Title: Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea.
Journal: Toxicology letters 20180901
Title: Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin.
Journal: Chemico-biological interactions 20180625
Title: Silibinin phosphodiester glyco-conjugates: Synthesis, redox behaviour and biological investigations.
Journal: Bioorganic chemistry 20180401
Title: Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201
Title: Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolism.
Journal: Chemico-biological interactions 20170801
Title: Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer.
Journal: Chemico-biological interactions 20170801
Title: Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan.
Journal: Toxicology and applied pharmacology 20170715
Title: Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity.
Journal: Journal of biochemical and molecular toxicology 20170701
Title: Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170701
Title: Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.
Journal: Toxicology letters 20170515
Title: Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170401
Title: Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice.
Journal: Chemico-biological interactions 20150625
Title: Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice.
Journal: Chemico-biological interactions 20150325
Title: Blockade of lipid accumulation by silibinin in adipocytes and zebrafish.
Journal: Chemico-biological interactions 20150205
Title: Silibinin combination with arsenic strongly inhibits survival and invasiveness of human prostate carcinoma cells.
Journal: Nutrition and cancer 20150101
Title: Protective role of silymarin against manganese-induced nephrotoxicity and oxidative stress in rat.
Journal: Environmental toxicology 20141001
Title: Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats.
Journal: Chemico-biological interactions 20140605
Title: Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease.
Journal: Toxicology 20140507
Title: The binding of silibinin to ERp57.
Journal: Chemico-biological interactions 20140425
Title: Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.
Journal: Chemico-biological interactions 20140325
Title: Silibinin potentially attenuates arsenic-induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats.
Journal: Cardiovascular toxicology 20140301
Title: Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study.
Journal: Environmental toxicology 20140201
Title: Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach.
Journal: Toxicology and applied pharmacology 20140115
Title: Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.
Journal: Mediators of inflammation 20140101
Title: Silibinin as a potential therapeutic for sulfur mustard injuries.
Journal: Chemico-biological interactions 20131205
Title: Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism.
Journal: Molecular and cellular biochemistry 20131201
Title: Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking.
Journal: Cellular microbiology 20131101
Title: Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement.
Journal: Systems biology in reproductive medicine 20131001
Title: Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats.
Journal: Toxicology letters 20130523
Title: Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.
Journal: Chemico-biological interactions 20130125
Title: Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.
Journal: Cancer letters 20121229
Title: Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.
Journal: Medical oncology (Northwood, London, England) 20121201
Title: CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation.
Journal: Journal of cellular biochemistry 20121201
Title: Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.
Journal: Cellular signalling 20121201
Title: Silymarin attenuates benzo(a)pyrene induced toxicity by mitigating ROS production, DNA damage and calcium mediated apoptosis in peripheral blood mononuclear cells (PBMC).
Journal: Ecotoxicology and environmental safety 20121201
Title: Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats.
Journal: Molecular biology reports 20121201
Title: Hepatoprotective and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-induced liver injury in rats.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20121101
Title: Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells.
Journal: Free radical research 20121101
Title: Potential protective effect of honey against paracetamol-induced hepatotoxicity.
Journal: Archives of Iranian medicine 20121101
Title: Silibinin for cyclopeptide mushroom poisonings.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20121101
Title: Protection by silibinin against experimental ischemic stroke: up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression.
Journal: Neuroscience letters 20121031
Title: Silibinin attenuates allergic airway inflammation in mice.
Journal: Biochemical and biophysical research communications 20121026
Title: Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20121015
Title: Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.
Journal: Molecular carcinogenesis 20121001
Title: Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries.
Journal: Toxicology and applied pharmacology 20121001
Title: In vivo evaluation of silybin nanosuspensions targeting liver.
Journal: Journal of biomedical nanotechnology 20121001
Title: Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells.
Journal: Epigenetics 20121001
Title: Preventive and protective effects of silymarin on doxorubicin-induced testicular damages correlate with changes in c-myc gene expression.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120915
Title: Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats.
Journal: Life sciences 20120904
Title: Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.
Journal: Phytotherapy research : PTR 20120901
Title: Long-term administration of Silymarin augments proinflammatory mediators in the hippocampus of rats: evidence for antioxidant and pro-oxidant effects.
Journal: Human & experimental toxicology 20120901
Title: P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells.
Journal: Free radical research 20120901
Title: Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901
Title: Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: analysis of isolated hepatic stellate cells.
Journal: International journal of molecular medicine 20120901
Title: Therapeutic efficacy of silibinin on human neuroblastoma cells: Akt and NF-κB expressions may play an important role in silibinin-induced response.
Journal: Neurochemical research 20120901
Title: Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.
Journal: International journal of oncology 20120901
Title: Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway.
Journal: Oncology reports 20120901
Title: Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women.
Journal: Journal of reproductive immunology 20120901
Title: Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model.
Journal: Human & experimental toxicology 20120801
Title: Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning.
Journal: Current pharmaceutical biotechnology 20120801
Title: The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.
Journal: Apoptosis : an international journal on programmed cell death 20120801
Title: Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: a comparative evaluation with piracetam and protocatachuic acid.
Journal: Pharmacology, biochemistry, and behavior 20120801
Title: Novel antiosteoclastogenic activity of phloretin antagonizing RANKL-induced osteoclast differentiation of murine macrophages.
Journal: Molecular nutrition & food research 20120801
Title: Hepatitis C therapy in non-genotype 1 patients: the near future.
Journal: Journal of viral hepatitis 20120801
Title: High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy.
Journal: Journal of viral hepatitis 20120801
Title: A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120801
Title: Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial.
Journal: JAMA 20120718
Title: Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice.
Journal: Drug and chemical toxicology 20120701
Title: Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models.
Journal: Surgical endoscopy 20120701
Title: Injectable and biodegradable poly(organophosphazene) gel containing silibinin: its physicochemical properties and anticancer activity.
Journal: Journal of pharmaceutical sciences 20120701
Title: Silibinin inhibits tumor growth in a murine orthotopic hepatocarcinoma model and activates the TRAIL apoptotic signaling pathway.
Journal: Anticancer research 20120701
Title: Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120615
Title: Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
Journal: Journal of medicinal chemistry 20120614
Title: Formulation of microemulsion systems for dermal delivery of silymarin.
Journal: AAPS PharmSciTech 20120601
Title: Biochemical and immunological basis of silymarin effect, a milk thistle (Silybum marianum) against ethanol-induced oxidative damage.
Journal: Toxicology mechanisms and methods 20120601
Title: Complementary and alternative medicines in prostate cancer: from bench to bedside?
Journal: The oncologist 20120601
Title: Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
Journal: Translational research : the journal of laboratory and clinical medicine 20120601
Title: Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120515
Title: Antioxidant effects of Citharexylum spinosum in CCl₄ induced nephrotoxicity in rat.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120501
Title: Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis.
Journal: Journal of the science of food and agriculture 20120501
Title: Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.
Journal: Journal of cellular biochemistry 20120501
Title: Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats.
Journal: Toxicology mechanisms and methods 20120501
Title: Understanding silibinin's modes of action against HCV using viral kinetic modeling.
Journal: Journal of hepatology 20120501
Title: Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: Effect of silymarin and harpagoside on inflammation reaction of BEAS-2B cells, on ciliary beat frequency (CBF) of trachea explants and on mucociliary clearance (MCC).
Journal: Planta medica 20120501
Title: [Acute hepatic failure after ingestion of mushrooms].
Journal: Der Internist 20120501
Title: Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells.
Journal: Cell biochemistry and function 20120401
Title: Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120401
Title: Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.
Journal: Biochemical and biophysical research communications 20120316
Title: Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity.
Journal: Neurochemical research 20120301
Title: Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner.
Journal: Carcinogenesis 20120301
Title: P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.
Journal: Free radical research 20120301
Title: Anti-apoptotic effects of tamarind leaves against ethanol-induced rat liver injury.
Journal: The Journal of pharmacy and pharmacology 20120301
Title: Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin.
Journal: The journal of pain : official journal of the American Pain Society 20120301
Title: Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120214
Title: Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line.
Journal: Neurochemical research 20120201
Title: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C.
Journal: Clinical trials (London, England) 20120201
Title: Metabolic effects of silibinin in the rat liver.
Journal: Chemico-biological interactions 20120125
Title: Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats.
Journal: European journal of pharmacology 20120115
Title: Silymarin in the prevention and treatment of liver diseases and primary liver cancer.
Journal: Current pharmaceutical biotechnology 20120101
Title: Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by silymarin in proliferating mesenchymal stem cells: comparison with glutathione modifiers.
Journal: Journal of natural medicines 20120101
Title: Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts.
Journal: Journal of cellular biochemistry 20120101
Title: Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Methyl jasmonate influence on silymarin production and plant stress responses in Silybum marianum hairy root cultures in a bioreactor.
Journal: Natural product research 20120101
Title: Silibinin is a potent sensitizer of UVA radiation-induced oxidative stress and apoptosis in human keratinocyte HaCaT cells.
Journal: Photochemistry and photobiology 20120101
Title: Silymarin, a molecule of interest for topical photoprotection.
Journal: Natural product research 20120101
Title: Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis.
Journal: Parasites & vectors 20120101
Title: Silymarin and hepatoprotection.
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20120101
Title: In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles.
Journal: International journal of nanomedicine 20120101
Title: In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell.
Journal: Journal of Asian natural products research 20120101
Title: Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trial.
Journal: BMC gastroenterology 20120101
Title: Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.
Journal: PloS one 20120101
Title: Cellulose acetate electrospun fiber mats for controlled release of silymarin.
Journal: Journal of nanoscience and nanotechnology 20120101
Title: Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation.
Journal: Journal of Asian natural products research 20120101
Title: Metabolic acidosis during treatment of mushroom poisoning: a diagnostic pitfall.
Journal: Internal medicine (Tokyo, Japan) 20120101
Title: [Pharmacological effects of Abies polyprenols and carsil on alcohol-induced hepatitis].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20120101
Title: In vitro and in vivo antioxidant activity of alfalfa (Medicago sativa L.) on carbon tetrachloride intoxicated rats.
Journal: The American journal of Chinese medicine 20120101
Title: Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.
Journal: PloS one 20120101
Title: Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.
Journal: PloS one 20120101
Title: Protective role of standardized Feronia limonia stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity.
Journal: Annals of hepatology 20120101
Title: The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis.
Journal: Fundamental & clinical pharmacology 20111201
Title: Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss).
Journal: Fish physiology and biochemistry 20111201
Title: Silymarin glyceryl monooleate/poloxamer 407 liquid crystalline matrices: physical characterization and enhanced oral bioavailability.
Journal: AAPS PharmSciTech 20111201
Title: Comparison of early treatment with low doses of nilotinib, imatinib and a clinically relevant dose of silymarin in thioacetamide-induced liver fibrosis.
Journal: European journal of pharmacology 20111130
Title: Synergistic effects between silibinin and antibiotics on methicillin-resistant Staphylococcus aureus isolated from clinical specimens.
Journal: Biotechnology journal 20111101
Title: Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells.
Journal: Free radical research 20111101
Title: Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice.
Journal: Pharmaceutical biology 20111101
Title: Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast cancer cells.
Journal: Anticancer research 20111101
Title: Neuroprotective effect of silibinin in diabetic mice.
Journal: Neuroscience letters 20111031
Title: Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats.
Journal: Journal of the neurological sciences 20111015
Title: The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats.
Journal: Molecules (Basel, Switzerland) 20111012
Title: Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel.
Journal: Molecular carcinogenesis 20111001
Title: Silymarin selectively protects human renal cells from cisplatin-induced cell death.
Journal: Pharmaceutical biology 20111001
Title: Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways.
Journal: European journal of pharmacology 20111001
Title: Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells.
Journal: Apoptosis : an international journal on programmed cell death 20111001
Title: Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats.
Journal: Carcinogenesis 20111001
Title: The cytotoxicity of OPA-modified CdSe/ZnS core/shell quantum dots and its modulation by silibinin in human skin cells.
Journal: Journal of biomedical nanotechnology 20111001
Title: A profile of bioactive compounds of Rumex vesicarius L.
Journal: Journal of food science 20111001
Title: Protective effects of Wu-Ling-Shen (Xylaria nigripes) on carbon tetrachloride-induced hepatotoxicity in mice.
Journal: Immunopharmacology and immunotoxicology 20110901
Title: Improved antifibrotic effect of a combination of verapamil and silymarin in rat-induced liver fibrosis.
Journal: Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 20110901
Title: Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment.
Journal: Behavioural brain research 20110801
Title: Silibinin mode of action against hepatitis C virus: a controversy yet to be resolved.
Journal: Hepatology (Baltimore, Md.) 20110801
Title: Manganese induces oxidative stress, redox state unbalance and disrupts membrane bound ATPases on murine neuroblastoma cells in vitro: protective role of silymarin.
Journal: Neurochemical research 20110801
Title: Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells.
Journal: Cancer prevention research (Philadelphia, Pa.) 20110801
Title: Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110801
Title: Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats.
Journal: Asian Pacific journal of tropical medicine 20110801
Title: Silymarin efficacy against influenza A virus replication.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110715
Title: Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies.
Journal: International journal of pharmaceutics 20110715
Title: In vitro and in vivo antioxidant activity of Symplocos cochinchinensis S. Moore leaves containing phenolic compounds.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110701
Title: Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells.
Journal: Free radical research 20110701
Title: Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo.
Journal: Acta pharmacologica Sinica 20110701
Title: Hepatoprotective studies on Haloxylon Salicornicum: a plant from Cholistan desert.
Journal: Pakistan journal of pharmaceutical sciences 20110701
Title: Effect of silybin on high-fat-induced fatty liver in rats.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110701
Title: Effect of silymarin on curcumin-induced mortality in zebrafish (Danio rerio) embryos and larvae.
Journal: Indian journal of experimental biology 20110701
Title: The art and science of new advances in cosmeceuticals.
Journal: Clinics in plastic surgery 20110701
Title: Hepatoprotective effects of lychee (Litchi chinensis Sonn.): a combination of antioxidant and anti-apoptotic activities.
Journal: Journal of ethnopharmacology 20110614
Title: Molecular mechanism of silymarin-induced apoptosis in a highly metastatic lung cancer cell line anip973.
Journal: Cancer biotherapy & radiopharmaceuticals 20110601
Title: Molecular dynamics simulation of drug uptake by polymer.
Journal: Journal of molecular modeling 20110501
Title: Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats.
Journal: Ecotoxicology and environmental safety 20110501
Title: Identification and initial SAR of silybin: an Hsp90 inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.
Journal: Archives of pharmacal research 20110501
Title: [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501
Title: Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol.
Journal: Journal of agricultural and food chemistry 20110427
Title: Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis.
Journal: Toxicology and applied pharmacology 20110415
Title: Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV.
Journal: World journal of gastroenterology 20110407
Title: Nilotinib counteracts thioacetamide-induced hepatic oxidative stress and attenuates liver fibrosis progression.
Journal: Fundamental & clinical pharmacology 20110401
Title: Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives.
Journal: Journal of enzyme inhibition and medicinal chemistry 20110401
Title: Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.
Journal: Carcinogenesis 20110401
Title: Hepatoprotective and antioxidant activities of Tamarix nilotica flowers.
Journal: Pharmaceutical biology 20110401
Title: A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression.
Journal: Phytochemistry 20110401
Title: Hepatoprotective activity of punarnavashtak kwath, an Ayurvedic formulation, against CCl4-induced hepatotoxicity in rats and on the HepG2 cell line.
Journal: Pharmaceutical biology 20110401
Title: Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures.
Journal: Journal of veterinary pharmacology and therapeutics 20110401
Title: Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110401
Title: Stripping voltammetric determination of silymarin in formulations and human blood utilizing bare and modified carbon paste electrodes.
Journal: Talanta 20110315
Title: Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Journal: Journal of pineal research 20110301
Title: Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.
Journal: Planta medica 20110301
Title: Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence.
Journal: Pharmacology, biochemistry, and behavior 20110301
Title: Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins.
Journal: Journal of cellular biochemistry 20110301
Title: Curative effect of the Egyptian marine Erugosquilla massavensis extract on carbon tetrachloride-induced oxidative stress in rat liver and erythrocytes.
Journal: European review for medical and pharmacological sciences 20110301
Title: Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110215
Title: Silymarin: a novel antioxidant with antiglycation and antiinflammatory properties in vitro and in vivo.
Journal: Antioxidants & redox signaling 20110201
Title: Silymarin potentiates the antinociceptive effect of morphine in mice.
Journal: Phytotherapy research : PTR 20110201
Title: Hepatoprotective activity of Glycosmis pentaphylla against paracetamol-induced hepatotoxicity in Swiss albino mice.
Journal: Pharmaceutical biology 20110201
Title: In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa.
Journal: Inflammopharmacology 20110201
Title: Silibinin: a novel inhibitor of Aβ aggregation.
Journal: Neurochemistry international 20110201
Title: Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger.
Journal: The Journal of pharmacy and pharmacology 20110201
Title: Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle.
Journal: Toxicologic pathology 20110201
Title: Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy.
Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20110201
Title: Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.
Journal: European journal of pharmacology 20110110
Title: Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin.
Journal: Human & experimental toxicology 20110101
Title: Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1.
Journal: Pharmaceutical biology 20110101
Title: Methyl jasmonate increases silymarin production in Silybum marianum (L.) Gaernt cell cultures treated with β-cyclodextrins.
Journal: Biotechnology letters 20110101
Title: Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway.
Journal: Cancer investigation 20110101
Title: Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria.
Journal: Molecular cancer therapeutics 20110101
Title: Silibinin activated ROS-p38-NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells.
Journal: Journal of Asian natural products research 20110101
Title: Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer.
Journal: Nutrition and cancer 20110101
Title: Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.
Journal: PloS one 20110101
Title: Comparative effects of silymarin and vitamin E supplementation on oxidative stress markers, and hemoglobin levels among patients on hemodialysis.
Journal: Renal failure 20110101
Title: Inhibition of HCV 3a core gene through Silymarin and its fractions.
Journal: Virology journal 20110101
Title: Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: Aminoguanidine potentiates the hepatoprotective effect of silymarin in CCL4 treated rats.
Journal: Annals of hepatology 20110101
Title: Frosted branch angiitis, neuroretinitis as initial ocular manifestation in Behçet disease.
Journal: Indian journal of ophthalmology 20110101
Title: Prophylactic and curative effects of purslane on bile duct ligation-induced hepatic fibrosis in albino rats.
Journal: Annals of hepatology 20110101
Title: Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs.
Journal: Journal of veterinary internal medicine 20110101
Title: Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat.
Journal: BMC complementary and alternative medicine 20110101
Title: Silymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by nucleotide excision repair mechanism.
Journal: PloS one 20110101
Title: Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats.
Journal: International journal of molecular sciences 20110101
Title: Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity.
Journal: International journal of nanomedicine 20110101
Title: Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
Journal: Cardiovascular diabetology 20110101
Title: Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells.
Journal: PloS one 20110101
Title: Natural antioxidants and vascular calcification: a possible benefit.
Journal: Journal of nephrology 20110101
Title: Silibinin causes apoptosis and cell cycle arrest in some human pancreatic cancer cells.
Journal: International journal of molecular sciences 20110101
Title: Using biochemical findings to study the effect of silymarin on the liver of pregnant rat that consumed ethanol.
Journal: Acta medica Iranica 20110101
Title: [Some issues of death cap (Amanita phalloides) poisoning based on cases treated in Poznan Department of Toxicology in 2010].
Journal: Przeglad lekarski 20110101
Title: Intravenous silibinin as 'rescue treatment' for on-treatment non-responders to pegylated interferon/ribavirin combination therapy.
Journal: Antiviral therapy 20110101
Title: [Hepatoprotectors in therapy of the alcoholic liver disease (clinical and experimental research)].
Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101
Title: [Hepatoprotective effect of thiophane in rats with experimental carbon tetrachloride-induced hepatitis].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101
Title: Protective effects of silymarin against doxorubicin-induced toxicity.
Journal: Asian Pacific journal of cancer prevention : APJCP 20110101
Title: [Study of clinical efficiency of essential phospholipids and silymarin combination in nonalcoholic and alcoholic steatohepatitis].
Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101
Title: Hepatoprotective effects and antioxidant role of Scutia myrtina on paracetamol induced hepatotoxicity in rats.
Journal: Journal of complementary & integrative medicine 20110101
Title: Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats.
Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20101201
Title: 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201
Title: Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201
Title: Reduction of oxidative stress and liver injury following silymarin and praziquantel treatment in mice with Mesocestoides vogae (Cestoda) infection.
Journal: Parasitology international 20101201
Title: Modulation of early stress-related biomarkers in cytoplasm by the antioxidants silymarin and quercetin using a cellular model of acute arsenic poisoning.
Journal: Basic & clinical pharmacology & toxicology 20101201
Title: Alginate-based ferrofluid and magnetic microsphere thereof.
Journal: International journal of biological macromolecules 20101201
Title: Silymarin inhibits endothelial progenitor cells' senescence and protects against the antiproliferative activity of rapamycin: preliminary study.
Journal: Journal of cardiovascular pharmacology 20101201
Title: Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation.
Journal: Molecular cancer therapeutics 20101201
Title: Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).
Journal: Cell cycle (Georgetown, Tex.) 20101115
Title: A new monoterpene acid from Marrubium vulgare with potential antihepatotoxic activity.
Journal: Natural product research 20101101
Title: Antioxidant and hepatoprotective activities of Egyptian moraceous plants against carbon tetrachloride-induced oxidative stress and liver damage in rats.
Journal: Pharmaceutical biology 20101101
Title: Protective effects of Pergularia daemia roots against paracetamol and carbon tetrachloride-induced hepatotoxicity in rats.
Journal: Pharmaceutical biology 20101101
Title: Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes.
Journal: Natural product research 20101101
Title: Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response.
Journal: Investigational new drugs 20101001
Title: Milk thistle in liver diseases: past, present, future.
Journal: Phytotherapy research : PTR 20101001
Title: Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules.
Journal: Pharmaceutical research 20101001
Title: Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20101001
Title: Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101001
Title: Antihepatotoxic and antioxidant activities of methanol extract and isolated compounds from Ficus chlamydocarpa.
Journal: Natural product communications 20101001
Title: Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model.
Journal: European journal of pharmacology 20100915
Title: Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica.
Journal: Journal of ethnopharmacology 20100915
Title: Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100915
Title: Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors.
Journal: Hematological oncology 20100901
Title: Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study.
Journal: Toxicology and applied pharmacology 20100901
Title: Effects of silymarin on gossypol toxicosis in divergent lines of chickens.
Journal: Poultry science 20100901
Title: Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer.
Journal: Cancer metastasis reviews 20100901
Title: The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial.
Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20100901
Title: Cytoprotective effects of silymarin on epithelial cells against arsenic-induced apoptosis in contrast with quercetin cytotoxicity.
Journal: Life sciences 20100828
Title: Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: involvement of estrogen receptors and oxidative stress.
Journal: Neuroscience letters 20100823
Title: Tumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants.
Journal: Cancer biology & therapy 20100815
Title: Chronic treatment of silymarin improves hyperalgesia and motor nerve conduction velocity in diabetic neuropathic rat.
Journal: Phytotherapy research : PTR 20100801
Title: Silibinin attenuates cardiac hypertrophy and fibrosis through blocking EGFR-dependent signaling.
Journal: Journal of cellular biochemistry 20100801
Title: Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.
Journal: Nutrition and cancer 20100801
Title: Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20100701
Title: Effects of plant-derived polyphenols on TNF-alpha and nitric oxide production induced by advanced glycation endproducts.
Journal: Molecular nutrition & food research 20100701
Title: Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats.
Journal: Renal failure 20100701
Title: Hepatoprotective and behavioral effects of jigrine in galactosamine-induced hepatopathy in rats.
Journal: Pharmaceutical biology 20100701
Title: Effects of silybinin, CYP3A4 and P-glycoprotein inhibitor in vitro, on the bioavailability of loratadine in rats.
Journal: Die Pharmazie 20100701
Title: Protective effects of silybin and analogues against X-ray radiation-induced damage.
Journal: Acta biochimica et biophysica Sinica 20100701
Title: Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis.
Journal: Toxicon : official journal of the International Society on Toxinology 20100615
Title: Downregulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis.
Journal: Life sciences 20100605
Title: Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer.
Journal: Investigational new drugs 20100601
Title: A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer.
Journal: The Prostate 20100601
Title: Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver.
Journal: Toxicology and applied pharmacology 20100601
Title: Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601
Title: Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability.
Journal: AAPS PharmSciTech 20100601
Title: Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors.
Journal: Oncology reports 20100601
Title: Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats.
Journal: Renal failure 20100601
Title: Multiple effects of silymarin on the hepatitis C virus lifecycle.
Journal: Hepatology (Baltimore, Md.) 20100601
Title: Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles.
Journal: Acta pharmacologica Sinica 20100601
Title: Preparation and in vitro evaluation of povidone-sodium cholate-phospholipid mixed micelles for the solubilization of poorly soluble drugs.
Journal: Archives of pharmacal research 20100601
Title: Preparation and evaluation of galactosylated vesicular carrier for hepatic targeting of silibinin.
Journal: Drug development and industrial pharmacy 20100501
Title: Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.
Journal: Cancer letters 20100501
Title: Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2).
Journal: Mutagenesis 20100501
Title: Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy.
Journal: Medical hypotheses 20100501
Title: Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100501
Title: Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells.
Journal: Free radical research 20100501
Title: [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II].
Journal: Revista de neurologia 20100501
Title: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling.
Journal: Neoplasia (New York, N.Y.) 20100501
Title: [Protective effect of silibinin on liver injury induced by antituberculosis drugs].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100501
Title: [Advances in the study of polymeric micelles used in oral administration].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100501
Title: Effect of chrysin on hepatoprotective and antioxidant status in D-galactosamine-induced hepatitis in rats.
Journal: European journal of pharmacology 20100410
Title: Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats.
Journal: Inflammopharmacology 20100401
Title: Hepatoprotective effect of three herbal extracts on aflatoxin B1-intoxicated rat liver.
Journal: Singapore medical journal 20100401
Title: [An updated review at molecular pharmacological level for the mechanism of anti-tumor, antioxidant and immunoregulatory action of silibinin].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401
Title: Identification of hepatoprotective flavonolignans from silymarin.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20100330
Title: Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.
Journal: Journal of agricultural and food chemistry 20100324
Title: Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
Journal: Bioorganic & medicinal chemistry 20100315
Title: Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin.
Journal: Cancer research 20100315
Title: Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.
Journal: Behavioural brain research 20100305
Title: Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators.
Journal: Molecular carcinogenesis 20100301
Title: Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Journal: Gastroenterology 20100301
Title: Silymarin secretion and its elicitation by methyl jasmonate in cell cultures of Silybum marianum is mediated by phospholipase D-phosphatidic acid.
Journal: Journal of experimental botany 20100301
Title: A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Silibinin--a promising new treatment for cancer.
Journal: Anti-cancer agents in medicinal chemistry 20100301
Title: Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100301
Title: Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9.
Journal: Anti-cancer drugs 20100301
Title: Comparison of the prophylactic effect of silymarin and deferoxamine on iron overload-induced hepatotoxicity in rat.
Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100301
Title: Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1.
Journal: Journal of ethnopharmacology 20100217
Title: Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100201
Title: Targeting silibinin in the antiproliferative pathway.
Journal: Expert opinion on investigational drugs 20100201
Title: Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat.
Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20100201
Title: Evaluation of prophylactic and therapeutic effects of silymarin and N-acetylcysteine in acetaminophen-induced hepatotoxicity in cats.
Journal: Journal of veterinary pharmacology and therapeutics 20100201
Title: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model.
Journal: Fitoterapia 20100101
Title: Radioprotection of plasmid and cellular DNA and Swiss mice by silibinin.
Journal: Mutation research 20100101
Title: Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells.
Journal: Free radical research 20100101
Title: Comparative evaluation of different extracts of leaves of Psidium guajava Linn. for hepatoprotective activity.
Journal: Pakistan journal of pharmaceutical sciences 20100101
Title: Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats.
Journal: Anticancer research 20100101
Title: Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway.
Journal: Journal of pharmacological sciences 20100101
Title: Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats.
Journal: Pharmacology 20100101
Title: Hepatoprotective effect of Scoparia dulcis on carbon tetrachloride induced acute liver injury in mice.
Journal: The American journal of Chinese medicine 20100101
Title: Evaluation of silymarin as a promising radioprotector.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101
Title: Novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury.
Journal: Forschende Komplementarmedizin (2006) 20100101
Title: [Prevention of abnormal physiological and biochemical characteristics of red blood cells in carbon disulfide intoxication].
Journal: Gigiena i sanitariia 20100101
Title: Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.
Journal: Journal of medicinal chemistry 20091210
Title: Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats.
Journal: Chemico-biological interactions 20091210
Title: Silibinin inhibits expression of HIF-1alpha through suppression of protein translation in prostate cancer cells.
Journal: Biochemical and biophysical research communications 20091204
Title: Effect of carvacrol on hepatic marker enzymes and antioxidant status in D-galactosamine-induced hepatotoxicity in rats.
Journal: Fundamental & clinical pharmacology 20091201
Title: Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice.
Journal: Fundamental & clinical pharmacology 20091201
Title: Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.
Journal: Pharmaceutical research 20091201
Title: Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin.
Journal: Journal of drug targeting 20091201
Title: Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.
Journal: Journal of ethnopharmacology 20091112
Title: Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway.
Journal: Molecules (Basel, Switzerland) 20091026
Title: Role of tacrolimus (FK506) 0.1% ointment WW in vitiligo in children and imperatives of combine therapy with Trioxsalen and Silymarin suspension in progressive vitiligo.
Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20091001
Title: Anti- and pro-mutagenic effects of silymarin in the Ames bacterial reverse mutation assay.
Journal: Phytotherapy research : PTR 20091001
Title: Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats.
Journal: Basic & clinical pharmacology & toxicology 20091001
Title: Elicitation of silymarin in cell cultures of Silybum marianum: effect of subculture and repeated addition of methyl jasmonate.
Journal: Biotechnology letters 20091001
Title: Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20091001
Title: Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001
Title: The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells.
Journal: Journal of pharmacological sciences 20091001
Title: Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20090901
Title: Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090901
Title: Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in wistar rats.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090901
Title: Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.
Journal: Cell biology international 20090901
Title: Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090901
Title: Nanoparticles of polyethylene sebacate: a new biodegradable polymer.
Journal: AAPS PharmSciTech 20090901
Title: Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer.
Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20090901
Title: Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties.
Journal: Bioorganic & medicinal chemistry 20090901
Title: Free radical scavenging reactions and antioxidant activities of silybin: mechanistic aspects and pulse radiolytic studies.
Journal: Free radical research 20090901
Title: Silibinin inhibits osteoclast differentiation mediated by TNF family members.
Journal: Molecules and cells 20090901
Title: Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts.
Journal: Alternative medicine review : a journal of clinical therapeutic 20090901
Title: Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat livers.
Journal: Life sciences 20090812
Title: Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo.
Journal: Neurochemical research 20090801
Title: Extraction of co-products from biomass: example of thermal degradation of silymarin compounds in subcritical water.
Journal: Applied biochemistry and biotechnology 20090801
Title: Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801
Title: Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.
Journal: British journal of pharmacology 20090801
Title: Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression.
Journal: Acta pharmacologica Sinica 20090801
Title: Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft.
Journal: Molecular cancer therapeutics 20090801
Title: Attenuation of carbon tetrachloride-induced hepatotoxicity by cow urine distillate in rats.
Journal: Biomedical and environmental sciences : BES 20090801
Title: Micronization of silybin by the emulsion solvent diffusion method.
Journal: International journal of pharmaceutics 20090706
Title: Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
Journal: Journal of applied toxicology : JAT 20090701
Title: PEGylated lactoferrin enhanced its hepatoprotective effects on acute liver injury induced by carbon tetrachloride in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090701
Title: Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin.
Journal: Gastroenterology 20090701
Title: Hepatoprotective effect of Trichosanthes cucumerina Var cucumerina L. on carbon tetrachloride induced liver damage in rats.
Journal: Journal of ethnopharmacology 20090622
Title: Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis.
Journal: Investigational new drugs 20090601
Title: Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090601
Title: Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers.
Journal: European journal of clinical pharmacology 20090601
Title: Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial.
Journal: Fundamental & clinical pharmacology 20090601
Title: Preparation and evaluation of gastroretentive floating tablets of Silymarin.
Journal: Chemical & pharmaceutical bulletin 20090601
Title: Silibinin inhibits translation initiation: implications for anticancer therapy.
Journal: Molecular cancer therapeutics 20090601
Title: [Development of Silymarin nanocrystals lyophilized power applying nanosuspension technology].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601
Title: The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar rats offspring.
Journal: Journal of Asian natural products research 20090601
Title: Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis.
Journal: Chemico-biological interactions 20090515
Title: A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090501
Title: Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20090501
Title: Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
Journal: International journal of molecular medicine 20090501
Title: Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.
Journal: Cancer research 20090501
Title: Silibinin attenuates mast cell-mediated anaphylaxis-like reactions.
Journal: Biological & pharmaceutical bulletin 20090501
Title: Therapeutic use of cytoprotective agents in canine and feline hepatobiliary disease.
Journal: The Veterinary clinics of North America. Small animal practice 20090501
Title: Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice.
Journal: World journal of gastroenterology 20090428
Title: Protective effect of iridoid glucosides from Boschniakia rossica on acute liver injury induced by carbon tetrachloride in rats.
Journal: Bioscience, biotechnology, and biochemistry 20090423
Title: In vitro antioxidant activity of silymarin.
Journal: Journal of enzyme inhibition and medicinal chemistry 20090401
Title: Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells.
Journal: Molecular nutrition & food research 20090401
Title: Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats.
Journal: Fundamental & clinical pharmacology 20090401
Title: Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells.
Journal: Cell proliferation 20090401
Title: Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.
Journal: Journal of natural products 20090401
Title: Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20090301
Title: Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090301
Title: Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090301
Title: The influence of iron loading and iron chelation on the proliferation and telomerase activity of human peripheral blood mononuclear cells.
Journal: Iranian journal of immunology : IJI 20090301
Title: Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats.
Journal: Acta pharmaceutica (Zagreb, Croatia) 20090301
Title: Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: involvement of inducible nitric oxide synthase and hemoxygenase-1.
Journal: Nitric oxide : biology and chemistry 20090201
Title: Effect of schisandrin B and sesamin mixture on CCl(4)-induced hepatic oxidative stress in rats.
Journal: Phytotherapy research : PTR 20090201
Title: Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090201
Title: Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy.
Journal: Oncogene 20090122
Title: Drug-drug interactions of silymarin on the perspective of pharmacokinetics.
Journal: Journal of ethnopharmacology 20090121
Title: Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090115
Title: [Effects of supplementation with the antioxidant flavonoid, silymarin, in chronic hepatitis C patients treated with peg-interferon + ribavirin. A placebo-controlled double blind study].
Journal: Orvosi hetilap 20090111
Title: Assessment of oxidative stress in leukocytes and granulocyte function following oral administration of a silibinin-phosphatidylcholine complex in cats.
Journal: American journal of veterinary research 20090101
Title: Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Journal: Cancer prevention research (Philadelphia, Pa.) 20090101
Title: Anti-inflammatory activity of silymarin in patients with knee osteoarthritis. A comparative study with piroxicam and meloxicam.
Journal: Saudi medical journal 20090101
Title: Effect of Clausena dentata (Willd.) M. Roem. against paracetamol induced hepatotoxicity in rats.
Journal: Pakistan journal of pharmaceutical sciences 20090101
Title: Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101
Title: Failure of benzylpenicillin, N-acetylcysteine and silibinin to reduce alpha-amanitin hepatotoxicity.
Journal: In vivo (Athens, Greece) 20090101
Title: Pharmacokinetic interaction between oltipraz and silymarin in rats.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101
Title: Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box-Behnken experimental design.
Journal: Phytochemical analysis : PCA 20090101
Title: Cosmeceuticals and silibinin.
Journal: Clinics in dermatology 20090101
Title: Hepatoprotective activity of Cleome viscosa Linn. extract against thioacetamide-induced hepatotoxicity in rats.
Journal: Natural product research 20090101
Title: Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity.
Journal: International journal of biological sciences 20090101
Title: Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats.
Journal: In vivo (Athens, Greece) 20090101
Title: Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride.
Journal: The American journal of Chinese medicine 20090101
Title: Hepatoprotective effect of pentoxifylline against D-galactosamine-induced hepatotoxicity in rats.
Journal: Annals of hepatology 20090101
Title: Affect of silymarin on serum levels of ALT and GGT in ethanol induced hepatotoxicity in albino rats.
Journal: Journal of Ayub Medical College, Abbottabad : JAMC 20090101
Title: Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.
Journal: International journal of cancer 20081215
Title: Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma.
Journal: Cancer letters 20081208
Title: Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20081201
Title: Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.
Journal: Chemical & pharmaceutical bulletin 20081201
Title: The challenge of herbal therapies for prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081201
Title: Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081201
Title: Influence of diabetes on liver injury induced by antitubercular drugs and on silymarin hepatoprotection in rats.
Journal: Methods and findings in experimental and clinical pharmacology 20081201
Title: The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice.
Journal: Chemico-biological interactions 20081125
Title: Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081101
Title: Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.
Journal: Gastroenterology 20081101
Title: Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines.
Journal: Phytotherapy research : PTR 20081101
Title: Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection.
Journal: Journal of medical virology 20081101
Title: Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues.
Journal: Journal of radiation research 20081101
Title: Multitargeted therapy of cancer by silymarin.
Journal: Cancer letters 20081008
Title: [Amanita poisoning--comparison of silibinin with a combination of silibinin and penicillin].
Journal: Deutsche medizinische Wochenschrift (1946) 20081001
Title: Interspecies comparison of the glucuronidation processes in the man, monkey, pig, dog and rat.
Journal: Neuro endocrinology letters 20081001
Title: Cell growth inhibition and down-regulation of survivin by silibinin in a laryngeal squamous cell carcinoma cell line.
Journal: The Annals of otology, rhinology, and laryngology 20081001
Title: Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
Journal: Cancer prevention research (Philadelphia, Pa.) 20081001
Title: Some common signal transduction events are not necessary for the elicitor-induced accumulation of silymarin in cell cultures of Silybum marianum.
Journal: Journal of plant physiology 20080929
Title: Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.
Journal: European journal of pharmacology 20080904
Title: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
Journal: Medicinal research reviews 20080901
Title: Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells.
Journal: Pharmaceutical research 20080901
Title: Impact of treatment with praziquantel, silymarin and/or beta-glucan on pathophysiological markers of liver damage and fibrosis in mice infected with Mesocestoides vogae (Cestoda) tetrathyridia.
Journal: Journal of helminthology 20080901
Title: Silybin treatment is associated with reduction in serum ferritin in patients with chronic hepatitis C.
Journal: Journal of clinical gastroenterology 20080901
Title: Hepatoprotective effect of Ginkgoselect Phytosome in rifampicin induced liver injury in rats: evidence of antioxidant activity.
Journal: Fitoterapia 20080901
Title: The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901
Title: Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080901
Title: Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.
Journal: Cancer research 20080815
Title: Effect of silymarin supplement on the pharmacokinetics of rosuvastatin.
Journal: Pharmaceutical research 20080801
Title: Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080801
Title: Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line.
Journal: Cell biology international 20080801
Title: Synergistic antibacterial effect between silybin and N,N'-dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates.
Journal: Journal of microbiology (Seoul, Korea) 20080801
Title: The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: a comparison with desferrioxamine.
Journal: European journal of pharmacology 20080728
Title: Effect of silymarin on metabolic factors of food-restricted over conditioned Wistar rats.
Journal: Pakistan journal of biological sciences : PJBS 20080715
Title: Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.
Journal: Cancer chemotherapy and pharmacology 20080701
Title: Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats.
Journal: Journal of viral hepatitis 20080701
Title: Hepatoprotective and antioxidant activity of methanol extract of Ficus glomerata.
Journal: Journal of natural medicines 20080701
Title: Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
Journal: International journal of cancer 20080701
Title: Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701
Title: Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro.
Journal: Pakistan journal of pharmaceutical sciences 20080701
Title: Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells.
Journal: Journal of pharmacological sciences 20080701
Title: Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.
Journal: Molecular cancer therapeutics 20080701
Title: [Regulatory effect of bushen jianpi recipe on cellular immunity of patients with primary liver cancer after intervention therapy].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080701
Title: Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride.
Journal: World journal of gastroenterology 20080621
Title: Milk thistle extracts inhibit the oxidation of low-density lipoprotein (LDL) and subsequent scavenger receptor-dependent monocyte adhesion.
Journal: Journal of agricultural and food chemistry 20080611
Title: The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants.
Journal: International journal of food sciences and nutrition 20080601
Title: Silymarin in the treatment of patients with primary sclerosing cholangitis: an open-label pilot study.
Journal: Digestive diseases and sciences 20080601
Title: Effects of carvacrol on defects of ischemia-reperfusion in the rat liver.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080601
Title: Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.
Journal: Molecular and cellular biochemistry 20080601
Title: Hepatoprotective effect of Pergularia daemia (Forsk.) ethanol extract and its fraction.
Journal: Indian journal of experimental biology 20080601
Title: Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes.
Journal: Life sciences 20080523
Title: Pretreatment of milk thistle seed to increase the silymarin yield: an alternative to petroleum ether defatting.
Journal: Bioresource technology 20080501
Title: Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin.
Journal: Biochimica et biophysica acta 20080501
Title: Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury.
Journal: The Journal of surgical research 20080401
Title: Assessment of drug-drug interaction for silymarin.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080401
Title: Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.
Journal: European journal of cancer (Oxford, England : 1990) 20080401
Title: Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach.
Journal: Archives of pharmacal research 20080401
Title: Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice.
Journal: Cancer research 20080315
Title: Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.
Journal: Cancer research 20080315
Title: Beneficial drugs for liver diseases.
Journal: Journal of applied toxicology : JAT 20080301
Title: Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080301
Title: Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301
Title: Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation.
Journal: Journal of cosmetic dermatology 20080301
Title: Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury.
Journal: Journal of ethnopharmacology 20080212
Title: Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study.
Journal: The journal of physical chemistry. A 20080207
Title: Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201
Title: Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial.
Journal: Hepatology (Baltimore, Md.) 20080201
Title: Separation and determination of flavonoids using microemulsion EKC with electrochemical detection.
Journal: Electrophoresis 20080201
Title: In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating.
Journal: Planta medica 20080201
Title: What's in a name?
Journal: Canadian family physician Medecin de famille canadien 20080201
Title: An updated systematic review with meta-analysis for the clinical evidence of silymarin.
Journal: Forschende Komplementarmedizin (2006) 20080201
Title: New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum.
Journal: Journal of chromatographic science 20080201
Title: Development of a differential pulse voltammetric method for the determination of Silymarin/Vitamin E acetate mixture in pharmaceuticals.
Journal: Talanta 20080115
Title: Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves.
Journal: Journal of ethnopharmacology 20080104
Title: Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats.
Journal: Phytotherapy research : PTR 20080101
Title: Cell cycle control as a basis for cancer chemoprevention through dietary agents.
Journal: Frontiers in bioscience : a journal and virtual library 20080101
Title: Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080101
Title: Preparation and properties of a silybin-phospholipid complex.
Journal: Die Pharmazie 20080101
Title: Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats.
Journal: International urology and nephrology 20080101
Title: Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice.
Journal: The American journal of Chinese medicine 20080101
Title: Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells.
Journal: Anticancer research 20080101
Title: Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats.
Journal: Indian journal of experimental biology 20080101
Title: [Influence of silymarin and doxorubicin on the myocardial function in rats].
Journal: Medicinski pregled 20080101
Title: Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats.
Journal: Journal of basic and clinical physiology and pharmacology 20080101
Title: Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice.
Journal: International immunopharmacology 20071215
Title: Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
Journal: Carcinogenesis 20071201
Title: Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice.
Journal: Molecular cancer therapeutics 20071201
Title: Effect of silimarin, succinic acid, and their combination on bioenergetics of the brain in experimental encephalopathy.
Journal: Bulletin of experimental biology and medicine 20071201
Title: Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application.
Journal: Journal of pharmaceutical and biomedical analysis 20071130
Title: Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
Journal: Cancer research 20071115
Title: Silymarin and epithelial cancer chemoprevention: how close we are to bedside?
Journal: Toxicology and applied pharmacology 20071101
Title: Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury.
Journal: Burns : journal of the International Society for Burn Injuries 20071101
Title: Silybin is metabolized by cytochrome P450 2C8 in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101
Title: Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.
Journal: The Journal of surgical research 20071101
Title: The effect of silymarin on oral nifedipine pharmacokinetics.
Journal: Planta medica 20071101
Title: Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.
Journal: The Journal of pharmacy and pharmacology 20071101
Title: Effects and mechanisms of silibinin on human hepatoma cell lines.
Journal: World journal of gastroenterology 20071028
Title: Differential effects of quercetin and silymarin on arsenite-induced cytotoxicity in two human breast adenocarcinoma cell lines.
Journal: Life sciences 20071013
Title: Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice.
Journal: Environmental toxicology 20071001
Title: Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs.
Journal: Journal of veterinary pharmacology and therapeutics 20071001
Title: Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation.
Journal: Basic & clinical pharmacology & toxicology 20071001
Title: p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.
Journal: Molecular cancer therapeutics 20071001
Title: Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Journal: Archives of pharmacal research 20071001
Title: Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070901
Title: Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
Journal: Annals of emergency medicine 20070901
Title: Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms.
Journal: Acta pharmacologica Sinica 20070901
Title: Effects of silibinin hemisuccinate on the intraocular pressure in normotensive rabbits.
Journal: Saudi medical journal 20070901
Title: Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.
Journal: Cancer research 20070901
Title: Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes.
Journal: Journal of medicinal food 20070901
Title: Renal and hepatic injury with elevated cardiac enzymes in Amanita phalloides poisoning: a case report.
Journal: Human & experimental toxicology 20070901
Title: Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells.
Journal: Journal of cancer research and clinical oncology 20070801
Title: Therapeutic value of orally administered silibinin in renal cell carcinoma: manipulation of insulin-like growth factor binding protein-3 levels.
Journal: BJU international 20070801
Title: Preparation and characterization of solid lipid nanoparticles containing silibinin.
Journal: Drug delivery 20070801
Title: Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.
Journal: Carcinogenesis 20070701
Title: Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.
Journal: Carcinogenesis 20070701
Title: Protective effect of silymarin on erythrocyte haemolysate against benzo(a)pyrene and exogenous reactive oxygen species (H2O2) induced oxidative stress.
Journal: Chemosphere 20070701
Title: Hypolipidemic effects of silymarin are not mediated by the peroxisome proliferator-activated receptor alpha.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070701
Title: Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus.
Journal: Bulletin of experimental biology and medicine 20070701
Title: Effect of silymarin on pyrogallol- and rifampicin-induced hepatotoxicity in mouse.
Journal: European journal of pharmacology 20070622
Title: Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy.
Journal: Journal of biotechnology 20070615
Title: Effects of the plant flavonoids silymarin and quercetin on arsenite-induced oxidative stress in CHO-K1 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070601
Title: Iron chelation or anti-oxidants prevent renal cell damage in the rewarming phase after normoxic, but not hypoxic cold incubation.
Journal: Cryobiology 20070601
Title: Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent.
Journal: Acta pharmacologica Sinica 20070601
Title: Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes.
Journal: Basic & clinical pharmacology & toxicology 20070601
Title: Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy.
Journal: Integrative cancer therapies 20070601
Title: Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice.
Journal: Journal of ethnopharmacology 20070504
Title: Silymarin synthesis and degradation by peroxidases of cell suspension cultures of Silybum marianum.
Journal: Journal of plant physiology 20070501
Title: Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2.
Journal: Carcinogenesis 20070501
Title: Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070501
Title: Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells.
Journal: International journal of cancer 20070501
Title: Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice.
Journal: Journal of ethnopharmacology 20070420
Title: Simultaneous determination of lithospermic acid B and its three metabolites by liquid chromatography/tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20070411
Title: Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats.
Journal: European journal of pharmacology 20070410
Title: Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites.
Journal: Journal of agricultural and food chemistry 20070404
Title: Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070401
Title: A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients.
Journal: Investigational new drugs 20070401
Title: Herbal medicine in the treatment of liver diseases.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070401
Title: Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20070401
Title: Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.
Journal: Cancer research 20070401
Title: An updated systematic review of the pharmacology of silymarin.
Journal: Forschende Komplementarmedizin (2006) 20070401
Title: [Amatoxin poisoning due to soup from personally picked deathcap mushrooms (Amanita phalloides)].
Journal: Nederlands tijdschrift voor geneeskunde 20070331
Title: Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells.
Journal: Biochemical and biophysical research communications 20070302
Title: Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Journal: Experimental oncology 20070301
Title: [Protective effect of silibinin against isoproterenol-induced injury to cardiac myocytes and its mechanism].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070301
Title: Protective effect of silymarin on oxidative stress in rat brain.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20070201
Title: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Journal: Carcinogenesis 20070201
Title: Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells.
Journal: Journal of cellular physiology 20070201
Title: Influence of silybin on biophysical properties of phospholipid bilayers.
Journal: Acta pharmacologica Sinica 20070201
Title: Silibinin inhibits renal cell carcinoma via mechanisms that are independent of insulin-like growth factor-binding protein 3.
Journal: BJU international 20070201
Title: Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats.
Journal: Journal of ethnopharmacology 20070119
Title: Formulation and biopharmaceutical evaluation of silymarin using SMEDDS.
Journal: Archives of pharmacal research 20070101
Title: [Effects of silymarin and its combination with succinic acid on brain bioenergetics in rats with experimental inhibition of beta-oxidation of fatty acids].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20070101
Title: (+)-Silybin, a pharmacologically active constituent of Silybum marianum: fragmentation studies by atmospheric pressure chemical ionization quadrupole time-of-flight tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers.
Journal: Drug metabolism and drug interactions 20070101
Title: Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats.
Journal: TheScientificWorldJournal 20070101
Title: The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perfused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Title: Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats.
Journal: The American journal of Chinese medicine 20070101
Title: Restoration of histoarchitecture in the paracetamol-induced liver damaged rat by earthworm extract, Lampito mauritii (Kinberg).
Journal: European review for medical and pharmacological sciences 20070101
Title: Expression of osteoblast marker genes in rat calvarial osteoblast-like cells, and effects of the endocrine disrupters diphenylolpropane, benzophenone-3, resveratrol and silymarin.
Journal: Chemico-biological interactions 20061215
Title: Silymarin and its components scavenge phenylglyoxylic ketyl radicals.
Journal: Fitoterapia 20061201
Title: Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.
Journal: Burns : journal of the International Society for Burn Injuries 20061201
Title: Endocrine disruptors and rat adrenocortical function: studies on freshly dispersed and cultured cells.
Journal: International journal of molecular medicine 20061201
Title: Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1.
Journal: Journal of pharmacological sciences 20061201
Title: [Influence factors on the entrapment of drugs in a novel proliposomes].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061201
Title: Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicity in rats.
Journal: Journal of biochemistry and molecular biology 20061130
Title: Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Journal: Carcinogenesis 20061101
Title: New therapies in hepatitis C virus and chronic liver disease: antifibrotics.
Journal: Clinics in liver disease 20061101
Title: Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
Journal: The Indian journal of medical research 20061101
Title: The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury.
Journal: Journal of ethnopharmacology 20061011
Title: Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells.
Journal: International journal of molecular medicine 20061001
Title: Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A.
Journal: Biochemistry. Biokhimiia 20061001
Title: Protective effects of silymarin, a milk thistle (Silybium marianum) derivative on ethanol-induced oxidative stress in liver.
Journal: Indian journal of biochemistry & biophysics 20061001
Title: Anti-fibrotic effects of tetrandrine on bile-duct ligated rats.
Journal: Canadian journal of physiology and pharmacology 20061001
Title: [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats].
Journal: Zhonghua yi xue za zhi 20060926
Title: Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements.
Journal: Carcinogenesis 20060901
Title: Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle.
Journal: Biological & pharmaceutical bulletin 20060901
Title: Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3'-di(beta-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots on CCl4-induced liver damage.
Journal: Free radical research 20060901
Title: Purification and characterization of a 43 kD hepatoprotective protein from the herb Cajanus indicus L.
Journal: The protein journal 20060901
Title: Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance.
Journal: International journal of pharmaceutics 20060817
Title: Effects of silymarin on the proliferation and glutathione levels of peripheral blood mononuclear cells from beta-thalassemia major patients.
Journal: International immunopharmacology 20060801
Title: Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice.
Journal: Molecular cancer therapeutics 20060801
Title: Synthesis and antioxidant evaluation of novel silybin analogues.
Journal: Journal of enzyme inhibition and medicinal chemistry 20060801
Title: Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.
Journal: Cancer letters 20060708
Title: Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20060701
Title: Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060701
Title: Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice.
Journal: Molecular cancer therapeutics 20060701
Title: Hepatoprotective studies on Hedyotis corymbosa (L.) Lam.
Journal: Journal of ethnopharmacology 20060630
Title: Effect of silibinin on the growth and progression of primary lung tumors in mice.
Journal: Journal of the National Cancer Institute 20060621
Title: Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats.
Journal: Chemico-biological interactions 20060610
Title: Prostate cancer chemoprevention by silibinin: bench to bedside.
Journal: Molecular carcinogenesis 20060601
Title: Silibinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway.
Journal: Biological & pharmaceutical bulletin 20060601
Title: Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.
Journal: Journal of chromatography. A 20060526
Title: Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060501
Title: Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells.
Journal: Molecular cancer therapeutics 20060501
Title: Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization.
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060501
Title: Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Journal: Pakistan journal of pharmaceutical sciences 20060401
Title: The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060301
Title: Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway.
Journal: Journal of dental research 20060301
Title: Silymarin protects against acute ethanol-induced hepatotoxicity in mice.
Journal: Alcoholism, clinical and experimental research 20060301
Title: Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.
Journal: Cell biology and toxicology 20060301
Title: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn.
Journal: Journal of ethnopharmacology 20060220
Title: Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
Journal: Oncogene 20060216
Title: Determination of DPPH free radical scavenging activity by reversed-phase HPLC: a sensitive screening method for polyherbal formulations.
Journal: Journal of pharmaceutical and biomedical analysis 20060213
Title: Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation.
Journal: International journal of pharmaceutics 20060203
Title: Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats.
Journal: Pharmacological research 20060201
Title: Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats.
Journal: Fitoterapia 20060201
Title: The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis.
Journal: International immunopharmacology 20060201
Title: Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats.
Journal: Life sciences 20060111
Title: The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats.
Journal: International journal of pharmaceutics 20060103
Title: In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide.
Journal: Acta tropica 20060101
Title: Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060101
Title: Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C.
Journal: Journal of gastroenterology and hepatology 20060101
Title: [Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
Journal: Recenti progressi in medicina 20060101
Title: Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.
Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20060101
Title: Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.
Journal: Current medicinal chemistry 20060101
Title: Proinflammatory cytokine-induced NF-kappaB activation in human mesangial cells is mediated through intracellular calcium but not ROS: effects of silymarin.
Journal: Nephron. Experimental nephrology 20060101
Title: Anticancer potential of silymarin: from bench to bed side.
Journal: Anticancer research 20060101
Title: [The role of small molecules in regulation of activity of cytoplasmatic dehydrogenases].
Journal: Biomeditsinskaia khimiia 20060101
Title: Evaluation of silymarin in the treatment on asymptomatic Giardia infections in dogs.
Journal: Parasitology research 20051201
Title: Silibinin efficacy against human hepatocellular carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051201
Title: Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Journal: Neoplasia (New York, N.Y.) 20051201
Title: Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Archives of pharmacal research 20051201
Title: Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.
Journal: Toxicology 20051105
Title: Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20051101
Title: [Effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparticles].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101
Title: Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways.
Journal: Chemico-biological interactions 20051020
Title: Protective effects of silybin on human umbilical vein endothelial cell injury induced by H2O2 in vitro.
Journal: Vascular pharmacology 20051001
Title: Herbal medicines for liver diseases.
Journal: Digestive diseases and sciences 20051001
Title: Enhanced silymarin accumulation is related to calcium deprivation in cell suspension cultures of Silybum marianum (L.) Gaertn.
Journal: Journal of plant physiology 20051001
Title: [Progress in research of aldose reductase inhibitors in traditional medicinal herbs].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001
Title: Yeast extract and methyl jasmonate-induced silymarin production in cell cultures of Silybum marianum (L.) Gaertn.
Journal: Journal of biotechnology 20050922
Title: Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation.
Journal: The Journal of surgical research 20050901
Title: Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20050901
Title: A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
Journal: Alternative medicine review : a journal of clinical therapeutic 20050901
Title: Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.
Journal: Life sciences 20050826
Title: Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin.
Journal: Carcinogenesis 20050801
Title: Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).
Journal: Carcinogenesis 20050801
Title: Non-interferon-based therapy: an option for amelioration of necro-inflammation in hepatitis C patients who cannot afford interferon therapy.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20050801
Title: Iron and iron chelating agents modulate Mycobacterium tuberculosis growth and monocyte-macrophage viability and effector functions.
Journal: FEMS immunology and medical microbiology 20050801
Title: Two-year results of a randomised double-blinded trial evaluating silymarin for chronic hepatitis C.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20050701
Title: Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050701
Title: Inhibition of P-glycoprotein by natural products in human breast cancer cells.
Journal: Archives of pharmacal research 20050701
Title: [Preparation of silybin-phospholipid complex and its bioavailability in rats].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050701
Title: Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide.
Journal: Life sciences 20050624
Title: Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate B in beagle dog serum.
Journal: Journal of pharmaceutical and biomedical analysis 20050601
Title: [Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study].
Journal: Minerva gastroenterologica e dietologica 20050601
Title: The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin.
Journal: Chinese journal of integrative medicine 20050601
Title: Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.
Journal: The Journal of biological chemistry 20050527
Title: Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells.
Journal: The Prostate 20050501
Title: Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.
Journal: Basic & clinical pharmacology & toxicology 20050501
Title: Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050501
Title: Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP.
Journal: Biochemical pharmacology 20050401
Title: Alcohol and liver cancer.
Journal: Alcohol (Fayetteville, N.Y.) 20050401
Title: Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis.
Journal: World journal of gastroenterology 20050227
Title: Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimens.
Journal: European journal of medical research 20050227
Title: Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy.
Journal: Oncogene 20050210
Title: Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation.
Journal: Molecular cancer therapeutics 20050201
Title: Treatment of patients with alcoholic liver disease.
Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20050201
Title: Amelioration of lead toxicity on rat liver with Vitamin C and silymarin supplements.
Journal: Toxicology 20050105
Title: Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review).
Journal: International journal of oncology 20050101
Title: Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
Journal: Medical hypotheses 20050101
Title: Metal-induced oxidative damage in cultured hepatocytes and hepatic lysosomal fraction: beneficial effect of a curcumin/absinthium compound.
Journal: Chinese journal of digestive diseases 20050101
Title: Effect of Asteracantha longifolia Nees. against CCl4 induced liver dysfunction in rat.
Journal: Indian journal of experimental biology 20050101
Title: [Freeze-drying of silymarin-loaded solid lipid nanoparticles (SM-SLN)].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101
Title: Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes.
Journal: Journal of biochemical and molecular toxicology 20050101
Title: Influence of silymarin administration on hepatic glutathione-conjugating enzyme system in rats treated with antitubercular drugs.
Journal: Drugs in R&D 20050101
Title: Comparative study of different silymarin formulations: formulation, characterisation and in vitro/in vivo evaluation.
Journal: Current drug delivery 20050101
Title: Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years.
Journal: Roczniki Akademii Medycznej w Bialymstoku (1995) 20050101
Title: Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
Title: Protective efficacy and the recovery profile of certain chemoprotectants against lethal poisoning by microcystin-LR in mice.
Journal: Toxicon : official journal of the International Society on Toxinology 20041201
Title: A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer.
Journal: Mutation research 20041102
Title: Oxidised derivatives of silybin and their antiradical and antioxidant activity.
Journal: Bioorganic & medicinal chemistry 20041101
Title: Use of herbal supplements for chronic liver disease.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20041101
Title: Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks.
Journal: Poultry science 20041101
Title: Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20041101
Title: Silymarin induces recovery of pancreatic function after alloxan damage in rats.
Journal: Life sciences 20040917
Title: Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Journal: Carcinogenesis 20040901
Title: Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Journal: Cancer research 20040901
Title: Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.
Journal: Carcinogenesis 20040801
Title: Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040801
Title: Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats.
Journal: Pharmacological research 20040801
Title: [Antioxidants in liver protection].
Journal: Orvosi hetilap 20040704
Title: Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
Journal: Molecular carcinogenesis 20040701
Title: Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows.
Journal: Journal of dairy science 20040701
Title: Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601
Title: Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity.
Journal: Pharmacological research 20040501
Title: Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells.
Journal: The Journal of urology 20040501
Title: Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells.
Journal: Planta medica 20040501
Title: [Silybum marianum in vitro].
Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040501
Title: Silymarin, a possible hepatoprotector in dairy cows: biochemical and histological observations.
Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20040301
Title: Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells.
Journal: Oncology reports 20040201
Title: Effects of silymarin and vitamins E and C on liver damage induced by prolonged biliary obstruction in the rat.
Journal: Basic & clinical pharmacology & toxicology 20040201
Title: Prostate cancer prevention by silibinin.
Journal: Current cancer drug targets 20040201
Title: Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.
Journal: Phytotherapy research : PTR 20040201
Title: Effect of silybin on phorbol myristate actetate-induced protein kinase C translocation, NADPH oxidase activity and apoptosis in human neutrophils.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20040201
Title: Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes.
Journal: Carcinogenesis 20040101
Title: Involvement of NF-kappaB and caspases in silibinin-induced apoptosis of endothelial cells.
Journal: International journal of molecular medicine 20040101
Title: Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin.
Journal: Biochemical pharmacology 20040101
Title: Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.
Journal: Journal of applied toxicology : JAT 20040101
Title: Anti-oxidant activities of Acanthopanax senticosus stems and their lignan components.
Journal: Archives of pharmacal research 20040101
Title: The effects of ethanol and silymarin treatment during gestation on spatial working memory.
Journal: BMC complementary and alternative medicine 20040101
Title: Study on the influence of silymarin pretreatment on metabolism and disposition of metronidazole.
Journal: Arzneimittel-Forschung 20040101
Title: Silymarin extraction from milk thistle using hot water.
Journal: Applied biochemistry and biotechnology 20040101
Title: [Investigation of the hepatoprotector action of natural flavonoids].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20040101
Title: [Effect of the phytohepatoprotective agent maxar on the hepatic morphofunctional status in patients with chronic hepatitis].
Journal: Klinicheskaia meditsina 20040101
Title: [The role of stomach epithelial cells being immunopositive for NO synthase in the formation of chronic cholecystitis].
Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20040101
Title: Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
Journal: Biochemical and biophysical research communications 20031226
Title: Comparative bioavailability of silibinin in healthy male volunteers.
Journal: International journal of clinical pharmacology and therapeutics 20031201
Title: Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine.
Journal: Human & experimental toxicology 20031201
Title: Effects of flavonoids on the resistance of microsomes to lipid peroxidation in vitro and ex vivo.
Journal: Bulletin of experimental biology and medicine 20031201
Title: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Journal: Oncogene 20031113
Title: [Amanita poisoning during pregnancy].
Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20031101
Title: Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20031101
Title: Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons.
Journal: Journal of clinical gastroenterology 20031001
Title: Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Journal: Toxicology 20030930
Title: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death.
Journal: International journal of cancer 20030920
Title: Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905
Title: Silibinin protects mice from T cell-dependent liver injury.
Journal: Journal of hepatology 20030901
Title: Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030901
Title: Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa.
Journal: Archives of pharmacal research 20030901
Title: [The effects of silymarin on hepatic microsomal and mitochondrial membrane fluidity in mice].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030901
Title: Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats.
Journal: Toxicology 20030828
Title: Combined amiodarone and silymarin treatment, but not amiodarone alone, prevents sustained atrial flutter in dogs.
Journal: Journal of cardiovascular electrophysiology 20030801
Title: Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells.
Journal: Pharmaceutical research 20030801
Title: Gram-positive bacteria specific properties of silybin derived from Silybum marianum.
Journal: Archives of pharmacal research 20030801
Title: Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats.
Journal: The Journal of steroid biochemistry and molecular biology 20030801
Title: Preventive effect of silymarin against taurolithocholate-induced cholestasis in the rat.
Journal: Biochemical pharmacology 20030715
Title: Coadministration of milk thistle and indinavir in healthy subjects.
Journal: Pharmacotherapy 20030701
Title: Anti-angiogenic effect of silymarin on colon cancer LoVo cell line.
Journal: The Journal of surgical research 20030701
Title: Plasma lipoproteins in transport of silibinin, an antioxidant flavonolignan from Silybum marianum.
Journal: Phytotherapy research : PTR 20030501
Title: Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport.
Journal: The Journal of pharmacology and experimental therapeutics 20030301
Title: Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system.
Journal: Die Pharmazie 20030301
Title: Protective mechanism of salvia miltiorrhiza on carbon tetrachloride-induced acute hepatotoxicity in rats.
Journal: Journal of pharmacological sciences 20030301
Title: Effects of polyphenolic fraction of silymarin on lipoprotein profile in rats fed cholesterol-rich diets.
Journal: Pharmacological research 20030101
Title: Extraction of nutraceuticals from milk thistle: I. Hot water extraction.
Journal: Applied biochemistry and biotechnology 20030101
Title: Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents.
Journal: Applied biochemistry and biotechnology 20030101
Title: [St. Mary's Thistle: an overview].
Journal: Journal de pharmacie de Belgique 20030101
Title: Traditional Chinese medicine prevents inflammation in CCl4-related liver injury in mice.
Journal: The American journal of Chinese medicine 20030101
Title: Preparation and pharmacological evaluation of silibinin liposomes.
Journal: Arzneimittel-Forschung 20030101
Title: Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells.
Journal: Anticancer research 20030101
Title: Primary human hepatocytes are protected against prolonged and repeated exposure to ethanol by silibinin-dihemisuccinate.
Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20030101
Title: Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line.
Journal: Cancer biology & therapy 20030101
Title: Silibinin: a thorny therapeutic for EGF-R expressing tumors?
Journal: Cancer biology & therapy 20030101
Title: Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity.
Journal: Therapie 20030101
Title: [Hepatoprotective effects of silymarin in androgenic-anabolic steroid-induced liver damage].
Journal: Medicinski pregled 20030101
Title: Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin.
Journal: International journal of oncology 20021201
Title: Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation.
Journal: The European journal of neuroscience 20021201
Title: Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells.
Journal: The Prostate 20021101
Title: Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.
Journal: Phytotherapy research : PTR 20021101
Title: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021101
Title: Pyrogallol-induced hepatotoxicity in rats: a model to evaluate antioxidant hepatoprotective agents.
Journal: Methods and findings in experimental and clinical pharmacology 20021001
Title: Management of nonalcoholic steatohepatitis: an analytic review.
Journal: Journal of clinical gastroenterology 20020901
Title: Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: I induction of transforming growth factor beta1 and c-myc in liver with marginal effects on other genes.
Journal: Planta medica 20020801
Title: Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent.
Journal: Diabetes, nutrition & metabolism 20020801
Title: Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages.
Journal: The Journal of pharmacology and experimental therapeutics 20020701
Title: Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels.
Journal: Cancer research 20020601
Title: Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.
Journal: Planta medica 20020601
Title: Pharmacologically active ellagitannins from Terminalia myriocarpa.
Journal: Planta medica 20020601
Title: [Fatal Lepiota brunneoincarnata poisoning].
Journal: Anales de medicina interna (Madrid, Spain : 1984) 20020601
Title: Radioprotective effect of silymarin against radiation induced hepatotoxicity.
Journal: Pharmacological research 20020601
Title: Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers.
Journal: Pharmacotherapy 20020501
Title: Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Journal: Carcinogenesis 20020501
Title: Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo.
Journal: Pharmacology & toxicology 20020501
Title: Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention.
Journal: Molecular cancer therapeutics 20020501
Title: Botanical antioxidants for chemoprevention of photocarcinogenesis.
Journal: Frontiers in bioscience : a journal and virtual library 20020401
Title: [Serious mushroom poisoning by Cortinarius and Amanita virosa].
Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020320
Title: Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis.
Journal: Oncogene 20020307
Title: Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis.
Journal: Carcinogenesis 20020301
Title: Antioxidant properties of silybin glycosides.
Journal: Phytotherapy research : PTR 20020301
Title: Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on alpha-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats.
Journal: Phytotherapy research : PTR 20020301
Title: Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin.
Journal: Phytotherapy research : PTR 20020301
Title: Extrahepatic biliary obstruction: can silymarin protect liver function?
Journal: Phytotherapy research : PTR 20020301
Title: Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs.
Journal: European journal of pharmacology 20020215
Title: Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin.
Journal: Journal of bioenergetics and biomembranes 20020201
Title: Effects of silymarin MZ-80 on hepatic oxidative stress in rats with biliary obstruction.
Journal: Pharmacology 20020101
Title: Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice.
Journal: Japanese journal of cancer research : Gann 20020101
Title: Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis. Results of a randomized, double-blind, placebo-controlled clinical study.
Journal: International journal of clinical pharmacology and therapeutics 20020101
Title: Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin.
Journal: BMC complementary and alternative medicine 20020101
Title: The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.
Journal: Cell cycle (Georgetown, Tex.) 20020101
Title: [Hepatoprotective effects of gamma-L-glutamylhistamine].
Journal: Voprosy meditsinskoi khimii 20020101
Title: [Use of ursodeoxycholic acid combined with silymarin in the treatment of chronic ethyl-toxic hepatopathy].
Journal: La Clinica terapeutica 20020101
Title: The evaluation of reno- and hepatoprotective effects of huai-shan-yao (Rhizome Dioscoreae).
Journal: The American journal of Chinese medicine 20020101
Title: [Chronic liver diseases. The nihilism has gone].
Journal: MMW Fortschritte der Medizin 20011213
Title: Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Planta medica 20011101
Title: Hepatoprotective activity of Trichilia roka on carbon tetrachloride-induced liver damage in rats.
Journal: The Journal of pharmacy and pharmacology 20011101
Title: Effect of silibinin and vitamin E on restoration of cellular immune response after partial hepatectomy.
Journal: Journal of ethnopharmacology 20011001
Title: The in vitro effect of Helichrysi flos on microsomal lipid peroxidation.
Journal: Journal of ethnopharmacology 20010901
Title: Pharmacokinetic study of iodine-labeled silibinins in rat.
Journal: Pharmacological research 20010901
Title: Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP.
Journal: Carcinogenesis 20010901
Title: Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil.
Journal: Transplantation proceedings 20010901
Title: Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets.
Journal: Hepatology (Baltimore, Md.) 20010801
Title: Hepatoprotective activity of Luffa echinata fruits.
Journal: Journal of ethnopharmacology 20010701
Title: Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C.
Journal: Biochemical pharmacology 20010615
Title: Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin.
Journal: Phytotherapy research : PTR 20010601
Title: Silybin, a new iron-chelating agent.
Journal: Journal of inorganic biochemistry 20010601
Title: Oxidative insult to human red blood cells induced by free radical initiator AAPH and its inhibition by a commercial antioxidant mixture.
Journal: Life sciences 20010525
Title: Evaluation of hepatoprotective activity of legumes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010501
Title: Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells.
Journal: Molecular carcinogenesis 20010401
Title: Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells.
Journal: The Prostate 20010201
Title: Clinical studies with silymarin: fibrosis progression is the end point.
Journal: Hepatology (Baltimore, Md.) 20010201
Title: Restoration of the cellular thiol status of peritoneal macrophages from CAPD patients by the flavonoids silibinin and silymarin.
Journal: Free radical research 20010201
Title: Effects of silymarin on the acute stage of the trinitrobenzenesulphonic acid model of rat colitis.
Journal: Planta medica 20010201
Title: Antioxidants in chemoprevention of skin cancer.
Journal: Current problems in dermatology 20010101
Title: Dissolution test for silymarin tablets and capsules.
Journal: Drug development and industrial pharmacy 20010101
Title: Silymarin: a review of its clinical properties in the management of hepatic disorders.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20010101
Title: [Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride].
Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101
Title: Silymarin and vitamin E do not attenuate and vitamin E might even enhance the antiarrhythmic activity of amiodarone in a rat reperfusion arrhythmia model.
Journal: Cardiovascular drugs and therapy 20010101
Title: The use of silymarin in the treatment of liver diseases.
Journal: Drugs 20010101
Title: Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells.
Journal: Nutrition and cancer 20010101
Title: Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin.
Journal: Carcinogenesis 20000401
Title: Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.
Journal: The Journal of pharmacology and experimental therapeutics 19990901
Title: Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats.
Journal: Hepatology (Baltimore, Md.) 19970901
Title: Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1.
Journal: Chemico-biological interactions 19940401
Title: [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion].
Journal: Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology 19861001
Title: Characterization of a transporting system in rat hepatocytes. Studies with competitive and non-competitive inhibitors of phalloidin transport.
Journal: Biochimica et biophysica acta 19860807
Title: An-Shen Lin, et al. Cancer Preventive Agents. 7. Antitumor-Promoting Effects of Seven Active Flavonolignans from Milk Thistle (Silybum marianum.) on Epstein-Barr Virus Activation, Pharmaceutical Biology, 45:10, 735-738.
Title: Sciacca MFM, et al. Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry. ACS Chem Neurosci. 2017 Aug 16;8(8):1767-1778.
