Home Other Building Blocks 143257-98-1
143257-98-1,MFCD00865529
Catalog No.:AA009HSN

143257-98-1 | Lerisetron

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$916.00   $642.00
- +
10mg
98%
in stock  
$1,284.00   $899.00
- +
25mg
98%
in stock  
$2,204.00   $1,543.00
- +
50mg
98%
in stock  
$3,491.00   $2,444.00
- +
100mg
98%
in stock  
$5,515.00   $3,860.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009HSN
Chemical Name:
Lerisetron
CAS Number:
143257-98-1
Molecular Formula:
C18H20N4
Molecular Weight:
292.3782
MDL Number:
MFCD00865529
SMILES:
N1CCN(CC1)c1nc2c(n1Cc1ccccc1)cccc2
Properties
Computed Properties
 
Complexity:
349  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.8  

Literature

Title: Pharmacokinetic-pharmacodynamic modeling of the hydroxy lerisetron metabolite L6-OH in rats: an integrated parent-metabolite model.

Journal: Pharmaceutical research 20051101

Title: Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.

Journal: Journal of computer-aided molecular design 20041001

Title: Lerisetron. FAES.

Journal: Current opinion in investigational drugs (London, England : 2000) 20030701

Title: Age-related changes in pharmacokinetics and pharmacodynamics of lerisetron in the rat: a population pharmacokinetic model.

Journal: Gerontology 20030101

Title: Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.

Journal: Bioorganic & medicinal chemistry letters 20020121

Title: Pharmacokinetics and pharmacological effect of lerisetron, a new 5-HT3 antagonist, in rats.

Journal: Journal of pharmaceutical sciences 20020101

Title: Functional group interactions of a 5-HT3R antagonist.

Journal: BMC biochemistry 20020101

Title: Identification of critical residues in loop E in the 5-HT3ASR binding site.

Journal: BMC biochemistry 20020101

Title: Effects of lerisetron, a new 5-HT3 receptor antagonist, on ipecacuanha-induced emesis in healthy volunteers.

Journal: Arzneimittel-Forschung 20020101

Title: 5-HT(3)R binding of lerisetron: an interdisciplinary approach to drug-Receptor interactions.

Journal: Bioorganic & medicinal chemistry letters 20010820

Title: Altered disposition and effect of lerisetron in rats with elevated alpha 1-acid glycoprotein levels.

Journal: Pharmaceutical research 20010601

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SDS
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