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142439-96-1
Catalog No.:AA01EPBE

142439-96-1 | 5,6-dichloro-1-[3,5-O-[(S)-mercaptophosphinylidene]-β-D-ribofuranosyl]-1H-benzimidazole,monosodiumsalt

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1mg
≥99%
in stock  
$346.00   $242.00
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5mg
≥99%
in stock  
$1,036.00   $725.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EPBE
Chemical Name:
5,6-dichloro-1-[3,5-O-[(S)-mercaptophosphinylidene]-β-D-ribofuranosyl]-1H-benzimidazole,monosodiumsalt
CAS Number:
142439-96-1
Molecular Formula:
C12H10Cl2N2NaO5PS
Molecular Weight:
419.1527
SMILES:
O[C@@H]1[C@@H]2O[P@@](=O)([S-])OC[C@H]2O[C@H]1n1cnc2c1cc(Cl)c(c2)Cl.[Na+]
Properties
Computed Properties
 
Complexity:
540  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  

Literature

Title: Relationship between cyclic AMP-dependent protein tyrosine phosphorylation and extracellular calcium during hyperactivation of boar spermatozoa.

Journal: Molecular reproduction and development 20121001

Title: Guanine-nucleotide exchange factors (RAPGEF3/RAPGEF4) induce sperm membrane depolarization and acrosomal exocytosis in capacitated stallion sperm.

Journal: Biology of reproduction 20110701

Title: Hyperactivated motility of frozen-thawed spermatozoa from fertile and subfertile Japanese black bulls induced by cyclic adenosine 3',5'-monophosphate analogue, cBiMPS.

Journal: The Journal of reproduction and development 20100201

Title: Calyculin A-sensitive protein phosphatases are involved in maintenance of progressive movement in mouse spermatozoa in vitro by suppression of autophosphorylation of protein kinase A.

Journal: The Journal of reproduction and development 20090601

Title: Changes of PKA and PDK1 in the principal piece of boar spermatozoa treated with a cell-permeable cAMP analog to induce flagellar hyperactivation.

Journal: Molecular reproduction and development 20080901

Title: Effects of protein phosphatase inhibitor calyculin a on the postacrosomal protein serine/threonine phosphorylation state and acrosome reaction in boar spermatozoa incubated with a cAMP analog.

Journal: The Journal of reproduction and development 20080601

Title: Activation of cyclic AMP pathway prevents CD34(+) cell apoptosis.

Journal: Experimental hematology 20061001

Title: Urocortin-induced decrease in Ca2+ sensitivity of contraction in mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase.

Journal: Circulation research 20060512

Title: Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.

Journal: American journal of physiology. Endocrinology and metabolism 20060301

Title: A cyclic adenosine 3',5'-monophosphate stimulates phospholipase Cgamma1-calcium signaling via the activation of tyrosine kinase in boar spermatozoa.

Journal: Journal of andrology 20050101

Title: Action of protein kinase A regulators on secretory activity of porcine granulosa cells in vitro.

Journal: Animal reproduction science 20040301

Title: Involvement of cytoplasmic free calcium in boar sperm: head-to-head agglutination induced by a cell-permeable cyclic adenosine monophosphate analog.

Journal: Journal of andrology 20030101

Title: Viability and protein phosphorylation patterns of boar spermatozoa agglutinated by treatment with a cell-permeable cyclic adenosine 3',5'-monophosphate analog.

Journal: Journal of andrology 20030101

Title: Modulation by PKA of the hyperpolarization-activated current (Ih) in cultured rat olfactory receptor neurons.

Journal: The Journal of membrane biology 20020715

Title: PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle.

Journal: American journal of physiology. Cell physiology 20020301

Title: Two critical periods for cAMP-dependent protein kinase activity during long-term memory consolidation in the crab Chasmagnathus.

Journal: Neurobiology of learning and memory 20020301

Title: The human PER1 gene is inducible by interleukin-6.

Journal: Journal of molecular neuroscience : MN 20020101

Title: Bicarbonate stimulation of boar sperm motility via a protein kinase A-dependent pathway: between-cell and between-ejaculate differences are not due to deficiencies in protein kinase A activation.

Journal: Journal of andrology 20020101

Title: Urocortin relaxes rat tail arteries by a PKA-mediated reduction of the sensitivity of the contractile apparatus for calcium.

Journal: British journal of pharmacology 20011201

Title: A dopamine- and protein kinase A-dependent mechanism for network adaptation in retinal ganglion cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011101

Title: Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes.

Journal: Journal of pineal research 20010901

Title: Inhibition of rat cardiac fibroblast growth by cAMP--but not by cGMP-dependent protein kinase.

Journal: Basic research in cardiology 20010401

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Tags:142439-96-1 Molecular Formula|142439-96-1 MDL|142439-96-1 SMILES|142439-96-1 5,6-dichloro-1-[3,5-O-[(S)-mercaptophosphinylidene]-β-D-ribofuranosyl]-1H-benzimidazole,monosodiumsalt