Catalog No.:AA01DQ82

1418274-28-8 | Cilofexor

Name: Name:Cilofexor
Brand: AABLOCKS
SKU: AA01DQ82
Availability: InStock
Rating: 90 (10 reviews)

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Purity

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1mg

≥98%

in stock

$56.00 $39.00

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10mg

≥98%

in stock

$519.00 $363.00

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25mg

≥98%

in stock

$1,065.00 $745.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01DQ82

Chemical Name:

Cilofexor

CAS Number:

1418274-28-8

Molecular Formula:

C28H22Cl3N3O5

Molecular Weight:

586.8504

MDL Number:

MFCD31731099

SMILES:

OC(=O)c1ccnc(c1)N1CC(C1)(O)c1ccc(cc1Cl)OCc1c(onc1c1c(Cl)cccc1Cl)C1CC1

Properties

Downstream Synthesis Route

1418274-28-8

77-86-1

C28H22Cl3N3O5*C4H11NO3

[1]CurrentPatentAssignee:GILEADSCIENCESINC-WO2020/172075,2020,A1Locationinpatent:Paragraph0315;0323;0337

[2]CurrentPatentAssignee:GILEADSCIENCESINC-WO2020/185686,2020,A1Locationinpatent:Paragraph0290

1418274-28-8

104-15-4

C28H22Cl3N3O5*C7H8O3S

[1]CurrentPatentAssignee:GILEADSCIENCESINC-WO2020/172075,2020,A1Locationinpatent:Paragraph0339

Literature

Title: Trauner M, et al. The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. Hepatology. 2019 Sep;70(3):788-801.

Title: Patel K, et al. Cilofexor, a Nonsteroidal FXR Agonist, in Non-Cirrhotic Patients with Nonalcoholic Steatohepatitis: A Phase 2 Randomized Controlled Trial. Hepatology. 2020 Mar 1.

Title: P. Schwab, et al. The FXR agonist GS-9674 reduces fibrosis and portal hypertension in a rat model of NASH. April 2018,Volume 68, Supplement 1, Pages S471-S472.

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SDS