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142878-12-4,MFCD00211221
Catalog No.:AA007KHZ

142878-12-4 | U-73343

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007KHZ
Chemical Name:
U-73343
CAS Number:
142878-12-4
Molecular Formula:
C29H42N2O3
Molecular Weight:
466.6554
MDL Number:
MFCD00211221
SMILES:
COc1ccc2c(c1)CCC1C2CCC2(C1CCC2NCCCCCCN1C(=O)CCC1=O)C
Properties
Computed Properties
 
Complexity:
725  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
3.6  

Literature

Title: Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

Journal: International journal of molecular sciences 20150101

Title: Regulation of hippocampal long-term potentiation and long-term depression by diacylglycerol kinase ζ.

Journal: Hippocampus 20120501

Title: Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.

Journal: Biochimica et biophysica acta 20120201

Title: The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida.

Journal: Asian journal of andrology 20110101

Title: Contribution of the inositol 1,4,5-trisphosphate transduction cascade to the detection of 'bitter' compounds in blowflies.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20090701

Title: Characterization of phospholipases C beta and gamma and their possible roles in Chaetopterus egg activation.

Journal: Molecular reproduction and development 20090501

Title: UVA-induced calcium oscillations in rat mast cells.

Journal: Cell calcium 20090101

Title: Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT.

Journal: Journal of neurochemistry 20090101

Title: Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators.

Journal: Pflugers Archiv : European journal of physiology 20081001

Title: Muscarinic M(1) modulation of N and L types of calcium channels is mediated by protein kinase C in neostriatal neurons.

Journal: Neuroscience 20080909

Title: Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.

Journal: American journal of physiology. Heart and circulatory physiology 20080801

Title: Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1.

Journal: Molecular and cellular neurosciences 20070401

Title: Effects of pilocarpine on the secretory acinar cells in human submandibular glands.

Journal: Life sciences 20061125

Title: Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability.

Journal: The Journal of physiology 20060415

Title: Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20060101

Title: Nonylphenol-induced Ca2+ elevation and Ca2+-independent cell death in human osteosarcoma cells.

Journal: Toxicology letters 20051230

Title: Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line.

Journal: Biochimica et biophysica acta 20051115

Title: Endothelial cell calpain activity facilitates lymphocyte diapedesis.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051101

Title: The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions.

Journal: Plant physiology 20051101

Title: Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.

Journal: Neuropharmacology 20050601

Title: Involvement of phospholipase C and intracellular calcium signaling in the gonadotropin-releasing hormone regulation of prolactin release from lactotrophs of tilapia (Oreochromis mossambicus).

Journal: General and comparative endocrinology 20050515

Title: Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.

Journal: European journal of pharmacology 20050509

Title: Src homology domains in phospholipase C-gamma1 mediate its anti-apoptotic action through regulating the enzymatic activity.

Journal: Journal of neurochemistry 20050501

Title: Inhibition of phospholipase C-independent exocytotic responses in rat peritoneal mast cells by U73122.

Journal: Regulatory peptides 20050215

Title: Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis.

Journal: Neuropharmacology 20050101

Title: Anatomical and functional evidence for a role of arginine-vasopressin (AVP) in rat olfactory epithelium cells.

Journal: The European journal of neuroscience 20040801

Title: Phospholipase C involvement in activation of the muscarinic receptor-operated cationic current in Guinea pig ileal smooth muscle cells.

Journal: Journal of pharmacological sciences 20040601

Title: Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040101

Title: Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells.

Journal: British journal of pharmacology 20040101

Title: Phospholipase C inhibitors suppress spontaneous mechanical activity of guinea pig urinary bladder smooth muscle.

Journal: Biological & pharmaceutical bulletin 20030801

Title: Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning.

Journal: Developmental biology 20030715

Title: Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.

Journal: Brain research 20030613

Title: Role of cyclooxygenase-1 and -2, phospholipase C, and protein kinase C in prostaglandin-mediated gastroprotection.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Polyamines as olfactory stimuli in the goldfish Carassius auratus.

Journal: The Journal of experimental biology 20030501

Title: Chlorophyll antenna size adjustments by irradiance in Dunaliella salina involve coordinate regulation of chlorophyll a oxygenase (CAO) and Lhcb gene expression.

Journal: Plant molecular biology 20030301

Title: Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells.

Journal: The Journal of biological chemistry 20021108

Title: PGD(2) modulates fibroblast-mediated native collagen gel contraction.

Journal: American journal of respiratory cell and molecular biology 20020901

Title: Mechanisms of bradykinin-induced glucagon release in clonal alpha-cells In-R1-G9: involvement of Ca(2+)-dependent and -independent pathways.

Journal: Molecular and cellular endocrinology 20020628

Title: Protease-activated receptor-2-mediated Ca2+ signaling in guinea pig tracheal epithelial cells.

Journal: Life sciences 20020621

Title: Luminal Ca(2+) and the activity of sarcoplasmic reticulum Ca(2+) pumps modulate histamine-induced all-or-none Ca(2+) release in smooth muscle cells.

Journal: Cellular signalling 20020601

Title: Somatostatin-induced paradoxical increase in intracellular Ca2+ concentration and insulin release in the presence of arginine vasopressin in clonal HIT-T15 beta-cells.

Journal: The Biochemical journal 20020515

Title: Purinergic receptor signaling at the basolateral membrane of macula densa cells.

Journal: Journal of the American Society of Nephrology : JASN 20020501

Title: Phospholipase D contributes to transmural pressure control of prorenin processing in juxtaglomerular cell.

Journal: Hypertension (Dallas, Tex. : 1979) 20020201

Title: Blockade of maitotoxin-induced oncotic cell death reveals zeiosis.

Journal: BMC physiology 20020101

Title: Bradykinin and angiotensin II-induced [Ca2+]i rise in cultured rat pituitary folliculo-stellate cells.

Journal: Journal of neuroendocrinology 20011101

Title: Stimulatory effect of phenylephrine on the secretion of beta-endorphin from rat adrenal medulla in vitro.

Journal: Autonomic neuroscience : basic & clinical 20011008

Title: Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates.

Journal: American journal of respiratory cell and molecular biology 20011001

Title: In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries.

Journal: The Journal of physiology 20010715

Title: Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.

Journal: The Journal of biological chemistry 20010518

Title: U73122 inhibits the dephosphorylation and translocation of cofilin in activated macrophage-like U937 cells.

Journal: Cellular signalling 20010101

Title: Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.

Journal: British journal of pharmacology 20000401

Title: Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor.

Journal: The Journal of biological chemistry 19990924

Title: Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.

Title: A Tatrai, et al. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. Biochim Biophys Acta. 1994 Dec 30;1224(3):575-82.

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Tags:142878-12-4 Molecular Formula|142878-12-4 MDL|142878-12-4 SMILES|142878-12-4 U-73343