Title: Characterization of unexplored amidohydrolase enzyme-pterin deaminase.
Journal: Applied microbiology and biotechnology 20160601
Title: Erythropoietin prevents endothelial dysfunction in GTP-cyclohydrolase I-deficient hph1 mice.
Journal: Journal of cardiovascular pharmacology 20141201
Title: Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling.
Journal: Journal of neurochemistry 20141101
Title: α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
Journal: Free radical biology & medicine 20140201
Title: Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism.
Journal: Hypertension (Dallas, Tex. : 1979) 20130801
Title: Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.
Journal: Cardiovascular research 20121201
Title: Cloning, expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm, Bombyx mori.
Journal: Molecular biology reports 20121201
Title: Simultaneous quantification of tetrahydrobiopterin, dihydrobiopterin, and biopterin by liquid chromatography coupled electrospray tandem mass spectrometry.
Journal: Analytical biochemistry 20121115
Title: PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice.
Journal: Brain research 20121105
Title: Efficacy and safety of BH4 before the age of 4 years in patients with mild phenylketonuria.
Journal: Journal of inherited metabolic disease 20121101
Title: Tetrahydrobiopterin (BH4) in PKU: effect on dietary treatment, metabolic control, and quality of life.
Journal: Journal of inherited metabolic disease 20121101
Title: An international survey of patients with tetrahydrobiopterin deficiencies presenting with hyperphenylalaninaemia.
Journal: Journal of inherited metabolic disease 20121101
Title: A volumetric study of basal ganglia structures in individuals with early-treated phenylketonuria.
Journal: Molecular genetics and metabolism 20121101
Title: The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
Journal: Thrombosis and haemostasis 20121101
Title: Long-term treatment with tetrahydrobiopterin in phenylketonuria: treatment strategies and prediction of long-term responders.
Journal: Molecular genetics and metabolism 20121101
Title: Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice.
Journal: Circulation research 20121012
Title: The mechanism of BH4 -responsive hyperphenylalaninemia--as it occurs in the ENU1/2 genetic mouse model.
Journal: Human mutation 20121001
Title: Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study.
Journal: American journal of hypertension 20121001
Title: Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20121001
Title: Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock.
Journal: Critical care medicine 20121001
Title: Tetrahydrobiopterin (BH4) in septic shock: a key to solving the nitric oxide puzzle and opening the microcirculation?
Journal: Critical care medicine 20121001
Title: Association between the levels of circulating adhesion molecules and biopterins in type-2 diabetic normotensive patients adhesion molecules and biopterins.
Journal: Endocrine, metabolic & immune disorders drug targets 20120901
Title: Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
Journal: Molecular pharmacology 20120901
Title: Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling.
Journal: Current heart failure reports 20120901
Title: Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice.
Journal: Journal of neurochemistry 20120901
Title: Utility of phenylalanine hydroxylase genotype for tetrahydrobiopterin responsiveness classification in patients with phenylketonuria.
Journal: Molecular genetics and metabolism 20120901
Title: Assessment of tetrahydrobiopterin (BH(4))-responsiveness and spontaneous phenylalanine reduction in a phenylalanine hydroxylase deficiency population.
Journal: Molecular genetics and metabolism 20120901
Title: Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Journal: Circulation research 20120831
Title: Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice.
Journal: The Journal of surgical research 20120801
Title: Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Journal: Free radical biology & medicine 20120715
Title: Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase.
Journal: Biophysical journal 20120703
Title: Recommendations for the use of sapropterin in phenylketonuria.
Journal: Molecular genetics and metabolism 20120701
Title: Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by re-establishing tetrahydrobiopterin levels.
Journal: Diabetes 20120701
Title: Positive effect of a simplified diet on blood phenylalanine control in different phenylketonuria variants, characterized by newborn BH4 loading test and PAH analysis.
Journal: Molecular genetics and metabolism 20120701
Title: Endothelial nitric oxide synthase impairment is restored by clofibrate treatment in an animal model of hypertension.
Journal: European journal of pharmacology 20120615
Title: Methotrexate increases expression of cell cycle checkpoint genes via JNK activation.
Journal: Arthritis and rheumatism 20120601
Title: Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.
Journal: Journal of cardiovascular pharmacology 20120601
Title: Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension.
Journal: American journal of physiology. Heart and circulatory physiology 20120601
Title: Five novel mutations and two large deletions in a population analysis of the phenylalanine hydroxylase gene.
Journal: Molecular genetics and metabolism 20120601
Title: [Risk-sharing scheme in Israel--Kuvan as an allegory].
Journal: Harefuah 20120601
Title: Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells.
Journal: Molecular and cellular endocrinology 20120515
Title: Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status.
Journal: Free radical biology & medicine 20120515
Title: Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501
Title: The spectrum of mutations identified in Cypriot patients with phenylalanine hydroxylase deficiency detected through neonatal screening.
Journal: Clinical biochemistry 20120501
Title: Novel pharmacological chaperones that correct phenylketonuria in mice.
Journal: Human molecular genetics 20120415
Title: Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.
Journal: International journal of cardiology 20120405
Title: Nitric oxide synthases: regulation and function.
Journal: European heart journal 20120401
Title: Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase.
Journal: The Biochemical journal 20120401
Title: HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation.
Journal: Archives of biochemistry and biophysics 20120401
Title: Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.
Journal: Molecular genetics and metabolism 20120401
Title: Evolving patient selection and clinical benefit criteria for sapropterin dihydrochloride (Kuvan®) treatment of PKU patients.
Journal: Molecular genetics and metabolism 20120401
Title: Rapid clearance of supplemented tetrahydrobiopterin is driven by high-capacity transporters in the kidney.
Journal: Molecular genetics and metabolism 20120401
Title: Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?
Journal: The Journal of pediatrics 20120401
Title: Dopamine agonists in dihydropteridine reductase deficiency.
Journal: Molecular genetics and metabolism 20120401
Title: Direct detection of tetrahydrobiopterin (BH4) and dopamine in rat brain using liquid chromatography coupled electrospray tandem mass spectrometry.
Journal: Biochemical and biophysical research communications 20120323
Title: Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
Journal: Circulation 20120320
Title: Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120315
Title: Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Journal: Cardiovascular research 20120315
Title: [Treatment and control of patients with phenylketonuria: results from the Collaborative Group of Spanish Follow-up Units].
Journal: Medicina clinica 20120303
Title: Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20120301
Title: Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase.
Journal: Journal of inorganic biochemistry 20120301
Title: Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women.
Journal: American journal of physiology. Heart and circulatory physiology 20120301
Title: Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway.
Journal: Cardiovascular drugs and therapy 20120201
Title: START, a double blind, placebo-controlled pharmacogenetic test of responsiveness to sapropterin dihydrochloride in phenylketonuria patients.
Journal: Molecular genetics and metabolism 20120201
Title: Changes in eNOS phosphorylation contribute to increased arteriolar NO release during juvenile growth.
Journal: American journal of physiology. Heart and circulatory physiology 20120201
Title: Propofol protects against high glucose-induced endothelial dysfunction in human umbilical vein endothelial cells.
Journal: Anesthesia and analgesia 20120201
Title: Analgesia by inhibiting tetrahydrobiopterin synthesis.
Journal: Current opinion in pharmacology 20120201
Title: The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R).
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120101
Title: Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid.
Journal: Hypertension (Dallas, Tex. : 1979) 20120101
Title: Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.
Journal: Journal of inorganic biochemistry 20120101
Title: Tetrahydrobiopterin, L-arginine and vitamin C actsynergistically to decrease oxidative stress, increase nitricoxide and improve blood flow after induction of hindlimbischemia in the rat.
Journal: Molecular medicine (Cambridge, Mass.) 20120101
Title: Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.
Journal: PloS one 20120101
Title: Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
Journal: International journal of molecular sciences 20120101
Title: Effects of tetrahydrobiopterin on cerebral infarction after transient focal ischemia in rats.
Journal: Neurological research 20111201
Title: Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
Journal: American journal of physiology. Heart and circulatory physiology 20111201
Title: Using change in plasma phenylalanine concentrations and ability to liberalize diet to classify responsiveness to tetrahydrobiopterin therapy in patients with phenylketonuria.
Journal: Molecular genetics and metabolism 20111201
Title: The tetrahydrobiopterin pathway: a novel target for the treatment of depression.
Journal: Pharmacogenomics 20111201
Title: Asymmetric uptake of sepiapterin and 7,8-dihydrobiopterin as a gateway of the salvage pathway of tetrahydrobiopterin biosynthesis from the lumenal surface of rat endothelial cells.
Journal: Molecular genetics and metabolism 20111101
Title: Autophagy induction by tetrahydrobiopterin deficiency.
Journal: Autophagy 20111101
Title: Natural phenylalanine hydroxylase variants that confer a mild phenotype affect the enzyme's conformational stability and oligomerization equilibrium.
Journal: Biochimica et biophysica acta 20111101
Title: Dual function of nitric oxide in carcinogenesis, reappraisal.
Journal: Current drug metabolism 20111101
Title: Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina.
Journal: Microbiology (Reading, England) 20111101
Title: Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
Journal: Brain & development 20111101
Title: Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction.
Journal: American journal of physiology. Heart and circulatory physiology 20111101
Title: Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.
Journal: American journal of physiology. Heart and circulatory physiology 20111101
Title: [Lipid peroxidation and biomechanical properties of artery in hyperlipemia rats after treating with tetrahydrobiopterin].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20111101
Title: Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Journal: Circulation 20111025
Title: Tetrahydrobiopterin is functionally distinguishable from tetrahydrodictyopterin in Dictyostelium discoideum Ax2.
Journal: FEBS letters 20111003
Title: Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin.
Journal: Journal of molecular and cellular cardiology 20111001
Title: GCH1, BH4 and pain.
Journal: Current pharmaceutical biotechnology 20111001
Title: Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
Journal: Journal of molecular and cellular cardiology 20111001
Title: Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production.
Journal: Free radical biology & medicine 20111001
Title: Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart.
Journal: Free radical research 20111001
Title: Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans.
Journal: The Journal of physiology 20111001
Title: Tetrahydrobiopterin: biochemistry and pathophysiology.
Journal: The Biochemical journal 20110915
Title: Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110901
Title: Gender bias in gastroparesis: is nitric oxide the answer?
Journal: Digestive diseases and sciences 20110901
Title: Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK.
Journal: Arthritis and rheumatism 20110901
Title: Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo.
Journal: American journal of physiology. Heart and circulatory physiology 20110901
Title: Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase.
Journal: American journal of physiology. Lung cellular and molecular physiology 20110901
Title: eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity.
Journal: The Journal of endocrinology 20110901
Title: A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin.
Journal: Journal of biomolecular screening 20110901
Title: Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism.
Journal: American journal of physiology. Heart and circulatory physiology 20110901
Title: Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Journal: Nitric oxide : biology and chemistry 20110801
Title: Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice.
Journal: Clinical and experimental pharmacology & physiology 20110801
Title: Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats.
Journal: Journal of cardiovascular pharmacology 20110801
Title: Blood phenylalanine clearance and BH(4)-responsiveness in classic phenylketonuria.
Journal: Molecular genetics and metabolism 20110801
Title: Loss of NRF2 impairs gastric nitrergic stimulation and function.
Journal: Free radical biology & medicine 20110801
Title: Safety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: results of a phase 3b study.
Journal: Molecular genetics and metabolism 20110801
Title: Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin.
Journal: Hypertension (Dallas, Tex. : 1979) 20110801
Title: Tetrahydrobiopterin: important endothelial mediator independent of endothelial nitric oxide synthase.
Journal: Hypertension (Dallas, Tex. : 1979) 20110801
Title: Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.
Journal: Circulation 20110719
Title: Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia.
Journal: Cardiovascular research 20110715
Title: Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.
Journal: Cardiovascular research 20110701
Title: Adjusting diet with sapropterin in phenylketonuria: what factors should be considered?
Journal: The British journal of nutrition 20110701
Title: Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20110701
Title: The interplay between genotype, metabolic state and cofactor treatment governs phenylalanine hydroxylase function and drug response.
Journal: Human molecular genetics 20110701
Title: GTP-cyclohydrolase deficiency responsive to sapropterin and 5-HTP supplementation: relief of treatment-refractory depression and suicidal behaviour.
Journal: BMJ case reports 20110609
Title: A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants.
Journal: The pharmacogenomics journal 20110601
Title: Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.
Journal: Aging cell 20110601
Title: Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Journal: Free radical biology & medicine 20110601
Title: Elevated oxidative stress and endothelial dysfunction in right coronary artery of right ventricular hypertrophy.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20110601
Title: Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Journal: Journal of inherited metabolic disease 20110601
Title: Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats.
Journal: Endocrinology 20110601
Title: Role of tetrahydrobiopterin (BH4) in hyperhomocysteinemia-induced endothelial dysfuction: new indication for this orphan-drug?
Journal: American journal of physiology. Endocrinology and metabolism 20110601
Title: A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.
Journal: Nature chemical biology 20110601
Title: Tetrahydrobiopterin attenuates superoxide-induced reduction in nitric oxide.
Journal: Frontiers in bioscience (Scholar edition) 20110601
Title: [Phenylketonuria (PKU) in Iceland].
Journal: Laeknabladid 20110601
Title: Tetrahydrobiopterin and phenylketonuria.
Journal: The Journal of pediatrics 20110501
Title: Tetrahydrobiopterin responsiveness of patients with phenylalanine hydroxylase deficiency.
Journal: Jornal de pediatria 20110501
Title: Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation.
Journal: The Journal of biological chemistry 20110422
Title: Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders.
Journal: Free radical biology & medicine 20110401
Title: Tetrahydrobiopterin is present in high quantity in human milk and has a vasorelaxing effect on newborn rat mesenteric arteries.
Journal: Pediatric research 20110401
Title: The effect of blood phenylalanine concentration on Kuvan™ response in phenylketonuria.
Journal: Molecular genetics and metabolism 20110401
Title: Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.
Journal: Journal of inherited metabolic disease 20110401
Title: Molecular characterization of phenylketonuria and tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Japan.
Journal: Journal of human genetics 20110401
Title: Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110321
Title: Tetrahydrobiopterin therapy for phenylketonuria in infants and young children.
Journal: The Journal of pediatrics 20110301
Title: Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin.
Journal: International journal of radiation oncology, biology, physics 20110301
Title: Tetrahydrobiopterin and PKU: into the future.
Journal: The Journal of pediatrics 20110301
Title: Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats.
Journal: American journal of physiology. Heart and circulatory physiology 20110301
Title: Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart.
Journal: Journal of molecular and cellular cardiology 20110301
Title: Tetrahydrobiopterin and hypertension: more than an emigrating story.
Journal: American journal of physiology. Heart and circulatory physiology 20110301
Title: Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency.
Journal: American journal of human genetics 20110211
Title: Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.
Journal: Journal of the American Chemical Society 20110209
Title: Phenotyping and treatment of phenylketonuria.
Journal: Lancet (London, England) 20110205
Title: Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension.
Journal: Experimental lung research 20110201
Title: Molecular genetics and impact of residual in vitro phenylalanine hydroxylase activity on tetrahydrobiopterin responsiveness in Turkish PKU population.
Journal: Molecular genetics and metabolism 20110201
Title: Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties.
Journal: European journal of pharmacology 20110110
Title: Endothelin-1 antagonism and nitric oxide augmentation prevents cyclosporine-induced vasomotor impairment.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110101
Title: Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20110101
Title: Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis.
Journal: Molecular genetics and metabolism 20110101
Title: Cilostazol inhibits cytokine-induced tetrahydrobiopterin biosynthesis in human umbilical vein endothelial cells.
Journal: Journal of atherosclerosis and thrombosis 20110101
Title: Effect of tetrahydrobiopterin on Phe/Tyr ratios and variation in Phe levels in tetrahydrobiopterin responsive PKU patients.
Journal: Molecular genetics and metabolism 20110101
Title: Phenylalanine hydroxylase deficiency: molecular epidemiology and predictable BH4-responsiveness in South Portugal PKU patients.
Journal: Molecular genetics and metabolism 20110101
Title: Diagnosis, classification, and genetics of phenylketonuria and tetrahydrobiopterin (BH4) deficiencies.
Journal: Molecular genetics and metabolism 20110101
Title: Up to date knowledge on different treatment strategies for phenylketonuria.
Journal: Molecular genetics and metabolism 20110101
Title: The 48-hour tetrahydrobiopterin loading test in patients with phenylketonuria: evaluation of protocol and influence of baseline phenylalanine concentration.
Journal: Molecular genetics and metabolism 20110101
Title: Optimized loading test to evaluate responsiveness to tetrahydrobiopterin (BH4) in Brazilian patients with phenylalanine hydroxylase deficiency.
Journal: Molecular genetics and metabolism 20110101
Title: Searching for the protein targets of bioactive molecules.
Journal: Chimia 20110101
Title: New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.
Journal: TheScientificWorldJournal 20110101
Title: [Nitric oxide and preeclampsia].
Journal: Orvosi hetilap 20101226
Title: Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology.
Journal: Heart (British Cardiac Society) 20101201
Title: Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia.
Journal: American journal of physiology. Endocrinology and metabolism 20101201
Title: Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101201
Title: Endothelial, sympathetic, and cardiac function in inherited (6R)-L-erythro-5,6,7,8-tetrahydro-L-biopterin deficiency.
Journal: Circulation. Cardiovascular genetics 20101201
Title: BH(4) therapy impacts the nutrition status and intake in children with phenylketonuria: 2-year follow-up.
Journal: Journal of inherited metabolic disease 20101201
Title: GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20101201
Title: Advances and challenges in phenylketonuria.
Journal: Journal of inherited metabolic disease 20101201
Title: Letter by Antoniades et al regarding article, 'Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction'.
Journal: Circulation 20101123
Title: New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Journal: Biochemical pharmacology 20101115
Title: Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin.
Journal: Current drug targets 20101101
Title: Dihydropteridine reductase activity in the brainstem of intrauterine growth-restricted rats.
Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20101101
Title: Roles of tetrahydrobiopterin in promoting tumor angiogenesis.
Journal: The American journal of pathology 20101101
Title: Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Journal: Journal of inherited metabolic disease 20101001
Title: Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.
Journal: The Journal of pharmacology and experimental therapeutics 20101001
Title: Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactor.
Journal: The Journal of biological chemistry 20101001
Title: Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20101001
Title: Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension.
Journal: Journal of hepatology 20100901
Title: Nitric oxide pathway in hypertrophied heart: new therapeutic uses of nitric oxide donors.
Journal: Journal of hypertension 20100901
Title: Maintenance of cellular tetrahydrobiopterin homeostasis.
Journal: BMB reports 20100901
Title: Alterations in dopamine and glutamate neurotransmission in tetrahydrobiopterin deficient spr-/- mice: relevance to schizophrenia.
Journal: BMB reports 20100901
Title: Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state.
Journal: Journal of the American Chemical Society 20100825
Title: Mechanism of dihydrofolate reductase downregulation in melanoma by 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.
Journal: Journal of cellular biochemistry 20100815
Title: Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction.
Journal: The European respiratory journal 20100801
Title: Nitric oxide synthase 3 contributes to ventilator-induced lung injury.
Journal: American journal of physiology. Lung cellular and molecular physiology 20100801
Title: Oral tetrahydrobiopterin improves the beneficial effect of adenoviral-mediated eNOS gene transfer after induction of hindlimb ischemia.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20100801
Title: Challenges and pitfalls in the management of phenylketonuria.
Journal: Pediatrics 20100801
Title: Sapropterin dihydrochloride: a new drug and a new concept in the management of phenylketonuria.
Journal: Drugs of today (Barcelona, Spain : 1998) 20100801
Title: Endothelial dysfunction: potential clinical implications.
Journal: Minerva medica 20100801
Title: Introduction of sapropterin dihydrochloride as standard of care in patients with phenylketonuria.
Journal: Molecular genetics and metabolism 20100701
Title: Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection.
Journal: American journal of physiology. Heart and circulatory physiology 20100701
Title: Tetrahydrobiopterin as a novel therapeutic intervention for autism.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20100701
Title: Potential therapeutic applications of tetrahydrobiopterin: from inherited hyperphenylalaninemia to mitochondrial diseases.
Journal: Annals of the New York Academy of Sciences 20100701
Title: Sapropterin dihydrochloride for phenylketonuria.
Journal: The Cochrane database of systematic reviews 20100616
Title: Synthesis of poly(methyl methacrylate) core/chitosan-mixed-polyethyleneimine shell nanoparticles and their antibacterial property.
Journal: Colloids and surfaces. B, Biointerfaces 20100601
Title: Sapropterin.
Journal: British journal of clinical pharmacology 20100601
Title: [The Dental and Pharmaceutical Benefits Agency misinterpret its mission].
Journal: Lakartidningen 20100601
Title: Sapropterin. Phenylketonuria: for a minority of patients.
Journal: Prescrire international 20100601
Title: Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo.
Journal: Human molecular genetics 20100515
Title: Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
Journal: Clinical science (London, England : 1979) 20100506
Title: The role of nitric oxide in the expression of renal aquaporin 2 in a cirrhotic rat model: does an AVP-independent mechanism exist for the regulation of AQP2 expression?
Journal: Digestive diseases and sciences 20100501
Title: Unresponsiveness to tetrahydrobiopterin of phenylalanine hydroxylase deficiency.
Journal: Metabolism: clinical and experimental 20100501
Title: Molecular mechanisms underlying the activation of eNOS.
Journal: Pflugers Archiv : European journal of physiology 20100501
Title: L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats.
Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100501
Title: An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning.
Journal: Experimental physiology 20100501
Title: Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501
Title: Endothelial dysfunction in diabetes: multiple targets for treatment.
Journal: Pflugers Archiv : European journal of physiology 20100501
Title: Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis.
Journal: Planta 20100501
Title: Nitric oxide and oxidative stress in vascular disease.
Journal: Pflugers Archiv : European journal of physiology 20100501
Title: Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.
Journal: Heart and vessels 20100501
Title: Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction.
Journal: The Journal of physiology 20100415
Title: Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition.
Journal: Biochemistry 20100413
Title: Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.
Journal: European journal of pharmacology 20100410
Title: Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke.
Journal: Cardiovascular research 20100401
Title: Long-chain polyunsaturated fatty acid status in phenylketonuric patients treated with tetrahydrobiopterin.
Journal: Clinical biochemistry 20100301
Title: Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms.
Journal: Anesthesiology 20100301
Title: Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption.
Journal: DNA and cell biology 20100301
Title: Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production.
Journal: Archives of biochemistry and biophysics 20100215
Title: GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.
Journal: Circulation research 20100205
Title: Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction.
Journal: Circulation 20100202
Title: NO way to relax: the complexities of coupling nitric oxide synthase pathways in the heart.
Journal: Circulation 20100202
Title: An enzymatic method to distinguish tetrahydrobiopterin from oxidized biopterins using UDP-glucose:tetrahydrobiopterin glucosyltransferase.
Journal: Analytical biochemistry 20100201
Title: Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100201
Title: A weapon of endothelial cells for fighting vascular disease.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100201
Title: Tetrahydrobiopterin responsiveness after extended loading test of 12 Danish PKU patients with the Y414C mutation.
Journal: Journal of inherited metabolic disease 20100201
Title: Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high salt.
Journal: Microcirculation (New York, N.Y. : 1994) 20100201
Title: Relative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: a randomized, open-label, crossover study in healthy adults.
Journal: Clinical therapeutics 20100201
Title: Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Journal: Cardiovascular research 20100101
Title: The effects of tetrahydrobiopterin on intracerebral hemorrhage-induced brain injury in mice.
Journal: Acta neurochirurgica. Supplement 20100101
Title: Regulation of nitric oxide production in health and disease.
Journal: Current opinion in clinical nutrition and metabolic care 20100101
Title: Evidence against tetrahydrobiopterin depletion of vascular tissue exposed to nitric oxide/superoxide or nitroglycerin.
Journal: Free radical biology & medicine 20100101
Title: Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways.
Journal: American journal of physiology. Heart and circulatory physiology 20100101
Title: The tetrahydrobiopterin pathway and pain.
Journal: Current opinion in investigational drugs (London, England : 2000) 20100101
Title: [Phenylketonuria--toward a better carry-over care].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20100101
Title: Cognitive functions in patients with phenylketonuria in long-term treatment with tetrahydrobiopterin.
Journal: Molecular genetics and metabolism 20100101
Title: Clear correlation of tetrahydrobiopterin with nitric oxide bioavailability in continuous ambulatory peritoneal dialysis.
Journal: Blood purification 20100101
Title: Reaching out to the lost generation of adults with early-treated phenylketonuria (PKU).
Journal: Molecular genetics and metabolism 20100101
Title: Sapropterin therapy increases stability of blood phenylalanine levels in patients with BH4-responsive phenylketonuria (PKU).
Journal: Molecular genetics and metabolism 20100101
Title: Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications.
Journal: Advances in pharmacology (San Diego, Calif.) 20100101
Title: Impaired endothelial function may be due to decreased aortic tetrahydrobiopterin, assessed by a new flow-mediated vasodilation in vivo in hypercholesterolemic/atherogenic mice.
Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20091201
Title: Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091201
Title: Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels.
Journal: The Journal of biological chemistry 20091113
Title: Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide.
Journal: Cardiovascular research 20091101
Title: Examination of tetrahydrobiopterin pathway genes in autism.
Journal: Genes, brain, and behavior 20091101
Title: Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats.
Journal: American journal of physiology. Heart and circulatory physiology 20091101
Title: Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels.
Journal: Proteomics 20091101
Title: Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailability.
Journal: Cardiovascular research 20091101
Title: Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.
Journal: Journal of molecular and cellular cardiology 20091101
Title: eNOS uncoupling and endothelial dysfunction in aged vessels.
Journal: American journal of physiology. Heart and circulatory physiology 20091101
Title: Tetrahydrobiopterin, superoxide, and vascular dysfunction.
Journal: Free radical biology & medicine 20091015
Title: Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways.
Journal: The Journal of biological chemistry 20091009
Title: Do sauna therapy and exercise act by raising the availability of tetrahydrobiopterin?
Journal: Medical hypotheses 20091001
Title: Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats.
Journal: Journal of neurochemistry 20091001
Title: Nitric oxide and pain: 'Something old, something new'.
Journal: Acta anaesthesiologica Scandinavica 20091001
Title: [Fusion of field and laboratory studies on the investigation of arsenic].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001
Title: Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages.
Journal: American journal of physiology. Cell physiology 20090901
Title: Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20090901
Title: Sapropterin: a new therapeutic agent for phenylketonuria.
Journal: The Annals of pharmacotherapy 20090901
Title: [Research advance in the treatment of phenylketonuria].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090901
Title: Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain.
Journal: Annals of neurology 20090901
Title: Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method.
Journal: Analytica chimica acta 20090819
Title: High-cholesterol diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model.
Journal: Clinical and experimental pharmacology & physiology 20090801
Title: GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP.
Journal: American journal of physiology. Lung cellular and molecular physiology 20090801
Title: Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans.
Journal: The Journal of physiology 20090801
Title: Blood phenylalanine concentrations in patients with PAH-deficient hyperphenylalaninaemia off diet without and with three different single oral doses of tetrahydrobiopterin: assessing responsiveness in a model of statistical process control.
Journal: Journal of inherited metabolic disease 20090801
Title: Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles.
Journal: The Journal of physiology 20090801
Title: Exercising an option to prevent age related decline of vascular BH4 and uncoupling of eNOS.
Journal: The Journal of physiology 20090801
Title: Detection of tetrahydrobiopterin by LC-MS/MS in plasma from multiple species.
Journal: Bioanalysis 20090801
Title: [Biomechanical properties of artery in spontaneously hypertensive rats after treating with tetrahydrobiopterin].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090801
Title: Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.
Journal: Journal of biochemistry 20090701
Title: Genotype-predicted tetrahydrobiopterin (BH4)-responsiveness and molecular genetics in Croatian patients with phenylalanine hydroxylase (PAH) deficiency.
Journal: Molecular genetics and metabolism 20090701
Title: Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability.
Journal: American journal of physiology. Heart and circulatory physiology 20090701
Title: Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.
Journal: Brain : a journal of neurology 20090701
Title: Disorders of biopterin metabolism.
Journal: Journal of inherited metabolic disease 20090601
Title: Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization.
Journal: The Journal of pharmacology and experimental therapeutics 20090601
Title: Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.
Journal: American journal of physiology. Endocrinology and metabolism 20090601
Title: PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.
Journal: Current genetics 20090601
Title: Tetrahydrobiopterin, endothelial nitric oxide synthase, and mitochondrial function in the heart.
Journal: Hypertension (Dallas, Tex. : 1979) 20090601
Title: Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis.
Journal: Hypertension (Dallas, Tex. : 1979) 20090601
Title: A limited spectrum of phenylalanine hydroxylase mutations is observed in phenylketonuria patients in western Poland and implications for treatment with 6R tetrahydrobiopterin.
Journal: Journal of human genetics 20090601
Title: Novel therapeutic strategies targeting vascular redox in human atherosclerosis.
Journal: Recent patents on cardiovascular drug discovery 20090601
Title: GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
Journal: The Journal of biological chemistry 20090515
Title: Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.
Journal: The Journal of biological chemistry 20090508
Title: L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.
Journal: Atherosclerosis 20090501
Title: Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction.
Journal: American journal of physiology. Heart and circulatory physiology 20090501
Title: Efficacy of sapropterin dihydrochloride in increasing phenylalanine tolerance in children with phenylketonuria: a phase III, randomized, double-blind, placebo-controlled study.
Journal: The Journal of pediatrics 20090501
Title: Flow-induced dilation is mediated by Akt-dependent activation of endothelial nitric oxide synthase-derived hydrogen peroxide in mouse cerebral arteries.
Journal: Stroke 20090501
Title: Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction.
Journal: American journal of physiology. Heart and circulatory physiology 20090501
Title: Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20090501
Title: Effects of tetrahydrobiopterin on venous bubble grade and acute diving-induced changes in cardiovascular function.
Journal: Clinical physiology and functional imaging 20090401
Title: Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.
Journal: Cardiovascular research 20090401
Title: Optimizing the use of sapropterin (BH(4)) in the management of phenylketonuria.
Journal: Molecular genetics and metabolism 20090401
Title: Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions.
Journal: Proteomics 20090401
Title: Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins.
Journal: The Biochemical journal 20090315
Title: Comparative computational analysis of active and inactive cofactors of nitric oxide synthase.
Journal: The journal of physical chemistry. B 20090312
Title: The solution electrochemistry of tetrahydrobiopterin revisited.
Journal: Nitric oxide : biology and chemistry 20090301
Title: Protective effect of bromocriptine against BH4-induced Cath.a cell death involving up-regulation of antioxidant enzymes.
Journal: Neuroscience letters 20090227
Title: Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients.
Journal: Journal of inherited metabolic disease 20090201
Title: Tetrahydrobiopterin deficiency in human rabies.
Journal: Journal of inherited metabolic disease 20090201
Title: Significance of genotype in tetrahydrobiopterin-responsive phenylketonuria.
Journal: Journal of inherited metabolic disease 20090201
Title: Transcellular relocation of tetrahydrobiopterin across Caco-2 cells: a model study of tetrahydrobiopterin absorption through epithelial cells of intestinal mucosa.
Journal: Journal of inherited metabolic disease 20090201
Title: Pharmacokinetics of tetrahydrobiopterin following oral loadings with three single dosages in patients with phenylketonuria.
Journal: Journal of inherited metabolic disease 20090201
Title: Tetrahydrobiopterin in intestinal lumen: its absorption and secretion in the small intestine and the elimination in the large intestine.
Journal: Journal of inherited metabolic disease 20090201
Title: Effect of BH(4) supplementation on phenylalanine tolerance.
Journal: Journal of inherited metabolic disease 20090201
Title: H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo.
Journal: Journal of inherited metabolic disease 20090201
Title: A new role for caveolin-1: regulation of guanosine triphosphate cyclohydrolase I and tetrahydrobiopterin in endothelial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20090201
Title: Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20090201
Title: Tetrahydrobiopterin in biomedical research.
Journal: Journal of inherited metabolic disease 20090201
Title: Proceedings of the International Conference on Tetrahydrobiopterin, Phenylketonuria, and Nitric Oxide Synthase, St. Moritz/Champér, Switzerland, March 23-28, 2008.
Journal: Journal of inherited metabolic disease 20090201
Title: Reactive oxygen species production and MAPK activation are implicated in tetrahydrobiopterin-induced SH-SY5Y cell death.
Journal: Neuroscience letters 20090116
Title: Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
Journal: The Journal of biological chemistry 20090109
Title: Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence.
Journal: Biological chemistry 20090101
Title: Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects.
Journal: Trends in pharmacological sciences 20090101
Title: [Biopterin and child neurologic disease].
Journal: No to hattatsu = Brain and development 20090101
Title: [Study of the photochemical properties of biopterin and its reduced forms].
Journal: Prikladnaia biokhimiia i mikrobiologiia 20090101
Title: Nitric oxide and vascular insulin resistance.
Journal: BioFactors (Oxford, England) 20090101
Title: Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia.
Journal: Drugs 20090101
Title: [Genotyping and treatment modification in patients with phenylketonuria: an introduction to pharmacogenomics].
Journal: Przeglad lekarski 20090101
Title: [A novel strategy to design specific iNOS inhibitors].
Journal: Medecine sciences : M/S 20090101
Title: Spotlight on sapropterin in primary hyperphenylalaninemia.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20090101
Title: Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.
Journal: The Clinical journal of pain 20090101
Title: Changing dietary practices in phenylketonuria.
Journal: The Turkish journal of pediatrics 20090101
Title: Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081201
Title: Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension.
Journal: American journal of physiology. Lung cellular and molecular physiology 20081201
Title: Bringing down the ROS: a new therapeutic approach for PPHN.
Journal: American journal of physiology. Lung cellular and molecular physiology 20081201
Title: Maternal phenylketonuria and tetrahydrobiopterin.
Journal: Pediatrics 20081201
Title: Diagnosis of tetrahydrobiopterin (BH4) responsive mild phenylketonuria in Japan over the past 10 years.
Journal: Annals of the Academy of Medicine, Singapore 20081201
Title: Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
Journal: The Journal of biological chemistry 20081128
Title: Crystal structure of tryptophan hydroxylase with bound amino acid substrate.
Journal: Biochemistry 20081118
Title: Safety and efficacy of 22 weeks of treatment with sapropterin dihydrochloride in patients with phenylketonuria.
Journal: American journal of medical genetics. Part A 20081115
Title: Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis.
Journal: The Journal of biological chemistry 20081114
Title: Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.
Journal: European journal of pain (London, England) 20081101
Title: Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs.
Journal: Nitric oxide : biology and chemistry 20081101
Title: Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells.
Journal: American journal of physiology. Heart and circulatory physiology 20081101
Title: Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes.
Journal: American journal of physiology. Heart and circulatory physiology 20081101
Title: A polarizable force-field model for quantum-mechanical-molecular-mechanical Hamiltonian using expansion of point charges into orbitals.
Journal: The Journal of chemical physics 20081021
Title: Ascorbate sustains neutrophil NOS expression, catalysis, and oxidative burst.
Journal: Free radical biology & medicine 20081015
Title: Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20081001
Title: Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes.
Journal: Free radical biology & medicine 20081001
Title: Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia.
Journal: American journal of physiology. Heart and circulatory physiology 20081001
Title: CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Journal: Circulation 20080930
Title: Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia.
Journal: Early human development 20080901
Title: Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
Journal: Hypertension (Dallas, Tex. : 1979) 20080901
Title: Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Journal: Hypertension (Dallas, Tex. : 1979) 20080901
Title: Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20080901
Title: Chronic immune stimulation correlates with reduced phenylalanine turnover.
Journal: Current drug metabolism 20080901
Title: The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Journal: Alternative medicine review : a journal of clinical therapeutic 20080901
Title: Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations.
Journal: Amino acids 20080801
Title: Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin.
Journal: Molecular genetics and metabolism 20080801
Title: Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats.
Journal: Journal of hepatology 20080801
Title: Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instability.
Journal: American journal of human genetics 20080711
Title: Regulation of eNOS-derived superoxide by endogenous methylarginines.
Journal: Biochemistry 20080708
Title: GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Journal: Journal of the American College of Cardiology 20080708
Title: Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase.
Journal: Journal of neurochemistry 20080701
Title: Exposure to inhaled particulate matter impairs cardiac function in senescent mice.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080701
Title: A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis.
Journal: Experimental dermatology 20080701
Title: Development of a model for assessment of phenylalanine hydroxylase activity in newborns with phenylketonuria receiving tetrahydrobiopterin: a potential for practical implementation.
Journal: Molecular genetics and metabolism 20080701
Title: Erythropoietin increases endothelial biosynthesis of tetrahydrobiopterin by activation of protein kinase B alpha/Akt1.
Journal: Hypertension (Dallas, Tex. : 1979) 20080701
Title: New drugs08, part 2.
Journal: Nursing 20080701
Title: Sapropterin (Kuvan) for phenylketonuria.
Journal: The Medical letter on drugs and therapeutics 20080602
Title: Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension.
Journal: Antioxidants & redox signaling 20080601
Title: Tetrahydrobiopterin: a novel antihypertensive therapy.
Journal: Journal of human hypertension 20080601
Title: Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?
Journal: The Journal of physiology 20080601
Title: Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080601
Title: Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
Journal: American journal of physiology. Heart and circulatory physiology 20080601
Title: Effect of pioglitazone on nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20080601
Title: Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin.
Journal: Acta biochimica et biophysica Sinica 20080601
Title: [BH4 in the management of phenylketonuria].
Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080601
Title: Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Journal: Circulation 20080520
Title: Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.
Journal: Atherosclerosis 20080501
Title: Regulation of melanogenesis--controversies and new concepts.
Journal: Experimental dermatology 20080501
Title: The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium.
Journal: Journal of molecular and cellular cardiology 20080501
Title: Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats.
Journal: Journal of pharmacological sciences 20080501
Title: Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.
Journal: The Journal of biological chemistry 20080425
Title: Microvascular function and ageing L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth.
Journal: The Journal of physiology 20080415
Title: Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.
Journal: Heart (British Cardiac Society) 20080401
Title: Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.
Journal: American journal of physiology. Heart and circulatory physiology 20080401
Title: [Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20080401
Title: Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase.
Journal: Archives of biochemistry and biophysics 20080315
Title: Letter by Thum et al regarding article, 'Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone'.
Journal: Circulation 20080311
Title: Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Journal: Molecular genetics and metabolism 20080301
Title: Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
Journal: American journal of physiology. Renal physiology 20080301
Title: IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080301
Title: Recently-approved sapropterin reduces phenylalanine levels.
Journal: Managed care (Langhorne, Pa.) 20080301
Title: Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
Journal: Circulation 20080226
Title: Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cells.
Journal: Free radical biology & medicine 20080215
Title: Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.
Journal: The Journal of physiology 20080215
Title: A novel mutation (c.64_65delGGinsAACC [p.G21fsX66]) in the GTP cyclohydrolase 1 gene that causes Segawa disease.
Journal: Journal of neurology, neurosurgery, and psychiatry 20080201
Title: Classifying tetrahydrobiopterin responsiveness in the hyperphenylalaninaemias.
Journal: Journal of inherited metabolic disease 20080201
Title: Sapropterin dihydrochloride, 6-R-L-erythro-5,6,7,8-tetrahydrobiopterin, in the treatment of phenylketonuria.
Journal: Expert opinion on investigational drugs 20080201
Title: Defining tetrahydrobiopterin (BH4)-responsiveness in PKU.
Journal: Journal of inherited metabolic disease 20080201
Title: Tetrahydrobiopterin.
Journal: Current hypertension reports 20080201
Title: Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production.
Journal: Vascular medicine (London, England) 20080201
Title: First drug approved for treatment of phenylketonuria.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080115
Title: Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.
Journal: Biochemistry 20080108
Title: A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
Journal: Brain & development 20080101
Title: Insulin resistance and endothelial cell dysfunction: studies in mammalian models.
Journal: Experimental physiology 20080101
Title: Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Journal: Human mutation 20080101
Title: Oral administration of tetrahydrobiopterin attenuates testicular damage by reducing nitric oxide synthase activity in a cryptorchid mouse model.
Journal: Journal of andrology 20080101
Title: Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation.
Journal: Neuroscience research 20080101
Title: Diabetes induces changes of catecholamines in primary mesangial cells.
Journal: The international journal of biochemistry & cell biology 20080101
Title: Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20080101
Title: Is sapropterin treatment suitable for all subjects with phenylketonuria?
Journal: Expert opinion on pharmacotherapy 20080101
Title: New drugs: nebivolol hydrochloride, nilotinib, and sapropterin dihydrochloride.
Journal: Journal of the American Pharmacists Association : JAPhA 20080101
Title: Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080101
Title: 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner.
Journal: Biochimica et biophysica acta 20080101
Title: Generalised cranial artery spasm in human rabies.
Journal: Developments in biologicals 20080101
Title: Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia.
Journal: Journal of anesthesia 20080101
Title: Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats.
Journal: Cardiovascular diabetology 20080101
Title: Pharmacokinetics of sapropterin in patients with phenylketonuria.
Journal: Clinical pharmacokinetics 20080101
Title: Effects of tetrahydrobiopterin on nitric oxide bioavailability and renal hemodynamics in healthy volunteers.
Journal: Journal of nephrology 20080101
Title: Metabolism of tetrahydrobiopterin: its relevance in monoaminergic neurons and neurological disorders.
Journal: Chemical record (New York, N.Y.) 20080101
Title: Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries.
Journal: Cardiovascular research 20071201
Title: Effects of tetrahydrobiopterin and phenylalanine on in vivo human phenylalanine hydroxylase by phenylalanine breath test.
Journal: Molecular genetics and metabolism 20071201
Title: Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20071201
Title: C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling.
Journal: Journal of molecular and cellular cardiology 20071201
Title: Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.
Journal: Clinical and experimental pharmacology & physiology 20071201
Title: Recommendations for evaluation of responsiveness to tetrahydrobiopterin (BH(4)) in phenylketonuria and its use in treatment.
Journal: Molecular genetics and metabolism 20071201
Title: Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension.
Journal: American journal of hypertension 20071201
Title: The potential anti-inflammatory effect of tetrahydrobiopterin administration in renal mass reduction-induced chronic renal failure in rats.
Journal: Saudi medical journal 20071201
Title: Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase.
Journal: Toxicology 20071120
Title: 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20071101
Title: Sapropterin dihydrochloride (Kuvan/phenoptin), an orally active synthetic form of BH4 for the treatment of phenylketonuria.
Journal: IDrugs : the investigational drugs journal 20071101
Title: Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
Journal: Biochemistry 20071023
Title: Regulation of tetrahydrobiopterin biosynthesis by shear stress.
Journal: Circulation research 20071012
Title: Endothelial cell tetrahydrobiopterin: going with the flow.
Journal: Circulation research 20071012
Title: The tetrahydrobiopterin loading test in 36 patients with hyperphenylalaninaemia: evaluation of response and subsequent treatment.
Journal: Journal of inherited metabolic disease 20071001
Title: The response of patients with phenylketonuria and elevated serum phenylalanine to treatment with oral sapropterin dihydrochloride (6R-tetrahydrobiopterin): a phase II, multicentre, open-label, screening study.
Journal: Journal of inherited metabolic disease 20071001
Title: Oxygen metabolism by endothelial nitric-oxide synthase.
Journal: The Journal of biological chemistry 20070928
Title: A simple method to calculate the accessible volume of protein-bound ligands: application for ligand selectivity.
Journal: Journal of molecular graphics & modelling 20070901
Title: Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.
Journal: Synapse (New York, N.Y.) 20070901
Title: [Molecular mechanism of cardiovascular damage induced by aldosterone].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070901
Title: Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease.
Journal: Journal of cardiovascular pharmacology 20070901
Title: Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
Journal: Circulation 20070821
Title: Interaction energies between tetrahydrobiopterin analogues and aromatic residues in tyrosine hydroxylase and phenylalanine hydroxylase.
Journal: The journal of physical chemistry. B 20070816
Title: Tetrahydrobiopterin for patients with phenylketonuria.
Journal: Lancet (London, England) 20070811
Title: Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study.
Journal: Lancet (London, England) 20070811
Title: Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation.
Journal: Biochemical and biophysical research communications 20070803
Title: Effects and clinical significance of tetrahydrobiopterin supplementation in phenylalanine hydroxylase-deficient hyperphenylalaninaemia.
Journal: Journal of inherited metabolic disease 20070801
Title: Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070701
Title: A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070701
Title: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease.
Journal: Clinical science (London, England : 1979) 20070701
Title: Nitric oxide accelerates the degradation of tetrahydrobiopterin but not total neopterin in cerebrospinal fluid; potential implications for the assessment of tetrahydrobiopterin metabolism.
Journal: Annals of clinical biochemistry 20070701
Title: Advances in melanocyte basic science research.
Journal: Dermatologic clinics 20070701
Title: Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production.
Journal: Journal of cardiovascular pharmacology 20070701
Title: Metabolic basis of sexual dimorphism in PKU mice after genome-targeted PAH gene therapy.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20070601
Title: (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601
Title: Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.
Journal: Stress (Amsterdam, Netherlands) 20070601
Title: Assessment of tetrahydrobiopterin (BH4) responsiveness in phenylketonuria.
Journal: The Journal of pediatrics 20070601
Title: Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis.
Journal: Arthritis and rheumatism 20070601
Title: [Clinical study of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency in southern and northern Chinese patients].
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20070601
Title: Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC.
Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20070501
Title: BH4 responsiveness associated to a PKU mutation with decreased binding affinity for the cofactor.
Journal: Clinica chimica acta; international journal of clinical chemistry 20070501
Title: Early initiation of L-dopa therapy enables stable development of executive function in tetrahydrobiopterin (BH4) deficiency.
Journal: Developmental medicine and child neurology 20070501
Title: Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells.
Journal: Biological chemistry 20070501
Title: Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states.
Journal: Journal of inherited metabolic disease 20070401
Title: Protective effect of sulforaphane against dopaminergic cell death.
Journal: The Journal of pharmacology and experimental therapeutics 20070401
Title: Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070401
Title: Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070401
Title: Phenylketonuria: dietary and therapeutic challenges.
Journal: Journal of inherited metabolic disease 20070401
Title: Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo.
Journal: Journal of neurochemistry 20070401
Title: [Screening for tetrahydrobiopterin metabolic disorders and related gene analysis among the patients with motor disturbance and mental retardation].
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20070401
Title: Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.
Journal: Brain research 20070330
Title: Intracortical inhibition of the motor cortex in Segawa disease (DYT5).
Journal: Neurology 20070327
Title: Interaction of genetic and environmental factors in a Drosophila parkinsonism model.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070307
Title: Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population.
Journal: Molecular genetics and metabolism 20070301
Title: Quantitation of total biopterin and tetrahydrobiopterin in plasma.
Journal: Clinical biochemistry 20070301
Title: Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat.
Journal: American journal of hypertension 20070301
Title: Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes.
Journal: Diabetes 20070301
Title: [Molecular imaging for drug development].
Journal: Brain and nerve = Shinkei kenkyu no shinpo 20070301
Title: Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
Journal: Journal of cardiovascular pharmacology 20070301
Title: Insulin enhances nitric oxide production in trabecular meshwork cells via de novo pathway for tetrahydrobiopterin synthesis.
Journal: Korean journal of ophthalmology : KJO 20070301
Title: Buthionine sulfoximine causes endothelium dependent hyper-relaxation and hypoadiponectinemia.
Journal: Life sciences 20070206
Title: Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo.
Journal: The Journal of investigative dermatology 20070201
Title: 17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.
Journal: The Journal of pharmacology and experimental therapeutics 20070201
Title: Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.
Journal: European journal of pharmacology 20070119
Title: Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
Journal: Experimental physiology 20070101
Title: Particular vulnerability of rat mesencephalic dopaminergic neurons to tetrahydrobiopterin: Relevance to Parkinson's disease.
Journal: Neurobiology of disease 20070101
Title: Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070101
Title: Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder.
Journal: Neurochemical research 20070101
Title: Tetrahydrobiopterin availability in Parkinson's and Alzheimer's disease; potential pathogenic mechanisms.
Journal: Neurochemical research 20070101
Title: Chemiluminescence assay for tetrahydrobiopterin based on the generation of hydrogen peroxide using isoluminol-microperoxidase in the presence of 1-methoxy PMS.
Journal: Luminescence : the journal of biological and chemical luminescence 20070101
Title: Effects of supplementation of BH4 after prolonged ischemia in skeletal muscle.
Journal: Microsurgery 20070101
Title: C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation.
Journal: Journal of vascular research 20070101
Title: Assessment of tetrahydrobiopterin responsiveness in Turkish hyperphenylalaninemic patients.
Journal: The Turkish journal of pediatrics 20070101
Title: Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin.
Journal: Genetic testing 20070101
Title: Paradoxical effects of two oximes on nitric oxide production by purified NO synthases, in cell culture and in animals.
Journal: Nitric oxide : biology and chemistry 20070101
Title: Glucocorticoids and oxidative stress.
Journal: Journal of basic and clinical physiology and pharmacology 20070101
Title: Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
Journal: Clinical hemorheology and microcirculation 20070101
Title: Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite.
Journal: Medical hypotheses 20070101
Title: Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects.
Journal: Journal of neural transmission. Supplementum 20070101
Title: Plasma pterins and folate in late life depression: the Rotterdam Study.
Journal: Psychiatry research 20061207
Title: Pharmacokinetics of orally administered tetrahydrobiopterin in patients with phenylalanine hydroxylase deficiency.
Journal: Journal of inherited metabolic disease 20061201
Title: [Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients].
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20061201
Title: Electronic structure, ionization potential, and electron affinity of the enzyme cofactor (6R)-5,6,7,8-tetrahydrobiopterin in the gas phase, solution, and protein environments.
Journal: The journal of physical chemistry. B 20061116
Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
Journal: Journal of molecular graphics & modelling 20061101
Title: GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes.
Journal: The Journal of investigative dermatology 20061101
Title: Tetrahydrobiopterin and cardiovascular disease.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20061101
Title: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.
Journal: Nature medicine 20061101
Title: Feeling pain? Who's your daddy...
Journal: Nature medicine 20061101
Title: Self-assembly of the 2-His-1-carboxylate facial triad in mononuclear iron(II) and zinc(II) models of metalloenzyme active sites.
Journal: Inorganic chemistry 20061002
Title: Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061001
Title: 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Journal: Circulation 20060912
Title: The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
Journal: Chemical communications (Cambridge, England) 20060907
Title: 6-Pyruvoyltetrahydropterin synthase orthologs of either a single or dual domain structure are responsible for tetrahydrobiopterin synthesis in bacteria.
Journal: FEBS letters 20060904
Title: Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901
Title: Systemic oxidative stress associated with lung resection during single lung ventilation.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901
Title: Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901
Title: Early determinants of H2O2-induced endothelial dysfunction.
Journal: Free radical biology & medicine 20060901
Title: Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase.
Journal: Human mutation 20060901
Title: Three-year audit of the hyperphenylalaninaemia/phenylketonuria spectrum in Victoria.
Journal: Journal of paediatrics and child health 20060901
Title: Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats.
Journal: Kidney international 20060801
Title: Pigment pattern formation in the quail mutant of the silkworm, Bombyx mori: parallel increase of pteridine biosynthesis and pigmentation of melanin and ommochromes.
Journal: Pigment cell research 20060801
Title: Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling.
Journal: Free radical biology & medicine 20060801
Title: Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells.
Journal: Biochemical and biophysical research communications 20060714
Title: Tetrahydrobiopterin stimulates L-DOPA release from striatal tissue.
Journal: European journal of pharmacology 20060710
Title: eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
Journal: Circulation research 20060707
Title: Manganese modulates pro-inflammatory gene expression in activated glia.
Journal: Neurochemistry international 20060701
Title: Endothelial NO synthase target of aldosterone.
Journal: Hypertension (Dallas, Tex. : 1979) 20060701
Title: Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity.
Journal: Hypertension (Dallas, Tex. : 1979) 20060701
Title: The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis.
Journal: Hepatology (Baltimore, Md.) 20060701
Title: Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060701
Title: Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production.
Journal: Atherosclerosis 20060601
Title: Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide.
Journal: American journal of physiology. Endocrinology and metabolism 20060601
Title: Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice.
Journal: American journal of physiology. Heart and circulatory physiology 20060601
Title: Regulation of inducible nitric oxide synthase in post-operative adhesions.
Journal: Human reproduction (Oxford, England) 20060601
Title: A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions.
Journal: Journal of neurochemistry 20060601
Title: Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution.
Journal: Free radical biology & medicine 20060601
Title: Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase.
Journal: Arthritis and rheumatism 20060601
Title: [Study on tetrahydrobiopterin deficiency in Northern Chinese population].
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20060601
Title: Catalase protects cardiomyocytes via its inhibition of nitric oxide synthesis.
Journal: Nitric oxide : biology and chemistry 20060501
Title: A murine model for human sepiapterin-reductase deficiency.
Journal: American journal of human genetics 20060401
Title: Circadian rhythms in RLS.
Journal: Sleep medicine 20060401
Title: Evaluation of electrospray-tandem mass spectrometry for the detection of phenylketonuria and other rare disorders.
Journal: Molecular nutrition & food research 20060401
Title: Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase.
Journal: Journal of biochemistry 20060401
Title: Cardioprotective effects of tetrahydrobiopterin in cold heart preservation after cardiac arrest.
Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20060401
Title: Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
Journal: The Journal of biological chemistry 20060324
Title: Analysis of the effect of tetrahydrobiopterin on PAH gene expression in hepatoma cells.
Journal: FEBS letters 20060320
Title: Administration of secretin for autism alters dopamine metabolism in the central nervous system.
Journal: Brain & development 20060301
Title: Functional identification of orthologous genes encoding pterin recycling activity in Plasmodium falciparum and Toxoplasma gondii.
Journal: Molecular and biochemical parasitology 20060301
Title: Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease.
Journal: Neurochemistry international 20060301
Title: High-pressure studies of the reaction mechanism of nitric-oxide synthase.
Journal: Biochimica et biophysica acta 20060301
Title: Dissociation and unfolding of inducible nitric oxide synthase oxygenase domain identifies structural role of tetrahydrobiopterin in modulating the heme environment.
Journal: Molecular and cellular biochemistry 20060301
Title: Evaluation of tetrahydrobiopterin (BH4) as a potential therapeutic agent to treat erectile dysfunction.
Journal: Asian journal of andrology 20060301
Title: Cytoprotective function of tetrahydrobiopterin in rat liver ischemia/reperfusion injury.
Journal: Surgery 20060301
Title: Tetrahydrobiopterin compounds prolong allograft survival independently of their effect on nitric oxide synthase activity.
Journal: Transplantation 20060227
Title: Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity.
Journal: Biochemistry 20060221
Title: eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.
Journal: American journal of physiology. Lung cellular and molecular physiology 20060201
Title: Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin.
Journal: American journal of physiology. Heart and circulatory physiology 20060201
Title: Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Journal: Molecular genetics and metabolism 20060201
Title: Reduction of myocardial infarct size by tetrahydrobiopterin: possible involvement of mitochondrial KATP channels activation through nitric oxide production.
Journal: Journal of cardiovascular pharmacology 20060201
Title: [Tetrahydrobiopterin therapy for hyperphenylalaninemia due to phenylalanine hydroxylase deficiency. When and how?].
Journal: Anales de pediatria (Barcelona, Spain : 2003) 20060201
Title: The spectrum of phenylalanine variations under tetrahydrobiopterin load in subjects affected by phenylalanine hydroxylase deficiency.
Journal: Journal of inherited metabolic disease 20060201
Title: Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin.
Journal: The Journal of biological chemistry 20060127
Title: Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis.
Journal: European journal of pharmacology 20060120
Title: Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111
Title: A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction?
Journal: Frontiers in bioscience : a journal and virtual library 20060101
Title: Neural tube closure depends on nitric oxide synthase activity.
Journal: Journal of neurochemistry 20060101
Title: Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats.
Journal: Journal of hypertension 20060101
Title: Tetrahydrobiopterin, but not L-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase.
Journal: Hypertension (Dallas, Tex. : 1979) 20060101
Title: Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
Journal: The FEBS journal 20060101
Title: [Dopa-responsive dystonia: clinical, genetic, and biochemical studies].
Journal: Rinsho shinkeigaku = Clinical neurology 20060101
Title: Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats.
Journal: Menopause (New York, N.Y.) 20060101
Title: Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin.
Journal: Journal of vascular research 20060101
Title: Activation energy determinations suggest that thiols reverse autooxidation of tetrahydrobiopterin by a different mechanism than ascorbate.
Journal: The international journal of biochemistry & cell biology 20060101
Title: Protection of endothelial function: targets for nutritional and pharmacological interventions.
Journal: Journal of cardiovascular pharmacology 20060101
Title: Nitric oxide and neopterin in bipolar affective disorder.
Journal: Neuropsychobiology 20060101
Title: Novel therapies targeting vascular endothelium.
Journal: Endothelium : journal of endothelial cell research 20060101
Title: Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.
Journal: Brain research. Molecular brain research 20051207
Title: The activity of wild-type and mutant phenylalanine hydroxylase and its regulation by phenylalanine and tetrahydrobiopterin at physiological and pathological concentrations: an isothermal titration calorimetry study.
Journal: Molecular genetics and metabolism 20051201
Title: Clinical and nutritional evaluation of phenylketonuric patients on tetrahydrobiopterin monotherapy.
Journal: Molecular genetics and metabolism 20051201
Title: Long-term treatment with tetrahydrobiopterin increases phenylalanine tolerance in children with severe phenotype of phenylketonuria.
Journal: Molecular genetics and metabolism 20051201
Title: Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients.
Journal: Molecular genetics and metabolism 20051201
Title: Tetrahydrobiopterin-responsive phenylketonuria: the New South Wales experience.
Journal: Molecular genetics and metabolism 20051201
Title: Response of patients with phenylketonuria in the US to tetrahydrobiopterin.
Journal: Molecular genetics and metabolism 20051201
Title: Accumulated BH4 in mouse liver caused by administration of either 6R- or 6SBH4 consisted solely of the 6R-diastereomer: evidence of oxidation to BH2 and enzymic reduction.
Journal: Molecular genetics and metabolism 20051201
Title: Spanish BH4-responsive phenylalanine hydroxylase-deficient patients: evolution of seven patients on long-term treatment with tetrahydrobiopterin.
Journal: Molecular genetics and metabolism 20051201
Title: Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process.
Journal: Molecular genetics and metabolism 20051201
Title: Neonatal hyperphenylalaninemia, perinatal hemochromatosis, and renal tubulopathy: a unique patient or a novel metabolic disorder?
Journal: Molecular genetics and metabolism 20051201
Title: Plasma biopterin levels and tetrahydrobiopterin responsiveness.
Journal: Molecular genetics and metabolism 20051201
Title: Incidence of BH4-responsiveness in phenylalanine-hydroxylase-deficient Italian patients.
Journal: Molecular genetics and metabolism 20051201
Title: Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20051201
Title: Long-term treatment of patients with mild and classical phenylketonuria by tetrahydrobiopterin.
Journal: Molecular genetics and metabolism 20051201
Title: Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4.
Journal: Molecular genetics and metabolism 20051201
Title: Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Journal: Molecular genetics and metabolism 20051201
Title: Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke.
Journal: Stroke 20051201
Title: Extended tetrahydrobiopterin loading test in the diagnosis of cofactor-responsive phenylketonuria: a pilot study.
Journal: Molecular genetics and metabolism 20051201
Title: Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice.
Journal: Molecular genetics and metabolism 20051201
Title: Tetrahydrobiopterin and maternal PKU.
Journal: Molecular genetics and metabolism 20051201
Title: Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases.
Journal: Dalton transactions (Cambridge, England : 2003) 20051107
Title: Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities.
Journal: Journal of neurochemistry 20051101
Title: Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.
Journal: The Journal of physiology 20051101
Title: Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
Journal: Circulation research 20051028
Title: Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation.
Journal: Free radical biology & medicine 20051015
Title: Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits.
Journal: Circulation 20051004
Title: Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction.
Journal: American journal of physiology. Heart and circulatory physiology 20051001
Title: Roles of Ca2+ and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes.
Journal: Journal of cellular biochemistry 20051001
Title: Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats.
Journal: Journal of cardiovascular pharmacology 20051001
Title: Tetrahydrobiopterin in the treatment of children with autistic disorder: a double-blind placebo-controlled crossover study.
Journal: Journal of clinical psychopharmacology 20051001
Title: Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system.
Journal: Journal of neurochemistry 20051001
Title: Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
Journal: Diabetologia 20050901
Title: Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050801
Title: An oxygraphic method for determining kinetic properties and catalytic mechanism of aromatic amino acid hydroxylases.
Journal: Analytical biochemistry 20050801
Title: [Tetrahydrobiopterin loading test in differential diagnosis among hyperphenylalaninemia patients].
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20050801
Title: Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
Journal: Journal of medicinal chemistry 20050728
Title: Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide.
Journal: Bioorganic & medicinal chemistry letters 20050715
Title: Correction of endothelial dysfunction by tetrahydrobiopterin: new hope for the treatment of arterial hypertension?
Journal: Journal of hypertension 20050701
Title: Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Journal: Journal of hypertension 20050701
Title: 6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Journal: Annals of neurology 20050701
Title: NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.
Journal: American journal of physiology. Renal physiology 20050601
Title: Severe mucitis after sublingual administration of tetrahydrobiopterin in a patient with tetrahydrobiopterin-responsive phenylketonuria.
Journal: European journal of pediatrics 20050601
Title: Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats.
Journal: Diabetologia 20050601
Title: Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production.
Journal: Journal of neurochemistry 20050601
Title: Cyclosporine-induced coronary endothelial dysfunction: is tetrahydrobiopterin the solution?
Journal: Transplantation proceedings 20050601
Title: Tetrahydrobiopterin and nitric oxide synthase dimer levels are not changed following hypoxia-ischemia in the newborn rat.
Journal: Brain research. Developmental brain research 20050512
Title: Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase.
Journal: Critical care medicine 20050501
Title: Reductive activation of Cr(Vi) by nitric oxide synthase.
Journal: Chemical research in toxicology 20050501
Title: [Screening and diagnosis of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency with tetrahydrobiopterin loading test].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20050501
Title: Tetrahydrobiopterin prevents cyclosporine-induced vasomotor dysfunction.
Journal: Transplantation 20050427
Title: Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse.
Journal: Circulation 20050426
Title: Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
Journal: Circulation 20050426
Title: Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice.
Journal: Circulation 20050426
Title: Regulation of tyrosinase by tetrahydropteridines--what is real? A comment on the work published by Wood et al. on December 24, 2004.
Journal: Biochemical and biophysical research communications 20050415
Title: Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20050401
Title: A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Journal: Biochemistry 20050329
Title: Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.
Journal: Neuron 20050324
Title: Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
Journal: European journal of pharmacology 20050321
Title: The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
Journal: The Journal of biological chemistry 20050311
Title: Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.
Journal: The Journal of biological chemistry 20050304
Title: The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II.
Journal: American journal of physiology. Renal physiology 20050301
Title: BH(4) (tetrahydrobiopterin)-dependent activation, but not the expression, of inducible NOS (nitric oxide synthase)-2 in proinflammatory cytokine-stimulated, cultured normal human astrocytes is mediated by MEK-ERK kinases.
Journal: Journal of cellular biochemistry 20050301
Title: Treatment with tetrahydrobiopterin reduces blood pressure in male SHR by reducing testosterone synthesis.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050301
Title: Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease.
Journal: Neurochemistry international 20050301
Title: Tetrahydrobiopterin and eNOS dimer/monomer ratio--a clue to eNOS uncoupling in diabetes?
Journal: Cardiovascular research 20050301
Title: Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
Journal: Cardiovascular research 20050301
Title: Sex difference in nitric oxide synthase-dependent dilatation of cerebral arterioles during long-term alcohol consumption.
Journal: Alcoholism, clinical and experimental research 20050301
Title: Nitric oxide: a major determinant of mast cell phenotype and function.
Journal: Memorias do Instituto Oswaldo Cruz 20050301
Title: Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?
Journal: Free radical biology & medicine 20050215
Title: Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.
Journal: Circulation research 20050204
Title: Transcribing the cross-talk of cytokine-induced tetrahydrobiopterin synthesis in endothelial cells.
Journal: Circulation research 20050204
Title: Exogenous NO suppresses flow-induced endothelium-derived NO production because of depletion of tetrahydrobiopterin.
Journal: American journal of physiology. Heart and circulatory physiology 20050201
Title: Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.
Journal: The European journal of neuroscience 20050201
Title: Esrom, an ortholog of PAM (protein associated with c-myc), regulates pteridine synthesis in the zebrafish.
Journal: Developmental biology 20050115
Title: Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.
Journal: Psychopharmacology 20050101
Title: Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia.
Journal: European journal of nuclear medicine and molecular imaging 20050101
Title: Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050101
Title: Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin.
Journal: FEMS microbiology letters 20050101
Title: Estrogen modifies stress response of catecholamine biosynthetic enzyme genes and cardiovascular system in ovariectomized female rats.
Journal: Neuroscience 20050101
Title: Beneficial effect of tetrahydrobiopterin on the survival of rats exposed to hepatic ischemia-reperfusion injury.
Journal: Transplantation proceedings 20050101
Title: Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors.
Journal: Blood purification 20050101
Title: Evidence for a tetrahydrobiopterin deficit in schizophrenia.
Journal: Neuropsychobiology 20050101
Title: Tetrahydrobiopterin as combined electron/proton donor in nitric oxide biosynthesis: cryogenic UV-Vis and EPR detection of reaction intermediates.
Journal: Methods in enzymology 20050101
Title: Platelet serotonin concentrations in PKU patients under dietary control and tetrahydrobiopterin treatment.
Journal: Journal of inherited metabolic disease 20050101
Title: Regulation of tyrosinase by tetrahydropteridines and H2O2.
Journal: Biochemical and biophysical research communications 20041224
Title: Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin.
Journal: American journal of physiology. Heart and circulatory physiology 20041201
Title: GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201
Title: Tetrahydrobiopterin responsiveness in patients with phenylketonuria.
Journal: Clinical biochemistry 20041201
Title: Malfunction of vascular control in lifestyle-related diseases: endothelial nitric oxide (NO) synthase/NO system in atherosclerosis.
Journal: Journal of pharmacological sciences 20041201
Title: Evidence of cellular immune activation in children with opsoclonus-myoclonus: cerebrospinal fluid neopterin.
Journal: Journal of child neurology 20041201
Title: Alpha-Tocopherol and endothelial nitric oxide synthesis.
Journal: Annals of the New York Academy of Sciences 20041201
Title: Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: implications for tetrahydrobiopterin-responsive hyperphenylalaninemia.
Journal: FEBS letters 20041119
Title: Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity.
Journal: Journal of medicinal chemistry 20041118
Title: The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase.
Journal: Life sciences 20041112
Title: Gene expression profiling of inflamed human endothelial cells and influence of activated protein C.
Journal: Circulation 20041102
Title: Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease.
Journal: American journal of physiology. Endocrinology and metabolism 20041101
Title: In vivo studies of phenylalanine hydroxylase by phenylalanine breath test: diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Journal: Pediatric research 20041101
Title: Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations.
Journal: Human mutation 20041101
Title: Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
Journal: Trends in cardiovascular medicine 20041101
Title: Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase.
Journal: Journal of the American Chemical Society 20041027
Title: Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.
Journal: Biochemistry 20041019
Title: Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthase.
Journal: Free radical biology & medicine 20041001
Title: Reversible parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency.
Journal: Movement disorders : official journal of the Movement Disorder Society 20041001
Title: Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process.
Journal: Journal of pharmacological sciences 20041001
Title: Substrate regulation of serotonin and dopamine synthesis in Drosophila.
Journal: Invertebrate neuroscience : IN 20041001
Title: Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment.
Journal: AJNR. American journal of neuroradiology 20041001
Title: Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents.
Journal: Medicinal research reviews 20040901
Title: Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040901
Title: Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040901
Title: Alpha-tocopherol amplifies phosphorylation of endothelial nitric oxide synthase at serine 1177 and its short-chain derivative trolox stabilizes tetrahydrobiopterin.
Journal: Free radical biology & medicine 20040901
Title: Comparison of tetrahydrobiopterin and L-arginine on cerebral blood flow after controlled cortical impact injury in rats.
Journal: Journal of neurotrauma 20040901
Title: [Mechanisms of nitric oxide production].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040901
Title: [Diabetic macroangiopathy and NO].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040901
Title: The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity.
Journal: The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20040901
Title: Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4).
Journal: American journal of physiology. Heart and circulatory physiology 20040801
Title: Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin.
Journal: Free radical biology & medicine 20040801
Title: Tetrahydropteridines suppress gene expression and induce apoptosis of activated RAW264.7 cells via formation of hydrogen peroxide.
Journal: Free radical biology & medicine 20040801
Title: Trends in enzyme therapy for phenylketonuria.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20040801
Title: Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.
Journal: The Journal of biological chemistry 20040730
Title: Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration.
Journal: Brain research 20040723
Title: Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder.
Journal: Biological psychiatry 20040715
Title: Functional tetrahydrobiopterin synthesis in human platelets.
Journal: Circulation 20040713
Title: Spectrophotometric analysis of the protective effect of ascorbate against spontaneous oxidation of tetrahydrobiopterin in aqueous solution: kinetic characteristics and potentiation by catalase of ascorbate action.
Journal: The international journal of biochemistry & cell biology 20040701
Title: Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.
Journal: The Journal of physiology 20040701
Title: Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR.
Journal: British journal of pharmacology 20040701
Title: Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin.
Journal: Journal of inorganic biochemistry 20040701
Title: CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin.
Journal: Journal of inorganic biochemistry 20040701
Title: Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
Journal: Molecular genetics and metabolism 20040701
Title: Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
Journal: Free radical biology & medicine 20040615
Title: Dysfunction of endothelial nitric oxide synthase and atherosclerosis.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040601
Title: The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Journal: Molecular genetics and metabolism 20040601
Title: Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression.
Journal: Annals of the New York Academy of Sciences 20040601
Title: Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20040501
Title: Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?
Journal: Journal of neurochemistry 20040501
Title: 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide.
Journal: The Journal of biological chemistry 20040430
Title: Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain.
Journal: Neuroscience letters 20040408
Title: Inhibition of nuclear factor kappa B activation and inducible nitric oxide synthase transcription by prolonged exposure to high glucose in the human keratinocyte cell line HaCaT.
Journal: The British journal of dermatology 20040401
Title: Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat.
Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20040401
Title: [Tetrahydrobiopterin and endothelial dysfunction].
Journal: Sheng li ke xue jin zhan [Progress in physiology] 20040401
Title: Endothelial dysfunction in heart failure: mechanisms and therapeutic approaches.
Journal: Current vascular pharmacology 20040401
Title: Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040301
Title: Long-term treatment and diagnosis of tetrahydrobiopterin-responsive hyperphenylalaninemia with a mutant phenylalanine hydroxylase gene.
Journal: Pediatric research 20040301
Title: Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040301
Title: Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin in the mouse hippocampus.
Journal: Neuropharmacology 20040301
Title: JNK activation by tetrahydrobiopterin: implication for Parkinson's disease.
Journal: Journal of neuroscience research 20040301
Title: Tetrahydrobiopterin: mediator of endothelial protection.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040301
Title: [Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040301
Title: [NO and hypertension].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040301
Title: Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide.
Journal: Biochimica et biophysica acta 20040224
Title: Indirect oxidation of 6-tetrahydrobiopterin by tyrosinase.
Journal: Biochemical and biophysical research communications 20040220
Title: Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform.
Journal: The Journal of biological chemistry 20040206
Title: In vivo expression and function of recombinant GTPCH I in the rabbit carotid artery.
Journal: American journal of physiology. Heart and circulatory physiology 20040201
Title: Long-term follow-up of a patient with mild tetrahydrobiopterin-responsive phenylketonuria.
Journal: Molecular genetics and metabolism 20040201
Title: More transgenic mouse models of dopamine deficiency.
Journal: Annals of neurology 20040201
Title: Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress.
Journal: The Journal of investigative dermatology 20040201
Title: Nuclear localization of tetrahydrobiopterin biosynthetic enzymes.
Journal: Biochimica et biophysica acta 20040105
Title: Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta.
Journal: International journal of molecular medicine 20040101
Title: Glucocorticoids decrease GTP cyclohydrolase and tetrahydrobiopterin-dependent vasorelaxation through glucocorticoid receptors.
Journal: Journal of cardiovascular pharmacology 20040101
Title: Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension.
Journal: Journal of cardiovascular pharmacology 20040101
Title: GTP cyclohydrolase I utilizes metal-free GTP as its substrate.
Journal: European journal of biochemistry 20040101
Title: New approaches to treat PKU: how far are we?
Journal: Molecular genetics and metabolism 20040101
Title: Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration.
Journal: Molecular genetics and metabolism 20040101
Title: The fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria.
Journal: Molecular genetics and metabolism 20040101
Title: Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease.
Journal: Journal of inherited metabolic disease 20040101
Title: Efficiency of long-term tetrahydrobiopterin monotherapy in phenylketonuria.
Journal: Journal of inherited metabolic disease 20040101
Title: The two faces of endothelial nitric oxide synthase in the pathophysiology of atherosclerosis.
Journal: Endothelium : journal of endothelial cell research 20040101
Title: Wild-type phenylalanine hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo: an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
Journal: Molecular genetics and metabolism 20040101
Title: Tetrahydrobiopterin responsiveness: results of the BH4 loading test in 31 Spanish PKU patients and correlation with their genotype.
Journal: Molecular genetics and metabolism 20040101
Title: Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells.
Journal: Cell biochemistry and biophysics 20040101
Title: Radical reactions of nitric oxide synthases.
Journal: Biochemical Society symposium 20040101
Title: Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells.
Journal: The Journal of biological chemistry 20031212
Title: Utilization of exogenous tetrahydrobiopterin in nitric oxide synthesis in human neuroblastoma cell line.
Journal: Neuroscience letters 20031204
Title: Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways.
Journal: Biochemical Society transactions 20031201
Title: Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats.
Journal: Hepatology (Baltimore, Md.) 20031201
Title: Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria.
Journal: Pediatrics 20031201
Title: Potential role of tetrahydrobiopterin in the treatment of maternal phenylketonuria.
Journal: Pediatrics 20031201
Title: Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects.
Journal: Experimental biology and medicine (Maywood, N.J.) 20031201
Title: [Involvement of tetrahydrobiopterin in local change of endothelium-dependent vasorelaxation in pulmonary hypertension].
Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20031201
Title: A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase.
Journal: The Journal of biological chemistry 20031121
Title: Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.
Journal: Biochemistry 20031118
Title: Critical role of interleukin-1beta for transcriptional regulation of endothelial 6-pyruvoyltetrahydropterin synthase.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20031101
Title: Expression of phenylalanine hydroxylase (PAH) in erythrogenic bone marrow does not correct hyperphenylalaninemia in Pah(enu2) mice.
Journal: The journal of gene medicine 20031101
Title: cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.
Journal: Journal of pharmacological sciences 20031101
Title: 2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding.
Journal: Journal of molecular biology 20031031
Title: Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells.
Journal: Free radical biology & medicine 20031015
Title: Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes.
Journal: Diabetologia 20031001
Title: Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide.
Journal: Molecular pharmacology 20031001
Title: Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice.
Journal: British journal of pharmacology 20031001
Title: Genetic engineering of Escherichia coli for production of tetrahydrobiopterin.
Journal: Metabolic engineering 20031001
Title: Role of ascorbate in the regulation of nitric oxide generation by polymorphonuclear leukocytes.
Journal: Biochemical and biophysical research communications 20030912
Title: Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.
Journal: Circulation 20030909
Title: Mechanism of aromatic hydroxylation by an activated FeIV=O core in tetrahydrobiopterin-dependent hydroxylases.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20030905
Title: Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
Journal: The Journal of clinical investigation 20030901
Title: Immune function in children with classical phenylketonuria and tetrahydrobiopterin deficiencies.
Journal: Indian pediatrics 20030901
Title: Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
Journal: Archives of biochemistry and biophysics 20030815
Title: Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase.
Journal: The Biochemical journal 20030801
Title: Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects.
Journal: American journal of physiology. Heart and circulatory physiology 20030801
Title: Regulation of noradrenergic function by inflammatory cytokines and depolarization.
Journal: Journal of neurochemistry 20030801
Title: Exogenous biopterins requirement for iNOS function in vascular smooth muscle cells.
Journal: Journal of cardiovascular pharmacology 20030801
Title: Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes.
Journal: Parkinsonism & related disorders 20030801
Title: Kainic acid lesion-induced nigral neuronal death.
Journal: Journal of chemical neuroanatomy 20030801
Title: Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin.
Journal: The Journal of biological chemistry 20030725
Title: Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier.
Journal: Brain research 20030718
Title: The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen.
Journal: The Journal of biological chemistry 20030704
Title: Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease.
Journal: Journal of neurochemistry 20030701
Title: A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits.
Journal: Free radical biology & medicine 20030701
Title: Degeneration of the nigrostriatal pathway and induction of motor deficit by tetrahydrobiopterin: an in vivo model relevant to Parkinson's disease.
Journal: Neurobiology of disease 20030701
Title: A hypothesis on the biochemical mechanism of BH(4)-responsiveness in phenylalanine hydroxylase deficiency.
Journal: Amino acids 20030701
Title: [Recent advances in cardiac protection].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030701
Title: Physarum polycephalum expresses a dihydropteridine reductase with selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution.
Journal: Biological chemistry 20030701
Title: Characterization of Drosophila nitric oxide synthase: a biochemical study.
Journal: Biochemical and biophysical research communications 20030627
Title: Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.
Journal: The Journal of biological chemistry 20030620
Title: Overexpression of V-1 prevents nitric oxide-induced cell death: involvement of enhanced tetrahydrobiopterin biosynthesis.
Journal: Journal of neuroscience research 20030615
Title: Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations.
Journal: Journal of biomolecular structure & dynamics 20030601
Title: Involvement of apoptosis and calcium mobilization in tetrahydrobiopterin-induced dopaminergic cell death.
Journal: Experimental neurology 20030601
Title: Tetrahydrobiopterin radical enzymology.
Journal: Chemical reviews 20030601
Title: [Neural and molecular mechanisms of fatigue and recovery from fatigue].
Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20030601
Title: Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
Journal: Free radical biology & medicine 20030515
Title: Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells.
Journal: Circulation 20030513
Title: Novel inhibitors of neuronal nitric oxide synthase.
Journal: Experimental biology and medicine (Maywood, N.J.) 20030501
Title: Possible impact of tetrahydrobiopterin and sepiapterin on endothelial dysfunction.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030501
Title: [Structure-function relationships of NO synthase: electron transfer reaction].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20030501
Title: Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction.
Journal: Molecular and cellular biochemistry 20030501
Title: Tetrahydrobiopterin and mild phenylketonuria.
Journal: The New England journal of medicine 20030424
Title: Tetrahydrobiopterin and mild phenylketonuria.
Journal: The New England journal of medicine 20030424
Title: Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.
Journal: The Journal of clinical investigation 20030415
Title: Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Journal: Biochemistry 20030408
Title: Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.
Journal: Journal of neurochemistry 20030401
Title: Tetrahydrobiopterin sensitivity in German patients with mild phenylalanine hydroxylase deficiency.
Journal: Human mutation 20030401
Title: Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401
Title: Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia.
Journal: Journal of biochemistry 20030401
Title: [An eighteen-year study on phenylketonuria].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20030401
Title: Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism.
Journal: Basic research in cardiology 20030301
Title: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase.
Journal: European journal of biochemistry 20030301
Title: Tetrahydrobiopterin-responsive hyperphenylalaninaemia due to homozygous mutations in the phenylalanine hydroxylase gene.
Journal: European journal of pediatrics 20030301
Title: Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.
Journal: Journal of pharmacological sciences 20030301
Title: BH4-sensitive hyperphenylalaninemia: new case and review of literature.
Journal: Pediatric neurology 20030301
Title: New approaches to overcome tolerance to nitrates.
Journal: Cardiovascular drugs and therapy 20030301
Title: Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons.
Journal: Brain research 20030227
Title: Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats.
Journal: Biochemical and biophysical research communications 20030227
Title: Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Journal: Biochemistry 20030225
Title: Diminished production of nitric oxide synthase cofactor tetrahydrobiopterin by rosiglitazone in adipocytes.
Journal: Biochemical pharmacology 20030215
Title: Increased nitric oxide production and protection from malaria.
Journal: Lancet (London, England) 20030215
Title: Impairment of nitric oxide synthase-dependent dilatation of cerebral arterioles during infusion of nicotine.
Journal: American journal of physiology. Heart and circulatory physiology 20030201
Title: HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030201
Title: Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency, state of the art.
Journal: Molecular genetics and metabolism 20030201
Title: Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts.
Journal: The Journal of cardiovascular surgery 20030201
Title: The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.
Journal: Free radical research 20030201
Title: Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity.
Journal: Circulation research 20030110
Title: Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin.
Journal: Hypertension (Dallas, Tex. : 1979) 20030101
Title: A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR.
Journal: Hypertension (Dallas, Tex. : 1979) 20030101
Title: Peripheral administration of lipopolysaccharide enhances the expression of guanosine triphosphate cyclohydrolase I mRNA in murine locus coeruleus.
Journal: Neuroscience 20030101
Title: Tetrahydrobiopterin control in phenylketonuria.
Journal: Genetics in medicine : official journal of the American College of Medical Genetics 20030101
Title: Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin.
Journal: Journal of vascular research 20030101
Title: Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy.
Journal: Nephron. Physiology 20030101
Title: Folic acid says NO to vascular diseases.
Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20030101
Title: Danger of high-protein dietary supplements to persons with hyperphenylalaninaemia.
Journal: Journal of inherited metabolic disease 20030101
Title: Phenylketonuria detected by the neonatal screening program in Thailand.
Journal: The Southeast Asian journal of tropical medicine and public health 20030101
Title: 6-pyruvoyl tetrahydropterin synthase deficiency: a case report.
Journal: The Southeast Asian journal of tropical medicine and public health 20030101
Title: Tetrahydrobiopterin and dietary restriction in mild phenylketonuria.
Journal: The New England journal of medicine 20021226
Title: Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria.
Journal: The New England journal of medicine 20021226
Title: Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.
Journal: The Journal of biological chemistry 20021206
Title: High frequency of tetrahydrobiopterin-responsiveness among hyperphenylalaninemias: a study of 1,919 patients observed from 1988 to 2002.
Journal: Molecular genetics and metabolism 20021201
Title: Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201
Title: The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform.
Journal: Archives of biochemistry and biophysics 20021101
Title: Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101
Title: Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats.
Journal: Critical care medicine 20021101
Title: The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity.
Journal: The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20021101
Title: [Regulations and pathophysiological significance of the biosynthesis of tetrahydrobiopterin in human endothelial cells].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: [V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide.
Journal: The Journal of biological chemistry 20021025
Title: Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.
Journal: The Journal of biological chemistry 20021011
Title: Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts.
Journal: The Journal of thoracic and cardiovascular surgery 20021001
Title: Sepiapterin treatment in atherosclerosis.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20021001
Title: Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20021001
Title: Why do nitric oxide synthases use tetrahydrobiopterin?
Journal: Journal of inorganic biochemistry 20020920
Title: Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20020901
Title: GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
Journal: Cardiovascular research 20020901
Title: Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia.
Journal: Journal of neurochemistry 20020901
Title: Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones.
Journal: Journal of neurochemistry 20020901
Title: Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells.
Journal: Neuroscience letters 20020809
Title: Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice.
Journal: The Journal of clinical investigation 20020801
Title: A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats.
Journal: Shock (Augusta, Ga.) 20020801
Title: Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide.
Journal: Drug metabolism reviews 20020801
Title: Tetrahydrobiopterin responsiveness in a large series of phenylketonuria patients.
Journal: Journal of inherited metabolic disease 20020801
Title: Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation.
Journal: Journal of molecular biology 20020726
Title: Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates.
Journal: Journal of molecular biology 20020712
Title: 6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.
Journal: Brain research 20020712
Title: Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701
Title: Tetrahydrobiopterin monotherapy for phenylketonuria patients with common mild mutations.
Journal: European journal of pediatrics 20020701
Title: Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension.
Journal: Biological research for nursing 20020701
Title: Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
Journal: Biochemistry 20020618
Title: Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function.
Journal: American journal of physiology. Heart and circulatory physiology 20020601
Title: Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation.
Journal: The Journal of thoracic and cardiovascular surgery 20020601
Title: Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells.
Journal: Biochemical and biophysical research communications 20020510
Title: Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin.
Journal: Brain research 20020510
Title: Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
Journal: The Journal of biological chemistry 20020503
Title: Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability.
Journal: British journal of pharmacology 20020501
Title: Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor.
Journal: Physiological measurement 20020501
Title: Involvement of nitric oxide in glucose toxicity on differentiated PC12 cells: prevention of glucose toxicity by tetrahydrobiopterin, a cofactor for nitric oxide synthase.
Journal: Neuroscience research 20020501
Title: Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin.
Journal: Cytokine 20020421
Title: Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells.
Journal: The Journal of biological chemistry 20020412
Title: Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid.
Journal: Biochemical and biophysical research communications 20020412
Title: Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Journal: Circulation 20020409
Title: Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals.
Journal: American journal of hypertension 20020401
Title: Biopterin analogues: novel nitric oxide synthase inhibitors with immunosuppressive action.
Journal: Current drug metabolism 20020401
Title: Disorders of tetrahydrobiopterin metabolism and their treatment.
Journal: Current drug metabolism 20020401
Title: Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines.
Journal: Current drug metabolism 20020401
Title: Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects.
Journal: Current drug metabolism 20020401
Title: Pteridine derivatives as modulators of oxidative stress.
Journal: Current drug metabolism 20020401
Title: cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.
Journal: Life sciences 20020322
Title: The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study.
Journal: The Biochemical journal 20020315
Title: Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite.
Journal: The Journal of clinical investigation 20020315
Title: Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
Journal: Biochemistry 20020312
Title: Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?
Journal: The Journal of biological chemistry 20020301
Title: Evaluation of 6-year application of the enzymatic colorimetric phenylalanine assay in the setting of neonatal screening for phenylketonuria.
Journal: Clinica chimica acta; international journal of clinical chemistry 20020301
Title: Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia.
Journal: Heart (British Cardiac Society) 20020301
Title: Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes.
Journal: Glia 20020301
Title: Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure.
Journal: Journal of cardiovascular pharmacology 20020301
Title: Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity.
Journal: Molecular human reproduction 20020301
Title: Evidence for a role of nitric oxide in the mediation of antiproliferative UVA effects in keratinocytes.
Journal: Pharmacological research 20020301
Title: Mental illness in mild PKU responds to biopterin.
Journal: Molecular genetics and metabolism 20020301
Title: Mutations of GCH1 in Dopa-responsive dystonia.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020301
Title: Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.
Journal: Brain research. Molecular brain research 20020227
Title: [Role of tetrahydrobiopterin in the regulation of activity of human placental nitric oxide synthase in normal and pre-eclamptic pregnancies].
Journal: Orvosi hetilap 20020224
Title: Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate.
Journal: Free radical biology & medicine 20020201
Title: Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency: possible regulation of gene expression in a patient with the homozygous L48S mutation.
Journal: Molecular genetics and metabolism 20020201
Title: Screening for tetrahydrobiopterin deficiency among hyperphenylalaninemia patients in Southern China.
Journal: Chinese medical journal 20020201
Title: Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.
Journal: Progress in neurobiology 20020201
Title: Tetrahydrobiopterin responsiveness in phenylketonuria. Two new cases and a review of molecular genetic findings.
Journal: Journal of inherited metabolic disease 20020201
Title: Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties.
Journal: Bioorganic & medicinal chemistry letters 20020107
Title: Citrulline is not the major product using the standard 'NOS activity' assay on renal cortical homogenates.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020101
Title: Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity.
Journal: International journal of molecular medicine 20020101
Title: Folates and cardiovascular disease.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20020101
Title: Inhibition of N-methyl-D-aspartic acid-nitric oxide synthase in rat hippocampal slices by ethanol. Evidence for the involvement of tetrahydrobiopterin but not lipid peroxidation.
Journal: Journal of biomedical science 20020101
Title: Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency.
Journal: Journal of neurochemistry 20020101
Title: Tetrahydrobiopterin improves vascular endothelial function in ovariectomized rats.
Journal: Journal of biomedical science 20020101
Title: [Screening of tetrahydrobiopterin deficiency among hyperphenylalaninemic patients].
Journal: Annales de biologie clinique 20020101
Title: Plasma biopterin levels and depressive state in pregnancy and the early puerperal period.
Journal: Neuropsychobiology 20020101
Title: Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20020101
Title: Cranial MR spectroscopy of tetrahydrobiopterin deficiency.
Journal: AJNR. American journal of neuroradiology 20020101
Title: Redox role for tetrahydrobiopterin in nitric oxide synthase catalysis: low-temperature optical absorption spectral detection.
Journal: Methods in enzymology 20020101
Title: Regulation of endothelial cell proliferation by nitric oxide.
Journal: Methods in enzymology 20020101
Title: [Novel PKU treatment methods].
Journal: Medycyna wieku rozwojowego 20020101
Title: [Atypical phenylketonuria treatment effectiveness].
Journal: Medycyna wieku rozwojowego 20020101
Title: Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin.
Journal: The Journal of biological chemistry 20011228
Title: Impaired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase.
Journal: Circulation 20011211
Title: Tetrahydrobiopterin attenuates cholesterol induced coronary hyperreactivity to endothelin.
Journal: Heart (British Cardiac Society) 20011201
Title: Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells.
Journal: Nitric oxide : biology and chemistry 20011201
Title: Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress.
Journal: Journal of the American College of Cardiology 20011201
Title: [Perspectives on tetrahydrobiopterin research].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201
Title: Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway.
Journal: Free radical research 20011201
Title: Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Journal: Journal of inherited metabolic disease 20011201
Title: Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells.
Journal: Biochemical and biophysical research communications 20011130
Title: High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin.
Journal: Journal of molecular biology 20011123
Title: Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.
Journal: Biochemistry 20011113
Title: Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation.
Journal: Circulation 20011113
Title: Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice.
Journal: The Journal of biological chemistry 20011102
Title: Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption.
Journal: American journal of physiology. Heart and circulatory physiology 20011101
Title: Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
Journal: Clinica chimica acta; international journal of clinical chemistry 20011101
Title: Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter.
Journal: Journal of neurochemistry 20011101
Title: Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20011101
Title: Current strategies and perspectives for correcting endothelial dysfunction in atherosclerosis.
Journal: Journal of cardiovascular pharmacology 20011101
Title: A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Journal: Biochemistry 20011030
Title: Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Journal: Biochemistry 20011030
Title: Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical.
Journal: Free radical biology & medicine 20011015
Title: Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons.
Journal: The Journal of biological chemistry 20010914
Title: Treatable neurotransmitter deficiency in mild phenylketonuria.
Journal: Neurology 20010911
Title: Survival and graft function in a large animal lung transplant model after 30 h preservation and substitution of the nitric oxide pathway.
Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010901
Title: Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?
Journal: American journal of physiology. Heart and circulatory physiology 20010901
Title: Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells.
Journal: Japanese journal of pharmacology 20010901
Title: Molecular cloning and disruption of a novel gene encoding UDP-glucose: tetrahydrobiopterin alpha-glucosyltransferase in the cyanobacterium Synechococcus sp. PCC 7942.
Journal: FEBS letters 20010803
Title: Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells.
Journal: Oncogene 20010802
Title: Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia.
Journal: American journal of human genetics 20010801
Title: Tetrahydrobiopterin levels regulate endothelial cell proliferation.
Journal: American journal of physiology. Heart and circulatory physiology 20010801
Title: Effects of tetrahydrobiopterin on ataxia in Machado-Joseph disease may be based upon the theory of 'cerebellar long-term depression'.
Journal: Medical hypotheses 20010801
Title: X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.
Journal: Journal of biochemistry 20010801
Title: Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease.
Journal: Journal of the American College of Cardiology 20010801
Title: Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection.
Journal: Brain research. Brain research protocols 20010801
Title: [Orphan drugs and metabolic disorders].
Journal: Revista de neurologia 20010801
Title: Use of surface plasmon resonance for real-time measurements of the global conformational transition in human phenylalanine hydroxylase in response to substrate binding and catalytic activation.
Journal: Analytical biochemistry 20010715
Title: Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells.
Journal: American journal of physiology. Renal physiology 20010701
Title: Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010701
Title: Role of nitric oxide synthase in the light-induced development of sporangiophores in Phycomyces blakesleeanus.
Journal: Plant physiology 20010701
Title: Homomeric and heteromeric interactions between wild-type and mutant phenylalanine hydroxylase subunits: evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia.
Journal: Molecular genetics and metabolism 20010701
Title: Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction?
Journal: American journal of physiology. Heart and circulatory physiology 20010601
Title: Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery.
Journal: European journal of pharmacology 20010601
Title: Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates.
Journal: Journal of inherited metabolic disease 20010601
Title: Pterin interactions with distinct reductase activities of NO synthase.
Journal: The Biochemical journal 20010515
Title: Inhibition of neuronal nitric oxide synthase by 6-nitrocatecholamines, putative reaction products of nitric oxide with catecholamines under oxidative stress conditions.
Journal: The Biochemical journal 20010515
Title: Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA.
Journal: The Journal of laboratory and clinical medicine 20010501
Title: NO or H(2)O(2) for endothelium-dependent vasorelaxation: Tetrahydrobiopterin makes the difference.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010501
Title: Successful treatment of phenylketonuria with tetrahydrobiopterin.
Journal: European journal of pediatrics 20010501
Title: Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase.
Journal: The Journal of biological chemistry 20010427
Title: Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
Journal: Biochemical and biophysical research communications 20010420
Title: Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin.
Journal: Science (New York, N.Y.) 20010413
Title: Thiouracil antithyroid drugs as a new class of neuronal nitric oxide synthase inhibitors.
Journal: Biochemical and biophysical research communications 20010406
Title: Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes.
Journal: Protein science : a publication of the Protein Society 20010401
Title: Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase.
Journal: Nitric oxide : biology and chemistry 20010401
Title: [Studies on neonatal screening, clinical and gene analysis for tetrahydrobiopterin deficiency in Southern Chinese].
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20010401
Title: Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20010401
Title: Tetrahydrobiopterin reverses the impairment of acetylcholine-induced vasodilatation in diabetic ocular microvasculature.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010401
Title: A structural hypothesis for BH4 responsiveness in patients with mild forms of hyperphenylalaninaemia and phenylketonuria.
Journal: Journal of inherited metabolic disease 20010401
Title: Circulating tetrahydrobiopterin concentrations in patients with septic shock.
Journal: British journal of anaesthesia 20010401
Title: Tetrahydrobiopterin improves endothelium-dependent vasodilation in nitroglycerin-tolerant rats.
Journal: European journal of pharmacology 20010330
Title: Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support.
Journal: The Journal of biological chemistry 20010323
Title: Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.
Journal: Circulation 20010306
Title: The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species.
Journal: Free radical biology & medicine 20010301
Title: Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Journal: Clinical chemistry 20010301
Title: Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells.
Journal: Journal of cardiovascular pharmacology 20010301
Title: Differential nitric oxide synthase activity, cofactor availability and cGMP accumulation in the central nervous system during anaesthesia.
Journal: British journal of anaesthesia 20010301
Title: Tetrahydrobiopterin increases myocardial blood flow in healthy volunteers: a double-blind, placebo-controlled study.
Journal: Swiss medical weekly 20010224
Title: Kinetics of CO and NO ligation with the Cys(331)-->Ala mutant of neuronal nitric-oxide synthase.
Journal: The Journal of biological chemistry 20010216
Title: Expression of GTP cyclohydrolase I in murine locus ceruleus is enhanced by peripheral administration of lipopolysaccharide.
Journal: Brain research 20010202
Title: Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide.
Journal: Nitric oxide : biology and chemistry 20010201
Title: Paracrine neuroprotective effect of nitric oxide in the developing retina.
Journal: Journal of neurochemistry 20010201
Title: The optical interconversion of the P-450 and P-420 forms of neuronal nitric oxide synthase: effects of sodium cholate, mercury chloride and urea.
Journal: The international journal of biochemistry & cell biology 20010201
Title: Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Journal: Chemical research in toxicology 20010201
Title: Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
Journal: Environmental health perspectives 20010201
Title: Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase.
Journal: FEBS letters 20010119
Title: Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
Journal: The Journal of biological chemistry 20010105
Title: L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin.
Journal: The Journal of biological chemistry 20010105
Title: Reconstitution of pterin-free inducible nitric-oxide synthase.
Journal: The Journal of biological chemistry 20010105
Title: Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase.
Journal: The international journal of biochemistry & cell biology 20010101
Title: Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent processes?
Journal: The Journal of investigative dermatology 20010101
Title: CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome.
Journal: Movement disorders : official journal of the Movement Disorder Society 20010101
Title: Prolonged survival of murine cardiac allografts by treatment with the 4-amino analog of tetrahydrobiopterin.
Journal: Transplantation proceedings 20010101
Title: Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function.
Journal: Experimental biology and medicine (Maywood, N.J.) 20010101
Title: Parallel induction of nitric oxide and tetrahydrobiopterin synthesis in alveolar macrophages.
Journal: Respiration; international review of thoracic diseases 20010101
Title: Identification of three novel 6-pyruvoyl-tetrahydropterin synthase gene mutations (226C>T, IVS3+1G>A, 116-119delTGTT) in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency.
Journal: Human mutation 20010101
Title: Tetrahydrobiopterin deficiencies without hyperphenylalaninemia: diagnosis and genetics of dopa-responsive dystonia and sepiapterin reductase deficiency.
Journal: Molecular genetics and metabolism 20010101
Title: Tetrahydrobiopterin biosynthesis, regeneration and functions.
Journal: The Biochemical journal 20000401
Title: Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.
Journal: Diabetes 19991201
Title: Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity.
Journal: American journal of respiratory cell and molecular biology 19960901
Title: Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules.
Journal: Journal of the American Society of Nephrology : JASN 19950201
Title: Tetrahydrobiopterin cofactor biosynthesis: GTP cyclohydrolase I mRNA expression in rat brain and superior cervical ganglia.
Journal: Journal of neurochemistry 19930901
Title: Substitutive therapy in a case of methotrexate neurotoxicity.
Journal: European journal of cancer (Oxford, England : 1990) 19920101
Title: [Early neurotoxicity of high-dose of methotrexate and tetrahydrobiopterin deficiency].
Journal: Archives francaises de pediatrie 19911201
Title: The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2'-oxo)reductase.
Journal: The Journal of biological chemistry 19890515
