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1419609-94-1,MFCD30489344
Catalog No.:AA01N15X

1419609-94-1 | GSK2798745

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$1,154.00   $808.00
- +
10mg
99%
1 week  
$2,035.00   $1,424.00
- +
50mg
99%
1 week  
$4,781.00   $3,347.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01N15X
Chemical Name:
GSK2798745
CAS Number:
1419609-94-1
Molecular Formula:
C25H28N6O3
Molecular Weight:
460.5282
MDL Number:
MFCD30489344
SMILES:
N#Cc1ccc2c(c1)n(cn2)C[C@@]1(C)CCC[C@@]2(C1)OC(=O)N(C2)c1cnc(cn1)C(O)(C)C
Properties

Literature

Title: Goyal N, et al. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342.

Title: Brooks CA, et al. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.

Title: Xiaoping Xu, et al. Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo. J Pharmacol Exp Ther. 2021 Mar;376(3):436-443.

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SDS
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