Molecular Weight:
294.3462
MDL Number:
MFCD26522892
SMILES:
ONC(=O)CCCCCONC(=O)c1cc(C)cc(c1)C
Properties
Computed Properties
 
Complexity:
326  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
1.8  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,#2,p.427-436

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2013,vol.56,p.427-436

C14H14ClNO4 
  1418033-25-6 

[1]JournalofMedicinalChemistry,2013,vol.56,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,p.427-436

[1]JournalofMedicinalChemistry,2013,vol.56,p.427-436

Literature

Title: Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J Med Chem. 2013 Jan 24;56(2):427-36.

Title: Li A, et al. HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer. Oncotarget. 2016 Jun 21;7(25):37966-37978.

Title: Trazzi S, et al. HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder. Hum Mol Genet. 2016 Sep 15;25(18):3887-3907.

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